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Research Article

Efficacy of Oxime Plus Atropine Treatment Against Soman Poisoning in the Atropinesterase-Free Rabbit

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Pages 117-126 | Published online: 27 Sep 2008

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Michael W. Perkins, Zdenka Pierre, Praveena Sabnekar, Alfred M. Sciuto, Jian Song, Iswarduth Soojhawon, Samuel Oguntayo, Bhupendra P. Doctor & Madhusoodana P. Nambiar. (2012) Aerosolized delivery of oxime MMB-4 in combination with atropine sulfate protects against soman exposure in guinea pigs. Inhalation Toxicology 24:9, pages 539-549.
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Jiri Kassa, Daniel Jun & Kamil Kuca. (2007) A comparison of reactivating efficacy of newly developed oximes (K074, K075) and currently available oximes (obidoxime, HI-6) in cyclosarin-and tabun-poisoned rats. Journal of Enzyme Inhibition and Medicinal Chemistry 22:3, pages 297-300.
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Kamil Kuča & Jiří Patočka. (2004) Reactivation of Cyclosarin-inhibited Rat Brain Acetylcholinesterase by Pyridinium–Oximes. Journal of Enzyme Inhibition and Medicinal Chemistry 19:1, pages 39-43.
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Ghosh C. Bandyopadhyay & S. Medda. (1998) Protective Role of Thyroxine in Methylparathion Intoxicated Chick Embryos. Drug and Chemical Toxicology 21:4, pages 495-506.
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Articles from other publishers (10)

Meghan Gage, Nikhil S. Rao, Manikandan Samidurai, Marson Putra, Suraj S. Vasanthi, Christina Meyer, Chong Wang & Thimmasettappa Thippeswamy. (2022) Soman (GD) Rat Model to Mimic Civilian Exposure to Nerve Agent: Mortality, Video-EEG Based Status Epilepticus Severity, Sex Differences, Spontaneously Recurring Seizures, and Brain Pathology. Frontiers in Cellular Neuroscience 15.
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James B. Machamer, James P. Apland, Brittany M. Winner, Sarah E. Wolfe, Kathleen T. Pagarigan, Kevin M. Bounader, Shane A. Kasten, Michael Adler & Patrick M. McNutt. (2020) Functional basis for dose-dependent antagonism of rat and rabbit neuromuscular transmission by the bis-pyridinium oxime MMB4. Archives of Toxicology 94:11, pages 3877-3891.
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Kamil Kuca, Jiri Cabal, Yung Sik Jung, Kamil Musilek, Ondrej Soukup, Daniel Jun, Miroslav Pohanka, Lucie Musilova, Jana Karasová, Ladislav Novotný & Martina Hrabinova. (2009) Reactivation of Human Brain Homogenate Cholinesterases Inhibited by Tabun using Newly Developed Oximes K117 and K127. Basic & Clinical Pharmacology & Toxicology 105:3, pages 207-210.
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Nageswararao Chilukuri, Chunyuan Luo, Bhupendra Doctor, Ashima Saxena & Donald Maxwell. 2007. Chemical Warfare Agents. Chemical Warfare Agents.
F. Worek, P. Eyer, N. Aurbek, L. Szinicz & H. Thiermann. (2007) Recent advances in evaluation of oxime efficacy in nerve agent poisoning by in vitro analysis. Toxicology and Applied Pharmacology 219:2-3, pages 226-234.
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J. Kassa & J. Cabal. (1999) A comparison of the efficacy of a new asymmetric bispyridinium oxime BI-6 with currently available oximes and H oximes against soman by in vitro and in vivo methods. Toxicology 132:2-3, pages 111-118.
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Jiří Kassa & Jiří Cabal. (2017) A Comparison of the Efficacy of Acetylcholinesterase Reactivators against Cyclohexyl Methylphosphonofluoridate (GF Agent) by in vitro and in vivo Methods . Pharmacology & Toxicology 84:1, pages 41-45.
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R. M. Dawson. (2006) Review of oximes available for treatment of nerve agent poisoning. Journal of Applied Toxicology 14:5, pages 317-331.
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Irwin Koplovitz & James R. Stewart. (1994) A comparison of the efficacy of HI6 and 2-PAM against soman, tabun, sarin, and VX in the rabbit. Toxicology Letters 70:3, pages 269-279.
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Tsung -Ming Shih. (1993) Comparison of several oximes on reactivation of soman-inhibited blood, brain and tissue cholinesterase activity in rats. Archives of Toxicology 67:9, pages 637-646.
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