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Research Article

Modulation of protein release from chitosan-alginate microcapsules using the pH-sensitive polymer hydroxypropyl methylcellulose acetate succinate

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Pages 497-508 | Received 10 Sep 1994, Accepted 25 Jan 1996, Published online: 27 Sep 2008

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Ali Delbari, Fatemeh Fadaei, Mohammad Salehi, Reza Mastery Farahani, Abbas Piryaei, Mohammad Hassan Heidari, Mohsen Nourozian & Vahid Mansouri. (2014) A simple method for generating small calcium-alginate beads by syringe. Journal of Histotechnology 37:4, pages 132-137.
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Sabyasachi Maiti, Somasree Ray & Biswanath Sa. (2009) Controlled delivery of bovine serum albumin from carboxymethyl xanthan microparticles. Pharmaceutical Development and Technology 14:2, pages 165-172.
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Sabyasachi Maiti, Somasree Ray, Balaram Mandal, Srimanta Sarkar & Biswanath Sa. (2007) Carboxymethyl xanthan microparticles as a carrier for protein delivery. Journal of Microencapsulation 24:8, pages 743-756.
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A. D. Sezer & J. Akbuğa. (2006) Fucosphere—New microsphere carriers for peptide and protein delivery: Preparation and in vitro characterization. Journal of Microencapsulation 23:5, pages 513-522.
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Fwu-Long Mi, Hsiang-Fa Liang, Yung-Chih Wu, Yu-Shin Lin, Ting-Fan Yang & Hsing-Wen Sung. (2005) pH-sensitive behavior of two-component hydrogels composed of N,O-carboxymethyl chitosan and alginate. Journal of Biomaterials Science, Polymer Edition 16:11, pages 1333-1345.
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Hanne Hjorth Tønnesen & Jan Karlsen. (2002) Alginate in Drug Delivery Systems. Drug Development and Industrial Pharmacy 28:6, pages 621-630.
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Seçil Önal & Figen Zihniğlu. (2002) ENCAPSULATION OF INSULIN IN CHITOSAN-COATED ALGINATE BEADS: ORAL THERAPEUTIC PEPTIDE DELIVERY. Artificial Cells, Blood Substitutes, and Biotechnology 30:3, pages 229-237.
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Gilberto Coppi, Valentina Iannuccelli, Eliana Leo, Maria Teresa Bernabei & Riccardo Cameroni. (2001) Chitosan-Alginate Microparticles as a Protein Carrier. Drug Development and Industrial Pharmacy 27:5, pages 393-400.
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Maria Luisa Torre, Paolo Giunchedi, Lauretta Maggi, Rosanna Stefli, Evelyn Ochoa Machiste & Ubaldo Conte. (1998) Formulation and Characterization of Calcium Alginate Beads Containing Ampicillin. Pharmaceutical Development and Technology 3:2, pages 193-198.
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Olivia Felt, Pierre Buri & Robert Gurny. (1998) Chitosan: A Unique Polysaccharide for Drug Delivery. Drug Development and Industrial Pharmacy 24:11, pages 979-993.
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P. R. Hari & C. P. Sharma. (1998) Letter to the editor. Journal of Microencapsulation 15:4, pages 525-526.
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. (1997) Literature Alerts. Journal of Microencapsulation 14:2, pages 263-272.
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H. Süheyla Kas. (1997) Chitosan: Properties, preparations and application to microparticulate systems. Journal of Microencapsulation 14:6, pages 689-711.
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. (1997) Literature Alerts. Journal of Microencapsulation 14:5, pages 665-683.
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Catarina M. Silva, António J. Ribeiro, Domingos Ferreira & Francisco Veiga. (2006) Insulin encapsulation in reinforced alginate microspheres prepared by internal gelation. European Journal of Pharmaceutical Sciences 29:2, pages 148-159.
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Catarina M. Silva, António J. Ribeiro, Margarida Figueiredo, Domingos Ferreira & Francisco Veiga. (2005) Microencapsulation of hemoglobin in chitosan-coated alginate microspheres prepared by emulsification/internal gelation. The AAPS Journal 7:4, pages E903-E913.
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Sung-Ching Chen, Yung-Chih Wu, Fwu-Long Mi, Yu-Hsin Lin, Lin-Chien Yu & Hsing-Wen Sung. (2004) A novel pH-sensitive hydrogel composed of N,O-carboxymethyl chitosan and alginate cross-linked by genipin for protein drug delivery. Journal of Controlled Release 96:2, pages 285-300.
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Ibrahim El-Gibaly. (2002) Development and in vitro evaluation of novel floating chitosan microcapsules for oral use: comparison with non-floating chitosan microspheres. International Journal of Pharmaceutics 249:1-2, pages 7-21.
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Andreas R. DeGroot & Ronald J. Neufeld. (2001) Encapsulation of urease in alginate beads and protection from α-chymotrypsin with chitosan membranes. Enzyme and Microbial Technology 29:6-7, pages 321-327.
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K Chang. (2000) Swelling behavior and the release of protein from chitosan–pectin composite particles. Carbohydrate Polymers 43:2, pages 163-169.
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Augustine O. Okhamafe & Mattheus F. A. Goosen. 1999. Cell Encapsulation Technology and Therapeutics. Cell Encapsulation Technology and Therapeutics 53 62 .
Cenk Aral & Julide Akbuğa. (1998) Alternative approach to the preparation of chitosan beads. International Journal of Pharmaceutics 168:1, pages 9-15.
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