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Original Article

Efficacy of Topical Bevacizumab for Inhibiting Growth of Impending Recurrent Pterygium

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Pages 17-22 | Received 16 Feb 2009, Accepted 07 Oct 2009, Published online: 18 Dec 2009

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (2)

Justyna Klos-Rola, Maria Tulidowicz-Bielak & Tomasz Zarnowski. (2013) Effects of topical bevacizumab application on early bleb failure after trabeculectomy: observational case series. Clinical Ophthalmology 7, pages 1929-1935.
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Volkan Hurmeric, Pravin Vaddavalli, Anat Galor, Victor L Perez, Janika San Roman & Sonia H Yoo. (2013) Single and multiple injections of subconjunctival ranibizumab for early, recurrent pterygium. Clinical Ophthalmology 7, pages 467-473.
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Articles from other publishers (49)

Eunyu Yoon, Minji Park & Jaewon Choi. (2023) Effects of Subconjunctival Bevacizumab Injection after Primary Pterygium Surgery. Journal of the Korean Ophthalmological Society 64:8, pages 688-693.
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Bowen Zhang, Xingmei Dong & Yi Sun. (2023) Efficacy and safety of anti-vascular endothelial growth factor agents in the treatment of primary pterygium. Frontiers in Medicine 10.
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梦欣 贺. (2023) Pathogenesis and Advances in the Clinical Management of Pterygium. Advances in Clinical Medicine 13:11, pages 18209-18216.
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Sanaz Sadig Baheran, Raid G. Alany, Sianne Schwikkard, Wisam Muen, Lena Namaan Salman, Nicholas Freestone & Ali A. Al-Kinani. (2023) Pharmacological treatment strategies of pterygium: Drugs, biologics, and novel natural products. Drug Discovery Today 28:1, pages 103416.
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Brendon W.H. Lee, Amitouj S. Sidhu, Ian C. Francis & Minas T. Coroneo. (2022) 5-Fluorouracil in primary, impending recurrent and recurrent pterygium: Systematic review of the efficacy and safety of a surgical adjuvant and intralesional antimetabolite. The Ocular Surface 26, pages 128-141.
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Leila Ghiasian, Bijan Samavat, Yasaman Hadi, Mona Arbab & Navid Abolfathzadeh. (2021) Recurrent pterygium: A review. Journal of Current Ophthalmology 33:4, pages 367.
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Li-Juan Xu, Shi-Song Rong, Ye-Sheng Xu, Li-Bin Zheng, Wen-Ya Qiu, Xia Zhang, Lou-Jing Jiang, Run-Ping Duan, Tian Tian & Yu-Feng Yao. (2020) Anti-fibrosis potential of pirarubicin via inducing apoptotic and autophagic cell death in rabbit conjunctiva. Experimental Eye Research 200, pages 108215.
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Hee Kyung Yang, Yun Ji Lee, Joon Young Hyon, Kwang Gi Kim & Sang Beom Han. (2020) Efficacy of bevacizumab injection after pterygium excision and limbal conjunctival autograft with limbal fixation suture. Graefe's Archive for Clinical and Experimental Ophthalmology 258:7, pages 1451-1457.
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Wai Kit Chu, Hiu Lam Choi, Amar K. Bhat & Vishal Jhanji. (2020) Pterygium: new insights. Eye 34:6, pages 1047-1050.
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Enrique O. Graue-HernandezAndrea CórdobaAida Jimenez-CoronaArturo Ramirez-MirandaAlejandro NavasJuan C. Serna-Ojeda & Mark J. Mannis. (2019) Practice Patterns in the Management of Primary Pterygium: A Survey Study. Cornea 38:11, pages 1339-1344.
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Yi Sun, Bowen Zhang, Xiuhua Jia, Shiqi Ling & Juan Deng. (2018) Efficacy and Safety of Bevacizumab in the Treatment of Pterygium: An Updated Meta-Analysis of Randomized Controlled Trials. Journal of Ophthalmology 2018, pages 1-9.
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Mehran Zarei-Ghanavati & Hamed Ghassemi. 2018. Ocular Surface Disease. Ocular Surface Disease 307 317 .
Wen Zeng, Zengming Liu, Hanjun Dai, Ming Yan, Hong Luo, Min Ke & Xiaojun Cai. (2017) Anti-fibrotic, anti-VEGF or radiotherapy treatments as adjuvants for pterygium excision: a systematic review and network meta-analysis. BMC Ophthalmology 17:1.
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Linda Rose, Julia M. Byrd & Yousuf Qaseem. (2017) Subtenon Injections of Ranibizumab Arrest Growth in Early Recurrent Pterygium. Eye & Contact Lens: Science & Clinical Practice 43:6, pages 399-405.
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Hong Kyu KimJi-Young ChoiSang Min ParkChang Rae RhoKyong Jin Cho & Sangmee Ahn Jo. (2017) Tyrosine Kinase Inhibitor, Vatalanib, Inhibits Proliferation and Migration of Human Pterygial Fibroblasts. Cornea 36:9, pages 1116-1123.
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Dilek Hacıoğlu & Hidayet Erdöl. (2016) Developments and current approaches in the treatment of pterygium. International Ophthalmology 37:4, pages 1073-1081.
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Reza Zarei, Masoumeh Masoumpour, Sasan Moghimi, Ghasem Fakhraei, Yadollah Eslami & Masoud Mohammadi. (2017) Evaluation of topical bevacizumab as an adjunct to mitomycin C augmented trabeculectomy. Journal of Current Ophthalmology 29:2, pages 85-91.
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John A. Hovanesian, Christopher E. Starr, David T. Vroman, Francis S. Mah, Jose A.P. Gomes, Marjan Farid, Neda Shamie, Richard S. Davidson, Thomas John, Edward J. Holland & Terry Kim. (2017) Surgical techniques and adjuvants for the management of primary and recurrent pterygia. Journal of Cataract and Refractive Surgery 43:3, pages 405-419.
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Renata Kiri Mak, Tommy Chung Yan Chan, Marcus M Marcet, Bonnie Nga Kwan Choy, Jennifer Wei Huen Shum, Kendrick Co Shih, Ian Yat Hin Wong & Alex Lap Ki Ng. (2017) Use of anti-vascular endothelial growth factor in the management of pterygium. Acta Ophthalmologica 95:1, pages 20-27.
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Sameh M Fouda. (2017) Evaluation of the Additive Effect of Bevacizumab Eye Drops to Mitomycin C in Primary Pterygium. Advances in Ophthalmology & Visual System 6:2.
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Jun Seok LeeSang Won HaSung YuGwang Ja LeeYoung Jeung Park. (2017) Efficacy and Safety of a Large Conjunctival Autograft for Recurrent Pterygium. Korean Journal of Ophthalmology 31:6, pages 469.
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Sang Beom Han, Hyun Sun Jeon, Moosang Kim, Seung-Jun Lee, Hee Kyung Yang, Jeong-Min Hwang, Kwang Gi Kim, Joon Young Hyon & Won Ryang Wee. (2016) Risk Factors for Recurrence After Pterygium Surgery. Cornea 35:8, pages 1097-1103.
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Qader Motarjemizadeh, Naser Samadi Aidenloo & Siamak Sepehri. (2015) A comparative study of different concentrations of topical bevacizumab on the recurrence rate of excised primary pterygium: a short-term follow-up study. International Ophthalmology 36:1, pages 63-71.
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Sang Yeop KimSang Jun Ko. (2016) The Effect of Inferior Conjunctival Transposition Flap for Recurrent Pterygium. Journal of the Korean Ophthalmological Society 57:12, pages 1866.
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David Kuerten, Sandra Johnen, Nina Harmening, George Souteyrand, Peter Walter & Gabriele Thumann. (2015) Transplantation of PEDF-transfected pigment epithelial cells inhibits corneal neovascularization in a rabbit model. Graefe's Archive for Clinical and Experimental Ophthalmology 253:7, pages 1061-1069.
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Angel Nava-CastañedaIsabel Ulloa-OrozcoLilia Garnica-HayashiJoaquín Hernandez-OrgazMaria Carmen Jimenez-MartinezYonathan Garfias. (2015) Triple Subconjunctival Bevacizumab Injection for Early Corneal Recurrent Pterygium: One-Year Follow-Up. Journal of Ocular Pharmacology and Therapeutics 31:2, pages 106-113.
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Tomás Rojas, Cristian Cumsille, Rodrigo Castillo, Daniel García, Álvaro Henríquez, Rodrigo Lacroix & Javier Corvalan. (2014) Uso de terapia antifactor de crecimiento vascular endotelial en patología corneal. Revista Mexicana de Oftalmología 88:3, pages 113-119.
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Catherine Vumien Tonthat & Nick Di Girolamo. (2014) Nestin expression in pterygia: potential role in angiogenesis. British Journal of Ophthalmology 98:6, pages 801-807.
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Koray Gumus, Sarper Karakucuk, G Ertugrul Mirza, Hulya Akgun, Hatice Arda & Ayse O Oner. (2014) Overexpression of vascular endothelial growth factor receptor 2 in pterygia may have a predictive value for a higher postoperative recurrence rate. British Journal of Ophthalmology 98:6, pages 796-800.
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Sezin Akca Bayar, Cem Kucukerdonmez, Ozlem Oner & Yonca A. Akova. (2013) Subconjunctival bevacizumab in the impending recurrent pterygia. International Ophthalmology 34:3, pages 541-547.
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Ben J. Janson & Shameema Sikder. (2014) Surgical Management of Pterygium. The Ocular Surface 12:2, pages 112-119.
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Qiongwen Hu, Yanbing Qiao, Xin Nie, Xiaocheng Cheng & Yongping Ma. (2014) Bevacizumab in the Treatment of Pterygium. Cornea 33:2, pages 154-160.
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Julia Promesberger, Sharmila Kohli, Holger Busse & Constantin E. Uhlig. (2014) Pterygium Recurrence, Astigmatism and Visual Acuity following Bare-Sclera Excision and Conjunctival Autograft with or without Additional Phototherapeutic Keratectomy. Ophthalmic Research 51:1, pages 52-58.
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Engin B. Ozgurhan, Alper Agca, Necip Kara, Kemal Yuksel, Ali Demircan & Ahmet Demirok. (2013) Topical Application of Bevacizumab as an Adjunct to Recurrent Pterygium Surgery. Cornea 32:6, pages 835-838.
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Felix Bock, Kazuichi Maruyama, Birgit Regenfuss, Deniz Hos, Philipp Steven, Ludwig M. Heindl & Claus Cursiefen. (2013) Novel anti(lymph)angiogenic treatment strategies for corneal and ocular surface diseases. Progress in Retinal and Eye Research 34, pages 89-124.
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Michael Waisbourd, Eliya Levinger, David Varssano, Elad Moisseiev, Shiri Zayit-Soudri, Adiel Barak, Anat Loewenstein & Irina Barequet. (2013) High-Dose Topical Bevacizumab for Corneal Neovascularization. Pharmacology 92:5-6, pages 310-314.
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Lokman Aslan, Murat Aslankurt, Adnan Aksoy, Murat Özdemir & Erdem Yüksel. (2013) Comparison of Wide Conjunctival Flap and Conjunctival Autografting Techniques in Pterygium Surgery. Journal of Ophthalmology 2013, pages 1-5.
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Stephen C. Kaufman, Deborah S. Jacobs, W. Barry Lee, Sophie X. Deng, Mark I. Rosenblatt & Roni M. Shtein. (2013) Options and Adjuvants in Surgery for Pterygium. Ophthalmology 120:1, pages 201-208.
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Oscar Rúa, Ignacio M. Larráyoz, María T. Barajas, Sara Velilla & Alfredo Martínez. (2012) Oral Doxycycline Reduces Pterygium Lesions; Results from a Double Blind, Randomized, Placebo Controlled Clinical Trial. PLoS ONE 7:12, pages e52696.
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Sheng-Fu Cheng, Mohammad H. Dastjerdi, Giulio Ferrari, Andre Okanobo, Kraig S. Bower, Denise S. Ryan, Francisco Amparo, William Stevenson, Pedram Hamrah, Nambi Nallasamy & Reza Dana. (2012) Short-Term Topical Bevacizumab in the Treatment of Stable Corneal Neovascularization. American Journal of Ophthalmology 154:6, pages 940-948.e1.
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Maha M. Shahin, Amal M. Elbendary & Mohamed M. Elwan. (2012) Intraoperative Subconjunctival Bevacizumab as an Adjunctive Treatment in Primary Pterygium: A Preliminary Report. Ophthalmic Surgery, Lasers and Imaging Retina 43:6, pages 459-466.
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Jin-Hong Chang, Nitin K. Garg, Elisa Lunde, Kyu-Yeon Han, Sandeep Jain & Dimitri T. Azar. (2012) Corneal Neovascularization: An Anti-VEGF Therapy Review. Survey of Ophthalmology 57:5, pages 415-429.
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Irit Bahar, Sonia N. Yeung, Ruti Sella & Allan Slomovic. (2012) Anterior segment uses of bevacizumab. Current Opinion in Ophthalmology 23:4, pages 303-316.
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Hamid Hosseini, Mohammad H Nowroozzadeh, Ramin Salouti & Mahmood Nejabat. (2012) Anti-VEGF Therapy With Bevacizumab for Anterior Segment Eye Disease. Cornea 31:3, pages 322-334.
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Kaevalin Lekhanont, Thanikan Patarakittam, Prakairut Thongphiew, Olan Suwan-apichon & Prut Hanutsaha. (2012) Randomized Controlled Trial of Subconjunctival Bevacizumab Injection in Impending Recurrent Pterygium: A Pilot Study. Cornea 31:2, pages 155-161.
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Orapin Enkvetchakul, Onsiri Thanathanee, Ram Rangsin, Kaevalin Lekhanont & Olan Suwan-apichon. (2011) A Randomized Controlled Trial of Intralesional Bevacizumab Injection on Primary Pterygium: Preliminary Results. Cornea 30:11, pages 1213-1218.
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Achilleas Mandalos, Dimitrios Tsakpinis, Georgia Karayannopoulou, Ioannis Tsinopoulos, Georgios Karkavelas, Nikolaos Chalvatzis & Stavros Dimitrakos. (2010) The Effect of Subconjunctival Ranibizumab on Primary Pterygium: A Pilot Study. Cornea 29:12, pages 1373-1379.
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Omar M. Kirat & Hassan A. Al-Dhibi. (2010) Regression of aggressive corneal vascularization after photodynamic therapy, subconjunctival Avastin injections and topical cyclosporin-A 1% drops: A case report. Saudi Journal of Ophthalmology 24:4, pages 151-154.
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Mark C Gillies. (2010) Bevacizumab in ophthalmology: the controversy moves forward. Clinical & Experimental Ophthalmology 38:4, pages 333-334.
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