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Original Article

Ocular Surface and Dry Eye in Graves’ Disease

, , , , &
Pages 8-13 | Received 16 May 2010, Accepted 18 Sep 2010, Published online: 21 Dec 2010

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (9)

Ibrahim Y Allam, Sihem Lazreg, Mohamed Shafik Shaheen, Mohamed Fahmy Doheim & Mai A Mohammed. (2021) Ocular Surface Changes in Patients with Thyroid Eye Disease: An Observational Clinical Study. Clinical Ophthalmology 15, pages 2481-2488.
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Christopher Lo, Michael Yang & Daniel Rootman. (2021) Natural history of inflammatory and non-inflammatory dry eye in thyroid eye disease. Orbit 40:5, pages 389-393.
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Hasan Kiziltoprak, Mustafa Koc, Kemal Tekin, Rumeysa Hekimoglu, Merve Inanc, Aslıhan Araslı Yılmaz, Selin Elmaoğulları & Zehra Aycan. (2020) Local Ocular Surface Alterations in Children with Hashimoto’s Thyroiditis. Ocular Immunology and Inflammation 28:5, pages 791-797.
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Saud A Alanazi, Abdullah A Alomran, Ali Abusharha, Raied Fagehi, Naji J Al-Johani, Gamal A El-Hiti & Ali M Masmali. (2019) An assessment of the ocular tear film in patients with thyroid disorders. Clinical Ophthalmology 13, pages 1019-1026.
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Sinan Çalışkan, Mutlu Acar & Canan Gürdal. (2017) Choroidal Thickness in Patients with Graves’ Ophthalmopathy. Current Eye Research 42:3, pages 484-490.
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Lian-Qun Wu, Jin-Wei Cheng, Ji-Ping Cai, Qi-Hua Le, Xiao-Ye Ma, Lian-Di Gao & Rui-Li Wei. (2016) Observation of Corneal Langerhans Cells by In Vivo Confocal Microscopy in Thyroid-Associated Ophthalmopathy. Current Eye Research 41:7, pages 927-932.
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Jessica H Selter, Anisa I Gire & Shameema Sikder. (2015) The relationship between Graves’ ophthalmopathy and dry eye syndrome. Clinical Ophthalmology 9, pages 57-62.
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Selcuk Sizmaz, Rana Altan-Yaycioglu, Okan Sefa Bakiner, Emre Bozkirli, Muge Coban-Karatas & Burak Ulas. (2014) Assessment of Tear Meniscus with Optical Coherence Tomography in Thyroid-Associated Ophtalmopathy. Current Eye Research 39:4, pages 323-328.
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Articles from other publishers (51)

Edoardo APPOLLONI & Simone DONATI. (2023) Graves' ophthalmopathy and dry eye syndrome. Minerva Ophthalmology 65:1-2.
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Mutlu Acar, Huri Sabur & Neşe Arslan. (2023) Ocular surface and in vivo confocal microscopic findings in patients with active tyhroid eye disease treated with glucocorticoids. European Journal of Ophthalmology 33:3, pages 1354-1360.
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Shoaib Ugradar, Erin Zimmerman, Emanuil Parunakian, Julia Kang, Kimberly Cockerham & Raymond S. Douglas. (2023) Change in lacrimal gland volume and aqueous tear production following treatment with teprotumumab. Clinical & Experimental Ophthalmology 51:4, pages 339-348.
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Büşra Yilmaz Tuğan, Berna Özkan, Refref Yüksel, Ahmet Burak Güray & Nurşen Yüksel. (2022) Is Corneal Subbasal Nerve Loss Associated With Meibomian Gland Loss in Inactive Mild and Moderate-to-Severe Graves’ Ophthalmopathy?. Ophthalmic Plastic & Reconstructive Surgery 39:2, pages 174-181.
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Rou Sun, Muyue Yang, Chenyi Lin, Yu Wu, Jing Sun & Huifang Zhou. (2023) A clinical study of topical treatment for thyroid-associated ophthalmopathy with dry eye syndrome. BMC Ophthalmology 23:1.
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Jurate Jankauskiene & Dalia Jarusaitiene. (2023) Symptoms and signs of dry eye in children with Graves' ophthalmopathy. Saudi Journal of Ophthalmology 37:2, pages 149.
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Luigi Bartalena & Maria Laura Tanda. (2022) Current concepts regarding Graves’ orbitopathy. Journal of Internal Medicine 292:5, pages 692-716.
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Yijia Huang, Ting Fu, Xinwei Jiao, Sijing Liu, Yunxia Xue, Jun Liu & Zhijie Li. (2022) Hypothyroidism affects corneal homeostasis and wound healing in mice. Experimental Eye Research 220, pages 109111.
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Yasuhiro Takahashi, Aric Vaidya & Hirohiko Kakizaki. (2022) Changes in Dry Eye Status after Steroid Pulse and Orbital Radiation Therapies in Active Thyroid Eye Disease. Journal of Clinical Medicine 11:13, pages 3604.
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Ruojing Huang, Caiying Su, Lvjie Fang, Jiaqi Lu, Jiansu Chen & Yong Ding. (2022) Dry eye syndrome: comprehensive etiologies and recent clinical trials. International Ophthalmology 42:10, pages 3253-3272.
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Ralene Sim, Kenneth Yong, Yu-Chi Liu & Louis Tong. (2022) In Vivo Confocal Microscopy in Different Types of Dry Eye and Meibomian Gland Dysfunction. Journal of Clinical Medicine 11:9, pages 2349.
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Nidhi Paharia, Indu Arora, Nikhil Agrawal, Abha Mathur & Shruti Agrawal. (2022) Comparative Clinicopathological Evaluation of the Ocular Surface in Newly Diagnosed Patients of Hyperthyroidism and Hypothyroidism Compared to Healthy Subjects. Cureus.
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Ana Rita Carreira, Sandra Rodrigues-Barros, Filipe Moraes, Tomás Loureiro, Inês Machado, Paul Campos, João Nobre Cardoso & Nuno Campos. (2022) Impact of Graves Disease on Ocular Surface and Corneal Epithelial Thickness in Patients With and Without Graves Orbitopathy. Cornea 41:4, pages 443-449.
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Georgios Bontzos, Efrosini Papadaki, Michael Mazonakis, Thomas G. Maris, Nikolaos G. Tsakalis, Eleni E. Drakonaki & Efstathios T. Detorakis. (2022) Extraocular Muscle Volumetry for Assessment of Thyroid Eye Disease. Journal of Neuro-Ophthalmology 42:1, pages e274-e280.
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Alper Halil Bayat, Emre Aydemir, Gozde Aksoy Aydemir & Hasim Gencer. (2021) Assessment of Tear Film Anomalies in Childhood Obesity. Klinische Monatsblätter für Augenheilkunde 239:03, pages 331-337.
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TammyH Osaki, LucasG Monteiro & MidoriH Osaki. (2022) Management of eyelid retraction related to thyroid eye disease. Taiwan Journal of Ophthalmology 12:1, pages 12.
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Bahram Eshraghi, Mojgan Nikdel & Maryam Abbasi. (2022) Epidemiological status of thyroid eye disease in Central Iran. Journal of Current Ophthalmology 34:1, pages 106.
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Shengnan Cheng, Yueqi Yu, Jin Chen, Lin Ye, Xinghua Wang & Fagang Jiang. (2021) In vivo confocal microscopy assessment of meibomian glands microstructure in patients with Graves’ orbitopathy. BMC Ophthalmology 21:1.
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Katie Glover, Deepakkumar Mishra & Thakur Raghu Raj Singh. (2021) Epidemiology of Ocular Manifestations in Autoimmune Disease. Frontiers in Immunology 12.
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Büşra YILMAZ TUĞAN. (2021) Evaluation of Corneal Langerhans Cells in Patients with Thyroid Ophthalmopathy by Using an In vivo Confocal Microscopy: A Retrospective StudyTiroid Oftalmopati Hastalarında In vivo Konfokal Mikroskopi Kullanılarak Langerhans Hücrelerinin Değerlendirilmesi: Retrospektif Bir Çalışma. Kocaeli Üniversitesi Sağlık Bilimleri Dergisi 7:2, pages 181-184.
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Vannarut Satitpitakul, Tanavadee Rattanaphong & Vannakorn Pruksakorn. (2021) Meibomian glands dropout in patients with inactive thyroid related orbitopathy. PLOS ONE 16:4, pages e0250617.
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Paolo P. LIMONE, Marco MELLANO, Maria G. RUO REDDA, Annalisa MACERA, Vittorio FERRERO, Stefano SELLARI FRANCESCHINI & Maurilio DEANDREA. (2021) Graves' orbitopathy: a multidisciplinary approach. The Quarterly Journal of Nuclear Medicine and Molecular Imaging 65:2.
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Ahmed Z. Al-Maskari, Khalid Alarfaj, Mohamed S. Shaheen, Nada Al-Yousuf, Osama Giledi, Saeed Algehedan, Sam Navon & Sihem Lazreg. (2021) Middle East Preferred Practice Patterns for Dry Eye Disease: A Modified Delphi Consensus. The Open Ophthalmology Journal 15:1, pages 34-42.
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Sachiko Inoue, Motoko Kawashima, Reiko Arita, Ai Kozaki & Kazuo Tsubota. (2020) Investigation of Meibomian Gland Function and Dry Eye Disease in Patients with Graves’ Ophthalmopathy. Journal of Clinical Medicine 9:9, pages 2814.
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N. Xu, Y. Cui, D. Fu & F. Sun. (2020) Tear inflammatory cytokines and ocular surface changes in patients with active thyroid eye disease treated with high-dose intravenous glucocorticoids. Journal of Endocrinological Investigation 43:7, pages 901-910.
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Jonathan J. Dutton. 2020. Surgery in Thyroid Eye Disease. Surgery in Thyroid Eye Disease 3 23 .
Wenwen Xue, Xian Xu & Haidong Zou. (2018) A rating scale is a proper method to evaluate changes in quality of life due to dry eye symptoms. International Ophthalmology 39:3, pages 563-569.
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Jeong Kyu Lee. (2019) Treatment of Graves' Ophthalmopathy. International Journal of Thyroidology 12:2, pages 91.
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Chiaw-Ling Chng, Lay Leng Seah, Morgan Yang, Sunny Yu Shen, Siew Kwan Koh, Yan Gao, Lu Deng, Louis Tong, Roger Wilmer Beuerman & Lei Zhou. (2018) Tear Proteins Calcium binding protein A4 (S100A4) and Prolactin Induced Protein (PIP) are Potential Biomarkers for Thyroid Eye Disease. Scientific Reports 8:1.
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Mohsen Bahmani Kashkouli, Sayyed Amirpooya Alemzadeh, Hossein Aghaei, Farzad Pakdel, Parya Abdolalizadeh, Mahya Ghazizadeh & Farideh Moradpasandi. (2018) Subjective versus objective dry eye disease in patients with moderate-severe thyroid eye disease. The Ocular Surface 16:4, pages 458-462.
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Jonathan J. Dutton. (2018) Anatomic Considerations in Thyroid Eye Disease. Ophthalmic Plastic & Reconstructive Surgery 34:4S, pages S7-S12.
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Minjae KimSungwon YangJinhwan ParkHwa LeeSehyun Baek. (2018) Risk Factors for Structural Changes in Meibomian Gland in Thyroid Eye Disease. Journal of the Korean Ophthalmological Society 59:7, pages 599.
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Sima Das. 2018. Principles and Practice of Lacrimal Surgery. Principles and Practice of Lacrimal Surgery 69 82 .
Suzanne Hagan. (2017) Biomarkers of ocular surface disease using impression cytology. Biomarkers in Medicine 11:12, pages 1135-1147.
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M M Uzel, M Citirik, M Kekilli & P Cicek. (2017) Local ocular surface parameters in patients with systemic celiac disease. Eye 31:7, pages 1093-1098.
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Suppapong Tirakunwichcha, Vipavee Lerdchanapornchai, Usanee Reinprayoon, Preamjit Saonanon & Thiti Snabboon. (2017) Prevalence of dry eye disease in autoimmune thyroid disease and the association of dry eye with clinical signs of thyroid associated ophthalmopathy: observational, noncomparative, cross-sectional study. Asian Biomedicine 10:2, pages 133-138.
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Priscila Novaes, Ana Beatriz Diniz Grisolia & Terry J. Smith. (2016) Update on thyroid-associated Ophthalmopathy with a special emphasis on the ocular surface. Clinical Diabetes and Endocrinology 2:1.
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C. Aass, I. Norheim, E. F. Eriksen, E. C. Børnick, P. M. Thorsby & M. Pepaj. (2016) Comparative proteomic analysis of tear fluid in Graves' disease with and without orbitopathy. Clinical Endocrinology 85:5, pages 805-812.
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Hyoun-Do HuhJi-Hye KimSeong-Jae KimJi-Myong YooSeong-Wook Seo. (2016) The Change of Lacrimal Gland Volume in Korean Patients with Thyroid-associated Ophthalmopathy. Korean Journal of Ophthalmology 30:5, pages 319.
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Jun Young HaWon ChoiKyung Chul Yoon. (2016) Clinical Features of Dry Eye in Thyroid-Associated Ophthalmopathy According to Disease Activity. Journal of the Korean Ophthalmological Society 57:7, pages 1037.
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Michael J. Doughty. (2015) Assessment of Consistency in Assignment of Severe (Grade 3) Squamous Metaplasia to Human Bulbar Conjunctiva Impression Cytology Cell Samples. The Ocular Surface 13:4, pages 284-297.
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Yi-Hsuan Wei, Wei-Li Chen, Fung-Rong Hu & Shu-Lang Liao. (2015) In vivo confocal microscopy of bulbar conjunctiva in patients with Graves' ophthalmopathy. Journal of the Formosan Medical Association 114:10, pages 965-972.
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Young Shin Kim, Ae Young Kwak, Sang Yeul Lee, Jin Sook Yoon & Sun Young Jang. (2015) Meibomian gland dysfunction in Graves’ orbitopathy. Canadian Journal of Ophthalmology 50:4, pages 278-282.
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Sibel Kocabeyoglu, Mehmet C. Mocan, Yakup Cevik & Murat Irkec. (2015) Ocular Surface Alterations and In Vivo Confocal Microscopic Features of Corneas in Patients With Newly Diagnosed Graves' Disease. Cornea 34:7, pages 745-749.
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Sima Das. 2015. Principles and Practice of Lacrimal Surgery. Principles and Practice of Lacrimal Surgery 61 74 .
Etty Bitton & Walter Wittich. (2014) Influence of eye position on the Schirmer tear test. Contact Lens and Anterior Eye 37:4, pages 257-261.
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Emrah Kan, Elif Kılıçkan, Gulçin Ecemiş, Emrullah Beyazyildiz & Ramis Çolak. (2014) Presence of Dry Eye in Patients with Hashimoto’s Thyroiditis. Journal of Ophthalmology 2014, pages 1-4.
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Jennifer S. Harthan. (2014) Therapeutic use of mini-scleral lenses in a patient with Graves’ ophthalmopathy. Journal of Optometry 7:1, pages 62-66.
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Vasilis Achtsidis, Nicholas Tentolouris, Sofia Theodoropoulou, Dimitris Panagiotidis, Emmanuel Vaikoussis, Manuel Saldana, Pieter Gouws & Panagiotis G. Theodossiadis. (2013) Dry Eye in Graves’ Ophthalmopathy: Correlation with Corneal Hypoesthesia. European Journal of Ophthalmology 23:4, pages 473-479.
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Bernadett UjhelyiPeter GogolakAnnamaria ErdeiValeria NagyErzsebet BalazsEva RajnavolgyiAndras BertaEndre V. Nagy. (2012) Graves' Orbitopathy Results in Profound Changes in Tear Composition: A Study of Plasminogen Activator Inhibitor-1 and Seven Cytokines. Thyroid 22:4, pages 407-414.
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Bernadett Ujhelyi, Peter Gogolak, Annamaria Erdei, Valeria Nagy, Erzsebet Balazs, Eva Rajnavolgyi, Andras Berta & Endre V Nagy. (2011) Graves’ orbitopathy results in profound changes in tear composition; a study of Plasminogen activator inhibitor-1 (PAI-1) and seven cytokines. Thyroid, pages 111229135013004.
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