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Review Article

Microencapsulation techniques to develop formulations of insulin for oral delivery: a review

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Pages 409-424 | Received 08 Jun 2012, Accepted 10 Oct 2012, Published online: 13 Dec 2012

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Read on this site (6)

Fernando Villaverde Cendon, Regina Maria Matos Jorge, Regina Weinschutz & Alvaro Luiz Mathias. (2018) Effect of matrix composition, sphere size and hormone concentration on diffusion coefficient of insulin for controlled gastrointestinal delivery for diabetes treatment. Journal of Microencapsulation 35:1, pages 13-25.
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Evandro Martins, Denis Poncelet, Ramila Cristiane Rodrigues & Denis Renard. (2017) Oil encapsulation techniques using alginate as encapsulating agent: applications and drawbacks. Journal of Microencapsulation 34:8, pages 754-771.
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Evandro Martins, Denis Poncelet, Ramila Cristiane Rodrigues & Denis Renard. (2017) Oil encapsulation in core–shell alginate capsules by inverse gelation II: comparison between dripping techniques using W/O or O/W emulsions. Journal of Microencapsulation 34:6, pages 522-534.
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Mumuni A. Momoh, Franklin C. Kenechukwu, Petra O. Nnamani & Jennifer C. Umetiti. (2015) Influence of magnesium stearate on the physicochemical and pharmacodynamic characteristics of insulin-loaded Eudragit entrapped mucoadhesive microspheres. Drug Delivery 22:6, pages 837-848.
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F. Cárdenas-Bailón, G. Osorio-Revilla & T. Gallardo-Velázquez. (2015) Microencapsulation of insulin using a W/O/W double emulsion followed by complex coacervation to provide protection in the gastrointestinal tract. Journal of Microencapsulation 32:3, pages 308-316.
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Evandro Martins, Denis Renard, Joëlle Davy, Mélanie Marquis & Denis Poncelet. (2015) Oil core microcapsules by inverse gelation technique. Journal of Microencapsulation 32:1, pages 86-95.
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Articles from other publishers (21)

S. Spoorthi Shetty, Praveen Halagali, Asha P. Johnson, K.M. Asha Spandana & H.V. Gangadharappa. (2023) Oral insulin delivery: Barriers, strategies, and formulation approaches: A comprehensive review. International Journal of Biological Macromolecules 242, pages 125114.
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Shivali Singh Gaharwar, Vijay N. Mohakar & Anupama Kumar. 2023. Fruit and Vegetable Waste Utilization and Sustainability. Fruit and Vegetable Waste Utilization and Sustainability 253 268 .
Songping Mo, Shaofei Shan, Lijuan He, Lisi Jia & Ying Chen. (2022) Nanoencapsulation of Binary Sugar Alcohols at Neutral pH Conditions. Journal of Cluster Science 34:1, pages 547-556.
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Carlynne Choy, Lee Yong Lim, Lai Wah Chan, Zhixiang Cui, Shirui Mao & Tin Wui Wong. (2022) Exploring Intestinal Surface Receptors in Oral Nanoinsulin Delivery. Pharmacological Reviews 74:4, pages 962-983.
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Salah Uddin Ahmad, Bing Li, Jichao Sun, Safia Arbab, Zhen Dong, Fusheng Cheng, Xuzheng Zhou, Shad Mahfuz & Jiyu Zhang. (2021) Recent advances in microencapsulation of drugs for veterinary applications. Journal of Veterinary Pharmacology and Therapeutics 44:3, pages 298-312.
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Sarah L. Perry & David Julian McClements. (2020) Recent Advances in Encapsulation, Protection, and Oral Delivery of Bioactive Proteins and Peptides using Colloidal Systems. Molecules 25:5, pages 1161.
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Subhankar Chatterjee, Chandra Bhushan Sharma, Carl J. Lavie, Anjan Adhikari, Prakash Deedwania & James H. O'keefe. (2020) Oral insulin: an update. Minerva Endocrinologica 45:1.
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Edwin García-Miguel, Veera C.S.R. Chittepu, Poonam Kalhotra, José Proal-Nájera, Guillermo Osorio-Revilla & Tzayhrí Gallardo-Velázquez. (2019) In Vitro Digestion of Microcapsule Carriers for Oral Delivery of Bioactive Compounds for Diabetes Treatment and Their Inhibitory Effect on the DPP-4 Enzyme. Applied Sciences 9:23, pages 5041.
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Selvan Ravindran, Amlesh J. Tambe, Jitendra K. Suthar, Digamber S. Chahar, Joyleen M. Fernandes & Vedika Desai. (2019) Nanomedicine: Bioavailability, Biotransformation and Biokinetics. Current Drug Metabolism 20:7, pages 542-555.
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Quancai Sun, Zipei Zhang, Ruojie Zhang, Ruichang Gao & David Julian McClements. (2018) Development of Functional or Medical Foods for Oral Administration of Insulin for Diabetes Treatment: Gastroprotective Edible Microgels. Journal of Agricultural and Food Chemistry 66:19, pages 4820-4826.
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David Julian McClements. (2018) Encapsulation, protection, and delivery of bioactive proteins and peptides using nanoparticle and microparticle systems: A review. Advances in Colloid and Interface Science 253, pages 1-22.
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Ahmed Gedawy, Jorge Martinez, Hani Al-Salami & Crispin R Dass. (2018) Oral insulin delivery: existing barriers and current counter-strategies. Journal of Pharmacy and Pharmacology 70:2, pages 197-213.
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A. Momoh Mumuni, C. Jackson Tenderwealth, O. Musiliu Adedokun, F. Chimaobi Kenechukwu, C. Darlington Youngson & C. Ofokansi Kenneth. (2017) Microspheres of insulin-Eudragit complex: Formulation, characterization and in vivo studies. African Journal of Pharmacy and Pharmacology 11:29, pages 327-341.
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Lucia Zakharova, Tatiana Pashirova, Ruslan Kashapov, Dinar Gabdrakhmanov & Oleg Sinyashin. 2017. Nanostructures for Drug Delivery. Nanostructures for Drug Delivery 749 806 .
Juntao Yin, Cuiyu Xiang & Xiaoyong Song. (2016) Nanoencapsulation of psoralidin via chitosan and Eudragit S100 for enhancement of oral bioavailability. International Journal of Pharmaceutics 510:1, pages 203-209.
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Dhansukh Kaklotar, Poornima Agrawal, Allabakshi Abdulla, Rahul P Singh, Abhishesh K Mehata, Sanjay Singh, Brahmeshwar Mishra, Bajarangprasad L Pandey, Anshuman Trigunayat & Madaswamy S Muthu. (2016) Transition from passive to active targeting of oral insulin nanomedicines: enhancement in bioavailability and glycemic control in diabetes. Nanomedicine 11:11, pages 1465-1486.
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Ebbe Juel Bech Nielsen, Shinya Yoshida, Noriyasu Kamei, Ruisha Iwamae, El-Sayed Khafagy, Jørgen Olsen, Ulrik Lytt Rahbek, Betty Lomstein Pedersen, Kozo Takayama & Mariko Takeda-Morishita. (2014) In vivo proof of concept of oral insulin delivery based on a co-administration strategy with the cell-penetrating peptide penetratin. Journal of Controlled Release 189, pages 19-24.
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Sam Maher, Ben Ryan, Aoife Duffy & David J Brayden. (2014) Formulation strategies to improve oral peptide delivery. Pharmaceutical Patent Analyst 3:3, pages 313-336.
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Alice W. Du & Martina H. Stenzel. (2014) Drug Carriers for the Delivery of Therapeutic Peptides. Biomacromolecules 15:4, pages 1097-1114.
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Thundiparambil Azeez Sonia & Chandra P. Sharma. 2014. Oral Delivery of Insulin. Oral Delivery of Insulin 311 332 .
Yushen Jin, Yanyan Li, Hongjie Pan & Zhifei Dai. (2014) Liposomal nanohybrid cerasomes for controlled insulin release. RSC Adv. 4:81, pages 42808-42815.
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