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Research Article

Influence of plasticizer type and level on the properties of Eudragit® S100 matrix pellets prepared by hot-melt extrusion

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Pages 521-532 | Received 29 Jul 2009, Accepted 09 Mar 2010, Published online: 24 Jun 2010

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Theodoros Avgerinos, Nikolaos Kantiranis, Athanasia Panagopoulou, Stavros Malamataris, Kyriakos Kachrimanis & Ioannis Nikolakakis. (2018) Mechanical properties and drug release of venlafaxine HCl solid mini matrices prepared by hot-melt extrusion and hot or ambient compression. Drug Development and Industrial Pharmacy 44:2, pages 338-348.
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Raju Onkar Sonawane & Savita Dattatraya Patil. (2016) Formulation Aspects and Effect of Critical Factors for Designing Extended Release Pellets: An Updated Review. Polymer-Plastics Technology and Engineering 55:9, pages 976-989.
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Bo Lang, James W. McGinity & Robert O. Williams$suffix/text()$suffix/text(). (2014) Hot-melt extrusion – basic principles and pharmaceutical applications. Drug Development and Industrial Pharmacy 40:9, pages 1133-1155.
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Michael A Repka, Sejal Shah, Jiannan Lu, Sindhuri Maddineni, Joe Morott, Ketaki Patwardhan & Noorullah Naqvi Mohammed. (2012) Melt extrusion: process to product. Expert Opinion on Drug Delivery 9:1, pages 105-125.
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Articles from other publishers (36)

George Wypych. 2023. Handbook of Plasticizers. Handbook of Plasticizers 487 611 .
Jose Waimin, Sarath Gopalakrishnan, Ulisses Heredia-Rivera, Nicholas A. Kerr, Sina Nejati, Nicholas L. F. Gallina, Arun K. Bhunia & Rahim Rahimi. (2022) Low-Cost Nonreversible Electronic-Free Wireless pH Sensor for Spoilage Detection in Packaged Meat Products. ACS Applied Materials & Interfaces 14:40, pages 45752-45764.
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Ryan Varghese, Sahil Salvi, Purab Sood, Jainam Karsiya & Dileep Kumar. (2022) Recent advancements in additive manufacturing techniques employed in the pharmaceutical industry: A bird's eye view. Annals of 3D Printed Medicine 8, pages 100081.
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Prathmesh Kenjale & Varsha Pokharkar. (2022) Risk Assessment and QbD-Based Optimization of Sorafenib Tosylate Colon Targeted Bilayer Tablet: In Vitro Characterization, In Vivo Pharmacokinetic, and In Vivo Roentgenography Studies. AAPS PharmSciTech 23:6.
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Md Obyedul Kalam Azad, Md. Adnan, In Je Sung, Jung Dae Lim, Jong‐Suep Baek, Young Seok Lim & Cheol Ho Park. (2021) Development of value‐added functional food by fusion of colored potato and buckwheat flour through hot‐melt extrusion. Journal of Food Processing and Preservation 46:5.
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Harpreet Sandhu, Siva Ram Kiran Vaka, Dipen Desai, Paras Jariwala, Aruna Railkar, Wantanee Phuapradit & Navnit Shah. 2022. Oral Drug Delivery for Modified Release Formulations. Oral Drug Delivery for Modified Release Formulations 181 204 .
Sangseo Kim, Paris Fouladian, Franklin Afinjuomo, Yunmei Song, Souha H. Youssef, Sachin Vaidya & Sanjay Garg. (2022) Effect of plasticizers on drug-in-adhesive patches containing 5-fluorouracil. International Journal of Pharmaceutics 611, pages 121316.
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Ladawan Songtipya, Ponusa Songtipya, Thummanoon Prodpran, Ekwipoo Kalkornsurapranee & Jobish Johns. (2020) Fabrication of water-soluble loose-fill foam from tamarind ( Tamarindus indica L.) seed polysaccharide by mechanical frothing and freeze-drying process . Journal of Cellular Plastics 57:5, pages 643-658.
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Seth P. Forster, Erin Dippold & Tiffany Chiang. (2021) Twin-Screw Melt Granulation for Oral Solid Pharmaceutical Products. Pharmaceutics 13:5, pages 665.
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Nour Nashed, Matthew Lam & Ali Nokhodchi. (2021) A comprehensive overview of extended release oral dosage forms manufactured through hot melt extrusion and its combination with 3D printing. International Journal of Pharmaceutics 596, pages 120237.
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Anh Q. Vo, Gerd Kutz, Herman He, Sagar Narala, Suresh Bandari & Michael A. Repka. (2020) Continuous Manufacturing of Ketoprofen Delayed Release Pellets Using Melt Extrusion Technology: Application of QbD Design Space, Inline Near Infrared, and Inline Pellet Size Analysis. Journal of Pharmaceutical Sciences 109:12, pages 3598-3607.
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Marius Monschke, Kevin Kayser & Karl G. Wagner. (2020) Processing of Polyvinyl Acetate Phthalate in Hot-Melt Extrusion—Preparation of Amorphous Solid Dispersions. Pharmaceutics 12:4, pages 337.
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Md Obyedul Kalam Azad, Wie Soo Kang, Jung Dae Lim & Cheol Ho Park. (2019) Bio- Fortification of Angelica gigas Nakai Nano-Powder Using Bio-Polymer by Hot Melt Extrusion to Enhance the Bioaccessibility and Functionality of Nutraceutical Compounds. Pharmaceuticals 13:1, pages 3.
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Marius Monschke & Karl G. Wagner. (2019) Amorphous solid dispersions of weak bases with pH-dependent soluble polymers to overcome limited bioavailability due to gastric pH variability – An in-vitro approach. International Journal of Pharmaceutics 564, pages 162-170.
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Xu Xue, Guoguang Chen, Xiaoqing Xu, Jin Wang, Jingjing Wang & Lili Ren. (2019) A Combined Utilization of Plasdone-S630 and HPMCAS-HF in Ziprasidone Hydrochloride Solid Dispersion by Hot-Melt Extrusion to Enhance the Oral Bioavailability and No Food Effect. AAPS PharmSciTech 20:1.
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Ahmed Zidan, Alaadin Alayoubi, Sarah Asfari, James Coburn, Bahaa Ghammraoui, Sabir Aqueel, Celia N. Cruz & Muhammad Ashraf. (2019) Development of mechanistic models to identify critical formulation and process variables of pastes for 3D printing of modified release tablets. International Journal of Pharmaceutics 555, pages 109-123.
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J.F. Kelleher, G.C. Gilvary, A.M. Madi, D.S. Jones, S. Li, Y. Tian, A. Almajaan, Z. Senta-Loys, G.P. Andrews & A.M. Healy. (2018) A comparative study between hot-melt extrusion and spray-drying for the manufacture of anti-hypertension compatible monolithic fixed-dose combination products. International Journal of Pharmaceutics 545:1-2, pages 183-196.
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Matthias E. Lauer, Reto Maurer, Anne T. De Paepe, Cordula Stillhart, Laurence Jacob, Rajesh James, Yuki Kojima, Rene Rietmann, Tom Kissling, Joost A. van den Ende, Sabine Schwarz, Olaf Grassmann & Susanne Page. (2018) A Miniaturized Extruder to Prototype Amorphous Solid Dispersions: Selection of Plasticizers for Hot Melt Extrusion. Pharmaceutics 10:2, pages 58.
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Jiannan Lu, Sakae Obara, Fei Liu, Wanyi Fu, Wen Zhang & Shingo Kikuchi. (2017) Melt Extrusion for a High Melting Point Compound with Improved Solubility and Sustained Release. AAPS PharmSciTech 19:1, pages 358-370.
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James DiNunzioSeth ForsterChad Brown. 2017. Concise Encyclopedia of Biomedical Polymers and Polymeric Biomaterials. Concise Encyclopedia of Biomedical Polymers and Polymeric Biomaterials 827 844 .
Alvaro Goyanes, Fabrizio Fina, Annalisa Martorana, Daniel Sedough, Simon Gaisford & Abdul W. Basit. (2017) Development of modified release 3D printed tablets (printlets) with pharmaceutical excipients using additive manufacturing. International Journal of Pharmaceutics 527:1-2, pages 21-30.
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Jari Pajander, Alexia Rensonnet, Sami Hietala, Jukka Rantanen & Stefania Baldursdottir. (2017) The evaluation of physical properties of injection molded systems based on poly(ethylene oxide) (PEO). International Journal of Pharmaceutics 518:1-2, pages 203-212.
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. 2017. Handbook of Plasticizers. Handbook of Plasticizers 495 605 .
David S. Jones, Yiwei Tian, Shu Li, Tao Yu, Osama A. Abu-Diak & Gavin P. Andrews. (2016) The Use of Binary Polymeric Networks in Stabilizing Polyethylene Oxide Solid Dispersions. Journal of Pharmaceutical Sciences 105:10, pages 3064-3072.
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Justin S. LaFountaine, Scott V. Jermain, Leena Kumari Prasad, Chris Brough, Dave A. Miller, Dieter Lubda, James W. McGinity & Robert O. WilliamsIIIIII. (2016) Enabling thermal processing of ritonavir–polyvinyl alcohol amorphous solid dispersions by KinetiSol® Dispersing. European Journal of Pharmaceutics and Biopharmaceutics 101, pages 72-81.
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Justin S. LaFountaine, James W. McGinity & Robert O. WilliamsIIIIII. (2015) Challenges and Strategies in Thermal Processing of Amorphous Solid Dispersions: A Review. AAPS PharmSciTech 17:1, pages 43-55.
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Feng Zhang. (2015) Melt-Extruded Eudragit® FS-Based Granules for Colonic Drug Delivery. AAPS PharmSciTech 17:1, pages 56-67.
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James DiNunzio, Seth Forster & Chad Brown. 2015. Encyclopedia of Biomedical Polymers and Polymeric Biomaterials. Encyclopedia of Biomedical Polymers and Polymeric Biomaterials 4468 4486 .
Milica Stanković, Henderik W. Frijlink & Wouter L.J. Hinrichs. (2015) Polymeric formulations for drug release prepared by hot melt extrusion: application and characterization. Drug Discovery Today 20:7, pages 812-823.
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B. Kállai-Szabó, M. Sinka, B. Stiedl, I. Sebe, I. Antal & R. Zelkó. (2014) Tracking of the solubility enhancement and drug release stability of melt extrudates containing mebendazole. Journal of Drug Delivery Science and Technology 24:5, pages 514-518.
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Sejal Shah, Sindhuri Maddineni, Jiannan Lu & Michael A. Repka. (2013) Melt extrusion with poorly soluble drugs. International Journal of Pharmaceutics 453:1, pages 233-252.
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Sejal Shah & Michael A. Repka. 2013. Melt Extrusion. Melt Extrusion 3 46 .
Kathrin Nollenberger & Jessica Albers. 2012. Hot‐Melt Extrusion: Pharmaceutical Applications. Hot‐Melt Extrusion: Pharmaceutical Applications 113 144 .
Geert Verreck. 2012. Hot‐Melt Extrusion: Pharmaceutical Applications. Hot‐Melt Extrusion: Pharmaceutical Applications 93 112 .
Ana Almeida, Bart Claeys, Jean Paul Remon & Chris Vervaet. 2012. Hot‐Melt Extrusion: Pharmaceutical Applications. Hot‐Melt Extrusion: Pharmaceutical Applications 43 69 .
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