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Original Article

Comparative In Vitro Toxicology Study of Travoprost Polyquad-preserved, Travoprost BAK-preserved, and Latanoprost BAK-preserved Ophthalmic Solutions on Human Conjunctival Epithelial Cells

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Pages 979-988 | Received 12 May 2010, Accepted 03 Apr 2011, Published online: 14 Oct 2011

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Read on this site (6)

Sowmya Andole & Sirisha Senthil. (2023) Ocular Surface Disease and Anti-Glaucoma Medications: Various features, Diagnosis, and Management Guidelines. Seminars in Ophthalmology 38:2, pages 158-166.
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Martina Cristaldi, Melania Olivieri, Gabriella Lupo, Carmelina D. Anfuso, Salvatore Pezzino & Dario Rusciano. (2018) N-hydroxymethylglycinate with EDTA is an efficient eye drop preservative with very low toxicity: an in vitro comparative study. Cutaneous and Ocular Toxicology 37:1, pages 71-76.
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Luciano Quaranta, Ivano Riva, Andreas Katsanos, Irene Floriani, Marco Centofanti & Anastasios G P Konstas. (2015) Safety and efficacy of travoprost solution for the treatment of elevated intraocular pressure. Clinical Ophthalmology 9, pages 633-643.
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Gemma Caterina Maria Rossi, Luigia Scudeller, Teresa Rolle, Gian Maria Pasinetti & Paolo Emilio Bianchi. (2015) From benzalkonium chloride-preserved Latanoprost to Polyquad-preserved Travoprost: a 6-month study on ocular surface safety and tolerability. Expert Opinion on Drug Safety 14:5, pages 619-623.
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Articles from other publishers (19)

Anne Hedengran, Josefine Freiberg, Pernille May Hansen, Gerard Boix-Lemonche, Tor P. Utheim, Darlene A. Dartt, Goran Petrovski, Steffen Heegaard & Miriam Kolko. (2024) Comparing the effect of benzalkonium chloride-preserved, polyquad-preserved, and preservative-free prostaglandin analogue eye drops on cultured human conjunctival goblet cells. Journal of Optometry 17:1, pages 100481.
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Anne Hedengran Nagstrup. (2023) The use of benzalkonium chloride in topical glaucoma treatment. Acta Ophthalmologica 101:S278, pages 3-21.
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Elsa Wilma Böhm, Francesco Buonfiglio, Anna Maria Voigt, Philipp Bachmann, Tarek Safi, Norbert Pfeiffer & Adrian Gericke. (2023) Oxidative stress in the eye and its role in the pathophysiology of ocular diseases. Redox Biology 68, pages 102967.
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Anne Hedengran & Miriam Kolko. (2023) The molecular aspect of anti-glaucomatous eye drops - are we harming our patients?. Molecular Aspects of Medicine 93, pages 101195.
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Judy Weng, Michael K. Fink & Ajay Sharma. (2023) A Critical Appraisal of the Physicochemical Properties and Biological Effects of Artificial Tear Ingredients and Formulations. International Journal of Molecular Sciences 24:3, pages 2758.
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Katarzyna Asendrych-Wicik, Jakub Zarczuk, Katarzyna Walaszek, Tomasz Ciach & Magdalena Markowicz-Piasecka. (2023) Trends in development and quality assessment of pharmaceutical formulations - F2α analogues in the glaucoma treatment. European Journal of Pharmaceutical Sciences 180, pages 106315.
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Anne Hedengran, Josefine Clement Freiberg, Pernille May Hansen, Jette Jacobsen, Susan Weng Larsen, Stine Harloff‐Helleberg, Kristine Freude, Gerard Boix‐Lemonche, Goran Petrovski, Steffen Heegaard & Miriam Kolko. (2022) Generic benzalkonium chloride‐preserved travoprost eye drops are not identical to the branded polyquarternium‐1‐preserved travoprost eye drop. Acta Ophthalmologica 100:7, pages 819-827.
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Fredrik Fineide, Neil Lagali, Muhammed Yasin Adil, Reiko Arita, Miriam Kolko, Jelle Vehof & Tor P. Utheim. (2022) Topical glaucoma medications – Clinical implications for the ocular surface. The Ocular Surface 26, pages 19-49.
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Omer Ersin Muz, Kenan Dagdelen, Tuncay Pirdal & Mete Guler. (2021) Comparison of BAK-preserved latanoprost and polyquad-preserved travoprost on ocular surface parameters in patients with glaucoma and ocular hypertension. International Ophthalmology 41:11, pages 3825-3835.
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Avani Kathuria, Kiumars Shamloo, Vishal Jhanji & Ajay Sharma. (2021) Categorization of Marketed Artificial Tear Formulations Based on Their Ingredients: A Rational Approach for Their Use. Journal of Clinical Medicine 10:6, pages 1289.
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Erin StahlDominique Bremond-GignacTheresa LandryMike CurtisKinfemichael GedifSami Al ShahwanEl Roy Dixon. (2017) Pharmacokinetics and Safety of Travoprost 0.004% Ophthalmic Solution Preserved with Polyquad in Pediatric Patients with Glaucoma. Journal of Ocular Pharmacology and Therapeutics 33:5, pages 361-365.
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Sabyasachi Maiti, Sayantan Sadhukhan & Paromita Bakshi. 2016. Nano-Biomaterials For Ophthalmic Drug Delivery. Nano-Biomaterials For Ophthalmic Drug Delivery 253 276 .
Joao F. Lopes, Douglas A. Hubatsch & Patricia Amaris. (2015) Effect of benzalkonium chloride–free travoprost on intraocular pressure and ocular surface symptoms in patients with glaucoma previously on latanoprost: an open-label study. BMC Ophthalmology 15:1.
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Fernando Pérez-Roca, Esther Rodrigo-Morales, Ingrid Garzón, Ana-Celeste Oliveira, Miguel-Ángel Martín-Piedra, Víctor Carriel, Ana-Isabel Ortiz-Pérez, Indalecio Sánchez-Montesinos, Antonio Campos & Miguel Alaminos. (2015) Effects of Four Formulations of Prostaglandin Analogs on Eye Surface Cells. A Comparative Study. PLOS ONE 10:6, pages e0129419.
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Betül İlkay Sezgin AkçayEsra GüneyTahir Kansu BozkurtCumhur Selçuk TopalJülide Canan Umurhan AkkanCihan Ünlü. (2014) Effects of Polyquaternium- and Benzalkonium-Chloride-Preserved Travoprost on Ocular Surfaces: An Impression Cytology Study. Journal of Ocular Pharmacology and Therapeutics 30:7, pages 548-553.
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Manlong XuJacob G. SivakDavid J. McCanna. (2013) Comparison of the Effects of Ophthalmic Solutions on Human Corneal Epithelial Cells Using Fluorescent Dyes. Journal of Ocular Pharmacology and Therapeutics 29:9, pages 794-802.
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Makoto Aihara, Hiromi Oshima & Makoto Araie. (2012) Effects of SofZia‐preserved travoprost and benzalkonium chloride‐preserved latanoprost on the ocular surface – a multicentre randomized single‐masked study. Acta Ophthalmologica 91:1.
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K.K. Huber-van der Velden, H. Thieme & M. Eichhorn. (2012) Morphologische Ver?nderungen durch Konservierungsmittel in AugentropfenMorphological alterations induced by preservatives in eye drops. Der Ophthalmologe 109:11, pages 1077-1081.
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Jess T. Whitson & W. Matthew Petroll. (2012) Corneal Epithelial Cell Viability Following Exposure to Ophthalmic Solutions Containing Preservatives and/or Antihypertensive Agents. Advances in Therapy 29:10, pages 874-888.
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