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International Journal of Hyperthermia Volume 11, 1995 - Issue 2
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Original Article

Changes in microregional perfusion, oxygenation, ATP and lactate distribution in subcutaneous rat tumours upon water-filtered IR-A hyperthermia

D. K. Kelleher Institute of Physiology and Pathophysiology, University of Mainz, D-55099, Mainz, Germany
,
T. Engel Institute of Physiology and Pathophysiology, University of Mainz, D-55099, Mainz, Germany
&
P. W. Vaupel Institute of Physiology and Pathophysiology, University of Mainz, D-55099, Mainz, Germany
Pages 241-255 | Received 29 Oct 1993, Accepted 11 Apr 1994, Published online: 09 Jul 2009

Citations (41)

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Helmut Piazena, Werner Müller & Peter Vaupel. (2020) wIRA-heating of piglet skin and subcutis in vivo: proof of accordance with ESHO criteria for superficial hyperthermia. International Journal of Hyperthermia 37:1, pages 887-896.
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Helmut Piazena, Werner Müller, Wolfgang Pendl, Sereina von Ah, Veronika H. Cap, Petra J. Hug, Xaver Sidler, Gerd Pluschke & Peter Vaupel. (2019) Thermal field formation during wIRA-hyperthermia: temperature measurements in skin and subcutis of piglets as a basis for thermotherapy of superficial tumors and local skin infections caused by thermosensitive microbial pathogens. International Journal of Hyperthermia 36:1, pages 937-951.
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Peter Vaupel, Helmut Piazena, Werner Müller & Markus Notter. (2018) Biophysical and photobiological basics of water-filtered infrared-A hyperthermia of superficial tumors. International Journal of Hyperthermia 35:1, pages 26-36.
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Peter W. Vaupel & Debra K. Kelleher. (2010) Pathophysiological and vascular characteristics of tumours and their importance for hyperthermia: Heterogeneity is the key issue. International Journal of Hyperthermia 26:3, pages 211-223.
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Steffen L. Hokland, Thomas Nielsen, Morten Busk & Michael R. Horsman. (2010) Imaging tumour physiology and vasculature to predict and assess response to heat. International Journal of Hyperthermia 26:3, pages 264-272.
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D. K. Kelleher, O. Thews, J. Rzeznik, A. Scherz, Y. Salomon, P. Vaupel. (1999) Hot Topic Water-filtered infrared-A radiation: a novel technique for localized hyperthermia in combination with bacteriochlorophyll-based photodynamic therapy. International Journal of Hyperthermia 15:6, pages 467-474.
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P. Tamulevicius & C. Streffer. (1997) Bioluminescence imaging of metabolites in a human tumour xenograft after treatment with hyperthermia and/or the radiosensitizer pimonidazole. International Journal of Hyperthermia 13:2, pages 235-245.
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J. G. Rhee, H. A. Eddy, J. J. Hong, M. Suntharalingam & P. W. Vaupel. (1996) Divergent changes of flow through individual blood vessels upon localized heating. International Journal of Hyperthermia 12:6, pages 757-769.
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Articles from other publishers (33)

Mark W. Dewhirst, James R. Oleson, John Kirkpatrick & Timothy W. Secomb. (2022) Accurate Three-Dimensional Thermal Dosimetry and Assessment of Physiologic Response Are Essential for Optimizing Thermoradiotherapy. Cancers 14:7, pages 1701.
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Nuria Vilaplana-Lopera, Maxym Besh & Eui Jung Moon. (2021) Targeting Hypoxia: Revival of Old Remedies. Biomolecules 11:11, pages 1604.
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Marjolein I. Priester, Sergio Curto, Gerard C. van Rhoon & Timo L. M. ten Hagen. (2021) External Basic Hyperthermia Devices for Preclinical Studies in Small Animals. Cancers 13:18, pages 4628.
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Jian Guo, Huating Zeng, Yimin Liu, Xinmeng Shi, Yuping Liu, Congyan Liu & Yan Chen. (2021) Multicomponent thermosensitive lipid complexes enhance desmoplastic tumor therapy through boosting anti-angiogenesis and synergistic strategy. International Journal of Pharmaceutics 601, pages 120533.
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Jesús J. Bosque, Gabriel F. Calvo, Víctor M. Pérez-García & María Cruz Navarro. (2021) The interplay of blood flow and temperature in regional hyperthermia: a mathematical approach. Royal Society Open Science 8:1, pages 201234.
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Oliver Thews & Peter Vaupel. (2015) Temporal changes in tumor oxygenation and perfusion upon normo- and hyperbaric inspiratory hyperoxiaZeitliche Veränderungen der Tumoroxygenierung und -durchblutung während normo- und hyperbarer inspiratorischer Hyperoxie. Strahlentherapie und Onkologie 192:3, pages 174-181.
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Mark Dewhirst, Paul R. Stauffer, Shiva Das, Oana I. Craciunescu & Zeljko Vujaskovic. 2016. Clinical Radiation Oncology. Clinical Radiation Oncology 381 398.e6 .
Catherine M. Clavel, Patrycja Nowak-Sliwinska, Emilia Păunescu & Paul J. Dyson. (2015) Thermoresponsive fluorinated small-molecule drugs: a new concept for efficient localized chemotherapy. MedChemComm 6:12, pages 2054-2062.
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Edward H. Abraham, Van H. Woo, Cheryl Harlin-Jones, Anja Heselich & Florian Frohns. Application and possible mechanisms of combining LLLT (low level laser therapy), infrared hyperthermia and ionizing radiation in the treatment of cancer. Application and possible mechanisms of combining LLLT (low level laser therapy), infrared hyperthermia and ionizing radiation in the treatment of cancer.
Sean Foxley, Xiaobing Fan, Jonathan River, Marta Zamora, Erica Markiewicz, Shunmugavelu Sokka & Gregory S Karczmar. (2012) Hyperthermically induced changes in high spectral and spatial resolution MR images of tumor tissue—a pilot study. Physics in Medicine and Biology 57:9, pages 2653-2666.
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Mark Dewhirst, Shiva Das, Paul Stauffer, Oana Craciunescu, Zeljko Vujaskovic & Donald Thrall. 2012. Clinical Radiation Oncology. Clinical Radiation Oncology 385 403 .
Christian Sturesson, Kjell Ivarsson, Unne Stenram, Stefan Andersson-Engels & Karl-Göran Tranberg. (2011) Interstitial laser thermotherapy of a rat liver tumour: Effect of hepatic inflow occlusion. Lasers in Surgery and Medicine 43:1, pages 29-35.
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Eui Jung Moon, Pierre Sonveaux, Paolo E. Porporato, Pierre Danhier, Bernard Gallez, Ines Batinic-Haberle, Yu-Chih Nien, Thies Schroeder & Mark W. Dewhirst. (2010) NADPH oxidase-mediated reactive oxygen species production activates hypoxia-inducible factor-1 (HIF-1) via the ERK pathway after hyperthermia treatment. Proceedings of the National Academy of Sciences 107:47, pages 20477-20482.
Crossref
Xinhua Liang, Hao Zhou, Xian Liu, Yongwen He, Yaling Tang, Guiquan Zhu, Min Zheng & Jing Yang. (2010) Effect of local hyperthermia on lymphangiogenic factors VEGF-C and -D in a nude mouse xenograft model of tongue squamous cell carcinoma. Oral Oncology 46:2, pages 111-115.
Crossref
Debra K. Kelleher & Peter Vaupel. 2010. Oxygen Transport to Tissue XXXI. Oxygen Transport to Tissue XXXI 393 398 .
Debra K. Kelleher & Peter Vaupel. 2006. Hyperthermia in Cancer Treatment: A Primer. Hyperthermia in Cancer Treatment: A Primer 99 109 .
Mehrdad Nikfarjam, Vijayaragavan Muralidharan & Christopher Christophi. (2005) Mechanisms of Focal Heat Destruction of Liver Tumors. Journal of Surgical Research 127:2, pages 208-223.
Crossref
Mehrdad Nikfarjam, Vijayaragavan Muralidharan, Caterina Malcontenti-Wilson & Christopher Christophi. (2005) Progressive microvascular injury in liver and colorectal liver metastases following laser induced focal hyperthermia therapy. Lasers in Surgery and Medicine 37:1, pages 64-73.
Crossref
O Thews, T Wolloscheck, W Dillenburg, S Kraus, D K Kelleher, M A Konerding & P Vaupel. (2004) Microenvironmental adaptation of experimental tumours to chronic vs acute hypoxia. British Journal of Cancer 91:6, pages 1181-1189.
Crossref
Juergen Frank, Christine Lambert, Hans Konrad Biesalski, Oliver Thews, Peter Vaupel & Debra K. Kelleher. (2003) Intensified oxidative and nitrosative stress following combined ALA‐based photodynamic therapy and local hyperthermia in rat tumors. International Journal of Cancer 107:6, pages 941-948.
Crossref
D K Kelleher, O Thews, A Scherz, Y Salomon & P Vaupel. (2003) Combined hyperthermia and chlorophyll-based photodynamic therapy: tumour growth and metabolic microenvironment. British Journal of Cancer 89:12, pages 2333-2339.
Crossref
D K Kelleher, J Bastian, O Thews & P Vaupel. (2003) Enhanced effects of aminolaevulinic acid-based photodynamic therapy through local hyperthermia in rat tumours. British Journal of Cancer 89:2, pages 405-411.
Crossref
E Gersing, D K Kelleher & P Vaupel. (2003) Tumour tissue monitoring during photodynamic and hyperthermic treatment using bioimpedance spectroscopy. Physiological Measurement 24:2, pages 625-637.
Crossref
Oliver Thews, Yanping Li, Debra K. Kelleher, Britton Chance & Peter Vaupel. 2003. Oxygen Transport to Tissue XXIV. Oxygen Transport to Tissue XXIV 237 247 .
O Thews, M Hummel, D K Kelleher, B Lecher & P Vaupel. (2002) Nifedipine improves blood flow and oxygen supply, but not steady-state oxygenation of tumours in perfusion pressure-controlled isolated limb perfusion. British Journal of Cancer 87:12, pages 1462-1469.
Crossref
Oliver Thews, Debra K. Kelleher & Peter Vaupel. (2002) Dynamics of tumor oxygenation and red blood cell flux in response to inspiratory hyperoxia combined with different levels of inspiratory hypercapnia. Radiotherapy and Oncology 62:1, pages 77-85.
Crossref
Ingvil Bjørnæs, Heidi Lyng, Gro A Dahle, Olav Kaalhus & Einar K Rofstad. (2000) Intratumor heterogeneity in perfusion in human melanoma xenografts measured by contrast-enhanced magnetic resonance imaging. Magnetic Resonance Imaging 18:8, pages 997-1002.
Crossref
Oliver Thews, Friedrich Zywietz, Bernd Lecher & Peter Vaupel. (1999) Quantitative changes of metabolic and bioenergetic parameters in experimental tumors during fractionated irradiation. International Journal of Radiation Oncology*Biology*Physics 45:5, pages 1281-1288.
Crossref
Peter Vaupel, DebraK Kelleher & Oliver Thews. (1998) Modulation of tumor oxygenation. International Journal of Radiation Oncology*Biology*Physics 42:4, pages 843-848.
Crossref
Debra K Kelleher, Oliver Thews & Peter Vaupel. (1998) Regional perfusion and oxygenation of tumors upon methylxanthine derivative administration. International Journal of Radiation Oncology*Biology*Physics 42:4, pages 861-864.
Crossref
Friedrich Zywietz, Wolfram Reeker & Eberhard Kochs. (1997) Changes in tumor oxygenation during a combined treatment with fractionated irradiation and hyperthermia: An experimental study. International Journal of Radiation Oncology*Biology*Physics 37:1, pages 155-162.
Crossref
M. Busse & P. Vaupel. (1996) Accumulation of purine catabolites in solid tumors exposed to therapeutic hyperthermia. Experientia 52:5, pages 469-473.
Crossref
P. W. Vaupel & D. K. Kelleher. 1995. Thermoradiotherapy and Thermochemotherapy. Thermoradiotherapy and Thermochemotherapy 157 176 .

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