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Journal of Microencapsulation
Micro and Nano Carriers
Volume 13, 1996 - Issue 4
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Research Article

Liquid-liquid emulsification by static mixers for use in microencapsulation

Y. F. Maa Department of Pharmaceutical Research and Development, Genentech, Inc., 460 Point San Bruno Boulevard, South San Francisco, CA, 94080, USA
&
C. Hsu Department of Pharmaceutical Research and Development, Genentech, Inc., 460 Point San Bruno Boulevard, South San Francisco, CA, 94080, USA
Pages 419-433 | Received 10 Feb 1995, Published online: 27 Sep 2008

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Ana Bettencourt & António J. Almeida. (2012) Poly(methyl methacrylate) particulate carriers in drug delivery. Journal of Microencapsulation 29:4, pages 353-367.
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Harri Heiskanen, Peter Denifl, Markku Hurme, Päivi Pitkänen & Marita Oksman. (2012) Effect of Physical Properties and Emulsification Conditions on the Microsphere Size Prepared Using a Solvent Extraction Process. Journal of Dispersion Science and Technology 33:2, pages 234-244.
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Faten Madani & Jean-Claude Chaumeil. (2008) Coating of indomethacin-loaded embolic microspheres for a successful embolization therapy. Journal of Microencapsulation 25:2, pages 121-133.
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S. Freitas, A. Walz, H. P. Merkle & B. Gander. (2003) Solvent extraction employing a static micromixer: A simple, robust and versatile technology for the microencapsulation of proteins. Journal of Microencapsulation 20:1, pages 67-85.
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P. MORANCAIS, K. HIRECH, G. CARNELLE & J. LEGRAND. (1999) FRICTION FACTOR IN STATIC MIXER AND DETERMINATION OF GEOMETRIC PARAMETERS OF SMX SULZER MIXERS. Chemical Engineering Communications 171:1, pages 77-93.
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Yuh-Fun Maa & Chung C. Hsu. (1999) Performance of Sonication and Microfluidization for Liquid–Liquid Emulsification. Pharmaceutical Development and Technology 4:2, pages 233-240.
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. (1997) Literature Alerts. Journal of Microencapsulation 14:1, pages 119-132.
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Y. F Maa & C. C. Hsu. (1997) Effect of primary emulsions on microsphere size and protein-loading in the double emulsion process. Journal of Microencapsulation 14:2, pages 225-241.
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Juan Pablo Valdes, Lyes Kahouadji, Fuyue Liang, Seungwon Shin, Jalel Chergui, Damir Juric & Omar K. Matar. (2023) On the dispersion dynamics of liquid–liquid surfactant-laden flows in a SMX static mixer. Chemical Engineering Journal 475, pages 146058.
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Juan P. Valdés, Lyes Kahouadji & Omar K. Matar. (2022) Current advances in liquid–liquid mixing in static mixers: A review. Chemical Engineering Research and Design 177, pages 694-731.
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Noureddine Lebaz & Nida Sheibat-Othman. (2019) Modeling Emulsification in Static Mixers: Equilibrium Correlations versus Population Balance Equations. Chemical Engineering & Technology.
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Yulong Xia, Meng Yuan, Mo Chen, Jin Li, Tianyuan Ci & Xue Ke. (2019) Liquid jet breakup: A new method for the preparation of poly lactic-co-glycolic acid microspheres. European Journal of Pharmaceutics and Biopharmaceutics 137, pages 140-147.
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M.P. Vasilev & R.Sh. Abiev. (2018) Turbulent droplets dispersion in a pulsating flow type apparatus – New type of static disperser. Chemical Engineering Journal 349, pages 646-661.
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M.P. Vasilev & R.Sh. Abiev. (2018) Intensity and efficiency of droplet dispersion: Pulsating flow type apparatus vs. static mixers. Chemical Engineering Research and Design 137, pages 329-349.
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Tomy J. Gutiérrez. 2018. Handbook of Nanomaterials for Industrial Applications. Handbook of Nanomaterials for Industrial Applications 989 1011 .
Yanlin Zhang, Robert W. Cattrall & Spas D. Kolev. (2017) Fast and Environmentally Friendly Microfluidic Technique for the Fabrication of Polymer Microspheres. Langmuir 33:51, pages 14691-14698.
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E. Chabanon, N. Sheibat-Othman, O. Mdere, J.P. Valour, S. Urbaniak & F. Puel. (2017) Drop size distribution monitoring of oil-in-water emulsions in SMX+ static mixers: Effect of operating and geometrical conditions. International Journal of Multiphase Flow 92, pages 61-69.
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Luis A. Trujillo-Cayado, M. Carmen Alfaro, M.C. García & J. Muñoz. (2017) Comparison of homogenization processes for the development of green O/W emulsions formulated with N,N-dimethyldecanamide. Journal of Industrial and Engineering Chemistry 46, pages 54-61.
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Edel Sah & Hongkee Sah. (2015) Recent Trends in Preparation of Poly(lactide- co -glycolide) Nanoparticles by Mixing Polymeric Organic Solution with Antisolvent . Journal of Nanomaterials 2015, pages 1-22.
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Ines Souilem, Christophe A. Serra, René Muller, Yves Holl, Michel Bouquey & Christophe Sutter. (2015) Dimensional analysis of a novel low-pressure device for the production of size-tunable nanoemulsions. AIChE Journal 61:1, pages 23-30.
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Fabien Salaön. 2013. Encapsulation Nanotechnologies. Encapsulation Nanotechnologies 137 173 .
Peng Zhai, X B Chen & David J Schreyer. (2013) Preparation and characterization of alginate microspheres for sustained protein delivery within tissue scaffolds. Biofabrication 5:1, pages 015009.
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Harri Heiskanen, Peter Denifl, Päivi Pitkänen & Markku Hurme. (2012) Effect of concentration and temperature on the properties of the microspheres prepared using an emulsion–solvent extraction process. Advanced Powder Technology 23:6, pages 779-786.
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H. Heiskanen, P. Denifl, M. Hurme & P. Pitkänen. (2010) Effect of Emulsification Conditions on the Properties of Microspheres Prepared by a Solvent Extraction Process. Chemical Engineering & Technology 33:10, pages 1635-1644.
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Jean-Antoine Meiners. 2009. Prebiotics and Probiotics Science and Technology. Prebiotics and Probiotics Science and Technology 805 823 .
Seid Mahdi Jafari, Elham Assadpoor, Yinghe He & Bhesh Bhandari. (2008) Re-coalescence of emulsion droplets during high-energy emulsification. Food Hydrocolloids 22:7, pages 1191-1202.
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J. Legrand, K. Hirech & A. Arhaliass. (2006) Effect of a liquid dispersed phase on the wall flow structure in static mixer. International Journal of Multiphase Flow 32:5, pages 593-605.
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Sergio Freitas, Hans P. Merkle & Bruno Gander. (2005) Microencapsulation by solvent extraction/evaporation: reviewing the state of the art of microsphere preparation process technology. Journal of Controlled Release 102:2, pages 313-332.
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Kathrin Schalper, Stephan Harnisch, Rainer H. M�ller & Gesine E. Hildebrand. (2005) Preparation of Microparticles by Micromixers: Characterization of Oil/Water Process and Prediction of Particle Size. Pharmaceutical Research 22:2, pages 276-284.
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Evgeniya Belyaeva, Dominique Della Valle, Ronald J. Neufeld & Denis Poncelet. (2004) New approach to the formulation of hydrogel beads by emulsification/thermal gelation using a static mixer. Chemical Engineering Science 59:14, pages 2913-2920.
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Franklin W. Okumu, Le N. Dao, Paul J. Fielder, Noel Dybdal, Dennis Brooks, Samir Sane & Jeffrey L. Cleland. (2002) Sustained delivery of human growth hormone from a novel gel system: SABERTM. Biomaterials 23:22, pages 4353-4358.
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J. Legrand, P. Morançais & G. Carnelle. (2001) Liquid-Liquid Dispersion in an SMX-Sulzer Static Mixer. Chemical Engineering Research and Design 79:8, pages 949-956.
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Anne André-Abrant, Jean-Louis Taverdet & Jacques Jay. (2001) Microencapsulation par évaporation de solvant. European Polymer Journal 37:5, pages 955-963.
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Robert Sparks, Irwin Jacobs & Norbert Mason. 1998. Pharmaceutical Unit Operations. Pharmaceutical Unit Operations 177 222 .
Yuh-Fun Maa & Chung Hsu. (1996) Liquid-liquid emulsification by rotor/stator homogenization. Journal of Controlled Release 38:2-3, pages 219-228.
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