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Research Article

Innovative Designs and Practices for Acute Systemic Toxicity Studies

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Pages 423-434 | Published online: 27 Sep 2008

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S. C. Gad, C. Reilly, K. Siino, F. A. Gavigan & G. Witz. (1985) Thirteen Cationic I0n0ph0res: Their Acute Toxicity, Neurobehavioral and Membrane Effects. Drug and Chemical Toxicology 8:6, pages 451-468.
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Articles from other publishers (41)

Shayne Cox Gad & Dexter SullivanJr.Jr.. 2023. Drug Safety Evaluation. Drug Safety Evaluation 143 172 .
Shayne Cox Gad & Dexter SullivanJr.Jr.. 2023. Drug Safety Evaluation. Drug Safety Evaluation 95 130 .
Shayne Cox Gad & Dexter SullivanJr.Jr.. 2023. Drug Safety Evaluation. Drug Safety Evaluation 801 803 .
Shayne Cox Gad. 2017. Oral Formulation Roadmap from Early Drug Discovery to Development. Oral Formulation Roadmap from Early Drug Discovery to Development 39 88 .
Shayne Cox Gad. 2016. Drug Safety Evaluation. Drug Safety Evaluation 129 158 .
Shayne Cox Gad. 2016. Drug Safety Evaluation. Drug Safety Evaluation 79 113 .
. 2016. Animal Models in Toxicology. Animal Models in Toxicology 889 906 .
Shayne Gad & Samantha Gad-McDonald. 2015. Biomaterials, Medical Devices, and Combination Products. Biomaterials, Medical Devices, and Combination Products 243 254 .
Mark Johnson, Shayne Gad & Christopher Kemper. 2015. Animal Models in Toxicology, Third Edition. Animal Models in Toxicology, Third Edition 153 283 .
. 2014. Hayes' Principles and Methods of Toxicology. Hayes' Principles and Methods of Toxicology 703 736 .
. 2014. Hayes' Principles and Methods of Toxicology. Hayes' Principles and Methods of Toxicology 29 60 .
. 2010. Drug Safety Evaluation. Drug Safety Evaluation 185 233 .
. 2010. Drug Safety Evaluation. Drug Safety Evaluation 121 184 .
. 2010. Pharmaceutical Sciences Encyclopedia. Pharmaceutical Sciences Encyclopedia 1 73 .
. 2010. Pharmaceutical Sciences Encyclopedia. Pharmaceutical Sciences Encyclopedia 1 49 .
Roy C. Myers & Bennett J. Varsho. 2009. General, Applied and Systems Toxicology. General, Applied and Systems Toxicology.
Shayne Gad, Shayne Gad & Marian McCord. 2008. Safety Evaluation in the Development of Medical Devices and Combination Products, Third Edition. Safety Evaluation in the Development of Medical Devices and Combination Products, Third Edition 143 150 .
Peter Folb. 2005. Clinical Trials of Drugs and Biopharmaceuticals. Clinical Trials of Drugs and Biopharmaceuticals 31 55 .
Shayne Gad. 2005. Statistics and Experimental Design for Toxicologists and Pharmacologists, Fourth Edition. Statistics and Experimental Design for Toxicologists and Pharmacologists, Fourth Edition 215 239 .
Kaoru Sekihashi, Ayumu Yamamoto, Yukie Matsumura, Shunji Ueno, Mie Watanabe-Akanuma, Fekadu Kassie, Siegfried Knasm?ller, Shuji Tsuda & Yu F Sasaki. (2002) Comparative investigation of multiple organs of mice and rats in the comet assay. Mutation Research/Genetic Toxicology and Environmental Mutagenesis 517:1-2, pages 53-75.
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Shuji Tsuda, Yoko Kosaka, Naonori Matsusaka & Yu F Sasaki. (1998) Detection of pyrimethamine-induced DNA damage in mouse embryo and maternal organs by the modified alkaline single cell gel electrophoresis assay. Mutation Research/Genetic Toxicology and Environmental Mutagenesis 415:1-2, pages 69-77.
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Yu F Sasaki, Ayako Saga, Makiko Akasaka, Satoko Ishibashi, Kumiko Yoshida, Ying Quan Su, Naonori Matsusaka & Shuji Tsuda. (1998) Organ-specific genotoxicity of the potent rodent colon carcinogen 1,2-dimethylhydrazine and three hydrazine derivatives: difference between intraperitoneal and oral administration. Mutation Research/Genetic Toxicology and Environmental Mutagenesis 415:1-2, pages 1-12.
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Yu F Sasaki, Emi Nishidate, Ying Quan Su, Naonori Matsusaka, Shuji Tsuda, Nobuyuki Susa, Yoshinori Furukawa & Shunji Ueno. (1998) Organ-specific genotoxicity of the potent rodent bladder carcinogens o-anisidine and p-cresidine. Mutation Research/Genetic Toxicology and Environmental Mutagenesis 412:2, pages 155-160.
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Shayne C. Gad & Christopher P. Chengelis. 1998. Acute Toxicology Testing. Acute Toxicology Testing 361 402 .
Shayne C. Gad & Christopher P. Chengelis. 1998. Acute Toxicology Testing. Acute Toxicology Testing 305 360 .
Shayne C. Gad & Christopher P. Chengelis. 1998. Acute Toxicology Testing. Acute Toxicology Testing 257 303 .
Shayne C. Gad & Christopher P. Chengelis. 1998. Acute Toxicology Testing. Acute Toxicology Testing 221 256 .
Shayne C. Gad & Christopher P. Chengelis. 1998. Acute Toxicology Testing. Acute Toxicology Testing 155 196 .
Shayne C. Gad & Christopher P. Chengelis. 1998. Acute Toxicology Testing. Acute Toxicology Testing 1 15 .
Yu F Sasaki, Ayako Saga, Makiko Akasaka, Kumiko Yoshida, Emi Nishidate, Ying Quan Su, Naonori Matsusaka & Shuji Tsuda. (1997) In vivo genotoxicity of ortho-phenylphenol, biphenyl, and thiabendazole detected in multiple mouse organs by the alkaline single cell gel electrophoresis assay. Mutation Research/Genetic Toxicology and Environmental Mutagenesis 395:2-3, pages 189-198.
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Yu F Sasaki, Ayako Saga, Makiko Akasaka, Emi Nishidate, Mie Watanabe-Akanuma, Toshihiro Ohta, Naonori Matsusaka & Shuji Tsuda. (1997) In vivo genotoxicity of heterocyclic amines detected by a modified alkaline single cell gel electrophoresis assay in a multiple organ study in the mouse. Mutation Research/Genetic Toxicology and Environmental Mutagenesis 395:1, pages 57-73.
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Y? F Sasaki, Fusako Izumiyama, Emi Nishidate, Toshihiro Ohta, Tomoko Ono, Naonori Matsusaka & Shuji Tsuda. (1997) Simple detection of in vivo genotoxicity of pyrimethamine in rodents by the modified alkaline single-cell gel electrophoresis assay. Mutation Research/Genetic Toxicology and Environmental Mutagenesis 392:3, pages 251-259.
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Yu F Sasaki, Emi Nishidate, Fusako Izumiyama, Naonori Matsusaka & Shuji Tsuda. (1997) Simple detection of chemical mutagens by the alkaline single-cell gel electrophoresis (Comet) assay in multiple mouse organs (liver, lung, spleen, kidney, and bone marrow). Mutation Research/Genetic Toxicology and Environmental Mutagenesis 391:3, pages 215-231.
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Y? F Sasaki, Fusako Izumiyama, Emi Nishidate, Naonori Matsusaka & Shuji Tsuda. (1997) Detection of rodent liver carcinogen genotoxicity by the alkaline single-cell gel electrophoresis (Comet) assay in multiple mouse organs (liver, lung, spleen, kidney, and bone marrow). Mutation Research/Genetic Toxicology and Environmental Mutagenesis 391:3, pages 201-214.
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Peter J. Vit. (1989) Approximate lethal dose versus median lethal dose in acute toxicity testing of pharmaceuticals. Archives of Toxicology 63:4, pages 343-344.
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Barbara L. Harper, Jonathan B. WardJr.Jr., V. M. Sadagopa Ramanujam, Marinel M. Ammenheuser, William W. Au, Mary Treinen Moslen & Marvin S. Legator. (2006) A combined testing protocol for assessing genotoxicity in individual animals: Application to environmental toxicology. Journal of Applied Toxicology 9:2, pages 97-102.
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Shayne C. Gad. (2016) Principles of Screening in Toxicology with Special Emphasis on Applications to Neurotoxicology. Journal of the American College of Toxicology 8:1, pages 21-27.
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Manoj Gandhi, Ramesh Lal, Alangudi Sankaranarayanan, Chander Kanta Banerjee & Pyare Lal Sharma. (1988) Acute toxicity study of the oil from Azadirachta indica seed (neem oil). Journal of Ethnopharmacology 23:1, pages 39-51.
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Dieter Pankow. (2010) Probleme toxikologischer Risikobeurteilung von Chemikalien. Zeitschrift für Chemie 28:4, pages 136-141.
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Shayne C. Gad, Brendan J. Dunn, Frances A. Gavigan, Christopher Reilly & John C. Peckham. (2006) Acute and neurotoxicity of two structurally related acetylenic compounds: 5,7,11‐dodecatriyn‐1‐ol and 5,7,11,13‐octadecatetrayne‐1,18‐diol. Journal of Applied Toxicology 8:1, pages 35-42.
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Tipton R. Tyler & Bryan Ballantyne. 1988. Perspectives in Basic and Applied Toxicology. Perspectives in Basic and Applied Toxicology 330 378 .

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