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Original Article

Effect of Cumulative Ozone Exposure on Ozone-Induced Nasal Epithelial Hyperplasia and Secretory Metaplasia in Rats

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Pages 589-600 | Received 26 Feb 1990, Accepted 23 May 1990, Published online: 02 Jul 2009

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L. Nikasinovic, I. Momas & N. Seta. (2003) Nasal Epithelial and Inflammatory Response to Ozone Exposure: A Review of Laboratory-Based Studies Published Since 1985. Journal of Toxicology and Environmental Health, Part B 6:5, pages 521-568.
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Richard B. Schlesinger, John E. Gorczynski, Joanne Dennison, Larry Richards, Patrick L. Kinney & Maarten C. Bosland. (1992) Long-Term Intermittent Exposure to Sulfuric Acid Aerosol, Ozone, and Their Combination: Alterations in Tracheobronchial Mucociliary Clearance and Epithelial Secretory Cells. Experimental Lung Research 18:4, pages 505-534.
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J. R. Harkema & J. A. Hotchkiss. (1991) In Vivo Effects of Endotoxin on Nasal Epithelial Mucosubstances: Quantitative Histochemistry. Experimental Lung Research 17:4, pages 743-761.
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Articles from other publishers (31)

Hye-Youn Cho, Soojung Park, Laura Miller, Huei-Chen Lee, Robert Langenbach & Steven R. Kleeberger. (2021) Role for Mucin-5AC in Upper and Lower Airway Pathogenesis in Mice. Toxicologic Pathology 49:5, pages 1077-1099.
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Fatemeh Kazemiparkouhi, Ki-Do Eum, Bingyu Wang, Justin Manjourides & Helen H. Suh. (2019) Long-term ozone exposures and cause-specific mortality in a US Medicare cohort. Journal of Exposure Science & Environmental Epidemiology 30:4, pages 650-658.
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. 2002. The MAK-Collection for Occupational Health and Safety. The MAK-Collection for Occupational Health and Safety 1 318 .
. 2002. The MAK‐Collection for Occupational Health and Safety. The MAK‐Collection for Occupational Health and Safety 172 199 .
. 2002. The MAK‐Collection for Occupational Health and Safety. The MAK‐Collection for Occupational Health and Safety 1 26 .
Hye-Youn Cho, Farhad Imani, Laura Miller-DeGraff, Dianne Walters, Guillermina A. Melendi, Masayuki Yamamoto, Fernando P. Polack & Steven R. Kleeberger. (2009) Antiviral Activity of Nrf2 in a Murine Model of Respiratory Syncytial Virus Disease. American Journal of Respiratory and Critical Care Medicine 179:2, pages 138-150.
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Jack R. Harkema & James G. Wagner. (2005) Epithelial and inflammatory responses in the airways of laboratory rats coexposed to ozone and biogenic substances: Enhancement of toxicant-induced airway injury. Experimental and Toxicologic Pathology 57, pages 129-141.
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Yohannes Tesfaigzi, J. Foster Harris, Jon A. Hotchkiss & Jack R. Harkema. (2004) DNA synthesis and Bcl-2 expression during development of mucous cell metaplasia in airway epithelium of rats exposed to LPS. American Journal of Physiology-Lung Cellular and Molecular Physiology 286:2, pages L268-L274.
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Sumihisa Sueyoshi, Yuki Miyata, Yoshihiro Masumoto, Yuji Ishibashi, Shigeki Matsuzawa, Naoki Harano, Kiyoyuki Tsuru & Shigeru Imai. (2004) Reduced Airway Inflammation and Remodeling in Parallel with Mucin 5AC Protein Expression Decreased by S-Carboxymethylcysteine, a Mucoregulant, in the Airways of Rats Exposed to Sulfur Dioxide. International Archives of Allergy and Immunology 134:4, pages 273-280.
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J. G. Wagner, S. J. Van Dyken, J. R. Wierenga, J. A. Hotchkiss & J. R. Harkema. (2003) Ozone Exposure Enhances Endotoxin-Induced Mucous Cell Metaplasia in Rat Pulmonary Airways. Toxicological Sciences 74:2, pages 437-446.
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J G WagnerJ A HotchkissJ R Harkema. (2001) Effects of ozone and endotoxin coexposure on rat airway epithelium: potentiation of toxicant-induced alterations.. Environmental Health Perspectives 109:suppl 4, pages 591-598.
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HYE Y. CHO, JON A. HOTCHKISS, CATHERINE B. BENNETT & JACK R. HARKEMA. (2000) Neutrophil-Dependent and Neutrophil-Independent Alterations in the Nasal Epithelium of Ozone-Exposed Rats. American Journal of Respiratory and Critical Care Medicine 162:2, pages 629-636.
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Hye Y. Cho, Jon A. Hotchkiss, Catherine B. Bennett & Jack R. Harkema. (1999) Effects of Pre-existing Rhinitis on Ozone-Induced Mucous Cell Metaplasia in Rat Nasal Epithelium. Toxicology and Applied Pharmacology 158:2, pages 92-102.
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Michelle V. Fanucchi, Jack R. Harkema, Charles G. Plopper & Jon A. Hotchkiss. (1999) In Vitro Culture of Microdissected Rat Nasal Airway Tissues . American Journal of Respiratory Cell and Molecular Biology 20:6, pages 1274-1285.
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Jack R. Harkema, Jon A. Hotchkiss, Edward B. Barr, Catherine B. Bennett, Marianne Gallup, Jong Kwon Lee & Carol Basbaum. (1999) Long-Lasting Effects of Chronic Ozone Exposure on Rat Nasal Epithelium. American Journal of Respiratory Cell and Molecular Biology 20:3, pages 517-529.
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L. Calderón-Garcidueñas, A. Rodriguez-Alcaraz, R. Garcia, G. Barragan, A. Villarreal-Calderón & M.C. Madden. (1999) Cell proliferation in nasal respiratory epithelium of people exposed to urbanpollution. Carcinogenesis 20:3, pages 383-389.
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Renee C. Paige & Charles G. Plopper. 1999. Air Pollution and Health. Air Pollution and Health 531 557 .
Michelle V. Fanucchi, Jon A. Hotchkiss & Jack R. Harkema. (1998) Endotoxin Potentiates Ozone-Induced Mucous Cell Metaplasia in Rat Nasal Epithelium. Toxicology and Applied Pharmacology 152:1, pages 1-9.
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Jon A. Hotchkiss, Roger Hilaski, Hyeyoun Cho, Karen Regan, Patty Spencer, Kate Slack & Jack R. Harkema. (1998) Fluticasone Propionate Attenuates Ozone-induced Rhinitis and Mucous Cell Metaplasia in Rat Nasal Airway Epithelium. American Journal of Respiratory Cell and Molecular Biology 18:1, pages 91-99.
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Jon A. Hotchkiss, Jack R. Harkema & Neil F. Johnson. (1997) Kinetics of Nasal Epithelial Cell Loss and Proliferation in F344 Rats Following a Single Exposure to 0.5 ppm Ozone. Toxicology and Applied Pharmacology 143:1, pages 75-82.
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Jack R. Harkema, Edward B. Barr & Jon A. Hotchkiss. (1997) Responses of rat nasal epithelium to short- and long-term exposures of ozone: Image analysis of epithelial injury, adaptation and repair. Microscopy Research and Technique 36:4, pages 276-286.
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Dechun Li & Peter K. Jeffery. 1997. Airway Mucus: Basic Mechanisms and Clinical Perspectives. Airway Mucus: Basic Mechanisms and Clinical Perspectives 227 273 .
Roger McClellan & Rogene HendersonDonald Dungworth, Fletcher Hahn & Kristen Nikula. 1995. Concepts In Inhalation Toxicology. Concepts In Inhalation Toxicology 535 578 .
M. Yeadon. 1995. Immunopharmacology of Free Radical Species. Immunopharmacology of Free Radical Species 215 232 .
Gary A. Boorman, Rick Hmley, Sondra Grumbein, Billy J. Chou, Ron A. Herbert, Thomas Goehl, Paul W. Mellick, Joseph H. Roycroft, Joseph K. Haseman & Robert Sills. (2016) Toxicology and Carcinogenesis Studies of Ozone and Ozone 4-(N-Nitrosomethylamino)-1-(3-Pyridyl)-1-Butanone in Fischer-344/N Rats. Toxicologic Pathology 22:5, pages 545-554.
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J M SametP W Cheng. (1994) The role of airway mucus in pulmonary toxicology.. Environmental Health Perspectives 102:suppl 2, pages 89-103.
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Flemming R. Cassee & Victor J. Feron. (1994) Biochemical and histopathological changes in nasal epithelium of rats after 3-day intermittent exposure to formaldehyde and ozone alone or in combination. Toxicology Letters 72:1-3, pages 257-268.
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Takaaki Ito, Yoshiaki Ikemi, Kaoru Ohmori, Hitoshi Kitamura & Masayoshi Kanisawa. (1994) Airway epithelial cell changes in rats exposed to 0.25 ppm ozone for 20 months. Experimental and Toxicologic Pathology 46:1, pages 1-6.
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L Calderon-GarcidueñasG Roy-Ocotla. (1993) Nasal cytology in southwest metropolitan Mexico City inhabitants: a pilot intervention study.. Environmental Health Perspectives 101:2, pages 138-144.
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Jack R. Harkema & Jon A. Hotchkiss. (1993) Ozone- and endotoxin-induced mucous cell metaplasias in rat airway epithelium: Novel animal models to study toxicant-induced epithelial transformation in airways. Toxicology Letters 68:1-2, pages 251-263.
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Jon A. Hotchkiss & Jack R. Harkema. (1992) Endotoxin or cytokines attenuate ozone-induced DNA synthesis in rat nasal transitional epithelium. Toxicology and Applied Pharmacology 114:2, pages 182-187.
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