Citations (22)
Keep up to date with the latest research on this topic with citation updates for this article.
Read on this site (3)
Peter P. Fu, Qingsu Xia, Ge Lin & Ming W. Chou. (2004) Pyrrolizidine Alkaloids—Genotoxicity, Metabolism Enzymes, Metabolic Activation, and Mechanisms. Drug Metabolism Reviews 36:1, pages 1-55.
Read now
Read now
Peter Hlavica. (2002) N-OXIDATIVE TRANSFORMATION OF FREE AND N-SUBSTITUTED AMINE FUNCTIONS BY CYTOCHROME P450 AS MEANS OF BIOACTIVATION AND DETOXICATION. Drug Metabolism Reviews 34:3, pages 451-477.
Read now
Read now
P.
P. Fu, M.
W. Chou, Q. Xia, Y.-C. Yang, J. Yan, D.
R. Doerge & P.
C. Chan. (2001) GENOTOXIC PYRROLIZIDINE ALKALOIDS AND PYRROLIZIDINE ALKALOID N-OXIDES—MECHANISMS LEADING TO DNA ADDUCT FORMATION AND TUMORIGENICITY. Journal of Environmental Science and Health, Part C 19:2, pages 353-385.
Read now
Read now
Articles from other publishers (19)
Yisheng He, Lin Zhu, Jiang Ma & Ge Lin. (2021) Metabolism-mediated cytotoxicity and genotoxicity of pyrrolizidine alkaloids. Archives of Toxicology 95:6, pages 1917-1942.
Crossref
Crossref
Jie Xu, Weiqian Wang, Xiao Yang, Aizhen Xiong, Li Yang & Zhengtao Wang. (2019) Pyrrolizidine alkaloids: An update on their metabolism and hepatotoxicity mechanism. Liver Research 3:3-4, pages 176-184.
Crossref
Crossref
Karl-Heinz Merz & Dieter Schrenk. (2016) Interim relative potency factors for the toxicological risk assessment of pyrrolizidine alkaloids in food and herbal medicines. Toxicology Letters 263, pages 44-57.
Crossref
Crossref
S Torok, A Vegvari, M Rezeli, T E Fehniger, J Tovari, S Paku, V Laszlo, B Hegedus, A Rozsas, B Dome & G Marko-Varga. (2015) Localization of sunitinib, its metabolites and its target receptors in tumour-bearing mice: a MALDI-MS imaging study. British Journal of Pharmacology 172:4, pages 1148-1163.
Crossref
Crossref
John A. Edgar, Russell J. Molyneux & Steven M. Colegate. (2014) Pyrrolizidine Alkaloids: Potential Role in the Etiology of Cancers, Pulmonary Hypertension, Congenital Anomalies, and Liver Disease. Chemical Research in Toxicology 28:1, pages 4-20.
Crossref
Crossref
Alexander V. LyubimovDeepak K. Dalvie & Cho‐Ming Loi. 2011. Encyclopedia of Drug Metabolism and Interactions. Encyclopedia of Drug Metabolism and Interactions
1
36
.
Alexander V. LyubimovDeepak K. Dalvie. 2011. Encyclopedia of Drug Metabolism and Interactions. Encyclopedia of Drug Metabolism and Interactions
1
54
.
Jieyu Dai, Fan Zhang & Jiang Zheng. (2010) Retrorsine, but not monocrotaline, is a mechanism-based inactivator of P450 3A4. Chemico-Biological Interactions 183:1, pages 49-56.
Crossref
Crossref
. (2007) Opinion of the Panel on contaminants in the food chain [CONTAM] related to pyrrolizidine alkaloids as undesirable substances in animal feed. EFSA Journal 5:5.
Crossref
Crossref
Michael Wink. 2007.
1
47
.
Jennifer M. Duringer, Donald R. Buhler & A. Morrie Craig. (2004) Comparison of hepatic in vitro metabolism of the pyrrolizidine alkaloid senecionine in sheep and cattle. American Journal of Veterinary Research 65:11, pages 1563-1572.
Crossref
Crossref
Woon-Gye Chung & Donald R. Buhler. (2004) Differential metabolism of the pyrrolizidine alkaloid, senecionine, in fischer 344 and sprague-dawley Rats. Archives of Pharmacal Research 27:5, pages 547-553.
Crossref
Crossref
Konnie H. Plumlee. 2004. Clinical Veterinary Toxicology. Clinical Veterinary Toxicology
337
442
.
Peter Fu, Qingsu Xia, Ge Lin & Ming Chou. (2002) Genotoxic Pyrrolizidine Alkaloids — Mechanisms Leading to DNA Adduct Formation and Tumorigenicity. International Journal of Molecular Sciences 3:9, pages 948-964.
Crossref
Crossref
Arungundrum S Prakash, Tamara N Pereira, Paul E.B Reilly & Alan A Seawright. (1999) Pyrrolizidine alkaloids in human diet. Mutation Research/Genetic Toxicology and Environmental Mutagenesis 443:1-2, pages 53-67.
Crossref
Crossref
Stephane Mabie, Kay Castagnoli & Neal Castagnoli. 1999. Handbook of Drug Metabolism. Handbook of Drug Metabolism
49
79
.
Jian-Ya Huan, Cristobal L. Miranda, Donald R. Buhler & Peter R. Cheeke. (1998) The Roles of CYP3A and CYP2B Isoforms in Hepatic Bioactivation and Detoxification of the Pyrrolizidine Alkaloid Senecionine in Sheep and Hamsters. Toxicology and Applied Pharmacology 151:2, pages 229-235.
Crossref
Crossref
Tamihide Matsunaga, Hiroyuki Tanaka, Akiko Komura, Kazuhito Watanabe, Ikuo Yamamoto & Hidetoshi Yoshimura. (1997) Microsomal Alcohol Oxygenase: Purification and Characterization of a Cytochrome P450 Responsible for Oxidation of 7-Hydroxy-Δ8-tetrahydrocannabinol to 7-Oxo-Δ8-tetrahydrocannabinol in Guinea Pig Liver. Archives of Biochemistry and Biophysics 348:1, pages 56-64.
Crossref
Crossref
Viviane Ribeiro Campesato, Ulrich Graf, Maria Luiza Reguly & Heloisa Helena Rodrigues de Andrade. (1997) Recombinagenic activity of integerrimine, a pyrrolizidine alkaloid fromSenecio brasiliensis, in somatic cells ofDrosophila melanogaster. Environmental and Molecular Mutagenesis 29:1, pages 91-97.
Crossref
Crossref