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Journal of Microencapsulation
Micro and Nano Carriers
Volume 28, 2011 - Issue 5
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Research Article

Insulin-loaded PLGA microparticles: flow focusing versus double emulsion/solvent evaporation

M. J. Cózar-BernalDepartment of Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, University of Seville, Seville, SpainCorrespondence[email protected]
,
M. A. HolgadoDepartment of Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, University of Seville, Seville, Spain
,
J. L. AriasDepartment of Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, University of Granada, Granada, Spain
,
I. Muñoz-RubioDepartment of Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, University of Seville, Seville, Spain
,
L. Martín-BanderasDepartment of Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, University of Seville, Seville, Spain
,
J. Álvarez-FuentesDepartment of Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, University of Seville, Seville, Spain
&
M. Fernández-ArévaloDepartment of Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, University of Seville, Seville, Spain
 show all
Pages 430-441 | Received 28 Nov 2010, Accepted 28 Mar 2011, Published online: 08 Jul 2011

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Fengjing Zhong, Chaoyu Yang, Qiang Wu, Shiyu Wang, Lei Cheng, Pankaj Dwivedi, Zhiqiang Zhu, Ting Si & Ronald X. Xu. (2020) Preparation of pesticide-loaded microcapsules by liquid-driven coaxial flow focusing for controlled release. International Journal of Polymeric Materials and Polymeric Biomaterials 69:13, pages 840-847.
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Junqiu Zhai, Yu-e Wang, Xiangping Zhou, Yan Ma & Shixia Guan. (2020) Long-term sustained release Poly(lactic-co-glycolic acid) microspheres of asenapine maleate with improved bioavailability for chronic neuropsychiatric diseases. Drug Delivery 27:1, pages 1283-1291.
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Fernando Villaverde Cendon, Regina Maria Matos Jorge, Regina Weinschutz & Alvaro Luiz Mathias. (2018) Effect of matrix composition, sphere size and hormone concentration on diffusion coefficient of insulin for controlled gastrointestinal delivery for diabetes treatment. Journal of Microencapsulation 35:1, pages 13-25.
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Rodrigo Molina Martins, Silvia Siqueira, Maria José Vieira Fonseca & Luis Alexandre Pedro Freitas. (2014) Skin penetration and photoprotection of topical formulations containing benzophenone-3 solid lipid microparticles prepared by the solvent-free spray-congealing technique. Journal of Microencapsulation 31:7, pages 644-653.
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Xue Bai, Siyuan Tang, Sam Butterworth & Annalisa Tirella. (2023) Design of PLGA nanoparticles for sustained release of hydroxyl-FK866 by microfluidics. Biomaterials Advances 154, pages 213649.
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Bunthoeun Nim, Sosna Sri Rahayu, Kamonchanok Thananukul, Chorney Eang, Mantana Opaprakasit, Atitsa Petchsuk, Chariya Kaewsaneha, Duangporn Polpanich & Pakorn Opaprakasit. (2023) Sizing down and functionalizing polylactide (PLA) resin for synthesis of PLA-based polyurethanes for use in biomedical applications. Scientific Reports 13:1.
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Fatemeh Ahangaran. 2023. Principles of Biomaterials Encapsulation : Volume One. Principles of Biomaterials Encapsulation : Volume One 377 392 .
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Jason Thomas Duskey, Ilaria Ottonelli, Arianna Rinaldi, Irene Parmeggiani, Barbara Zambelli, Leon Z. Wang, Robert K. Prud’homme, Maria Angela Vandelli, Giovanni Tosi & Barbara Ruozi. (2021) Tween® Preserves Enzyme Activity and Stability in PLGA Nanoparticles. Nanomaterials 11:11, pages 2946.
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Maria Quitério, Sandra Simões, Andreia Ascenso, Manuela Carvalheiro, Ana Paula Leandro, Isabel Correia, Ana Silveira Viana, Pedro Faísca, Lia Ascensão, Jesús Molpeceres, Maria Manuela Gaspar & Catarina Pinto Reis. (2021) Development of a Topical Insulin Polymeric Nanoformulation for Skin Burn Regeneration: An Experimental Approach. International Journal of Molecular Sciences 22:8, pages 4087.
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A. Alper Öztürkİrem NamlıAbdurrahman Aygül. (2021) Cefaclor Monohydrate-Loaded Colon-Targeted Nanoparticles for Use in COVID-19 Dependent Coinfections and Intestinal Symptoms: Formulation, Characterization, Release Kinetics, and Antimicrobial Activity. ASSAY and Drug Development Technologies 19:3, pages 156-175.
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Gracia García-García, Fátima Fernández-Álvarez, Laura Cabeza, Ángel V. Delgado, Consolación Melguizo, José C. Prados & José L. Arias. (2020) Gemcitabine-Loaded Magnetically Responsive Poly(ε-caprolactone) Nanoparticles against Breast Cancer. Polymers 12:12, pages 2790.
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Mariana Amaral, Ana Sofia Martins, José Catarino, Pedro Faísca, Pradeep Kumar, João F. Pinto, Rui Pinto, Isabel Correia, Lia Ascensão, Ricardo A. Afonso, M. Manuela Gaspar, Adília J. Charmier, Isabel Vitória Figueiredo & Catarina Pinto Reis. (2020) How Can Biomolecules Improve Mucoadhesion of Oral Insulin? A Comprehensive Insight using Ex-Vivo, In Silico, and In Vivo Models. Biomolecules 10:5, pages 675.
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Sihem Bouriche, María José Cózar-Bernal, Farouk Rezgui, Antonio María Rabasco Álvarez & María Luisa González-Rodríguez. (2019) Optimization of preparation method by W/O/W emulsion for entrapping metformin hydrochloride into poly (lactic acid) microparticles using Box-Behnken design. Journal of Drug Delivery Science and Technology 51, pages 419-429.
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Sima Rezvantalab & Mostafa Keshavarz Moraveji. (2019) Microfluidic assisted synthesis of PLGA drug delivery systems. RSC Advances 9:4, pages 2055-2072.
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Chun Y. Wong, Hani Al-Salami & Crispin R. Dass. (2018) Microparticles, microcapsules and microspheres: A review of recent developments and prospects for oral delivery of insulin. International Journal of Pharmaceutics 537:1-2, pages 223-244.
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Xiao‑Yu Li, Li Xu, Hong‑Li Li, Jing Du, Xue‑Song Liu & Feng‑Hua Li. (2017) Au-poly(lactic-co-glycolic) acid complex nanoparticles as ultrasound contrast agents: Preparation, characterization and in�vitro study. Molecular Medicine Reports.
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Yuwei Zhou, Ke Hu, Zhaobin Guo, Kun Fang, Xing Wang, Fang Yang & Ning Gu. (2017) PLLA microcapsules combined with silver nanoparticles and chlorhexidine acetate showing improved antibacterial effect. Materials Science and Engineering: C 78, pages 349-353.
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Sunandini Chopra, Nicolas Bertrand, Jong-Min Lim, Amy Wang, Omid C. Farokhzad & Rohit Karnik. (2017) Design of Insulin-Loaded Nanoparticles Enabled by Multistep Control of Nanoprecipitation and Zinc Chelation. ACS Applied Materials & Interfaces 9:13, pages 11440-11450.
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Saravanan S.Malathi S.Sesh P.S.L.Selvasubramanian S.Balasubramanian S.Pandiyan V.. (2017) Hydrophilic poly (ethylene glycol) capped poly (lactic-co-glycolic) acid nanoparticles for subcutaneous delivery of insulin in diabetic rats. International Journal of Biological Macromolecules 95, pages 1190-1198.
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Peng Liu, Hui Jiang, Shijun Li, Zhen Lin & Jianming Jiang. (2017) Determination of anti-tuberculosis drug concentration and distribution from sustained release microspheres in the vertebrae of a spinal tuberculosis rabbit model. Journal of Orthopaedic Research 35:1, pages 200-208.
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Claudia M. Baena-Aristizábal, Hatem Fessi, Abdelhamid Elaissari & Claudia E. Mora-Huertas. (2016) Biodegradable microparticles preparation by double emulsification—Solvent extraction method: A Systematic study. Colloids and Surfaces A: Physicochemical and Engineering Aspects 492, pages 213-229.
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Edel Sah & Hongkee Sah. (2015) Recent Trends in Preparation of Poly(lactide- co -glycolide) Nanoparticles by Mixing Polymeric Organic Solution with Antisolvent . Journal of Nanomaterials 2015, pages 1-22.
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José L. Arias, Juan D. Unciti-Broceta, José Maceira, Teresa del Castillo, José Hernández-Quero, Stefan Magez, Miguel Soriano & José A. García-Salcedo. (2015) Nanobody conjugated PLGA nanoparticles for active targeting of African Trypanosomiasis. Journal of Controlled Release 197, pages 190-198.
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Lihua Cao, Jun Luo, Kehua Tu, Li-Qun Wang & Hongliang Jiang. (2014) Generation of nano-sized core–shell particles using a coaxial tri-capillary electrospray-template removal method. Colloids and Surfaces B: Biointerfaces 115, pages 212-218.
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A.M. Gañán-Calvo, J.M. Montanero, L. Martín-Banderas & M. Flores-Mosquera. (2013) Building functional materials for health care and pharmacy from microfluidic principles and Flow Focusing. Advanced Drug Delivery Reviews 65:11-12, pages 1447-1469.
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Zhen‐Dong Shi, Xiao‐Min Qian, Chao‐Yong Liu, Lei Han, Kai‐Liang Zhang, Lu‐Yue Chen, Jun‐Xia Zhang, Pei‐Yu Pu, Xu‐Bo Yuan & Chun‐Sheng Kang. (2012) Aspirin‐/ TMZ ‐coloaded Microspheres Exert Synergistic Antiglioma Efficacy via Inhibition of β‐catenin Transactivation . CNS Neuroscience & Therapeutics 19:2, pages 98-108.
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Lucía Martín-Banderas, Eva Sáez-Fernández, Mª Ángeles Holgado, Mª Matilde Durán-Lobato, José C. Prados, Consolación Melguizo & José L. Arias. (2013) Biocompatible gemcitabine-based nanomedicine engineered by Flow Focusing® for efficient antitumor activity. International Journal of Pharmaceutics 443:1-2, pages 103-109.
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Beatriz Pérez-Artacho, Visitación Gallardo, M. Adolfina Ruiz & José L. Arias. (2012) Maghemite/poly(d,l-lactide-co-glycolyde) composite nanoplatform for therapeutic applications. Journal of Nanoparticle Research 14:4.
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C. Vilos & L. A. Velasquez. (2012) Therapeutic Strategies Based on Polymeric Microparticles. Journal of Biomedicine and Biotechnology 2012, pages 1-9.
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J. Álvarez-Fuentes, L. Martín-Banderas, I. Muñoz-Rubio, M. A. Holgado & M. Fernández-Arévalo. (2012) Development and Validation of an RP-HPLC Method for CB13 Evaluation in Several PLGA Nanoparticle Systems. The Scientific World Journal 2012, pages 1-9.
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