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Research Article

Inhibitory effect of ebselen on lactate dehydrogenase activity from mammals: a comparative study with diphenyl diselenide and diphenyl ditelluride

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Pages 66-76 | Received 11 Jan 2010, Accepted 11 Mar 2010, Published online: 18 Oct 2010

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Diones Bueno, Daiane Meinerz, Emily Waczuk, Diego de Souza & João Batista Rocha. (2018) Toxicity of organochalcogens in human leukocytes is associated, but not directly related with reactive species production, apoptosis and changes in antioxidant gene expression. Free Radical Research 52:10, pages 1158-1169.
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R. A. Saraiva, D. C. Bueno, P. A. Nogara & J. B. T. Rocha. (2012) Molecular Docking Studies of Disubstituted Diaryl Diselenides as Mammalian δ-Aminolevulinic Acid Dehydratase Enzyme Inhibitors. Journal of Toxicology and Environmental Health, Part A 75:16-17, pages 1012-1022.
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Articles from other publishers (25)

Yili Hu, Xiaocui Chai, Jun Men, Shen Rao, Xin Cong, Shuiyuan Cheng & Zhixian Qiao. (2022) Does Methionine Status Influence the Outcome of Selenomethinione Supplementation? A Comparative Study of Metabolic and Selenium Levels in HepG2 Cells. Nutrients 14:18, pages 3705.
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Cristina W. Nogueira, Nilda V. Barbosa & João B. T. Rocha. (2021) Toxicology and pharmacology of synthetic organoselenium compounds: an update. Archives of Toxicology 95:4, pages 1179-1226.
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Mostafa A. Rabie, Hala F. Zaki & Helmy M. Sayed. (2019) Telluric acid ameliorates hepatic ischemia reperfusion-induced injury in rats: Involvement of TLR4, Nrf2, and PI3K/Akt signaling pathways. Biochemical Pharmacology 168, pages 404-411.
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Christos T. Chasapis, Manousos Makridakis, Anastassios E. Damdimopoulos, Jerome Zoidakis, Vasiliki Lygirou, Manolis Mavroidis, Antonia Vlahou, Antonio Miranda-Vizuete, Giannis Spyrou & Alexios Vlamis-Gardikas. (2019) Implications of the mitochondrial interactome of mammalian thioredoxin 2 for normal cellular function and disease. Free Radical Biology and Medicine 137, pages 59-73.
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Rogério A. Saraiva, Pablo A. Nogara, Roner F. Costa, Eveline M. Bezerra, Helenicy N.H. Veras, Irwin R.A. Menezes, Umberto L. Fulco, Eudenilson L. Albuquerque, Valder N. Freire & João B.T. Rocha. (2018) Interaction energy profile for diphenyl diselenide in complex with δ-aminolevulinic acid dehydratase enzyme using quantum calculations and a molecular fragmentation method. Computational Toxicology 7, pages 9-19.
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Jéssie Haigert Sudati, Pablo Andrei Nogara, Rogério Aquino Saraiva, Caroline Wagner, Eduardo Eliezer Alberto, Antonio Luiz Braga, Roselei Fachinetto, Paulo Cesar Piquini & João Batista Teixeira Rocha. (2018) Diselenoamino acid derivatives as GPx mimics and as substrates of TrxR: in vitro and in silico studies . Organic & Biomolecular Chemistry 16:20, pages 3777-3787.
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Zhenzhen Chen, Zhongyao Jiang, Nan Chen, Qian Shi, Lili Tong, Fanpeng Kong, Xiufen Cheng, Hao Chen, Chu Wang & Bo Tang. (2018) Target discovery of ebselen with a biotinylated probe. Chemical Communications 54:68, pages 9506-9509.
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Nilda V. Barbosa, Cristina W. Nogueira, Pablo A. Nogara, Andreza F. de Bem, Michael Aschner & João B. T. Rocha. (2017) Organoselenium compounds as mimics of selenoproteins and thiol modifier agents. Metallomics 9:12, pages 1703-1734.
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B. Zadehvakili, S.M. McNeill, J.P. Fawcett & G.I. Giles. (2016) The design of redox active thiol peroxidase mimics: Dihydrolipoic acid recognition correlates with cytotoxicity and prooxidant action. Biochemical Pharmacology 104, pages 19-28.
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Yan A. Ivanenkov, Mark S. Veselov, Igor G. Rezekin, Dmitriy A. Skvortsov, Yuri B. Sandulenko, Marina V. Polyakova, Dmitry S. Bezrukov, Sergey V. Vasilevsky, Maxim E. Kukushkin, Anna A. Moiseeva, Alexander V. Finko, Victor E. Koteliansky, Natalia L. Klyachko, Lubov A. Filatova, Elena K. Beloglazkina, Nikolay V. Zyk & Alexander G. Majouga. (2016) Synthesis, isomerization and biological activity of novel 2-selenohydantoin derivatives. Bioorganic & Medicinal Chemistry 24:4, pages 802-811.
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Prachi Verma, Amit Kunwar, Kenta Arai, Michio Iwaoka & K. Indira Priyadarsini. (2016) Alkyl chain modulated cytotoxicity and antioxidant activity of bioinspired amphiphilic selenolanes. Toxicology Research 5:2, pages 434-445.
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Gajendra Kumar Azad & Raghuvir S. Tomar. (2014) Ebselen, a promising antioxidant drug: mechanisms of action and targets of biological pathways. Molecular Biology Reports 41:8, pages 4865-4879.
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Willian G. Salgueiro, Maurício C.D.F. Xavier, Luis Fernando B. Duarte, Daniela F. Câmara, Daiandra A. Fagundez, Ana Thalita G. Soares, Gelson Perin, Diego Alves & Daiana Silva Avila. (2014) Direct synthesis of 4-organylsulfenyl-7-chloro quinolines and their toxicological and pharmacological activities in Caenorhabditis elegans. European Journal of Medicinal Chemistry 75, pages 448-459.
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Xinhui WangJun-Won YunXin Gen Lei. (2014) Glutathione Peroxidase Mimic Ebselen Improves Glucose-Stimulated Insulin Secretion in Murine Islets. Antioxidants & Redox Signaling 20:2, pages 191-203.
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Laura Orian & Stefano Toppo. (2014) Organochalcogen peroxidase mimetics as potential drugs: a long story of a promise still unfulfilled. Free Radical Biology and Medicine 66, pages 65-74.
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Gajendra Kumar Azad, Vikash Singh, Papita Mandal, Prabhat Singh, Upendarrao Golla, Shivani Baranwal, Sakshi Chauhan & Raghuvir S. Tomar. (2014) Ebselen induces reactive oxygen species (ROS)-mediated cytotoxicity in Saccharomyces cerevisiae with inhibition of glutamate dehydrogenase being a target . FEBS Open Bio 4:1, pages 77-89.
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Caroline B. Quines, Suzan G. Rosa, José S. S. Neto, Gilson Zeni & Cristina W. Nogueira. (2013) Phenylethynyl-Butyltellurium Inhibits the Sulfhydryl Enzyme Na+, K+-ATPase: An Effect Dependent on the Tellurium Atom. Biological Trace Element Research 155:2, pages 261-266.
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Isabel Cordero-Herrera, Susana Cuello, Luis Goya, Yolanda Madrid, Laura Bravo, Carmen Cámara & Sonia Ramos. (2013) Molecular mechanisms involved in the protective effect of selenocystine against methylmercury-induced cell death in human HepG2 cells. Food and Chemical Toxicology 59, pages 554-563.
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Robson Luiz Puntel, Daniel Henrique Roos, Rodrigo Lopes Seeger, Michael Aschner & João Batista Teixeira Rocha. (2012) Organochalcogens Inhibit Mitochondrial Complexes I and II in Rat Brain: Possible Implications for Neurotoxicity. Neurotoxicity Research 24:2, pages 109-118.
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Robson L. Puntel, Daniel H. Roos, Rodrigo Lopes Seeger & João B.T. Rocha. (2013) Mitochondrial electron transfer chain complexes inhibition by different organochalcogens. Toxicology in Vitro 27:1, pages 59-70.
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Diones Caeran Bueno, Daiane Francine Meinerz, Josiane Allebrandt, Emily Pansera Waczuk, Danúbia Bonfanti dos Santos, Douglas Oscar Ceolin Mariano & João Batista Teixeira Rocha. (2013) Cytotoxicity and Genotoxicity Evaluation of Organochalcogens in Human Leucocytes: A Comparative Study between Ebselen, Diphenyl Diselenide, and Diphenyl Ditelluride. BioMed Research International 2013, pages 1-6.
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Hoi-Ling Seng & Edward R. T. Tiekink. (2012) Anti-cancer potential of selenium- and tellurium-containing species: opportunities abound!. Applied Organometallic Chemistry 26:12, pages 655-662.
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Bruna Comparsi, Daiane F. Meinerz, Jeferson L. Franco, Thaís Posser, Alessandro de Souza Prestes, Sílvio Terra Stefanello, Danúbia B. dos Santos, Caroline Wagner, Marcelo Farina, Michael Aschner, Alcir L. Dafre & João B. T. Rocha. (2012) Diphenyl ditelluride targets brain selenoproteins in vivo: inhibition of cerebral thioredoxin reductase and glutathione peroxidase in mice after acute exposure. Molecular and Cellular Biochemistry 370:1-2, pages 173-182.
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Gajendra K. Azad, Shah Jaimin Balkrishna, Narayanan Sathish, Sangit Kumar & Raghuvir S. Tomar. (2012) Multifunctional Ebselen drug functions through the activation of DNA damage response and alterations in nuclear proteins. Biochemical Pharmacology 83:2, pages 296-303.
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Cristina W. Nogueira & João B. T. Rocha. (2011) Toxicology and pharmacology of selenium: emphasis on synthetic organoselenium compounds. Archives of Toxicology 85:11, pages 1313-1359.
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