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International Journal of Hyperthermia Volume 6, 1990 - Issue 4
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Original Article

A DNA double-strand break repair-deficient mutant of CHO cells shows reduced radiosensitization after exposure to hyperthermic temperatures in the plateau phase of growth

G. Iliakis Thomas Jefferson University, Department of Radiation Oncology and Nuclear Medicine, Laboratory of Experimental Radiation Oncology, Philadelphia, PA, 19107, USA
&
R. Seaner Thomas Jefferson University, Department of Radiation Oncology and Nuclear Medicine, Laboratory of Experimental Radiation Oncology, Philadelphia, PA, 19107, USA
Pages 801-812 | Received 29 Jun 1989, Accepted 01 Dec 1989, Published online: 09 Jul 2009

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Yosuke Nakagawa, Atsuhisa Kajihara, Akihisa Takahashi, Akiho S. Murata, Masaya Matsubayashi, Soichiro S. Ito, Ichiro Ota, Takahiko Nakagawa, Masatoshi Hasegawa, Tadaaki Kirita, Takeo Ohnishi & Eiichiro Mori. (2018) BRCA2 protects mammalian cells from heat shock. International Journal of Hyperthermia 34:6, pages 795-801.
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Berina Eppink, Przemek M. Krawczyk, Jan Stap & Roland Kanaar. (2012) Hyperthermia-induced DNA repair deficiency suggests novel therapeutic anti-cancer strategies. International Journal of Hyperthermia 28:6, pages 509-517.
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George Iliakis, Wenqi Wu & Minli Wang. (2008) DNA double strand break repair inhibition as a cause of heat radiosensitization: Re-evaluation considering backup pathways of NHEJ. International Journal of Hyperthermia 24:1, pages 17-29.
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J. R. Dynlacht, M. Xu, R. K. Pandita, E. A. Wetzel & J. L. Roti Roti. (2004) Effects of heat shock on the Mre11/Rad50/Nbs1 complex in irradiated or unirradiated cells. International Journal of Hyperthermia 20:2, pages 144-156.
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H. H. Kampinga, J. R. Dynlacht & E. Dikomey. (2004) Mechanism of radiosensitization by hyperthermia (43°C) as derived from studies with DNA repair defective mutant cell lines. International Journal of Hyperthermia 20:2, pages 131-139.
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N. Umeda, Y. Matsumoto, H.‐L. Yin, M. Tomita, A. Enomoto, A. Morita, T. Mizukoshi, K. Sakai, Y. Hosoi & N. Suzuki. (2003) Difference in the heat sensitivity of DNA‐dependent protein kinase activity among mouse, hamster and human cells. International Journal of Radiation Biology 79:8, pages 671-680.
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G. P. RAAPHORST. (1999) Thermal radiosensitization and repair inhibition in human melanoma cells: a comparison of survival and DNA double strand breaks. International Journal of Hyperthermia 15:1, pages 17-27.
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R.S.L. Wong, J.R. Dynlacht, B. Cedervall & W.C. Dewey. (1995) Analysis by Pulsed-field Gel Electrophoresis of DNA Double-strand Breaks Induced by Heat and/or X-irradiation in Bulk and Replicating DNA of CHO Cells. International Journal of Radiation Biology 68:2, pages 141-152.
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B. Nevaldine, J. A. Longo & P. J. Hahn. (1994) Hyperthermia inhibits the repair of DNA double-strand breaks induced by ionizing radiation as determined by pulsed-field gel electrophoresis. International Journal of Hyperthermia 10:3, pages 381-388.
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G. P. Raaphorst, M. Thakar & C. E. Ng. (1993) Thermal radiosensitization in two pairs of CHO wild-type and radiation-sensitive mutant cell lines. International Journal of Hyperthermia 9:3, pages 383-391.
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G.P. Raaphorst, A. Bussey, M. Thakar, T. Bichay & C.E. Ng. (1993) Postirradiation Exposure to Hypotonic Saline Shows Normal Damage Processing in Radiation-sensitive Cell Lines. International Journal of Radiation Biology 64:5, pages 593-600.
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H.H. Kampinga, B. Kanon, A.W.T. Konings, M.A. Stackhouse & J.S. Bedford. (1993) Thermal Radiosensitization in Heat- and Radiation-sensitive Mutants of CHO Cells. International Journal of Radiation Biology 64:2, pages 225-230.
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G. Iliakis, R. Seaner & R. Okayasu. (1990) Effects of hyperthermia on the repair of radiation-induced DNA single-and double-strand breaks in DNA double-strand break repair-deficient and repair-proficient cell lines. International Journal of Hyperthermia 6:4, pages 813-833.
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Articles from other publishers (13)

Theodora Mantso, George Goussetis, Rodrigo Franco, Sotiris Botaitis, Aglaia Pappa & Mihalis Panayiotidis. (2016) Effects of hyperthermia as a mitigation strategy in DNA damage-based cancer therapies. Seminars in Cancer Biology 37-38, pages 96-105.
Crossref
Akihisa Takahashi. 2016. Hyperthermic Oncology from Bench to Bedside. Hyperthermic Oncology from Bench to Bedside 91 108 .
Arlene L. Oei, Lianne E. M. Vriend, Johannes Crezee, Nicolaas A. P. Franken & Przemek M. Krawczyk. (2015) Effects of hyperthermia on DNA repair pathways: one treatment to inhibit them all. Radiation Oncology 10:1.
Crossref
Stefan C. Genet, Yoshihiro Fujii, Junko Maeda, Masami Kaneko, Matthew D. Genet, Kiyoshi Miyagawa & Takamitsu A. Kato. (2013) Hyperthermia inhibits homologous recombination repair and sensitizes cells to ionizing radiation in a time- and temperature-dependent manner. Journal of Cellular Physiology 228:7, pages 1473-1481.
Crossref
Przemek M. KrawczykBerina EppinkJeroen Essers, Jan StapHans RodermondHanny OdijkAlex ZelenskyChris van BreeLukas J. Stalpers, Marrije R. BuistThomas Soullié, Joost Rens, Hence J. M. Verhagen, Mark J. O'Connor, Nicolaas A. P. Franken, Timo L. M. ten Hagen, Roland KanaarJacob A. Aten. (2011) Mild hyperthermia inhibits homologous recombination, induces BRCA2 degradation, and sensitizes cancer cells to poly (ADP-ribose) polymerase-1 inhibition. Proceedings of the National Academy of Sciences 108:24, pages 9851-9856.
Crossref
G.P. Raaphorst, J.M. LeBlanc, L.F. Li & D.P. Yang. (2005) Hyperthermia responses in cell lines with normal and deficient DNA repairs systems. Journal of Thermal Biology 30:6, pages 478-484.
Crossref
Joseph R. Dynlacht, M. Eric Bittner, Jody A. Bethel & Brian D. Beck. (2003) The non‐homologous end‐joining pathway is not involved in the radiosensitization of mammalian cells by heat shock. Journal of Cellular Physiology 196:3, pages 557-564.
Crossref
Zhao-Chong Zeng. (2002) DNA-PKcs subunits in radiosensitization by hyperthermia on hepatocellular carcinoma hepG2 cell line. World Journal of Gastroenterology 8:5, pages 797.
Crossref
Brian D. Beck & Joseph R. Dynlacht. (2001) Heat-Induced Aggregation of XRCC5 (Ku80) in Nontolerant and Thermotolerant Cells. Radiation Research 156:6, pages 767-774.
Crossref
Shinobu Okada, Kanako Ono, Nobuyuki Hamada, Tetsuo Inada & Nobuo Kubota. (2001) A low-pH culture condition enhances the radiosensitizing effect of wortmannin. International Journal of Radiation Oncology*Biology*Physics 49:4, pages 1149-1156.
Crossref
Arsenio Nueda, Farlyn Hudson, Nahid F. Mivechi & William S. Dynan. (1999) DNA-dependent Protein Kinase Protects against Heat-induced Apoptosis. Journal of Biological Chemistry 274:21, pages 14988-14996.
Crossref
Louis C Penning, Karmi Tijssen, J.Pierre J Boegheim, John van Steveninck & Tom M.A.R Dubbelman. (1994) Relationship between photodynamically induced damage to various cellular parameters and loss of clonogenicity in different cell types with hematoporphyrin derivative as sensitizer. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1221:3, pages 250-258.
Crossref
Antonius W.T. Konings. 1992. Congress Proceedings. Congress Proceedings 999 1003 .

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