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Research Article

Protective effects of silymarin on epirubicin-induced mucosal barrier injury of the gastrointestinal tract

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Pages 442-451 | Received 16 Apr 2014, Accepted 23 Nov 2014, Published online: 22 Jan 2015

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A. Hudita, I. C. Radu, B. Galateanu, O. Ginghina, H. Herman, C. Balta, M. Rosu, C. Zaharia, M. Costache, E. Tanasa, K. Velonia, A. Tsatsakis & A. Hermenean. (2021) Bioinspired silk fibroin nano-delivery systems protect against 5-FU induced gastrointestinal mucositis in a mouse model and display antitumor effects on HT-29 colorectal cancer cells in vitro. Nanotoxicology 15:7, pages 973-994.
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Long Cai, Ge Gao, Chenggang Yin, Rong Bai, Yanpin Li, Wenjuan Sun, Yu Pi, Xianren Jiang & Xilong Li. (2023) The Effects of Dietary Silybin Supplementation on the Growth Performance and Regulation of Intestinal Oxidative Injury and Microflora Dysbiosis in Weaned Piglets. Antioxidants 12:11, pages 1975.
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Mahsa Ghodousi, Hedyieh Karbasforooshan, Leila Arabi & Sepideh Elyasi. (2022) Silymarin as a preventive or therapeutic measure for chemotherapy and radiotherapy-induced adverse reactions: a comprehensive review of preclinical and clinical data. European Journal of Clinical Pharmacology 79:1, pages 15-38.
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Bei Yue, Ruiyang Gao, Cheng Lv, Zhilun Yu, Hao Wang, Xiaolong Geng, Zhengtao Wang & Wei Dou. (2021) Berberine Improves Irinotecan-Induced Intestinal Mucositis Without Impairing the Anti-colorectal Cancer Efficacy of Irinotecan by Inhibiting Bacterial β-glucuronidase. Frontiers in Pharmacology 12.
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Coralia Cotoraci, Alciona Sasu, Eftimie Miutescu, Dana Iovanescu, Sami Gharbia, Alina Ciceu, Hildegard Herman & Anca Hermenean. (2021) Immunohistochemical Expression Patterns of Tight Junction Proteins, Pro-Apoptotic and Anti-Apoptotic Factors on Progression of Intestinal Mucositis of Onco-Hematological Patients under Epirubicin-Based Chemotherapy. Applied Sciences 11:10, pages 4710.
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Diana Bachinger, Elisabeth Mayer, Theresa Kaschubek, Carina Schieder, Jürgen König & Klaus Teichmann. (2018) Influence of phytogenics on recovery of the barrier function of intestinal porcine epithelial cells after a calcium switch. Journal of Animal Physiology and Animal Nutrition 103:1, pages 210-220.
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Caroline Manto Chagas, Sara Moss & Laleh Alisaraie. (2018) Drug metabolites and their effects on the development of adverse reactions: Revisiting Lipinski’s Rule of Five. International Journal of Pharmaceutics 549:1-2, pages 133-149.
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Sepideh Elyasi, Farzaneh Sadat Rezazadeh Shojaee, Abolghasem Allahyari & Gholamreza Karimi. (2017) Topical Silymarin Administration for Prevention of Capecitabine-Induced Hand-Foot Syndrome: A Randomized, Double-Blinded, Placebo-Controlled Clinical Trial. Phytotherapy Research 31:9, pages 1323-1329.
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Mihaela Zaulet, Steliana Elvira Maria Kevorkian, Sorina Dinescu, Coralia Cotoraci, Maria Suciu, Hildegard Herman, Laura Buburuzan, Liliana Badulescu, Aurel Ardelean & Anca Hermenean. (2017) Protective effects of silymarin against bisphenol A-induced hepatotoxicity in mouse liver. Experimental and Therapeutic Medicine 13:3, pages 821-828.
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Claus Hellerbrand, Jörn M. Schattenberg, Philipp Peterburs, Anja Lechner & Reto Brignoli. (2016) The potential of silymarin for the treatment of hepatic disorders. Clinical Phytoscience 2:1.
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Sepideh Elyasi, Sare Hosseini, Mohammad Reza Niazi Moghadam, Seyed Amir Aledavood & Gholamreza Karimi. (2016) Effect of Oral Silymarin Administration on Prevention of Radiotherapy Induced Mucositis: A Randomized, Double-Blinded, Placebo-Controlled Clinical Trial. Phytotherapy Research 30:11, pages 1879-1885.
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