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Drug and Chemical Toxicology Volume 7, 1984 - Issue 5
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Research Article

Innovative Designs and Practices for Acute Systemic Toxicity Studies

S. C. Gad Department of Toxicology, Allied Corporation, Morristown, NJ, 07960
,
A. C. Smith Department of Toxicology, Allied Corporation, Morristown, NJ, 07960
,
A. L. Cramp Department of Toxicology, Allied Corporation, Morristown, NJ, 07960
,
F. A. Gavigan Department of Toxicology, Allied Corporation, Morristown, NJ, 07960
&
M. J. Derelanko Department of Toxicology, Allied Corporation, Morristown, NJ, 07960
Pages 423-434 | Published online: 27 Sep 2008

References

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  • Dagani R. Alternative Methods Could Cut Animal Use in Toxicity Tests. Chem. Eng. News (October 31, 1983); 12
  • Spira H. (June, 1983), Coalition to Abolish the LD50 Coordinators Report, 3
  • Goldman L. The Medical Sciences in Animals in Research, D. Sperlinger. John Wiley S. Sons, New York (1981); 112–116
  • Goldberg A. M. Quarterly Newsletter of The Johns Hopkins Center for Alternatives to Animal Testing. Symposium Proceedings: Alternative Tests for Product Safety. 1983, (4)2
  • Balazs T. Assessment of the Value of Systemic Toxicity Studies In Experimental Animals. New Concepts in Safety Evaluation Part 1, M. A. Mehlman, R. E. Shapiro, H. Blumenthal. John Wiley &. Sons, New York (1976); 142–146
  • Zbinden G., Flury-Roversi M. Significance of the LD50 test for the toxicological evaluation of chemical substances. Arch. Toxicol (1981); 47: 77–99
  • Brownlee K. A., Hodges J. L., Rosenblatt M. O. The up-and-down method with small samples. J. Amer. Statist. Ass. (1953); 48: 262–277
  • Dixon W. J. The up and down method for small samples. J. Amer. Statist. Ass. (1965); 60: 967–978
  • Eichhorn B. H., Zacks S. Dept. of Mathematics and Statistics, Case Western University, OhioUSA (1972), Sequential search of an optimal dosage: Technical Report No. 5
  • Gad S. C. A neuromuscular screen for use in industrial toxicology. J. Toxicol. Env. Hlth (1982); 9: 691–704

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