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Research Article

The Selective Phosphodiesterase 9 (PDE9) Inhibitor PF-04447943 Attenuates a Scopolamine-Induced Deficit in a Novel Rodent Attention Task

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Pages 120-126 | Received 25 Aug 2011, Accepted 03 Oct 2011, Published online: 09 Nov 2011

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Yinuo Wu, Zhe Li, Yi-You Huang, Deyan Wu & Hai-Bin Luo. (2018) Novel Phosphodiesterase Inhibitors for Cognitive Improvement in Alzheimer’s Disease. Journal of Medicinal Chemistry 61:13, pages 5467-5483.
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M S Alexander, M J Gasperini, P T Tsai, D E Gibbs, J M Spinazzola, J L Marshall, M J Feyder, M T Pletcher, E L P Chekler, C A Morris, M Sahin, J F Harms, C J Schmidt, R J Kleiman & L M Kunkel. (2016) Reversal of neurobehavioral social deficits in dystrophic mice using inhibitors of phosphodiesterases PDE5A and PDE9A. Translational Psychiatry 6:9, pages e901-e901.
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Jian Li, Chun-Na Liu, Ning Wei, Xi-Dong Li, Yuan-Yuan Liu, Rui Yang & Yu-Jie Jia. (2016) Protective effects of BAY 73-6691, a selective inhibitor of phosphodiesterase 9, on amyloid-β peptides-induced oxidative stress in in-vivo and in-vitro models of Alzheimer's disease. Brain Research 1642, pages 327-335.
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M. Huang, Y. Shao, J. Hou, W. Cui, B. Liang, Y. Huang, Z. Li, Y. Wu, X. Zhu, P. Liu, Y. Wan, H. Ke & H.-B. Luo. (2015) Structural Asymmetry of Phosphodiesterase-9A and a Unique Pocket for Selective Binding of a Potent Enantiomeric Inhibitor. Molecular Pharmacology 88:5, pages 836-845.
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Roland Seifert, Erich H. Schneider & Heike Bähre. (2015) From canonical to non-canonical cyclic nucleotides as second messengers: Pharmacological implications. Pharmacology & Therapeutics 148, pages 154-184.
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P.R.A. Heckman, A. Blokland, J. Ramaekers & J. Prickaerts. (2015) PDE and cognitive processing: Beyond the memory domain. Neurobiology of Learning and Memory 119, pages 108-122.
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Dávid Nagy, Francis D. TingleyIIIIII, Milan Stoiljkovic & Mihály Hajós. (2015) Application of neurophysiological biomarkers for Huntington's disease: Evaluating a phosphodiesterase 9A inhibitor. Experimental Neurology 263, pages 122-131.
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Jamison B. Tuttle & Bethany L. Kormos. 2015. Small Molecule Therapeutics for Schizophrenia. Small Molecule Therapeutics for Schizophrenia 255 316 .
Qin Zhihui. (2013) Modulating nitric oxide signaling in the CNS for Alzheimer’s disease therapy. Future Medicinal Chemistry 5:12, pages 1451-1468.
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Ana García-Osta, Mar Cuadrado-Tejedor, Carolina García-Barroso, Julen Oyarzábal & Rafael Franco. (2012) Phosphodiesterases as Therapeutic Targets for Alzheimer's Disease. ACS Chemical Neuroscience 3:11, pages 832-844.
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Michelle M. Claffey, Christopher J. Helal, Patrick R. Verhoest, Zhijun Kang, Kristina S. Fors, Stanley Jung, Jiaying Zhong, Mark W. Bundesmann, Xinjun Hou, Shenping Lui, Robin J. Kleiman, Michelle Vanase-Frawley, Anne W. Schmidt, Frank Menniti, Christopher J. Schmidt, William E. Hoffman, Mihaly Hajos, Laura McDowell, Rebecca E. O’Connor, Mary MacDougall-Murphy, Kari R. Fonseca, Stacey L. Becker, Frederick R. Nelson & Spiros Liras. (2012) Application of Structure-Based Drug Design and Parallel Chemistry to Identify Selective, Brain Penetrant, In Vivo Active Phosphodiesterase 9A Inhibitors. Journal of Medicinal Chemistry 55:21, pages 9055-9068.
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Patrick R. Verhoest, Kari R. Fonseca, Xinjun Hou, Caroline Proulx-LaFrance, Michael Corman, Christopher J. Helal, Michelle M. Claffey, Jamison B. Tuttle, Karen J. Coffman, Shenpinq Liu, Frederick Nelson, Robin J. Kleiman, Frank S. Menniti, Christopher J. Schmidt, Michelle Vanase-Frawley & Spiros Liras. (2012) Design and Discovery of 6-[(3 S ,4 S )-4-Methyl-1-(pyrimidin-2-ylmethyl)pyrrolidin-3-yl]-1-(tetrahydro-2 H -pyran-4-yl)-1,5-dihydro-4 H -pyrazolo[3,4- d ]pyrimidin-4-one (PF-04447943), a Selective Brain Penetrant PDE9A Inhibitor for the Treatment of Cognitive Disorders . Journal of Medicinal Chemistry 55:21, pages 9045-9054.
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Robin J. Kleiman, Douglas S. Chapin, Curt Christoffersen, Jody Freeman, Kari R. Fonseca, Kieran F. Geoghegan, Sarah Grimwood, Victor Guanowsky, Mihály Hajós, John F. Harms, Christopher J. Helal, William E. Hoffmann, Geralyn P. Kocan, Mark J. Majchrzak, Dina McGinnis, Stafford McLean, Frank S. Menniti, Fredrick Nelson, Robin Roof, Anne W. Schmidt, Patricia A. Seymour, Diane T. Stephenson, Francis David Tingley, Michelle Vanase-Frawley, Patrick R. Verhoest & Christopher J. Schmidt. (2012) Phosphodiesterase 9A Regulates Central cGMP and Modulates Responses to Cholinergic and Monoaminergic Perturbation In Vivo. Journal of Pharmacology and Experimental Therapeutics 341:2, pages 396-409.
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Sharma A, Goyal A & Garabadu D. (2019) Phosphodiesterase Inhibitors: A Therapeutic Augmentation for Treatment of Cognitive Impairment. SSRN Electronic Journal.
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