Advanced search
Publication Cover
Journal of Microencapsulation
Micro and Nano Carriers
Volume 28, 2011 - Issue 5
Submit an article Journal homepage
503
Views
33
CrossRef citations to date
0
Altmetric
Research Article

Insulin-loaded PLGA microparticles: flow focusing versus double emulsion/solvent evaporation

M. J. Cózar-BernalDepartment of Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, University of Seville, Seville, SpainCorrespondence[email protected]
,
M. A. HolgadoDepartment of Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, University of Seville, Seville, Spain
,
J. L. AriasDepartment of Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, University of Granada, Granada, Spain
,
I. Muñoz-RubioDepartment of Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, University of Seville, Seville, Spain
,
L. Martín-BanderasDepartment of Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, University of Seville, Seville, Spain
,
J. Álvarez-FuentesDepartment of Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, University of Seville, Seville, Spain
&
M. Fernández-ArévaloDepartment of Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, University of Seville, Seville, Spain
 show all
Pages 430-441 | Received 28 Nov 2010, Accepted 28 Mar 2011, Published online: 08 Jul 2011

Citations (33)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (4)

Fengjing Zhong, Chaoyu Yang, Qiang Wu, Shiyu Wang, Lei Cheng, Pankaj Dwivedi, Zhiqiang Zhu, Ting Si & Ronald X. Xu. (2020) Preparation of pesticide-loaded microcapsules by liquid-driven coaxial flow focusing for controlled release. International Journal of Polymeric Materials and Polymeric Biomaterials 69:13, pages 840-847.
Read now
Junqiu Zhai, Yu-e Wang, Xiangping Zhou, Yan Ma & Shixia Guan. (2020) Long-term sustained release Poly(lactic-co-glycolic acid) microspheres of asenapine maleate with improved bioavailability for chronic neuropsychiatric diseases. Drug Delivery 27:1, pages 1283-1291.
Read now
Fernando Villaverde Cendon, Regina Maria Matos Jorge, Regina Weinschutz & Alvaro Luiz Mathias. (2018) Effect of matrix composition, sphere size and hormone concentration on diffusion coefficient of insulin for controlled gastrointestinal delivery for diabetes treatment. Journal of Microencapsulation 35:1, pages 13-25.
Read now
Rodrigo Molina Martins, Silvia Siqueira, Maria José Vieira Fonseca & Luis Alexandre Pedro Freitas. (2014) Skin penetration and photoprotection of topical formulations containing benzophenone-3 solid lipid microparticles prepared by the solvent-free spray-congealing technique. Journal of Microencapsulation 31:7, pages 644-653.
Read now

Articles from other publishers (29)

Xue Bai, Siyuan Tang, Sam Butterworth & Annalisa Tirella. (2023) Design of PLGA nanoparticles for sustained release of hydroxyl-FK866 by microfluidics. Biomaterials Advances 154, pages 213649.
Crossref
Pei Zhang, Yingxin Liu, Guobing Feng, Cong Li, Jun Zhou, Chunyang Du, Yuancheng Bai, Shuai Hu, Tianhe Huang, Guan Wang, Peng Quan, Jouni Hirvonen, Jin Fan, Hélder A. Santos & Dongfei Liu. (2023) Controlled Interfacial Polymer Self‐Assembly Coordinates Ultrahigh Drug Loading and Zero‐Order Release in Particles Prepared under Continuous Flow. Advanced Materials 35:22.
Crossref
Bunthoeun Nim, Sosna Sri Rahayu, Kamonchanok Thananukul, Chorney Eang, Mantana Opaprakasit, Atitsa Petchsuk, Chariya Kaewsaneha, Duangporn Polpanich & Pakorn Opaprakasit. (2023) Sizing down and functionalizing polylactide (PLA) resin for synthesis of PLA-based polyurethanes for use in biomedical applications. Scientific Reports 13:1.
Crossref
Fatemeh Ahangaran. 2023. Principles of Biomaterials Encapsulation : Volume One. Principles of Biomaterials Encapsulation : Volume One 377 392 .
Maryam Arshad, Ishrat Mahjabeen, Abida Raza, Sumbal Javaid, Maria Fazal ul Haq, Masroor Alam & Ahmat Khurshid. (2022) In-vitro co-delivery of decarbazine and photosense using poly lactic-co-glycolic acid nanocarrier for combinational therapy. Photodiagnosis and Photodynamic Therapy 37, pages 102737.
Crossref
Matilde Durán-Lobato, Josefa Álvarez-Fuentes, Mercedes Fernández-Arévalo & Lucía Martín-Banderas. (2022) Receptor-targeted nanoparticles modulate cannabinoid anticancer activity through delayed cell internalization. Scientific Reports 12:1.
Crossref
Jason Thomas Duskey, Ilaria Ottonelli, Arianna Rinaldi, Irene Parmeggiani, Barbara Zambelli, Leon Z. Wang, Robert K. Prud’homme, Maria Angela Vandelli, Giovanni Tosi & Barbara Ruozi. (2021) Tween® Preserves Enzyme Activity and Stability in PLGA Nanoparticles. Nanomaterials 11:11, pages 2946.
Crossref
Maria Quitério, Sandra Simões, Andreia Ascenso, Manuela Carvalheiro, Ana Paula Leandro, Isabel Correia, Ana Silveira Viana, Pedro Faísca, Lia Ascensão, Jesús Molpeceres, Maria Manuela Gaspar & Catarina Pinto Reis. (2021) Development of a Topical Insulin Polymeric Nanoformulation for Skin Burn Regeneration: An Experimental Approach. International Journal of Molecular Sciences 22:8, pages 4087.
Crossref
A. Alper Öztürkİrem NamlıAbdurrahman Aygül. (2021) Cefaclor Monohydrate-Loaded Colon-Targeted Nanoparticles for Use in COVID-19 Dependent Coinfections and Intestinal Symptoms: Formulation, Characterization, Release Kinetics, and Antimicrobial Activity. ASSAY and Drug Development Technologies 19:3, pages 156-175.
Crossref
Gracia García-García, Fátima Fernández-Álvarez, Laura Cabeza, Ángel V. Delgado, Consolación Melguizo, José C. Prados & José L. Arias. (2020) Gemcitabine-Loaded Magnetically Responsive Poly(ε-caprolactone) Nanoparticles against Breast Cancer. Polymers 12:12, pages 2790.
Crossref
Mariana Amaral, Ana Sofia Martins, José Catarino, Pedro Faísca, Pradeep Kumar, João F. Pinto, Rui Pinto, Isabel Correia, Lia Ascensão, Ricardo A. Afonso, M. Manuela Gaspar, Adília J. Charmier, Isabel Vitória Figueiredo & Catarina Pinto Reis. (2020) How Can Biomolecules Improve Mucoadhesion of Oral Insulin? A Comprehensive Insight using Ex-Vivo, In Silico, and In Vivo Models. Biomolecules 10:5, pages 675.
Crossref
Sihem Bouriche, María José Cózar-Bernal, Farouk Rezgui, Antonio María Rabasco Álvarez & María Luisa González-Rodríguez. (2019) Optimization of preparation method by W/O/W emulsion for entrapping metformin hydrochloride into poly (lactic acid) microparticles using Box-Behnken design. Journal of Drug Delivery Science and Technology 51, pages 419-429.
Crossref
Sima Rezvantalab & Mostafa Keshavarz Moraveji. (2019) Microfluidic assisted synthesis of PLGA drug delivery systems. RSC Advances 9:4, pages 2055-2072.
Crossref
Chun Y. Wong, Hani Al-Salami & Crispin R. Dass. (2018) Microparticles, microcapsules and microspheres: A review of recent developments and prospects for oral delivery of insulin. International Journal of Pharmaceutics 537:1-2, pages 223-244.
Crossref
Xiao‑Yu Li, Li Xu, Hong‑Li Li, Jing Du, Xue‑Song Liu & Feng‑Hua Li. (2017) Au-poly(lactic-co-glycolic) acid complex nanoparticles as ultrasound contrast agents: Preparation, characterization and in�vitro study. Molecular Medicine Reports.
Crossref
Yuwei Zhou, Ke Hu, Zhaobin Guo, Kun Fang, Xing Wang, Fang Yang & Ning Gu. (2017) PLLA microcapsules combined with silver nanoparticles and chlorhexidine acetate showing improved antibacterial effect. Materials Science and Engineering: C 78, pages 349-353.
Crossref
Sunandini Chopra, Nicolas Bertrand, Jong-Min Lim, Amy Wang, Omid C. Farokhzad & Rohit Karnik. (2017) Design of Insulin-Loaded Nanoparticles Enabled by Multistep Control of Nanoprecipitation and Zinc Chelation. ACS Applied Materials & Interfaces 9:13, pages 11440-11450.
Crossref
Saravanan S.Malathi S.Sesh P.S.L.Selvasubramanian S.Balasubramanian S.Pandiyan V.. (2017) Hydrophilic poly (ethylene glycol) capped poly (lactic-co-glycolic) acid nanoparticles for subcutaneous delivery of insulin in diabetic rats. International Journal of Biological Macromolecules 95, pages 1190-1198.
Crossref
Peng Liu, Hui Jiang, Shijun Li, Zhen Lin & Jianming Jiang. (2017) Determination of anti-tuberculosis drug concentration and distribution from sustained release microspheres in the vertebrae of a spinal tuberculosis rabbit model. Journal of Orthopaedic Research 35:1, pages 200-208.
Crossref
Claudia M. Baena-Aristizábal, Hatem Fessi, Abdelhamid Elaissari & Claudia E. Mora-Huertas. (2016) Biodegradable microparticles preparation by double emulsification—Solvent extraction method: A Systematic study. Colloids and Surfaces A: Physicochemical and Engineering Aspects 492, pages 213-229.
Crossref
Edel Sah & Hongkee Sah. (2015) Recent Trends in Preparation of Poly(lactide- co -glycolide) Nanoparticles by Mixing Polymeric Organic Solution with Antisolvent . Journal of Nanomaterials 2015, pages 1-22.
Crossref
José L. Arias, Juan D. Unciti-Broceta, José Maceira, Teresa del Castillo, José Hernández-Quero, Stefan Magez, Miguel Soriano & José A. García-Salcedo. (2015) Nanobody conjugated PLGA nanoparticles for active targeting of African Trypanosomiasis. Journal of Controlled Release 197, pages 190-198.
Crossref
Lihua Cao, Jun Luo, Kehua Tu, Li-Qun Wang & Hongliang Jiang. (2014) Generation of nano-sized core–shell particles using a coaxial tri-capillary electrospray-template removal method. Colloids and Surfaces B: Biointerfaces 115, pages 212-218.
Crossref
A.M. Gañán-Calvo, J.M. Montanero, L. Martín-Banderas & M. Flores-Mosquera. (2013) Building functional materials for health care and pharmacy from microfluidic principles and Flow Focusing. Advanced Drug Delivery Reviews 65:11-12, pages 1447-1469.
Crossref
Zhen‐Dong Shi, Xiao‐Min Qian, Chao‐Yong Liu, Lei Han, Kai‐Liang Zhang, Lu‐Yue Chen, Jun‐Xia Zhang, Pei‐Yu Pu, Xu‐Bo Yuan & Chun‐Sheng Kang. (2012) Aspirin‐/ TMZ ‐coloaded Microspheres Exert Synergistic Antiglioma Efficacy via Inhibition of β‐catenin Transactivation . CNS Neuroscience & Therapeutics 19:2, pages 98-108.
Crossref
Lucía Martín-Banderas, Eva Sáez-Fernández, Mª Ángeles Holgado, Mª Matilde Durán-Lobato, José C. Prados, Consolación Melguizo & José L. Arias. (2013) Biocompatible gemcitabine-based nanomedicine engineered by Flow Focusing® for efficient antitumor activity. International Journal of Pharmaceutics 443:1-2, pages 103-109.
Crossref
Beatriz Pérez-Artacho, Visitación Gallardo, M. Adolfina Ruiz & José L. Arias. (2012) Maghemite/poly(d,l-lactide-co-glycolyde) composite nanoplatform for therapeutic applications. Journal of Nanoparticle Research 14:4.
Crossref
C. Vilos & L. A. Velasquez. (2012) Therapeutic Strategies Based on Polymeric Microparticles. Journal of Biomedicine and Biotechnology 2012, pages 1-9.
Crossref
J. Álvarez-Fuentes, L. Martín-Banderas, I. Muñoz-Rubio, M. A. Holgado & M. Fernández-Arévalo. (2012) Development and Validation of an RP-HPLC Method for CB13 Evaluation in Several PLGA Nanoparticle Systems. The Scientific World Journal 2012, pages 1-9.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.