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Original Article

Properties of drug-containing spherical pellets produced by a hot-melt extrusion and spheronization process

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Pages 613-625 | Received 19 Sep 2002, Accepted 20 Mar 2003, Published online: 02 Jul 2010

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Read on this site (5)

Sandra U. Schilling, Hélène L. Lirola, Navnit H. Shah, A. Waseem Malick & James W. McGinity. (2010) Influence of plasticizer type and level on the properties of Eudragit® S100 matrix pellets prepared by hot-melt extrusion. Journal of Microencapsulation 27:6, pages 521-532.
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Michael A Repka, Soumyajit Majumdar, Sunil Kumar Battu, Ramesh Srirangam & Sampada B Upadhye. (2008) Applications of hot-melt extrusion for drug delivery. Expert Opinion on Drug Delivery 5:12, pages 1357-1376.
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Michael A. Repka, Sunil Kumar Battu, Sampada B. Upadhye, Sridhar Thumma, Michael M. Crowley, Feng Zhang, Charles Martin & James W. McGinity. (2007) Pharmaceutical Applications of Hot-Melt Extrusion: Part II. Drug Development and Industrial Pharmacy 33:10, pages 1043-1057.
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Chistopher R. Young, Michael Crowley, Caroline Dietzsch & James W. McGinity. (2007) Physicochemical properties of film-coated melt-extruded pellets. Journal of Microencapsulation 24:1, pages 57-71.
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Christopher R Young, Caroline Dietzsch & James W McGinity. (2005) Compression of Controlled-Release Pellets Produced by a Hot-Melt Extrusion and Spheronization Process. Pharmaceutical Development and Technology 10:1, pages 133-139.
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Articles from other publishers (9)

Martin Spoerk, Ioannis Koutsamanis, Andreas Kottlan, Christian Makert, Michael Piller, Manuel Rajkovaca, Amrit Paudel & Johannes Khinast. (2022) Continuous Processing of Micropellets via Hot-Melt Extrusion. AAPS PharmSciTech 23:7.
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Daniel Zakowiecki, Maja Frankiewicz, Tobias Hess, Krzysztof Cal, Maciej Gajda, Justyna Dabrowska, Bartlomiej Kubiak, Jadwiga Paszkowska, Marcela Wiater, Dagmara Hoc, Grzegorz Garbacz & Dorota Haznar-Garbacz. (2021) Development of a Biphasic-Release Multiple-Unit Pellet System with Diclofenac Sodium Using Novel Calcium Phosphate-Based Starter Pellets. Pharmaceutics 13:6, pages 805.
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Markus Thommes & Peter Kleinebudde. 2017. Multiparticulate Drug Delivery. Multiparticulate Drug Delivery 37 63 .
Jie Zhao, Ting Geng, Qi Wang, Haihong Si, Xiaoping Sun, Qingming Guo, Yanjing Li, Wenzhe Huang, Gang Ding & Wei Xiao. (2015) Pharmacokinetics of Ginkgolide B after Oral Administration of Three Different Ginkgolide B Formulations in Beagle Dogs. Molecules 20:11, pages 20031-20041.
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N. Jedinger, J. Khinast & E. Roblegg. (2014) The design of controlled-release formulations resistant to alcohol-induced dose dumping – A review. European Journal of Pharmaceutics and Biopharmaceutics 87:2, pages 217-226.
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Justin M. Keen & James W. McGinity. 2013. Melt Extrusion. Melt Extrusion 243 260 .
Peter Kleinebudde. (2011) Pharmazeutisches Produktdesign: Gezielte Freisetzung von Wirkstoffen durch unterschiedliche Extrusionstechniken. Chemie Ingenieur Technik 83:5, pages 589-597.
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S. A. Jones, G. P. Martin, P. G. Royall & M. B. Brown. (2005) Biocompatible polymer blends: Effects of physical processing on the molecular interaction of poly(vinyl alcohol) and poly(vinyl pyrrolidone). Journal of Applied Polymer Science 98:5, pages 2290-2299.
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Christopher R. Young, Caroline Dietzsch, Matteo Cerea, Thomas Farrell, Kurt A. Fegely, Ali Rajabi-Siahboomi & James W. McGinity. (2005) Physicochemical characterization and mechanisms of release of theophylline from melt-extruded dosage forms based on a methacrylic acid copolymer. International Journal of Pharmaceutics 301:1-2, pages 112-120.
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