Journal of Neurogenetics, Volume 25, Issue 4 (2011)

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Journal of Neurogenetics, Volume 25, Issue 4 (2011)

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SPECIAL SECTION: PHARMACONEUROGENETICS

Article
Preface to the Special Issue “Novel Pharmaconeurogenetic Approaches Arising from Progress in Translational Genetics”
John J. Renger & Jonathan T. Kern
Pages: 117-119
Published online: 10 Nov 2011
First Page PreviewforPreface to the Special Issue “Novel Pharmaconeurogenetic Approaches Arising from Progress in Translational Genetics” | Full Text | References | PDF (93.3 KB)
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Research Article

Article
The Selective Phosphodiesterase 9 (PDE9) Inhibitor PF-04447943 Attenuates a Scopolamine-Induced Deficit in a Novel Rodent Attention Task
Joshua D. Vardigan, Antonella Converso, Pete H. Hutson & Jason M. Uslaner
Pages: 120-126
Published online: 09 Nov 2011
AbstractforThe Selective Phosphodiesterase 9 (PDE9) Inhibitor PF-04447943 Attenuates a Scopolamine-Induced Deficit in a Novel Rodent Attention Task | Full Text | References | PDF (312.4 KB)
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Article
Targeting Post-translational Modifications on Tau as a Therapeutic Strategy for Alzheimer's Disease
Jacob Newman Marcus & Joel Schachter
Pages: 127-133
Published online: 17 Nov 2011
AbstractforTargeting Post-translational Modifications on Tau as a Therapeutic Strategy for Alzheimer's Disease | Full Text | References | PDF (123.9 KB)
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Article
A Point Mutation at F1737 of the Human Nav1.7 Sodium Channel Decreases Inhibition by Local Anesthetics
Jacqueline Panigel & Sean Peter Cook
Pages: 134-139
Published online: 10 Nov 2011
AbstractforA Point Mutation at F1737 of the Human Nav1.7 Sodium Channel Decreases Inhibition by Local Anesthetics | Full Text | References | PDF (215.3 KB)
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Article
Leucine-Rich Repeat Kinase 2 (LRRK2) Cellular Biology: A Review of Recent Advances in Identifying Physiological Substrates and Cellular Functions
Robert E. Drolet, John M. Sanders & Jonathan T. Kern
Pages: 140-151
Published online: 11 Nov 2011
AbstractforLeucine-Rich Repeat Kinase 2 (LRRK2) Cellular Biology: A Review of Recent Advances in Identifying Physiological Substrates and Cellular Functions | Full Text | References | PDF (247.5 KB)
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Article
Characterization of an mGluR2/3 Negative Allosteric Modulator in Rodent Models of Depression
Brice Campo, Mikhail Kalinichev, Nathalie Lambeng, M. El Yacoubi, Isabelle Royer-Urios, Manfred Schneider, Coline Legrand, Delphine Parron, Francoise Girard, Abdelhak Bessif, Sonia Poli, Jean-Marie Vaugeois, Emmanuel Le Poul & Sylvain Celanire
Pages: 152-166
Published online: 17 Nov 2011
AbstractforCharacterization of an mGluR2/3 Negative Allosteric Modulator in Rodent Models of Depression | Full Text | References | PDF (331.6 KB)
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Article
Pharmacological Validation of Candidate Causal Sleep Genes Identified in an N2 Cross
Joseph I. Brunner, Anthony L. Gotter, Joshua Millstein, Susan Garson, Jacquelyn Binns, Steven V. Fox, Alan T. Savitz, He S. Yang, Karrie Fitzpatrick, Lili Zhou, Joseph R. Owens, Andrea L. Webber, Martha H. Vitaterna, Andrew Kasarskis, Victor N. Uebele, Fred Turek, John J. Renger & Christopher J. Winrow
Pages: 167-181
Published online: 17 Nov 2011
AbstractforPharmacological Validation of Candidate Causal Sleep Genes Identified in an N2 Cross | Full Text | References | PDF (1.3 MB) | Supplemental
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ORIGINAL RESEARCH ARTICLES

Article
Phenotypic Variability in a Large Czech Family with a Dynamin 2–Associated Charcot-Marie-Tooth Neuropathy
J. Haberlová, R. Mazanec, P. Ridzoň, L. Baránková, G. Nürnberg, P. Nürnberg, H. Sticht, K. Huehne, P. Seeman & B. Rautenstrauss
Pages: 182-188
Published online: 17 Nov 2011
AbstractforPhenotypic Variability in a Large Czech Family with a Dynamin 2–Associated Charcot-Marie-Tooth Neuropathy | Full Text | References | PDF (276.3 KB)
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Research Article

Article
High Frequency of Mutations in the PIK3CA Gene Helical and Kinase Coding Regions in a Group of Iranian Patients with High-Grade Glioblastomas: Five Novel Mutations
Pupak Derakhshandeh-Peykar, Jalil Alivi, Arash Hosseinnejad, Bernd Rautenstrauss, Reza Ebrahimzadeh Vesal & Afsoon Doriani
Pages: 189-194
Published online: 25 Oct 2011
AbstractforHigh Frequency of Mutations in the PIK3CA Gene Helical and Kinase Coding Regions in a Group of Iranian Patients with High-Grade Glioblastomas: Five Novel Mutations | Full Text | References | PDF (251.8 KB)
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Article
Genes Involved in Cerebrospinal Fluid Production as Candidate Genes for Late-Onset Alzheimer's Disease: A Hypothesis
Peter Wostyn, Debby van Dam, Kurt Audenaert & Peter Paul de Deyn
Pages: 195-200
Published online: 24 Oct 2011
AbstractforGenes Involved in Cerebrospinal Fluid Production as Candidate Genes for Late-Onset Alzheimer's Disease: A Hypothesis | Full Text | References | PDF (149.5 KB)
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Article
Overexpression of Human MRP1 in Neurons causes resistance to Antiepileptic Drugs in Drosophila Seizure Mutants
Guan-Shui Bao, Wen-An Wang, Tian-Zhe Wang, Jian-Kang Huang, Hua He, Zhenguo Liu & Fu-De Huang
Pages: 201-206
Published online: 25 Oct 2011
AbstractforOverexpression of Human MRP1 in Neurons causes resistance to Antiepileptic Drugs in Drosophila Seizure Mutants | Full Text | References | PDF (261.3 KB)
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