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Research Article

Novel chenodeoxycholic acid–sodium alginate matrix in the microencapsulation of the potential antidiabetic drug, probucol. An in vitro study

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Pages 589-597 | Received 12 Jan 2015, Accepted 04 Jun 2015, Published online: 20 Jul 2015

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (7)

Eslam Elkalla, Sumera Khizar, Mohamad Tarhini, Noureddine Lebaz, Nadia Zine, Nicole Jaffrezic-Renault, Abdelhamid Errachid & Abdelhamid Elaissari. (2023) Core-shell micro/nanocapsules: from encapsulation to applications. Journal of Microencapsulation 40:3, pages 125-156.
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Armin Mooranian, Thomas Foster, Corina M Ionescu, Louise Carey, Daniel Walker, Melissa Jones, Susbin Raj Wagle, Bozica Kovacevic, Jacqueline Chester, Edan Johnstone, Jafri Kuthubutheen, Daniel Brown, Marcus D Atlas, Momir Mikov & Hani Al-Salami. (2021) The Effects of Primary Unconjugated Bile Acids on Nanoencapsulated Pharmaceutical Formulation of Hydrophilic Drugs: Pharmacological Implications. Drug Design, Development and Therapy 15, pages 4423-4434.
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Sina Ilyaei, Reza Sourki & Yeganeh Haji Ali Akbari. (2021) Capsule-based healing systems in composite materials: a review. Critical Reviews in Solid State and Materials Sciences 46:6, pages 491-531.
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Armin Mooranian, Nassim Zamani, Momir Mikov, Svetlana Goločorbin-Kon, Goran Stojanovic, Frank Arfuso & Hani Al-Salami. (2018) Novel nano-encapsulation of probucol in microgels: scanning electron micrograph characterizations, buoyancy profiling, and antioxidant assay analyses. Artificial Cells, Nanomedicine, and Biotechnology 46:sup3, pages 741-747.
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Armin Mooranian, Rebecca Negrulj, Frank Arfuso & Hani Al-Salami. (2016) Multicompartmental, multilayered probucol microcapsules for diabetes mellitus: Formulation characterization and effects on production of insulin and inflammation in a pancreatic β-cell line. Artificial Cells, Nanomedicine, and Biotechnology 44:7, pages 1642-1653.
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Armin Mooranian, Rebecca Negrulj & Hani Al-Salami. (2016) The impact of allylamine-bile acid combinations on cell delivery microcapsules in diabetes. Journal of Microencapsulation 33:6, pages 569-574.
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Articles from other publishers (33)

Susbin R Wagle, Corina M Ionescu, Bozica Kovacevic, Melissa Jones, Thomas Foster, Patrick Lim, Michael Lewkowicz, Maja Ðanić, Momir Mikov, Armin Mooranian & Hani Al-Salami. (2023) Pharmaceutical characterization of probucol bile acid–lithocholic acid nanoparticles to prevent chronic hearing related and similar cellular oxidative stress pathologies. Nanomedicine 18:12, pages 923-940.
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Thomas Foster, Michael Lewkowicz, Christina Quintas, Corina Mihaela Ionescu, Melissa Jones, Susbin Raj Wagle, Bozica Kovacevic, Elaine Y. M. Wong, Armin Mooranian & Hani Al‐Salami. (2022) Novel Nanoencapsulation Technology and its Potential Role in Bile Acid‐Based Targeted Gene Delivery to the Inner Ear. Small 19:8.
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Bozica Kovacevic, Melissa Jones, Corina Ionescu, Daniel Walker, Susbin Wagle, Jacqueline Chester, Thomas Foster, Daniel Brown, Momir Mikov, Armin Mooranian & Hani Al-Salami. (2022) The emerging role of bile acids as critical components in nanotechnology and bioengineering: Pharmacology, formulation optimizers and hydrogel-biomaterial applications. Biomaterials 283, pages 121459.
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Armin Mooranian, Melissa Jones, Daniel Walker, Corina Mihaela Ionescu, Susbin Raj Wagle, Bozica Kovacevic, Jacqueline Chester, Thomas Foster, Edan Johnston, Jafri Kuthubutheen, Daniel Brown, Marcus D. Atlas, Momir Mikov & Hani Al-Salami. (2022) Pharmacological Dose-Effect Profiles of Various Concentrations of Humanised Primary Bile Acid in Encapsulated Cells. Nanomaterials 12:4, pages 647.
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Armin Mooranian, Melissa Jones, Corina Mihaela Ionescu, Daniel Walker, Susbin Raj Wagle, Bozica Kovacevic, Jacqueline Chester, Thomas Foster, Edan Johnston, Momir Mikov & Hani Al-Salami. (2022) Pharmaceutical formulation and polymer chemistry for cell encapsulation applied to the creation of a lab-on-a-chip bio-microsystem. Therapeutic Delivery 13:1, pages 51-65.
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Armin Mooranian, Louise Carey, Corina Mihaela Ionescu, Daniel Walker, Melissa Jones, Susbin Raj Wagle, Bozica Kovacevic, Thomas Foster, Jacqueline Chester, Edan Johnston, Momir Mikov & Hani Al-Salami. (2021) The Effects of Accelerated Temperature-Controlled Stability Systems on the Release Profile of Primary Bile Acid-Based Delivery Microcapsules. Pharmaceutics 13:10, pages 1667.
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Thomas Foster, Corina Ionescu, Daniel Walker, Melissa Jones, Susbin Wagle, Božica Kovacevic, Daniel Brown, Momir Mikov, Armin Mooranian & Hani Al-Salami. (2021) Chemotherapy-induced hearing loss: the applications of bio-nanotechnologies and bile acid-based delivery matrices. Therapeutic Delivery 12:10, pages 723-737.
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Armin Mooranian, Corina Mihaela Ionescu, Susbin Raj Wagle, Bozica Kovacevic, Daniel Walker, Melissa Jones, Jacqueline Chester, Edan Johnston, Maja Danic, Momir Mikov, Crispin Dass & Hani Al-Salami. (2021) Chenodeoxycholic Acid Pharmacology in Biotechnology and Transplantable Pharmaceutical Applications for Tissue Delivery: An Acute Preclinical Study. Cells 10:9, pages 2437.
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Susbin Raj Wagle, Bozica Kovacevic, Corina Mihaela Ionescu, Daniel Walker, Melissa Jones, Louise Carey, Ryusuke Takechi, Momir Mikov, Armin Mooranian & Hani Al-Salami. (2021) Pharmacological and Biological Study of Microencapsulated Probucol-Secondary Bile Acid in a Diseased Mouse Model. Pharmaceutics 13:8, pages 1223.
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Armin Mooranian, Thomas Foster, Corina M. Ionescu, Daniel Walker, Melissa Jones, Susbin Raj Wagle, Bozica Kovacevic, Jacqueline Chester, Edan Johnston, Elaine Wong, Marcus D. Atlas, Momir Mikov & Hani Al-Salami. (2021) Enhanced Bilosomal Properties Resulted in Optimum Pharmacological Effects by Increased Acidification Pathways. Pharmaceutics 13:8, pages 1184.
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Jacqueline Chester, Edan Johnston, Daniel Walker, Melissa Jones, Corina Mihaela Ionescu, Susbin Raj Wagle, Božica Kovacevic, Daniel Brown, Momir Mikov, Armin Mooranian & Hani Al-Salami. (2021) A Review on Recent Advancement on Age-Related Hearing Loss: The Applications of Nanotechnology, Drug Pharmacology, and Biotechnology. Pharmaceutics 13:7, pages 1041.
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Melissa Jones, Daniel Walker, Corina Mihaela Ionescu, Bozica Kovacevic, Susbin Raj Wagle, Armin Mooranian, Daniel Brown & Hani Al-Salami. (2020) Microencapsulation of Coenzyme Q10 and bile acids using ionic gelation vibrational jet flow technology for oral delivery. Therapeutic Delivery 11:12, pages 791-805.
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Susbin Raj Wagle, Bozica Kovacevic, Daniel Walker, Corina Mihaela Ionescu, Melissa Jones, Goran Stojanovic, Sanja Kojic, Armin Mooranian & Hani Al-Salami. (2020) Pharmacological and Advanced Cell Respiration Effects, Enhanced by Toxic Human-Bile Nano-Pharmaceuticals of Probucol Cell-Targeting Formulations. Pharmaceutics 12:8, pages 708.
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Sangeetha Mathavan, Corina M Ionescu, Bozica Kovacevic, Momir Mikov, Svetlana Golocorbin-Kon, Armin Mooranian, Crispin R Dass & Hani Al-Salami. (2020) Histological effects of pharmacologically active human bile acid nano/micro-particles in Type-1 diabetes. Therapeutic Delivery 11:3, pages 157-171.
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Armin Mooranian, Nassim Zamani, Momir Mikov, Svetlana Goločorbin-Kon, Goran Stojanovic, Frank Arfuso, Bozica Kovacevic & Hani Al-Salami. (2020) A second-generation micro/nano capsules of an endogenous primary un-metabolised bile acid, stabilized by Eudragit-alginate complex with antioxidant compounds. Saudi Pharmaceutical Journal 28:2, pages 165-171.
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Armin Mooranian, Susbin Raj Wagle, Bozica Kovacevic, Ryu Takechi, John Mamo, Virginie Lam, Gerald F. Watts, Momir Mikov, Svetlana Golocorbin-Kon, Goran Stojanovic, Hesham Al-Sallami & Hani Al-Salami. (2020) Bile acid bio-nanoencapsulation improved drug targeted-delivery and pharmacological effects via cellular flux: 6-months diabetes preclinical study. Scientific Reports 10:1.
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G. Kaur, M. Arora & M.N.V. Ravi Kumar. (2019) Oral Drug Delivery Technologies—A Decade of Developments. Journal of Pharmacology and Experimental Therapeutics 370:3, pages 529-543.
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Kadir Ozaltin, Pavel S. Postnikov, Marina E. Trusova, Vladimir Sedlarik & Antonio Di Martino. (2019) Polysaccharides based microspheres for multiple encapsulations and simultaneous release of proteases. International Journal of Biological Macromolecules 132, pages 24-31.
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Armin Mooranian, Nassim Zamani, Ryu Takechi, Giuseppe Luna, Momir Mikov, Svetlana Goločorbin-Kon, Magdy Elnashar, Frank Arfuso & Hani Al-Salami. (2019) An in vivo pharmacological study: Variation in tissue-accumulation for the drug probucol as the result of targeted microtechnology and matrix-acrylic acid optimization and stabilization techniques. PLOS ONE 14:4, pages e0214984.
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Armin Mooranian, Nassim Zamani, Momir Mikov, Svetlana Goločorbin-Kon, Goran Stojanovic, Frank Arfuso & Hani Al-Salami. (2019) Stability and biological testing of taurine-conjugated bile acid antioxidant microcapsules for diabetes treatment. Therapeutic Delivery 10:2, pages 99-106.
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Nebojša Pavlović, Svetlana Goločorbin-Kon, Maja Ðanić, Bojan Stanimirov, Hani Al-Salami, Karmen Stankov & Momir Mikov. (2018) Bile Acids and Their Derivatives as Potential Modifiers of Drug Release and Pharmacokinetic Profiles. Frontiers in Pharmacology 9.
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Armin Mooranian, Nassim Zamani, Momir Mikov, Svetlana Goločorbin-Kon, Goran Stojanovic, Frank Arfuso & Hani Al-Salami. (2018) Eudragit ® -based microcapsules of probucol with a gut-bacterial processed secondary bile acid . Therapeutic Delivery 9:11, pages 811-821.
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Armin Mooranian, Rebecca Negrulj, Ryu Takechi, John Mamo, Hesham Al-Sallami & Hani Al-Salami. (2018) The biological effects of the hypolipidaemic drug probucol microcapsules fed daily for 4 weeks, to an insulin-resistant mouse model: potential hypoglycaemic and anti-inflammatory effects. Drug Delivery and Translational Research 8:3, pages 543-551.
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Armin Mooranian, Rebecca Negrulj, Ryu Takechi, Emma Jamieson, Grant Morahan & Hani Al-Salami. (2017) Alginate-combined cholic acid increased insulin secretion of microencapsulated mouse cloned pancreatic β cells. Therapeutic Delivery 8:10, pages 833-842.
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Armin Mooranian, Ryu Tackechi, Emma Jamieson, Grant Morahan & Hani Al-Salami. (2017) Innovative Microcapsules for Pancreatic β-Cells Harvested from Mature Double-Transgenic Mice: Cell Imaging, Viability, Induced Glucose-Stimulated Insulin Measurements and Proinflammatory Cytokines Analysis. Pharmaceutical Research 34:6, pages 1217-1223.
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Chityal Ganesh Kumar, Yedla Poornachandra & Sujitha Pombala. 2017. Nanostructures for Drug Delivery. Nanostructures for Drug Delivery 1 61 .
Armin Mooranian, Rebecca Negrulj, Emma Jamieson, Grant Morahan & Hani Al-Salami. (2016) Biological Assessments of Encapsulated Pancreatic β-Cells: Their Potential Transplantation in Diabetes. Cellular and Molecular Bioengineering 9:4, pages 530-537.
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Armin Mooranian, Rebecca Negrulj & Hani Al-Salami. (2016) Primary Bile Acid Chenodeoxycholic Acid-Based Microcapsules to Examine β-cell Survival and the Inflammatory Response. BioNanoScience 6:2, pages 103-109.
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Armin Mooranian, Rebecca Negrulj & Hani Al-Salami. (2016) Alginate-deoxycholic Acid Interaction and Its Impact on Pancreatic Β-Cells and Insulin Secretion and Potential Treatment of Type 1 Diabetes. Journal of Pharmaceutical Innovation 11:2, pages 156-161.
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Armin Mooranian, Rebecca Negrulj & Hani Al-Salami. (2016) The Influence of Stabilized Deconjugated Ursodeoxycholic Acid on Polymer-Hydrogel System of Transplantable NIT-1 Cells. Pharmaceutical Research 33:5, pages 1182-1190.
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Armin Mooranian, Rebecca Negrulj & Hani Al-Salami. (2016) Flow vibration-doubled concentric system coupled with low ratio amine to produce bile acid-macrocapsules of β-cells. Therapeutic Delivery 7:3, pages 171-178.
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Armin Mooranian, Rebecca Negrulj & Hani Al-Salami. (2015) The incorporation of water-soluble gel matrix into bile acid-based microcapsules for the delivery of viable β-cells of the pancreas, in diabetes treatment: biocompatibility and functionality studies. Drug Delivery and Translational Research 6:1, pages 17-23.
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Armin Mooranian, Rebecca Negrulj, Frank Arfuso & Hani Al-Salami. (2015) The effect of a tertiary bile acid, taurocholic acid, on the morphology and physical characteristics of microencapsulated probucol: potential applications in diabetes: a characterization study. Drug Delivery and Translational Research 5:5, pages 511-522.
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