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Research Article

Acetaminophen perturbed redox homeostasis in Wistar rat liver: protective role of aqueous Pterocarpus osun leaf extract

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Pages 77-87 | Received 08 May 2009, Accepted 08 Jul 2009, Published online: 14 Dec 2009

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Sumaira Yousuf, Shabnam Shabir & Mahendra P. Singh. (2023) Protection Against Drug-Induced Liver Injuries Through Nutraceuticals via Amelioration of Nrf-2 Signaling. Journal of the American Nutrition Association 42:5, pages 495-515.
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O. B. Ibitoye, N. O. Aliyu & T. O. Ajiboye. (2020) Protective Influence of Phyllanthus Muellarianus on Ciprofloxacin-Induced Neurotoxicity in Male Rats. Journal of Dietary Supplements 17:3, pages 321-335.
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Nurudeen S. Adigun, A. Temidayo Oladiji & Taofeek O. Ajiboye. (2020) Hydro-Ethanolic Fruit Extract of Capsicum frutescens Reversed Triton-X-100–Induced Hyperlipidaemia in Rats. Journal of Dietary Supplements 17:1, pages 53-66.
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Taofeek O. Ajiboye, Fatimah M. Ahmad, Airat O. Daisi, Aminat A. Yahaya, Oluwayemisi B. Ibitoye, Hamdalat F. Muritala & Taofik O. Sunmonu. (2017) Hepatoprotective potential of Phyllanthus muellarianus leaf extract: studies on hepatic, oxidative stress and inflammatory biomarkers. Pharmaceutical Biology 55:1, pages 1662-1670.
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T. O. Ajiboye, F. A. Abdussalam, A. O. Adeleye, G. A. Iliasu, F. A. Ariyo, Z. A. Adediran, K. O. Raji & H. O. Raji. (2013) Bridelia ferruginea Promotes Reactive Oxygen Species Detoxification in N-Nitrosodiethylamine-Treated Rats. Journal of Dietary Supplements 10:3, pages 210-228.
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Taofeek O. Ajiboye, Nasir A. Salawu, Musa T. Yakubu, Adenike T. Oladiji, Musbau A. Akanji & Joseph I. Okogun. (2011) Antioxidant and drug detoxification potentials of Hibiscus sabdariffa anthocyanin extract. Drug and Chemical Toxicology 34:2, pages 109-115.
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T.O. Ajiboye, H. Aliyu, M.A. Tanimu, R.M. Muhammad & O.B. Ibitoye. (2016) Dioscoreophyllum cumminsii (Stapf) Diels leaves halt high-fructose induced metabolic syndrome: Hyperglycemia, insulin resistance, inflammation and oxidative stress. Journal of Ethnopharmacology 192, pages 471-479.
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Taofeek. O. Ajiboye. (2016) Lophirones B and C Attenuate Acetaminophen-Induced Liver Damage in Mice: Studies on Hepatic, Oxidative Stress and Inflammatory Biomarkers. Journal of Biochemical and Molecular Toxicology 30:10, pages 497-505.
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Taofeek O Ajiboye, Hikmat O Raji, Abdulwasiu O Adeleye, Nurudeen S Adigun, Oluwayemisi B Giwa, Oluwayemisi B Ojewuyi & Adenike T Oladiji. (2016) Hibiscus sabdariffa calyx palliates insulin resistance, hyperglycemia, dyslipidemia and oxidative rout in fructose-induced metabolic syndrome rats . Journal of the Science of Food and Agriculture 96:5, pages 1522-1531.
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Byoung Ok Cho, Hong Hua Yin, Chong Zhou Fang, Sang Jun Kim, Seung Il Jeong & Seon Il Jang. (2015) Hepatoprotective effect of Diospyros lotus leaf extract against acetaminophen-induced acute liver injury in mice. Food Science and Biotechnology 24:6, pages 2205-2212.
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H.O.B. Oloyede, T.O. Bello, T.O. Ajiboye & M.O. Salawu. (2015) Antidiabetic and antidyslipidemic activities of aqueous leaf extract of Dioscoreophyllum cumminsii (Stapf) Diels in alloxan-induced diabetic rats. Journal of Ethnopharmacology 166, pages 313-322.
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T. O. Ajiboye, K. A. Alabi, F. A. Ariyo, A. O. Adeleye, O. B. Ojewuyi, A. Balogun & T. O. Sunmonu. (2015) 2-(2-Nitrovinyl)furan Promotes Oxidation of Cellular Proteins, Lipids, and DNA of Male Rat Liver and Kidney. Journal of Biochemical and Molecular Toxicology 29:3, pages 114-122.
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Taofeek O Ajiboye, Yesirat O Komolafe, Musa T Yakubu & Simiat M Ogunbode. (2013) Effects of trona on the redox status of cellular system of male rats. Toxicology and Industrial Health 31:2, pages 179-187.
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Saheed Sabiu, Taofik O. Sunmonu, Emmanuel O. Ajani & Taofeek O. Ajiboye. (2015) Combined administration of silymarin and vitamin C stalls acetaminophen-mediated hepatic oxidative insults in Wistar rats. Revista Brasileira de Farmacognosia 25:1, pages 29-34.
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Taofeek O. Ajiboye, Musa T. Yakubu & Adenike T. Oladiji. (2014) Lophirones B and C Extenuate AFB 1 -Mediated Oxidative Onslaught on Cellular Proteins, Lipids, and DNA through Nrf-2 Expression . Journal of Biochemical and Molecular Toxicology 28:12, pages 558-567.
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O.B. Oloyede, T.O. Ajiboye, A.F. Abdussalam & A.O. Adeleye. (2014) Blighia sapida leaves halt elevated blood glucose, dyslipidemia and oxidative stress in alloxan-induced diabetic rats. Journal of Ethnopharmacology 157, pages 309-319.
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Abdulwasiu O. AdeleyeTaofeek O. AjiboyeGaniyat A. IliasuFolakemi A. AbdussalamAbdulazeez BalogunOluwayemisi B. OjewuyiMusa T. Yakubu. (2014) Phenolic Extract of Dialium guineense Pulp Enhances Reactive Oxygen Species Detoxification in Aflatoxin B 1 Hepatocarcinogenesis . Journal of Medicinal Food 17:8, pages 875-885.
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Adewale Adewuyi, Omolola H. Fasusi & Rotimi A. Oderinde. (2014) Antibacterial activities of acetonides prepared from the seed oils of Calophyllum inophyllum and Pterocarpus osun. Journal of Acute Medicine 4:2, pages 75-80.
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Taofeek O. Ajiboye, Musa T. Yakubu & Adenike T. Oladiji. (2013) Cytotoxic, Antimutagenic, and Antioxidant Activities of Methanolic Extract and Chalcone Dimers (Lophirones B and C) Derived From Lophira alata (Van Tiegh. Ex Keay) Stem Bark . Journal of Evidence-Based Complementary & Alternative Medicine 19:1, pages 20-30.
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Prashant Tiwari, Dheeraj Ahirwae, Anish Chandy & Bharti Ahirwar. (2014) Evaluation of hepatoprotective activity of alcoholic and aqueous extracts of Selaginella lepidophylla. Asian Pacific Journal of Tropical Disease 4, pages S81-S86.
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Taofeek O. Ajiboye, Musa T. Yakubu & Adenike T. Oladiji. (2014) Electrophilic and Reactive Oxygen Species Detoxification Potentials of Chalcone Dimers is Mediated by Redox Transcription Factor Nrf-2. Journal of Biochemical and Molecular Toxicology 28:1, pages 11-22.
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Oyelola Bukoye Oloyede, Taofeek Olakunle Ajiboye & Yesirat Omanike Komolafe. (2013) N-nitrosodiethylamine induced redox imbalance in rat liver: Protective role of polyphenolic extract of Blighia sapida arilli. Free Radicals and Antioxidants 3:1, pages 25-29.
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Sharida Fakurazi, Syazana Akmal Sharifudin & Palanisamy Arulselvan. (2012) Moringa oleifera Hydroethanolic Extracts Effectively Alleviate Acetaminophen-Induced Hepatotoxicity in Experimental Rats through Their Antioxidant Nature. Molecules 17:7, pages 8334-8350.
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Kuppan Nithianantham, Murugesan Shyamala, Yeng Chen, Lachimanan Yoga Latha, Subramanion L. Jothy & Sreenivasan Sasidharan. (2011) Hepatoprotective Potential of Clitoria ternatea Leaf Extract Against Paracetamol Induced Damage in Mice. Molecules 16:12, pages 10134-10145.
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Taofeek Olakunle Ajiboye, Musa Toyin Yakubu & Adenike Temidayo Oladiji. (2011) Electrophilic, Free Radical and Reactive Oxygen Species Scavenging and Detoxification Potentials of Lophiraalata Stem Bark Extract. Free Radicals and Antioxidants 1:3, pages 40-47.
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Taofeek Olakunle Ajiboye. (2010) In vivo antioxidant potentials of Piliostigma thonningii (Schum) leaves: Studies on hepatic marker enzyme, antioxidant system, drug detoxifying enzyme and lipid peroxidation. Human & Experimental Toxicology 30:1, pages 55-62.
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Taofeek Olakunle Ajiboye. (2010) Redox status of the liver and kidney of 2,2-dichlorovinyl dimethyl phosphate (DDVP) treated rats. Chemico-Biological Interactions 185:3, pages 202-207.
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