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Research Article

Chitosan–xanthan gum microparticle-based oral tablet for colon-targeted and sustained delivery of quercetin

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Pages 694-699 | Received 04 Nov 2013, Accepted 31 Mar 2014, Published online: 06 Jun 2014

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Crossref
Hans Merzendorfer. 2019. Extracellular Sugar-Based Biopolymers Matrices. Extracellular Sugar-Based Biopolymers Matrices 95 151 .
Yasamin Davatgaran Taghipour, Roodabeh Bahramsoltani, André M. Marques, Rozita Naseri, Roja Rahimi, Pouya Haratipour, Amin Iran Panah, Mohammad Hosein Farzaei & Mohammad Abdollahi. (2018) A systematic review of nano formulation of natural products for the treatment of inflammatory bowel disease: drug delivery and pharmacological targets. DARU Journal of Pharmaceutical Sciences 26:2, pages 229-239.
Crossref
Peng Wen, Teng-Gen Hu, Lin Li, Min-Hua Zong & Hong Wu. (2018) A colon-specific delivery system for quercetin with enhanced cancer prevention based on co-axial electrospinning. Food & Function 9:11, pages 5999-6009.
Crossref
Peng Wen, Min-Hua Zong, Teng-Gen Hu, Lin Li & Hong Wu. (2018) Preparation and Characterization of Electrospun Colon-Specific Delivery System for Quercetin and Its Antiproliferative Effect on Cancer Cells. Journal of Agricultural and Food Chemistry 66:44, pages 11550-11559.
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Chun Y. Wong, Jorge Martinez, Hani Al-Salami & Crispin R. Dass. (2018) Quantification of BSA-loaded chitosan/oligonucleotide nanoparticles using reverse-phase high-performance liquid chromatography. Analytical and Bioanalytical Chemistry 410:27, pages 6991-7006.
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Musammir Khan, Janne T. Koivisto, Terttu I. Hukka, Mikko Hokka & Minna Kellomäki. (2018) Composite Hydrogels Using Bioinspired Approach with in Situ Fast Gelation and Self-Healing Ability as Future Injectable Biomaterial. ACS Applied Materials & Interfaces 10:14, pages 11950-11960.
Crossref
Deepak M. Kasote, G. K. Jayaprakasha & Bhimanagouda S. Patil. 2018. Advances in Plant Phenolics: From Chemistry to Human Health. Advances in Plant Phenolics: From Chemistry to Human Health 239 259 .
Rudra Pangeni, Si-Won Kang, Minho Oak, Eun Young Park & Jin Woo Park. (2017) Oral delivery of quercetin in oil-in-water nanoemulsion: In vitro characterization and in vivo anti-obesity efficacy in mice. Journal of Functional Foods 38, pages 571-581.
Crossref
Niharika Lal, Juhi Dubey, Praveen Gaur, Navneet Verma & Anurag Verma. (2017) Chitosan based in situ forming polyelectrolyte complexes: A potential sustained drug delivery polymeric carrier for high dose drugs. Materials Science and Engineering: C 79, pages 491-498.
Crossref
Richard D. Horniblow, Daisy Henesy, Tariq H. Iqbal & Chris Tselepis. (2017) Modulation of iron transport, metabolism and reactive oxygen status by quercetin-iron complexes in vitro. Molecular Nutrition & Food Research 61:3, pages 1600692.
Crossref
Jieun Kim, Jangsun Hwang, Youngmin Seo, Yeonho Jo, Jaewoo Son & Jonghoon Choi. (2017) Engineered chitosan–xanthan gum biopolymers effectively adhere to cells and readily release incorporated antiseptic molecules in a sustained manner. Journal of Industrial and Engineering Chemistry 46, pages 68-79.
Crossref
Carla Caddeo, Ramon Pons, Claudia Carbone, Xavier Fernàndez-Busquets, Maria Cristina Cardia, Anna Maria Maccioni, Anna Maria Fadda & Maria Manconi. (2017) Physico-chemical characterization of succinyl chitosan-stabilized liposomes for the oral co-delivery of quercetin and resveratrol. Carbohydrate Polymers 157, pages 1853-1861.
Crossref
Ali Salaritabar, Behrad Darvishi, Farzaneh Hadjiakhoondi, Azadeh Manayi, Antoni Sureda, Seyed Fazel Nabavi, Leo R Fitzpatrick, Seyed Mohammad Nabavi & Anupam Bishayee. (2017) Therapeutic potential of flavonoids in inflammatory bowel disease: A comprehensive review. World Journal of Gastroenterology 23:28, pages 5097.
Crossref
Carla Caddeo, Amparo Nacher, Antonio Vassallo, Maria Francesca Armentano, Ramon Pons, Xavier Fernàndez-Busquets, Claudia Carbone, Donatella Valenti, Anna Maria Fadda & Maria Manconi. (2016) Effect of quercetin and resveratrol co-incorporated in liposomes against inflammatory/oxidative response associated with skin cancer. International Journal of Pharmaceutics 513:1-2, pages 153-163.
Crossref
Chayanika Deka, Deepanwita Deka, Montu Moni Bora, Dhruva Kumar Jha & Dilip Kumar Kakati. (2016) Synthesis of peppermint oil-loaded chitosan/alginate polyelectrolyte complexes and study of their antibacterial activity. Journal of Drug Delivery Science and Technology 35, pages 314-322.
Crossref
Renata Francielle Bombaldi de Souza, Fernanda Carla Bombaldi de Souza & Ângela Maria Moraes. (2016) Polysaccharide-based membranes loaded with erythromycin for application as wound dressings. Journal of Applied Polymer Science 133:22, pages n/a-n/a.
Crossref
Piyasi Mukhopadhyay, Subhajit Maity, Sandipan Chakraborty, Ruchira Rudra, Hiral Ghodadara, Manisha Solanki, Abhay Sankar Chakraborti, A. K. Prajapati & P. P. Kundu. (2016) Oral delivery of quercetin to diabetic animals using novel pH responsive carboxypropionylated chitosan/alginate microparticles. RSC Advances 6:77, pages 73210-73221.
Crossref
Carla Caddeo, Octavio Díez-Sales, Ramon Pons, Claudia Carbone, Guido Ennas, Giovanni Puglisi, Anna Maria Fadda & Maria Manconi. (2016) Cross-linked chitosan/liposome hybrid system for the intestinal delivery of quercetin. Journal of Colloid and Interface Science 461, pages 69-78.
Crossref
Roman Akasov, Tatiana Borodina, Ekaterina Zaytseva, Anastasia Sumina, Tatiana Bukreeva, Sergey Burov & Elena Markvicheva. (2015) Ultrasonically Assisted Polysaccharide Microcontainers for Delivery of Lipophilic Antitumor Drugs: Preparation and in Vitro Evaluation. ACS Applied Materials & Interfaces 7:30, pages 16581-16589.
Crossref
Ines Castangia, Amparo Nácher, Carla Caddeo, Virginia Merino, Octavio Díez-Sales, Ana Catalán-Latorre, Xavier Fernàndez-Busquets, Anna Maria Fadda & Maria Manconi. (2015) Therapeutic efficacy of quercetin enzyme-responsive nanovesicles for the treatment of experimental colitis in rats. Acta Biomaterialia 13, pages 216-227.
Crossref
Bo-Da Zhou, Ge Guo, Le-Min Zheng, Ling-Yun Zu & Wei Gao. (2015) Microparticles as Novel Biomarkers and Therapeutic Targets in Coronary Heart Disease. Chinese Medical Journal 128:2, pages 267-272.
Crossref
Piyasi Mukhopadhyay & A. K. Prajapati. (2015) Quercetin in anti-diabetic research and strategies for improved quercetin bioavailability using polymer-based carriers – a review. RSC Advances 5:118, pages 97547-97562.
Crossref

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