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Ultrastructural Pathology Volume 10, 1986 - Issue 6
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Original Article

Variability of Expression and Arrangement of Cytokeratin and Neurofilaments in Cutaneous Neuroendocrine Carcinomas (Merkel Cell Tumors): Immunocytochemical and Biochemical Analysis of Twelve Cases

Roland Moll Department of Pathology, University of Mainz, Institute of Cell and Tumor Biology, German Cancer Research Center, D-6500, Mainz, D-6900, Heidelberg, FRG
,
Mary Osborn Max Planck Institute for Biophysical Chemistry, D-3400, Goettingen, FRG
,
Wolfgang Hartschuh Department of Dermatology, University of Heidelberg, D-6900, Heidelberg, FRG
,
Ingrid Moll Department of Dermatology, Mannheim Medical School, University of Heidelberg, D-6800, Mannheim, FRG
,
Gustav Mahrle Department of Dermatology, University of Cologne, D-5000, Cologne, FRG
&
Klaus Weber Max Planck Institute for Biophysical Chemistry, D-3400, Goettingen, FRG
Pages 473-495 | Accepted 24 Apr 1986, Published online: 10 Jul 2009

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Ludvik R. Donner, V. O. Speights & Raymond A. Trompler. (1992) Merkel Cell Carcinoma with Pagetoid Spread. Ultrastructural Pathology 16:1-2, pages 25-28.
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Brian Eyden, Irving Dardick & Paul Bishop. (1991) Filamentous Inclusions of Unusual Composition and Architecture in a Metastatic Tumor Showing Myoepithelial Differentiation. Ultrastructural Pathology 15:6, pages 663-670.
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Hector Battifora. (1990) Expression of Keratins by Endothelial Cells: Atavism or Anarchy?. Ultrastructural Pathology 14:2, pages 107-109.
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Robert A. Erlandson. (1989) Cytoskeletal Proteins including Myofilaments in Human Tumors. Ultrastructural Pathology 13:2-3, pages 155-186.
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Articles from other publishers (55)

Gloria Mak, Suresh Menon & Jian-Qiang Lu. (2022) Neurofilaments in neurologic disorders and beyond. Journal of the Neurological Sciences 441, pages 120380.
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Amanda S. W. Loke, B. Jack Longley, Paul F. Lambert & Megan E. Spurgeon. (2021) A Novel In Vitro Culture Model System to Study Merkel Cell Polyomavirus–Associated MCC Using Three-Dimensional Organotypic Raft Equivalents of Human Skin. Viruses 13:1, pages 138.
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I. Moll. (2019) MerkelzellkarzinomMerkel-cell carcinoma. Der Pathologe 40:S3, pages 350-354.
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Christopher R. Jackson & Konstantinos Linos. (2019) SOX10 Dot-Like Paranuclear Positivity in Merkel Cell Carcinoma: Report of 2 Cases. The American Journal of Dermatopathology 41:9, pages 694-695.
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Benjamin Johansson, Helka Sahi, Virve Koljonen & Tom Böhling. (2019) The expression of terminal deoxynucleotidyl transferase and paired box gene 5 in Merkel cell carcinomas and its relation to the presence of Merkel cell polyomavirus DNA. Journal of Cutaneous Pathology 46:1, pages 26-32.
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Hugo R. Domínguez-Malagón, Michal Michal, Dmitry V. Kazakov, Claudia H. Caro-Sánchez & Leonardo S. Lino-Silva. (2016) Utility of CD99 Paranuclear Expression in the Differential Diagnosis of Merkel Cell Carcinoma. International Journal of Surgical Pathology 24:4, pages 293-296.
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Axel zur Hausen, Dorit Rennspiess, Veronique Winnepenninckx, Ernst-Jan Speel & Anna Kordelia Kurz. (2013) Early B-Cell Differentiation in Merkel Cell Carcinomas: Clues to Cellular Ancestry. Cancer Research 73:16, pages 4982-4987.
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Katalin Barbara Horváth, Péter Pankovics, Zita Battyáni, Endre Kálmán & Gábor Reuter. (2013) A probable etiological role for Merkel cell polyomavirus in the development of Merkel cell carcinoma. Orvosi Hetilap 154:3, pages 102-112.
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Ashwyn Rajagopalan, Debra Browning & Samih Salama. (2012) CD99 expression in Merkel cell carcinoma: a case series with an unusual paranuclear dot‐like staining pattern . Journal of Cutaneous Pathology 40:1, pages 19-24.
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Brian Eyden, S. Sankar Banerjee, Yongxin Ru & Paweł LiberskiBrian Eyden & S. Sankar Banerjee. 2013. The Ultrastructure of Human Tumours. The Ultrastructure of Human Tumours 547 641 .
Satoshi Kuwamoto. (2011) Recent advances in the biology of Merkel cell carcinoma. Human Pathology 42:8, pages 1063-1077.
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Anna M Werling, Yvette Doerflinger, Johanna M Brandner, Franca Fuchs, Jürgen C Becker, David Schrama, Hjalmar Kurzen, Sergij Goerdt & Wiebke K Peitsch. (2011) Homo- and heterotypic cell-cell contacts in Merkel cells and Merkel cell carcinomas: heterogeneity and indications for cadherin switching. Histopathology 58:2, pages 286-303.
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A.-C. Eispert, F. Fuchs, J. M. Brandner, P. Houdek, E. Wladykowski & Ingrid Moll. (2009) Evidence for distinct populations of human Merkel cells. Histochemistry and Cell Biology 132:1, pages 83-93.
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Rhonda V. Barrett & Dale R. Meyer. (2009) Eyelid and Periocular Cutaneous Merkel Cell Carcinoma (aka. Neuroendocrine or Trabecular Carcinoma). International Ophthalmology Clinics 49:4, pages 63-75.
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David M. Mills, Dale R. Meyer, Joseph W. Sassani, Ahmed A. Hidayat & Frederick A. Jakobiec. 2008. Albert &amp Jakobiec's Principles &amp Practice of Ophthalmology. Albert &amp Jakobiec's Principles &amp Practice of Ophthalmology 3379 3394 .
Nicholas Boulais & Laurent Misery. (2007) Merkel cells. Journal of the American Academy of Dermatology 57:1, pages 147-165.
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Virve Koljonen. (2006) Merkel cell carcinoma. World Journal of Surgical Oncology 4:1.
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Ingrid Moll, Marion Roessler, Johanna M. Brandner, Ann-Christin Eispert, Pia Houdek & Roland Moll. (2005) Human Merkel cells – aspects of cell biology, distribution and functions. European Journal of Cell Biology 84:2-3, pages 259-271.
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Maya Sieber-Blum, Viktor Szeder & Milos Grim. 2004. NGF and Related Molecules in Health and Disease. NGF and Related Molecules in Health and Disease 63 72 .
Cristina Corzo, Blanca Espinet, Josep Lloreta, Marta Salido, Mar Iglesias, Sergi Serrano & Francesc Solé. (2003) Additional i(1)(q10) in a primitive neuroectodermal tumor type Merkel cell carcinoma as a primary cytogenetic change. Cancer Genetics and Cytogenetics 142:2, pages 165-167.
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Zdenek Halata, Milos Grim & Klaus I. Bauman. (2003) Friedrich Sigmund Merkel and his “Merkel cell”, morphology, development, and physiology: Review and new results. The Anatomical Record Part A: Discoveries in Molecular, Cellular, and Evolutionary Biology 271A:1, pages 225-239.
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Ingrid Moll & Roland Moll. 2003. The Merkel Cell. The Merkel Cell 179 185 .
K. Sames, U. Schumacher, Z. Halata, E. J. M. Van Damme, W. J. Peumans, B. Asmus, R. Moll & I. Moll. (2001) Lectin and proteoglycan histochemistry of Merkel cell carcinomas. Experimental Dermatology 10:2, pages 100-109.
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Peiguo Chu & Lawrence Weiss. 2016. Modern Immunohistochemistry. Modern Immunohistochemistry 96 132 .
. 2000. Diagnostic Electron Microscopy. Diagnostic Electron Microscopy 147 216 .
Mauro Papotti, Luigia Macri’, Alberto Pagani, Filippo Aloi & Gianni Bussolati. (1999) Quantitation of somatostatin receptor type 2 in neuroendocrine (merkel cell) carcinoma of the skin by competitive RT-PCR. Endocrine Pathology 10:1, pages 37-46.
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Wolfgang Hartschuh. 1997. Dermatologische Onkologie. Dermatologische Onkologie 489 498 .
Ingrid Moll. 1997. Fortschritte der praktischen Dermatologie und Venerologie. Fortschritte der praktischen Dermatologie und Venerologie 8 15 .
M. Härle, N. Arens, I. Moll, W. Back, T. Schulz & H. Scherthan. (2006) Comparative genomic hybridization (CGH) discloses chromosomal and subchromosomal copy number changes in Merkel cell carcinomas. Journal of Cutaneous Pathology 23:5, pages 391-397.
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K.N. Christie, C. Thomson, D. Hopwood, A.A. Harper & G.R. Ogden. (1996) An immunocytochemical study of the carbonic anhydrase I isoenzyme in human oral Merkel cells. Archives of Oral Biology 41:8-9, pages 901-904.
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Ingrid Moll, Frank Gillardon, Stefan Waltering, Monika Schmelz & Roland Moll. (2006) Differences of bcl‐2 protein expression between Merkel cells and Merkel cell carcinomas. Journal of Cutaneous Pathology 23:2, pages 109-117.
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MICHAEL L. HAAG, FRANK L. GLASS & NEIL A. FENSKE. (1995) Merkel Cell Carcinoma Diagnosis and Treatment. Dermatologic Surgery 21:8, pages 669-683.
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Ingrid Moll, Caedilie Kuhn & Roland Moll. (1995) Cytokeratin 20 Is a General Marker of Cutaneous Merkel Cells While Certain Neuronal Proteins Are Absent. Journal of Investigative Dermatology 104:6, pages 910-915.
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R. Moll. (2018) Cytokeratins in the Histological Diagnosis of Malignant Tumors. The International Journal of Biological Markers 9:2, pages 63-69.
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I. Moll, E. Bohnert, C. Herbst, W. Förster, R. Moll & W.W Franke. (1994) Establishment and Characterization of Two Merkel Cell Tumor Cultures. Journal of Investigative Dermatology 102:3, pages 346-353.
Crossref
RAY B. NAGLE. 1994. Biochemical and Molecular Aspects of Selected Cancers. Biochemical and Molecular Aspects of Selected Cancers 387 410 .
Ray B. Nagle. (1994) A review of intermediate filament biology and their use in pathologic diagnosis. Molecular Biology Reports 19:1, pages 3-21.
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Eckart Haneke, Hans-Joachim Schulze & Gustav Mahrle. (1993) Immunohistochemical and immunoelectron microscopic demonstration of chromogranin A in formalin-fixed tissue of Merkel cell carcinoma. Journal of the American Academy of Dermatology 28:2, pages 222-226.
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Michèle Pitale, Roy B. Sessions & Shaista Husain. (2009) An analysis of prognostic factors in cutaneous neuroendocrine carcinoma. The Laryngoscope 102:3, pages 244-249.
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O. Bayrou, M.F. Avril, P. Charpentier, B. Caillou, J.C. Guillaume & M. Prade. (1991) Primary neuroendocrine carcinoma of the skin. Journal of the American Academy of Dermatology 24:2, pages 198-207.
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Tero Kivelä & Ahti Tarkkanen. (1990) The Merkel cell and associated neoplasms in the eyelids and periocular region. Survey of Ophthalmology 35:3, pages 171-187.
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LEIF Johansson, JAN Tennvall & MÅNS ÅKerman. (1990) Immunohistochemical examination of 25 cases of Merkel cell carcinoma: A comparison with small cell carcinoma of the lung and oesophagus, and a review of the literature. APMIS 98:7-12, pages 741-752.
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Takanori Hirose, Eiji Kudo, Tadashi Hasegawa, Jun-Ichi Abe & Kazuo Hizawa. (1990) Cytoskeletal properties of alveolar soft part sarcoma. Human Pathology 21:2, pages 204-211.
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Uwe Wollina. (1990) Immunohistochemical investigations in epidermal Merkel cells - a common phenotype with eccrine sweat gland epithelium. Acta Histochemica 88:1, pages 47-50.
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Martin Bak & Peter Stubbe Teglbjærg. (1989) Pleomorphic (giant cell) carcinoma of the intestine. An immunohistochemical and electron microscopic study. Cancer 64:12, pages 2557-2564.
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P. Leoncini, E. Bellizzi De Marco, M. Bugnoli, C. Mencarelli, C. Vindigni & M. Cintorino. (1989) Expression of Phosphorylated and Non-Phosphorylated Neurofilament Subunits and Cytokeratins in Neuroendocrine Lung Tumors. Pathology - Research and Practice 185:6, pages 848-855.
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H.-P. Fischer, H. Thomsen, M. Altmannsberger & U. Bertram. (1989) Malignant Rhabdoid Tumour of the Kidney Expressing Neurofilament Proteins. Pathology - Research and Practice 184:5, pages 541-547.
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Wenancjusz Domagala, Jerzy Lasota, Maria Chosia, Anna Szadowska, Klaus Weber & Mary Osborn. (1989) Diagnosis of major tumor categories in fine-needle aspirates is more accurate when light microscopy is combined with intermediate filament typing. A study of 403 cases. Cancer 63:3, pages 504-517.
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Noriko Kimura, Nobuaki Sasano, Tsuneo Namiki & Yoichi Nakazato. (1989) Coexpression of cytokeratin, neurofilament and vimentin in carcinoid tumors. Virchows Archiv A Pathological Anatomy and Histopathology 415:1, pages 69-77.
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G. Mahrle. 1989. Operationsplanung und Erfolgskontrolle. Operationsplanung und Erfolgskontrolle 86 91 .
H.-P Fischer, W. Doppl, M. Osborn & M. Altmannsberger. (1988) Evidence for a hepatocellular lineage in a combined hepatocellular-cholangiocarcinoma of transitional type. Virchows Archiv B Cell Pathology Including Molecular Pathology 56:1, pages 71-76.
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Jos L. V. Broers, Mirjam Klein Rot, Tineke Oostendorp, Gerold Bepler, Lou De Leij, Desmond N. Carney, G. Peter Vooijs & Frans C. S. Ramaekers. (1988) Spontaneous changes in intermediate filament protein expression patterns in lung cancer cell lines. Journal of Cell Science 91:1, pages 91-108.
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L. O. Whiteley & J. R. Leininger. (2016) Neuroendocrine (Merkel) Cell Tumors of the Canine Oral Cavity. Veterinary Pathology 24:6, pages 570-572.
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R. Moll. 1987. Morphological Tumor Markers. Morphological Tumor Markers 71 101 .
Roland Moll & Werner W. Franke. (1985) Cytoskeletal differences between human neuroendocrine tumors: A cytoskeletal protein of molecular weight 46,000 distinguishes cutaneous from pulmonary neuroendocrine neoplasms. Differentiation 30:2, pages 165-175.
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