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Journal of Microencapsulation
Micro and Nano Carriers
Volume 15, 1998 - Issue 5
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Research Article

Methotrexate loaded chitosan and chitin microspheres—in vitro characterization and pharmacokinetics in mice bearing Ehrlich ascites carcinoma

U. V. Singh College of Pharmaceutical Sciences, Kasturba Medical College, Manipal, 576 119, Karnataka, India
&
N. Udupa College of Pharmaceutical Sciences, Kasturba Medical College, Manipal, 576 119, Karnataka, India
Pages 581-594 | Received 10 Dec 1996, Accepted 10 Dec 1997, Published online: 27 Sep 2008

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Anna A Alekseeva, Ekaterina V Moiseeva, Natalia R Onishchenko, Ivan A Boldyrev, Alexander S Singin, Andrey P Budko, Zoya S Shprakh, Julian G Molotkovsky & Elena L Vodovozova. (2017) Liposomal formulation of a methotrexate lipophilic prodrug: assessment in tumor cells and mouse T-cell leukemic lymphoma. International Journal of Nanomedicine 12, pages 3735-3749.
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Zulfequar Ahamad Khan, Rahul Tripathi & Brahmeshwar Mishra. (2012) Methotrexate: a detailed review on drug delivery and clinical aspects. Expert Opinion on Drug Delivery 9:2, pages 151-169.
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Sunil Kumar Mandala Rayabandla, Kiran Aithal, Aravind Anandam, Gopal Shavi, Udupa Nayanabhirama, Karthik Arumugam, Prashant Musmade, Krishnamoorthy Bhat & Satish Rao Bola Sadashiva. (2010) Preparation, in vitro characterization, pharmacokinetic, and pharmacodynamic evaluation of chitosan-based plumbagin microspheres in mice bearing B16F1 melanoma. Drug Delivery 17:3, pages 103-113.
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MubarakA. Khan, Rashidul Alam, Md. Arifur Rahman, FarhanaG. Noor & RuhulA. Khan. (2009) Physico-Mechanical and Degradation Properties of Urea-Modified Chitosan Film Photocured with 1-Vinyl-2 Pyrrolidone. Polymer-Plastics Technology and Engineering 48:11, pages 1206-1215.
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Yu Sun, Fude Cui, Kai Shi, Jiamiao Wang, Mengmeng Niu & Ruijing Ma. (2009) The Effect of Chitosan Molecular Weight on the Characteristics of Spray-Dried Methotrexate-Loaded Chitosan Microspheres for Nasal Administration. Drug Development and Industrial Pharmacy 35:3, pages 379-386.
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Jaleh Varshosaz. (2007) The promise of chitosan microspheres in drug delivery systems. Expert Opinion on Drug Delivery 4:3, pages 263-273.
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Makarand V. Risbud, Ramesh R. Bhonde. (2000) Polyacrylamide-Chitosan Hydrogels: In Vitro Biocompatibility and Sustained Antibiotic Release Studies. Drug Delivery 7:2, pages 69-75.
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. (1999) LITERATURE ALERTS. Journal of Microencapsulation 16:4, pages 535-546.
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Articles from other publishers (18)

Manikandan Muthu, Suraj Shiv Charan Pushparaj, Judy Gopal & Iyyakkannu Sivanesan. (2023) A Review on the Antimicrobial Activity of Chitosan Microspheres: Milestones Achieved and Miles to Go. Journal of Marine Science and Engineering 11:8, pages 1480.
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Mousumi Tudu & Amalesh Samanta. (2023) Natural polysaccharides: Chemical properties and application in pharmaceutical formulations. European Polymer Journal 184, pages 111801.
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Md Ishak Khan, M. Imran Hossain, M. Khalid Hossain, M. H. K. Rubel, K. M. Hossain, A. M. U. B. Mahfuz & Muzahidul I. Anik. (2022) Recent Progress in Nanostructured Smart Drug Delivery Systems for Cancer Therapy: A Review. ACS Applied Bio Materials 5:3, pages 971-1012.
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Ahmed A. H. Abdellatif, Ahmed M. Mohammed, Imran Saleem, Mansour Alsharidah, Osamah Al Rugaie, Fatma Ahmed & Shaaban K. Osman. (2022) Smart Injectable Chitosan Hydrogels Loaded with 5-Fluorouracil for the Treatment of Breast Cancer. Pharmaceutics 14:3, pages 661.
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O. I. Bogdanova, A. P. Istomina & S. N. Chvalun. (2021) Composites Based on Chitin Nanoparticles and Biodegradable Polymers for Medical Use: Preparation and Properties. Nanobiotechnology Reports 16:1, pages 42-68.
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Wen-Jun Yu, Dong-Xu Huang, Shuang Liu, Ying-Li Sha, Feng-hui Gao & Hong Liu. (2020) Polymeric Nanoscale Drug Carriers Mediate the Delivery of Methotrexate for Developing Therapeutic Interventions Against Cancer and Rheumatoid Arthritis. Frontiers in Oncology 10.
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Sougata Jana, Kalyan Sen, Arijit Gandhi, Subrata Jana & Chandrani Roy. 2017. Industrial Applications of Marine Biopolymers. Industrial Applications of Marine Biopolymers 305 349 .
Classius Ferreira da Silva, Patrícia Severino, Fernanda Martins, Maria Helena A. Santana & Eliana B. Souto. (2015) Didanosine-loaded chitosan microspheres optimized by surface-response methodology: A modified “Maximum Likelihood Classification” approach formulation for reverse transcriptase inhibitors. Biomedicine & Pharmacotherapy 70, pages 46-52.
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Soumyarwit Manna, James J. Augsburger, Zelia M. Correa, Julio A. Landero & Rupak K. Banerjee. (2014) Development of Chitosan and Polylactic Acid Based Methotrexate Intravitreal Micro-Implants to Treat Primary Intraocular Lymphoma: An In Vitro Study. Journal of Biomechanical Engineering 136:2.
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Yoshiyuki Kimura, Mitsuko Onoyama, Toshiki Sera & Hiromichi Okuda. (2000) Antitumour Activity and Side Effects of Combined Treatment with Chitosan and Cisplatin in Sarcoma 180-Bearing Mice. Journal of Pharmacy and Pharmacology 52:7, pages 883-890.
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Oya Şanlı, İlker Karaca & Nuran Işıklan. (2008) Preparation, characterization, and salicylic acid release behavior of chitosan/poly(vinyl alcohol) blend microspheres. Journal of Applied Polymer Science 111:6, pages 2731-2740.
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Florence Delie & María Blanco-Príeto. (2005) Polymeric Particulates to Improve Oral Bioavailability of Peptide Drugs. Molecules 10:1, pages 65-80.
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V.R Sinha, A.K Singla, S Wadhawan, R Kaushik, R Kumria, K Bansal & S Dhawan. (2004) Chitosan microspheres as a potential carrier for drugs. International Journal of Pharmaceutics 274:1-2, pages 1-33.
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Rajesh R. Dubey & Rajesh H. Parikh. (2009) Two-stage optimization process for formulation of chitosan microspheres. AAPS PharmSciTech 5:1, pages 20-28.
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Rajesh R. Dubey & Rajesh H. Parikh. (2004) Two-stage optimization process for formulation of chitosan microspheres. AAPS PharmSciTech 5:1, pages 20-28.
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A. Lebugle, A. Rodrigues, P. Bonnevialle, J.J. Voigt, P. Canal & F. Rodriguez. (2002) Study of implantable calcium phosphate systems for the slow release of methotrexate. Biomaterials 23:16, pages 3517-3522.
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Amyl Ghanem & Denise Skonberg. (2002) Effect of preparation method on the capture and release of biologically active molecules in chitosan gel beads. Journal of Applied Polymer Science 84:2, pages 405-413.
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Yoshiyuki Kimura & Hiromichi Okuda. (2005) Prevention by Chitosan of Myelotoxicity, Gastrointestinal Toxicity and Immunocompetent Organic Toxicity Induced by 5‐Fluorouracil without Loss of Antitumor Activity in Mice. Japanese Journal of Cancer Research 90:7, pages 765-774.
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