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The American Journal of Drug and Alcohol Abuse
Encompassing All Addictive Disorders
Volume 42, 2016 - Issue 5
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Original Articles

Relationship between ABCB1 polymorphisms and serum methadone concentration in patients undergoing methadone maintenance therapy (MMT)

Zalina ZahariDepartment of Pharmacy, Hospital Universiti Sains Malaysia, Kelantan, Malaysia;Pharmacogenetics and Novel Therapeutics Cluster, Institute for Research in Molecular Medicine (INFORMM), Universiti Sains Malaysia (USM), Kelantan, MalaysiaCorrespondence[email protected]
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, MSc,
Chee Siong LeeDepartment of Emergency Medicine, School of Medical Sciences, USM, Kelantan, MalaysiaView further author information
, MMed,
Muslih Abdulkarim IbrahimPharmacogenetics and Novel Therapeutics Cluster, Institute for Research in Molecular Medicine (INFORMM), Universiti Sains Malaysia (USM), Kelantan, Malaysia;Department of Pharmacology and Toxicology, College of Pharmacy, Hawler Medical University, Hawler, IraqView further author information
, PhD,
Nurfadhlina MusaPharmacogenetics and Novel Therapeutics Cluster, Institute for Research in Molecular Medicine (INFORMM), Universiti Sains Malaysia (USM), Kelantan, MalaysiaView further author information
, MSc,
Mohd Azhar Mohd YasinPharmacogenetics and Novel Therapeutics Cluster, Institute for Research in Molecular Medicine (INFORMM), Universiti Sains Malaysia (USM), Kelantan, Malaysia;Department of Psychiatry, School of Medical Sciences, USM, Kelantan, MalaysiaView further author information
, MMed,
Yeong Yeh LeeSchool of Medical Sciences, USM, Kelantan, MalaysiaView further author information
, PhD,
Soo Choon TanPharmacogenetics and Novel Therapeutics Cluster, Institute for Research in Molecular Medicine (INFORMM), Universiti Sains Malaysia (USM), Kelantan, MalaysiaView further author information
, PhD,
Nasir MohamadPharmacogenetics and Novel Therapeutics Cluster, Institute for Research in Molecular Medicine (INFORMM), Universiti Sains Malaysia (USM), Kelantan, Malaysia;Faculty of Medicine & Health Sciences, Universiti Sultan Zainal Abidin, Terengganu, MalaysiaView further author information
, PhD &
Rusli IsmailPharmacogenetics and Novel Therapeutics Cluster, Institute for Research in Molecular Medicine (INFORMM), Universiti Sains Malaysia (USM), Kelantan, Malaysia;Centre of Excellence for Research in AIDS (CERiA), University of Malaya, Kuala Lumpur, MalaysiaView further author information
, PhD show all
Pages 587-596 | Received 02 Jan 2016, Accepted 23 Mar 2016, Published online: 10 Jun 2016

Citations (15)

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David Eapen-John, Ayeshah G. Mohiuddin & James L. Kennedy. (2022) A potential paradigm shift in opioid crisis management: The role of pharmacogenomics. The World Journal of Biological Psychiatry 23:6, pages 411-423.
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Articles from other publishers (14)

Nicola Ferri, Sara De Martin, James Stuart, Sergio Traversa, Franco Folli, Marco Pappagallo, Cedric O’Gorman, Clotilde Guidetti, Andrea Mattarei, Charles E. Inturrisi & Paolo L. Manfredi. (2023) Drug–Drug Interaction Studies of Esmethadone (REL-1017) Involving CYP3A4- and CYP2D6-Mediated Metabolism. Drugs in R&D.
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Flaminia Coluzzi, Maria Sole Scerpa, Monica Rocco & Diego Fornasari. (2022) The Impact of P-Glycoprotein on Opioid Analgesics: What’s the Real Meaning in Pain Management and Palliative Care?. International Journal of Molecular Sciences 23:22, pages 14125.
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Sarahbeth Howes, Alexandra R. Cloutet, Jaeyeon Kweon, Taylor L. Powell, Daniel Raza, Elyse M. Cornett & Alan D. Kaye. 2022. Pharmacogenomics in Drug Discovery and Development. Pharmacogenomics in Drug Discovery and Development 491 504 .
Leen Magarbeh, Ilona Gorbovskaya, Bernard Le Foll, Reuven Jhirad & Daniel J. Müller. (2021) Reviewing pharmacogenetics to advance precision medicine for opioids. Biomedicine & Pharmacotherapy 142, pages 112060.
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S. Iwersen-Bergmann, S. Plattner, S. Hischke, A. Müller, H. Andresen-Streichert, H. Jungen, R. Erb & B. Beer-Sandner. (2021) Brain/blood ratios of methadone and ABCB1 polymorphisms in methadone-related deaths. International Journal of Legal Medicine 135:2, pages 473-482.
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Senthil Packiasabapathy, Blessed W Aruldhas, Nicole Horn, Brian R Overholser, Sara K Quinney, Janelle S Renschler & Senthilkumar Sadhasivam. (2020) Pharmacogenomics of methadone: a narrative review of the literature. Pharmacogenomics 21:12, pages 871-887.
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Luxi DuanXingyuan LiJunxia YanYingyi ChenRui LuoQiang ZhangXiangling FengXingli Li. (2020) Association of COMT Gene Polymorphisms with Response to Methadone Maintenance Treatment Among Chinese Opioid-Dependent Patients . Genetic Testing and Molecular Biomarkers 24:6, pages 364-369.
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Zalina Zahari, CheeSiong Lee, MuslihAbdulkarim Ibrahim, Nurfadhlina Musa, MohdAzhar Mohd Yasin, YeongYeh Lee, SooChoon Tan, Nasir Mohamad & Rusli Ismail. (2020) Influence of DRD2polymorphisms on the clinical outcomes of opioiddependent patients on methadone maintenance therapy. Journal of Pharmacy And Bioallied Sciences 12:6, pages 787.
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Shengying Qin, Jingsong Ma, Cong Huai & Wei Zhou. 2020. Pharmacogenomics in Precision Medicine. Pharmacogenomics in Precision Medicine 107 122 .
Fatemeh Chalabianloo, Andreas A. Westin, Eirik Skogvoll, Jørgen G. Bramness & Olav Spigset. (2019) Methadone serum concentrations and influencing factors: A naturalistic observational study. Psychopharmacology 236:11, pages 3159-3167.
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Caroline Victorri‐Vigneau, Céline Verstuyft, Régis Bouquié, Edouard‐Jules Laforgue, Jean‐Benoit Hardouin, Juliette Leboucher, Bertrand Le Geay, Corine Dano, Gaëlle Challet‐Bouju & Marie Grall‐Bronnec. (2019) Relevance of CYP2B6 and CYP2D6 genotypes to methadone pharmacokinetics and response in the OPAL study . British Journal of Clinical Pharmacology 85:7, pages 1538-1543.
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Eva Montanari, Maria Paola Bonasoni, Federica Alessandrini, Raffaele Frazzi, Federico Mocchegiani, Francesco Paolo Busardò, Raffaele Giorgetti & Adriano Tagliabracci. (2019) CYP2B6, ABCB1 and OPRM1 profile in a stillborn affected by chronic methadone intoxication. Forensic Toxicology 37:2, pages 507-516.
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Richard C. Crist, Toni-Kim Clarke & Wade H. Berrettini. (2018) Pharmacogenetics of Opioid Use Disorder Treatment. CNS Drugs 32:4, pages 305-320.
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Francina Fonseca & Marta Torrens. (2017) Pharmacogenetics of Methadone Response. Molecular Diagnosis & Therapy 22:1, pages 57-78.
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