7
Views
34
CrossRef citations to date
0
Altmetric
Original Article

Effect of Cumulative Ozone Exposure on Ozone-Induced Nasal Epithelial Hyperplasia and Secretory Metaplasia in Rats

, &
Pages 589-600 | Received 26 Feb 1990, Accepted 23 May 1990, Published online: 02 Jul 2009

References

  • Stephens S J, Sloan M F, Evans M J, Freeman G. Early response of lung to low levels of ozone. Am J Pathol 1974; 74: 31–58
  • Dungworth D L. Noncarcinogenic responses of the respiratory tract to inhaled toxicants. Concepts in Inhalation Toxicology, R O McClellan, R F Henderson. Hemisphere, Washington, DC 1989; 273–298
  • Schwartz L W, Dungworth D L, Mustafa M G, Tarkington B K, Tyler W S. Pulmonary responses of rats to ambient levels of ozone. Effects of 7-day intermittent or continuous exposure. Lab Invest 1976; 34: 565–578
  • Last J A, Reiser K M, Tyler W S, Rucker R B. Long-term consequences of exposure to ozone. I. Lung collagen content. Toxicol Appl Pharmacol 1984; 72: 111–118
  • Hotchkiss J A, Harkema J R, Sun J D, Henderson R F. Comparison of acute ozone-induced nasal and pulmonary inflammatory responses in rats. Toxicol Appl Pharmacol 1989; 98: 289–302
  • Harkema J R, Hotchkiss J A, Henderson R F. Effects of 0.12 and 0.8 ppm ozone on rat nasal and nasopharyngeal epithelial mucosubstances: quantitative histochemistry. Toxicol Pathol 1989; 17: 525–535
  • Johnson N F, Hotchkiss J A, Harkema J R, Henderson R F. Proliferative responses of rat nasal epithelia to ozone. Toxicol Appl Pharmacol 1990; 103: 143–155
  • Hotchkiss J A, Harkema J R, Kirkpatrick D T, Henderson R F. Response of rat alveolar macrophages to ozone: quantitative assessment of population size, morphology, and proliferation following acute exposure. Exp Lung Res 1989; 15: 1–16
  • Harkema J R, Hotchkiss J A, Harmsen A G, Henderson R F. In vivo effects of transient neutrophil influx on nasal respiratory epithelial mucosubstances: quantitative histochemistry. Am J Pathol 1988; 130: 605–615
  • Young J T. Histopathologic examination of the rat nasal cavity. Fundam Appl Toxicol 1981; 1: 309–312
  • Harkema J R, Plopper C G, Hyde D M, St George J A, Dungworth D L. Effects of an ambient level of ozone on primate nasal epithelial mucosubstances: quantitative histochemistry. Am J Pathol 1987; 127: 90–96
  • Jeffery P K. Goblet cell increase in rat bronchial epithelium arising from irritation or drug administration: an experimental and electron microscopic study. University of London. 1973, PhD thesis
  • Neutra M, Leblond C P. Synthesis of the carbohydrate of mucus in the golgi complex as shown by electron microscope radioautography of goblet cells from rats injected with glucose-H3. J Cell Biol 1966; 30: 119–135
  • Mc Dowell E M, Combs J W, Newkirk C. Changes in secretory cells of hamster tracheal epithelium in response to acute sublethal injury: a quantitative study. Exp Lung Res 1983; 4: 227–243
  • Jones R, Phil M, Reid L. Secretory cell hyperplasia and modification of intracellular glycoprotein in rat airways induced by short periods of exposure to tobacco smoke, and the effect of the antiinflammatory agent phenylmethyloxadiazol. Lab Invest 1978; 39: 41–49
  • Bolduc P, Reid L. Mitotic index of the bronchial and alveolar lining of rat lung in various types of hypertrophy. University of London. 1976, PhD thesis
  • Wells A B, Lamerton L F. Regenerative response of the rat tracheal epithelium after acute exposure to tobacco smoke: a quantitative study. J Natl Cancer Inst 1975; 55: 887–891
  • Jeffery P K, Reid L. The respiratory mucous membrane. Respiratory Defense Mechanisms, Part 1 (Lung Biology in Health and Disease, Vol 5), J D Brain, D F Proctor, L Reid. Marcel Dekker, New York 1977; 193–238
  • Cross C E, Halliwell B, Allen A. Antioxidant protection: a function of tracheobronchial and gastrointestinal mucus. Lancet 1984; 1: 1328–1329
  • Miller F J, Menzell D B, Coffin D L. Similarity between man and laboratory animals in regional pulmonary deposition of ozone. Environ Res 1978; 17: 163–174
  • Spicer S S, Charkrin L W, Wardell J R, Jr. Effect of chronic sulfur dioxide inhalation on the carbohydrate histochemistry and histology of the canine respiratory tract. Am Rev Respir Dis 1974; 110: 13–24
  • Lamb D, Reid L. Mitotic rates, goblet cell increase and histochemical changes in mucus in rat bronchial epithelium during exposure to sulfur dioxide. J Pathol Bacteriol 1968; 96: 97–111
  • Rogers D F, Jeffery P K. Indomethacin and flurbiprofen speed recovery of rat bronchial epithelium after exposure to cigarette smoke. Exp Lung Res 1986; 10: 299–312
  • Baskerville A. The development and persistence of bronchial gland hypertrophy and goblet-cell hyperplasia in the pig after injection of isoprenaline. J Pathol 1976; 119: 35–47
  • Jones R, Reid L. Beta-adrenergic modulation of airway epithelial glycoprotein. Chest 1982; 81(Suppl)25S–26S
  • Jones R, Reid L. Beta-agonists and secretory cell number and intracellular glycoprotein in airway epithelium. Am J Pathol 1979; 95: 407–421

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.