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Experimental Lung Research Volume 36, 2010 - Issue 2
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Research Article

Inhibition of myristoylated alanine-rich C kinase substrate (MARCKS) protein inhibits ozone-induced airway neutrophilia and inflammation

Gautam DameraAirways Biology Initiative, Pulmonary, Allergy and Critical Care Division, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
,
William F. JesterAirways Biology Initiative, Pulmonary, Allergy and Critical Care Division, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
,
Meiqi JiangAirways Biology Initiative, Pulmonary, Allergy and Critical Care Division, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
,
Hengjiang ZhaoAirways Biology Initiative, Pulmonary, Allergy and Critical Care Division, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
,
Homer W. FogleAirways Biology Initiative, Pulmonary, Allergy and Critical Care Division, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
,
Michael MittelmanAirways Biology Initiative, Pulmonary, Allergy and Critical Care Division, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
,
Angela HaczkuAirways Biology Initiative, Pulmonary, Allergy and Critical Care Division, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
,
Edwin MurphyBioMarck Pharmaceuticals, Durham, North Carolina, USA
,
Indu ParikhBioMarck Pharmaceuticals, Durham, North Carolina, USA
&
Reynold A. Panettieri Jr.Airways Biology Initiative, Pulmonary, Allergy and Critical Care Division, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USACorrespondence[email protected]
 show all
Pages 75-84 | Received 27 Feb 2009, Accepted 19 Jun 2009, Published online: 05 Mar 2010

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Haleigh Conley, Rebecca L. Till, Alix K. Berglund, Samuel L. Jones & M. Katie Sheats. (2023) A myristoylated alanine-rich C-kinase substrate (MARCKS) inhibitor peptide attenuates neutrophil outside-in β2-integrin activation and signaling. Cell Adhesion & Migration 17:1, pages 1-16.
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Sowmya P Lakshmi, Aravind T Reddy & Raju C Reddy. (2017) Emerging pharmaceutical therapies for COPD. International Journal of Chronic Obstructive Pulmonary Disease 12, pages 2141-2156.
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Articles from other publishers (19)

Zhongxuan Gui, Wenjun Hu, Qi Kong, Can Liu, Yuechen Xu & Fan Wang. (2022) Esophageal stenosis as an independent factor of poor prognosis in patients with ESCC treated with definitive chemoradiotherapy. Future Oncology 18:38, pages 4193-4207.
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Chun-Lung Chiu, Hongjuan Zhao, Ching-Hsien Chen, Reen Wu & James D. Brooks. (2022) The Role of MARCKS in Metastasis and Treatment Resistance of Solid Tumors. Cancers 14:19, pages 4925.
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Zhilei Chen, Weici Zhang, Carlo Selmi, William M. Ridgway, Patrick S.C. Leung, Fengchun Zhang & M. Eric Gershwin. (2021) The myristoylated alanine-rich C-kinase substrates (MARCKS): A membrane-anchored mediator of the cell function. Autoimmunity Reviews 20:11, pages 102942.
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Deepak Narayanan Iyer, Omar Faruq, Lun Zhang, Nasrin Rastgoo, Aijun Liu & Hong Chang. (2021) Pathophysiological roles of myristoylated alanine-rich C-kinase substrate (MARCKS) in hematological malignancies. Biomarker Research 9:1.
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Sameera Iqbal, Tiffany R. Walsh, Alison Rodger & Nicolle H. Packer. (2020) Interaction between Polysialic Acid and the MARCKS-ED Peptide at the Molecular Level. ACS Chemical Neuroscience 11:13, pages 1944-1954.
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Marcelo C. Marinho, Ana Beatriz F. Pacheco, Giovani C. V. Costa, Nina D. Ortiz, Lenita Zajdenverg & Carmelo Sansone. (2019) Quantitative gingival crevicular fluid proteome in type 2 diabetes mellitus and chronic periodontitis. Oral Diseases 25:2, pages 588-595.
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Mary K. Sheats, Qi Yin, Shijing Fang, Joungjoa Park, Anne L. Crews, Indu Parikh, Brian Dickson & Kenneth B. Adler. (2019) MARCKS and Lung Disease. American Journal of Respiratory Cell and Molecular Biology 60:1, pages 16-27.
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Mohamed El Amri, Una Fitzgerald & Gerhard Schlosser. (2018) MARCKS and MARCKS-like proteins in development and regeneration. Journal of Biomedical Science 25:1.
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Lon Wolf R. Fong, David C. Yang & Ching-Hsien Chen. (2017) Myristoylated alanine-rich C kinase substrate (MARCKS): a multirole signaling protein in cancers. Cancer and Metastasis Reviews 36:4, pages 737-747.
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Mary K. Sheats, Eui Jae Sung, Kenneth B. Adler & Samuel L. Jones. (2014) In Vitro Neutrophil Migration Requires Protein Kinase C-Delta (?-PKC)-Mediated Myristoylated Alanine-Rich C-Kinase Substrate (MARCKS) Phosphorylation. Inflammation 38:3, pages 1126-1141.
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Kesavan S. Babu & Jaymin B. Morjaria. (2015) Emerging therapeutic strategies in COPD. Drug Discovery Today 20:3, pages 371-379.
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Jian Shi, Lutz Birnbaumer, William A. Large & Anthony P. Albert. (2013) Myristoylated alanine‐rich C kinase substrate coordinates native TRPC1 channel activation by phosphatidylinositol 4,5‐bisphosphate and protein kinase C in vascular smooth muscle. The FASEB Journal 28:1, pages 244-255.
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Jingjing Li, Melissa A. D’Annibale-Tolhurst, Kenneth B. Adler, Shijing Fang, Qui Yin, Adam J. Birkenheuer, Michael G. Levy, Samuel L. Jones, Eui Jae Sung, Eleanor C. Hawkins, Jeffrey A. Yoder & Shila K. Nordone. (2013) A Myristoylated Alanine-Rich C Kinase Substrate–Related Peptide Suppresses Cytokine mRNA and Protein Expression in LPS-Activated Canine Neutrophils. American Journal of Respiratory Cell and Molecular Biology 48:3, pages 314-321.
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Denuja Karunakaran, Maaike Kockx, Dylan M. Owen, John R. Burnett, Wendy Jessup & Leonard Kritharides. (2013) Protein Kinase C Controls Vesicular Transport and Secretion of Apolipoprotein E from Primary Human Macrophages. Journal of Biological Chemistry 288:7, pages 5186-5197.
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Atsuhiro Tanabe, Mitsuya Shiraishi & Yasuharu Sasaki. (2013) Dephosphorylation of myristoylated alanine-rich C kinase substrate accelerates wound-induced migration of SH-SY5Y cells. Advances in Bioscience and Biotechnology 04:08, pages 27-32.
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Aleksej Zuzek, Jerry D. Fan, Christopher S. Spaeth & George D. Bittner. (2012) Sealing of Transected Neurites of Rat B104 Cells Requires a Diacylglycerol PKC-Dependent Pathway and a PKA-Dependent Pathway. Cellular and Molecular Neurobiology 33:1, pages 31-46.
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Teresa D Green, Joungjoa Park, Qi Yin, Shijing Fang, Anne L Crews, Samuel L Jones & Kenneth B Adler. (2012) Directed migration of mouse macrophages in vitro involves myristoylated alanine-rich C-kinase substrate (MARCKS) protein. Journal of Leukocyte Biology 92:3, pages 633-639.
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Audreesh Banerjee, Chinmay M. Trivedi, Gautam Damera, Meiqi Jiang, William Jester, Toshinori Hoshi, Jonathan A. Epstein & Reynold A. PanettieriJr.Jr.. (2012) Trichostatin A Abrogates Airway Constriction, but Not Inflammation, in Murine and Human Asthma Models. American Journal of Respiratory Cell and Molecular Biology 46:2, pages 132-138.
Crossref
Teresa D. Green, Anne L. Crews, Joungjoa Park, Shijing Fang & Kenneth B. Adler. (2011) Regulation of mucin secretion and inflammation in asthma: A role for MARCKS protein?. Biochimica et Biophysica Acta (BBA) - General Subjects 1810:11, pages 1110-1113.
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