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Original Article

Augmentation of Macular Pigment Following Supplementation with All Three Macular Carotenoids: An Exploratory Study

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Pages 335-351 | Received 01 Aug 2009, Accepted 01 Dec 2009, Published online: 07 Apr 2010

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Crossref
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Ingrid KohlstadtGeoffrey Harris, Steven Pratt & Stuart Richer. 2012. Advancing Medicine with Food and Nutrients, Second Edition. Advancing Medicine with Food and Nutrients, Second Edition 3 30 .
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Crossref
Masaki Tanito, Akira Obana, Yuko Gohto, Shigetoshi Okazaki, Werner Gellermann & Akihiro Ohira. (2012) Macular pigment density changes in Japanese individuals supplemented with lutein or zeaxanthin: quantification via resonance Raman spectrophotometry and autofluorescence imaging. Japanese Journal of Ophthalmology 56:5, pages 488-496.
Crossref
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Crossref
Karen A. Weikel, Chung–Jung Chiu & Allen Taylor. (2012) Nutritional modulation of age-related macular degeneration. Molecular Aspects of Medicine 33:4, pages 318-375.
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John M. Nolan, Mukunda C. Akkali, James Loughman, Alan N. Howard & Stephen Beatty. (2012) Macular carotenoid supplementation in subjects with atypical spatial profiles of macular pigment. Experimental Eye Research 101, pages 9-15.
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Crossref
Rohini Vishwanathan & Elizabeth J. Johnson. 2012. Present Knowledge in Nutrition. Present Knowledge in Nutrition 939 981 .
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Crossref
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Crossref
J. M. Nolan. 2012. Studies on Retinal and Choroidal Disorders. Studies on Retinal and Choroidal Disorders 595 611 .
Dean A. VanNasdale, Ann E. Elsner, Timothy Hobbs & Stephen A. Burns. (2011) Foveal phase retardation changes associated with normal aging. Vision Research 51:21-22, pages 2263-2272.
Crossref
John M. Nolan, James Loughman, Mukunda C. Akkali, Jim Stack, Grainne Scanlon, Peter Davison & Stephen Beatty. (2011) The impact of macular pigment augmentation on visual performance in normal subjects: COMPASS. Vision Research 51:5, pages 459-469.
Crossref
Olivia Howells, Frank Eperjesi & Hannah Bartlett. (2011) Measuring macular pigment optical density in vivo: a review of techniques. Graefe's Archive for Clinical and Experimental Ophthalmology 249:3, pages 315-347.
Crossref
P N Youssef, N Sheibani & D M Albert. (2010) Retinal light toxicity. Eye 25:1, pages 1-14.
Crossref
A. Boltz, M. Lasta, D. Schmidl, S. Kaya, G. Garhöfer & L. Schmetterer. (2010) Risikofaktoren der altersbedingten MakuladegenerationRisk factors for age-related macular degeneration. Spektrum der Augenheilkunde 24:6, pages 296-304.
Crossref

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