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Review Article

A review of the molecular mechanism of HSV-1 latency

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Pages 1-13 | Received 17 Aug 1990, Accepted 12 Nov 1990, Published online: 02 Jul 2009

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Read on this site (4)

David M. Koelle & Homayon Ghiasi. (2005) Prospects for Developing an Effective Vaccine Against Ocular Herpes Simplex Virus Infection. Current Eye Research 30:11, pages 929-942.
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Ying-Hsiu Su, Michael Moxley, Rohini Kejariwal, Anand Mehta, Nigel W Fraser & Timothy M Block. (2000) The HSV 1 genome in quiescently infected NGF differentiated PC12 cells can not be stimulated by HSV superinfection. Journal of Neurovirology 6:4, pages 341-349.
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Walter A Tatarowicz, Claudia E Martin, Andrew S Pekosz, Stephen L Madden, Frank J Rauscher, Shu-Yuan Chiang, Terry A Beerman & Nigel W Fraser. (1997) Repression of the HSV-1 latency-associated transcript (LAT) promoter by the early growth response (EGR) proteins: Involvement of a binding site immediately downstream of the TATA box. Journal of Neurovirology 3:3, pages 212-224.
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Israel Steiner & Peter GE Kennedy. (1995) Herpes simplex virus latent infection in the nervous system. Journal of Neurovirology 1:1, pages 19-29.
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Articles from other publishers (31)

Shaohui Wang, Xueying SongAlex Rajewski, Chintda SantiskulvongHomayon Ghiasi. (2023) Stacking the odds: Multiple sites for HSV-1 latency. Science Advances 9:4.
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Sariah J. Allen, Pedram Hamrah, David Gate, Kevin R. Mott, Dimosthenis Mantopoulos, Lixin Zheng, Terrence Town, Clinton Jones, Ulrich H. von Andrian, Gordon J. Freeman, Arlene H. Sharpe, Lbachir BenMohamed, Rafi Ahmed, Steven L. Wechsler & Homayon Ghiasi. (2011) The Role of LAT in Increased CD8 + T Cell Exhaustion in Trigeminal Ganglia of Mice Latently Infected with Herpes Simplex Virus 1 . Journal of Virology 85:9, pages 4184-4197.
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Michel Drancourt & Luke Herbert. 2010. Infectious Diseases. Infectious Diseases 177 184 .
CM Filippi & MG von Herrath. (2008) IL-10 and the resolution of infections. The Journal of Pathology 214:2, pages 224-230.
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Sílvia Regina Ferreira Gonçalves Pereira, Fernando Portela Câmara, Maria Angélica Arpon Marandino Guimarães, Leonardo Vieira Neto, Daniel Segenreich, Antônio Carlos da Costa Guimarães & Vera Lucia Antunes Chagas. (2007) An immunofluorescence test for diagnosis of ophthalmic herpes in a mouse corneal model. Revista do Instituto de Medicina Tropical de São Paulo 49:2, pages 87-92.
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Dimitra Tsavachidou, Wawrzyniec Podrzucki, John Seykora & Shelley L. Berger. (2001) Gene Array Analysis Reveals Changes in Peripheral Nervous System Gene Expression following Stimuli That Result in Reactivation of Latent Herpes Simplex Virus Type 1: Induction of Transcription Factor Bcl-3. Journal of Virology 75:20, pages 9909-9917.
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Jia Zhu, Wen Kang, John H. Wolfe & Nigel W. Fraser. (2000) Significantly Increased Expression of β-Glucuronidase in the Central Nervous System of Mucopolysaccharidosis Type VII Mice from the Latency-Associated Transcript Promoter in a Nonpathogenic Herpes Simplex Virus Type 1 Vector. Molecular Therapy 2:1, pages 82-94.
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Sandeep Guliani, Gregory A Smith, Peter L Young, John S Mattick & Timothy J Mahony. (1999) Reactivation of a macropodid herpesvirus from the eastern grey kangaroo (Macropus giganteus) following corticosteroid treatment. Veterinary Microbiology 68:1-2, pages 59-69.
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Ruth Tal-Singer, Rath Pichyangkura, Eugene Chung, Todd M. Lasner, Bruce P. Randazzo, John Q. Trojanowski, Nigel W. Fraser & Steven J. Triezenberg. (1999) The Transcriptional Activation Domain of VP16 Is Required for Efficient Infection and Establishment of Latency by HSV-1 in the Murine Peripheral and Central Nervous Systems. Virology 259:1, pages 20-33.
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Homayon Ghiasi, Guey-Chuen Pemg, Florence M. Hofman, Steve Cai, Anthony B. Nesburn & Steven L. Wechsler. (1999) Specific and Nonspecific Immune Stimulation of MHC-II-Deficient Mice Results in Chronic HSV-1 Infection of the Trigeminal Ganglia Following Ocular Challenge. Virology 258:2, pages 208-216.
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Robert Jordan, Josh Pepe & Priscilla A. Schaffer. (1998) Characterization of a Nerve Growth Factor-Inducible Cellular Activity That Enhances Herpes Simplex Virus Type 1 Gene Expression and Replication of an ICP0 Null Mutant in Cells of Neural Lineage. Journal of Virology 72:7, pages 5373-5382.
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Mau T. Tran, David A. Dean, Robert N. Lausch & John E. Oakes. (1998) Membranes of Herpes Simplex Virus Type-1-Infected Human Corneal Epithelial Cells Are Not Permeabilized to Macromolecules and Therefore Do Not Release IL-1α. Virology 244:1, pages 74-78.
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Ruth Tal-Singer, Wawrzyniec Podrzucki, Todd M. Lasner, Aikaterini Skokotas, Jeffry J. Leary, Nigel W. Fraser & Shelley L. Berger. (1998) Use of Differential Display Reverse Transcription-PCR To Reveal Cellular Changes during Stimuli That Result in Herpes Simplex Virus Type 1 Reactivation from Latency: Upregulation of Immediate-Early Cellular Response Genes TIS7, Interferon, and Interferon Regulatory Factor-1. Journal of Virology 72:2, pages 1252-1261.
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Johnson Thomas & Barry T. Rouse. (1997) Immunopathogenesis of herpetic ocular disease. Immunologic Research 16:4, pages 375-386.
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Robin H. Lachmann & Stacey Efstathiou. (1997) The use of herpes simplex virus-based vectors for gene delivery to the nervous system. Molecular Medicine Today 3:9, pages 404-411.
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C KrummenacherJ M ZabolotnyN W Fraser. (1997) Selection of a nonconsensus branch point is influenced by an RNA stem-loop structure and is important to confer stability to the herpes simplex virus 2-kilobase latency-associated transcript. Journal of Virology 71:8, pages 5849-5860.
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Richard M. Gesser. (1997) The role of latency in herpesvirus infections. Seminars in Pediatric Infectious Diseases 8:3, pages 128-135.
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Mark S. Wallace & Michael N. Oxman. (1997) ACUTE HERPES ZOSTER AND POSTHERPETIC NEURALGIA. Anesthesiology Clinics of North America 15:2, pages 371-405.
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Santosh Kesari, Virginia M.-Y. Lee, S. Moira Brown, John Q. Trojanowski & Nigel W. Fraser. (1996) Selective Vulnerability of Mouse CNS Neurons to Latent Infection with a Neuroattenuated Herpes Simplex Virus-1. The Journal of Neuroscience 16:18, pages 5644-5653.
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Istael Steiner. (2006) Human Herpes Viruses Latent Infection in the Nervous System. Immunological Reviews 152:1, pages 157-173.
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J J Sasadeusz & S L Sacks. (1994) Herpes latency, meningitis, radiculomyelopathy and disseminated infection.. Sexually Transmitted Infections 70:6, pages 369-377.
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P. G. E. Kennedy & I. Steiner. (2008) A molecular and cellular model to explain the differences in reactivation from latency by herpes simplex and varicella–zoster viruses. Neuropathology and Applied Neurobiology 20:4, pages 368-374.
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M NicosiaS L DeshmaneJ M ZabolotnyT Valyi-NagyN W Fraser. (1993) Herpes simplex virus type 1 latency-associated transcript (LAT) promoter deletion mutants can express a 2-kilobase transcript mapping to the LAT region. Journal of Virology 67:12, pages 7276-7283.
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R L FawlB Roizman. (1993) Induction of reactivation of herpes simplex virus in murine sensory ganglia in vivo by cadmium. Journal of Virology 67:12, pages 7025-7031.
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Israel Steiner & Peter G. E. Kennedy. (1993) Molecular biology of herpes simplex virus type 1 latency in the nervous system. Molecular Neurobiology 7:2, pages 137-159.
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T Valyi-NagyS L DeshmaneB RaengsakulrachM NicosiaR M GesserM WysockaA DillnerN W Fraser. (1992) Herpes simplex virus type 1 mutant strain in1814 establishes a unique, slowly progressing infection in SCID mice. Journal of Virology 66:12, pages 7336-7345.
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Nigel W. Fraser, Timothy M. Block & Jordan G. Spivack. (1992) The latency-associated transcripts of herpes simplex virus: RNA in search of function. Virology 191:1, pages 1-8.
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John H. Wolfe, Satish L. Deshmane & Nigel W. Fraser. (1992) Herpesvirus vector gene transfer and expression of β–glucuronidase in the central nervous system of MRS VII mice. Nature Genetics 1:5, pages 379-384.
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Thomas J. Liesegang. (1992) Biology and Molecular Aspects of Herpes Simplex and Varicell-zoster Virus Infections. Ophthalmology 99:5, pages 781-799.
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M D TrousdaleI SteinerJ G SpivackS L DeshmaneS M BrownA R MacLeanJ H Subak-SharpeN W Fraser. (1991) In vivo and in vitro reactivation impairment of a herpes simplex virus type 1 latency-associated transcript variant in a rabbit eye model. Journal of Virology 65:12, pages 6989-6993.
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R NatarajanS DeshmaneT Valyi-NagyR EverettN W Fraser. (1991) A herpes simplex virus type 1 mutant lacking the ICP0 introns reactivates with normal efficiency. Journal of Virology 65:10, pages 5569-5573.
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