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Xenobiotica
the fate of foreign compounds in biological systems
Volume 24, 1994 - Issue 5
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Research Article

Metabolism of 2-ethylhexanol administered orally and dermally to the female Fischer 344 rat

P. J. Deisinger Biochemical Toxicology Section, Toxicological Sciences Laboratory, Corporate Health and Environment Laboratories, Eastman Kodak Company, Rochester, NY, 14652-6272, USA
,
R. J. Boatman Biochemical Toxicology Section, Toxicological Sciences Laboratory, Corporate Health and Environment Laboratories, Eastman Kodak Company, Rochester, NY, 14652-6272, USA
&
D. Guest Biochemical Toxicology Section, Toxicological Sciences Laboratory, Corporate Health and Environment Laboratories, Eastman Kodak Company, Rochester, NY, 14652-6272, USA
Pages 429-440 | Received 05 Aug 1993, Accepted 11 Nov 1993, Published online: 22 Sep 2008

References

  • Albro V. W. The metabolism of 2-FH in rats. Xenobiotica 1975; 5: 625–636
  • Albro P. W., Thomas R. O. Enzymatic hydrolysis of di-(2-ethylhexyl)phthalate by lipases. Biochimica et Biophysica Acta 1973; 360: 380–390
  • Astill B. D., Gingell R., Guest D., Hodgson J. R., Murphy S. R., Tyler T. R., Mellert W., Deckardt K., Gembardt Chr. Subacute and subchronic oral toxicity of 2-ethylhexanol to Fischer 344 rats and B6C3F1 mice. Toxicologist 1993; 13, Abs 172
  • Barber E. D., Teetsel N. M., Kolberg K. F., Guest D. A comparative study of the rates of in vitro percutaneous absorption of eight chemicals using rat and human skin. Fundamental and Applied Toxicology 1992; 19: 493–497
  • Daniel J. W., Bratt H. The absorption, metabolism and tissue distribution of di(2-ethylhexyl) phthalate in rats. Toxicology 1974; 2: 51–65
  • El-Hawari M., Murrill E., Stoltz M., Skalsky H., Guest D. Species differences in the disposition and metabolism of di-(2-ethylhexyl)adipate (DEHA). Toxicologist 1985; 5, Abs 947
  • English J. C., Deisinger P. J., Perry L. G., Guest D. Pharmacokinetic studies with [2-14C-hexyl]2-ethylhexanoic acid (14C-EHA) in the female Fischer 344 rat. Toxicologist 1989; 9, Abs 347
  • Gomeni R. PHARM: An interactive graphic program for individual and population pharmacokinetic parameter estimation. Computers and Biological Medicine 1984; 14: 25–34
  • Guest D., Gingell R., Astill B. D., Hodgson J. R., Murphy S. R., Tyler T. R., Kuettler K., Hellwig J., Mellert W. Oncogenicity testing of 2-ethylhexanol in Fischer 344 rats and B6C3F1 mice. Toxicologist 1993; 13, Abs. 173
  • Rowe V. K., McCollister S. B. Alcohols. Patty's Industrial Hygiene and Toxicology3rd edn, G. D. Clayton, F. E. Clayton. Wiley-Interscience, New York 1982; Vol. 2C: 4620–4624
  • Tyl R. W., Fisher L. C., Kubena M. F., Vrbanic M. A., Gingell R., Guest D., Hodgson J. R., Murphy S. R., Tyler T. R., Astill B. D. The developmental toxicity of 2-ethylhexanol applied dermally to pregnant Fischer 344 rats. Fundamental and Applied Toxicology 1992; 19: 176–185

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