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Original Article

The Evolution of Inhaler Technology

Pages 55-64 | Published online: 02 Jul 2009

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (3)

A. H. de Boer, P. Hagedoorn, M. Hoppentocht, F. Buttini, F. Grasmeijer & H. W. Frijlink. (2017) Dry powder inhalation: past, present and future. Expert Opinion on Drug Delivery 14:4, pages 499-512.
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Jesslynn Ooi, Daniela Traini, Ben J Boyd, Simon Gaisford & Paul M Young. (2015) Determination of physical and chemical stability in pressurised metered dose inhalers: potential new techniques. Expert Opinion on Drug Delivery 12:10, pages 1661-1675.
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David Lewis. (2007) Metered-dose inhalers: actuators old and new. Expert Opinion on Drug Delivery 4:3, pages 235-245.
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Articles from other publishers (50)

Allison Boboltz, Sahana Kumar & Gregg A. Duncan. (2023) Inhaled drug delivery for the targeted treatment of asthma. Advanced Drug Delivery Reviews 198, pages 114858.
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Suraj L. Dongare & Minal R. Narkhede. (2023) An Overview of Recently Published Patents on Pulmonary Drug Delivery Devices. Recent Advances in Drug Delivery and Formulation 17:2, pages 102-119.
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Friederike K. Klenk & Bianka Schulz. (2023) Inhalative Therapie chronischer Erkrankungen der unteren Atemwege bei Hund und Katze – eine Literaturübersicht. kleintier konkret 26:02, pages 31-45.
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Adrian Bertschi, Bozhidar-Adrian Stefanov, Shuai Xue, Ghislaine Charpin-El Hamri, Ana Palma Teixeira & Martin Fussenegger. (2023) Controlling therapeutic protein expression via inhalation of a butter flavor molecule. Nucleic Acids Research 51:5, pages e28-e28.
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Iftikhar Khan, Ali Al-Hasani, Mohsin H. Khan, Aamir N. Khan, Fakhr-e -Alam, Sajid K. Sadozai, Abdelbary Elhissi, Jehanzeb Khan & Sakib Yousaf. (2023) Impact of dispersion media and carrier type on spray-dried proliposome powder formulations loaded with beclomethasone dipropionate for their pulmonary drug delivery via a next generation impactor. PLOS ONE 18:3, pages e0281860.
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Friederike Karoline Klenk, Vanessa De Simoi, Yury Zablotski, Bianca Désirée Ballhausen, Georg Wolf & Bianka Schulz. (2023) Bacterial Contamination of Inhalation Chambers Used for Cats and Dogs with Chronic Airway Diseases. Pathogens 12:2, pages 275.
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Carrie J. Miller. 2023. Small Animal Critical Care Medicine. Small Animal Critical Care Medicine 967 971 .
Friederike K. Klenk & Bianka Schulz. (2022) Inhalative Therapie chronischer Erkrankungen der unteren Atemwege bei Hund und Katze – eine Literaturübersicht. Tierärztliche Praxis Ausgabe K: Kleintiere / Heimtiere 50:04, pages 279-292.
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Lindong Ma, Yuanxiao Hong, Xihui Chen & Xiaoyong Quan. (2022) Can Green Innovation and New Urbanization Be Synergistic Development? Empirical Evidence from Yangtze River Delta City Group in China. Sustainability 14:10, pages 5765.
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Elena Haettig & Marc Schneider. 2022. Essentials of Industrial Pharmacy. Essentials of Industrial Pharmacy 123 149 .
Iftikhar Khan, Rachel Needham, Sakib Yousaf, Chahinez Houacine, Yamir Islam, Ruba Bnyan, Sajid Khan Sadozai, Mohamed A. Elrayess & Abdelbary Elhissi. (2021) Impact of phospholipids, surfactants and cholesterol selection on the performance of transfersomes vesicles using medical nebulizers for pulmonary drug delivery. Journal of Drug Delivery Science and Technology 66, pages 102822.
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Ling Yang, Yang Liu, Ning Wang, Hong Wang, Kun Wang, Xiao-li Luo, Ruo-xuan Dai, Ru-jia Tao, Huai-ji Wang, Jia-wei Yang, Guo-qing Tao, Jie-ming Qu, Bao-xue Ge, Yong-yong Li & Jin-fu Xu. (2020) Albumin-Based LL37 Peptide Nanoparticles as a Sustained Release System against Pseudomonas aeruginosa Lung Infection . ACS Biomaterials Science & Engineering 7:5, pages 1817-1826.
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A. Lowe, G. Singh, H.-K. Chan, A.R. Masri, S. Cheng & A. Kourmatzis. (2021) Fragmentation dynamics of single agglomerate-to-wall impaction. Powder Technology 378, pages 561-575.
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Hu Ping, Xie Qun & Hu Zhong Ping. 2021. Simulation Tools and Techniques. Simulation Tools and Techniques 593 610 .
Kentaro Yumoto, Takashi Sato, Kentaro Nakashima, Fu Namai, Suguru Shigemori, Takeshi Shimosato & Takeshi Kaneko. (2020) Nasally Administered Lactococcus lactis Secreting Heme Oxygenase-1 Attenuates Murine Emphysema. Antioxidants 9:11, pages 1049.
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Sean D. McCarthy, Héctor E. González & Brendan D. Higgins. (2020) Future Trends in Nebulized Therapies for Pulmonary Disease. Journal of Personalized Medicine 10:2, pages 37.
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Roua Azmeh, Donald E. Greydanus, Marisha G. Agana, Cheryl A. Dickson, Dilip R. Patel, Mariam M. Ischander & Robert D. LloydJr.Jr.. (2020) Update in Pediatric Asthma: Selected Issues. Disease-a-Month 66:4, pages 100886.
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Rohitas Deshmukh, Nabamita Bandyopadhyay, Sara Nidal Abed, Shantanu Bandopadhyay, Yogendra Pal & Pran Kishore Deb. 2020. Drug Delivery Systems. Drug Delivery Systems 85 129 .
Kunal Maniar, Vandana Singh, Amal Moideen, Rajasri Bhattacharyya, Amitava Chakrabarti & Dibyajyoti Banerjee. (2018) Inhalational supplementation of metformin butyrate: A strategy for prevention and cure of various pulmonary disorders. Biomedicine & Pharmacotherapy 107, pages 495-506.
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Stephen P. Newman. (2018) Delivering drugs to the lungs: The history of repurposing in the treatment of respiratory diseases. Advanced Drug Delivery Reviews 133, pages 5-18.
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Surya Prakash Reddy Yanamala & Aruna Gorthi. (2018) COMPLIANCE, SYMPTOMATIC AND SPIROMETRIC IMPROVEMENT WITH DIFFERENT TYPES OF DRY POWDER INHALERS (DPIs) IN BRONCHIAL ASTHMA PATIENTS- A COMPARATIVE STUDY. Journal of Evidence Based Medicine and Healthcare 5:25, pages 1930-1935.
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Hao-Ying Li & En-Yu Xu. (2017) Innovative pMDI formulations of spray-dried nanoparticles for efficient pulmonary drug delivery. International Journal of Pharmaceutics 530:1-2, pages 12-20.
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Barry MurnaneCathal T. GallagherNoel SnellMark SandersRamin MoshksarDarragh Murnane. (2017) Dispersing the Mists: An Experimental History of Medicine Study into the Quality of Volatile Inhalations. Journal of Aerosol Medicine and Pulmonary Drug Delivery 30:3, pages 157-163.
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Paola Rogliani, Luigino Calzetta, Angelo Coppola, Francesco Cavalli, Josuel Ora, Ermanno Puxeddu, Maria Gabriella Matera & Mario Cazzola. (2017) Optimizing drug delivery in COPD: The role of inhaler devices. Respiratory Medicine 124, pages 6-14.
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Iftikhar Khan, Sakib Yousaf, Mohamed Albed Alhnan, Waqar Ahmed, Abdelbary Elhissi & Mark J. Jackson. 2016. Surgical Tools and Medical Devices. Surgical Tools and Medical Devices 573 591 .
Carrie J. Miller. 2015. Small Animal Critical Care Medicine. Small Animal Critical Care Medicine 903 906 .
M. Hoppentocht, P. Hagedoorn, H.W. Frijlink & A.H. de Boer. (2014) Technological and practical challenges of dry powder inhalers and formulations. Advanced Drug Delivery Reviews 75, pages 18-31.
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Stephen P. Newman. 2013. Drug Delivery Applications of Noninvasive Imaging. Drug Delivery Applications of Noninvasive Imaging 333 366 .
Iftikhar Khan, Abdelbary Elhissi, Mahmood Shah, Mohamed Albed Alhnan & Waqar Ahmed. 2013. Biomaterials and Medical Tribology. Biomaterials and Medical Tribology 395 443 .
Waseem Kaialy, Hassan LarhribMartyn TicehurstAli Nokhodchi. (2012) Influence of Batch Cooling Crystallization on Mannitol Physical Properties and Drug Dispersion from Dry Powder Inhalers. Crystal Growth & Design 12:6, pages 3006-3017.
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Timothy B. Op’t Holt. (2011) Evolution of the Inhalation of Vapors and Aerosols in the Care of Asthma and Other Respiratory Diseases. Journal of Asthma & Allergy Educators 2:2, pages 75-80.
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Hemal Tandel, Kiruba Florence & Ambikanandan Misra. 2011. Challenges in Delivery of Therapeutic Genomics and Proteomics. Challenges in Delivery of Therapeutic Genomics and Proteomics 429 479 .
Mohammed Ali. 2010. Handbook of Non-Invasive Drug Delivery Systems. Handbook of Non-Invasive Drug Delivery Systems 209 246 .
Jerry Z. Yang, Anthony L. Young, Po-Chang Chiang, Archie Thurston & Denise K. Pretzer. (2008) Fluticasone and budesonide nanosuspensions for pulmonary delivery: Preparation, characterization, and pharmacokinetic studies. Journal of Pharmaceutical Sciences 97:11, pages 4869-4878.
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Niamh Durcan, Charlotte Murphy & Sally-Ann Cryan. (2008) Inhalable siRNA: Potential as a Therapeutic Agent in the Lungs. Molecular Pharmaceutics 5:4, pages 559-566.
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N. R. Labiris & M. B. Dolovich. (2003) Pulmonary drug delivery. Part II: The role of inhalant delivery devices and drug formulations in therapeutic effectiveness of aerosolized medications. British Journal of Clinical Pharmacology 56:6, pages 600-612.
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S Fayas, M Estivals, B Gontier, L Têtu, G Rafalimanana & A Didier. (2003) Facteurs déterminants la qualité de la prise des traitements inhalés dans l’asthme. Revue Française d'Allergologie et d'Immunologie Clinique 43:6, pages 364-368.
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Carla C. Keirns. (2003) Better than nature: the changing treatment of asthma and hay fever in the United States, 1910–1945. Studies in History and Philosophy of Science Part C: Studies in History and Philosophy of Biological and Biomedical Sciences 34:3, pages 511-531.
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Jonathan Corren & Donald P. Tashkin. (2003) Evaluation of efficacy and safety of flunisolide hydrofluoroalkane for the treatment of asthma. Clinical Therapeutics 25:3, pages 776-798.
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F. Deulofeu i Fontanillas. (2003) Cómo mejorar la técnica inhalatoria de los pacientes asmáticos. Atención Primaria 32:5, pages 274-275.
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Chris O'Callaghan, Ola Nerbrink & Mika Vidgren. 2001. Drug Delivery to the Lung. Drug Delivery to the Lung 1 20 .
ALESSANDRA SANDRINI, ANDRÉIA JACOMOSSI, SONIA MARIA FARENSIN, ANA LUISA GODOY FERNANDES & JOSÉ ROBERTO JARDIM. (2001) Aprendizado do uso do inalador dosimetrado após explicação por pneumologista. Jornal de Pneumologia 27:1, pages 7-10.
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Igor Gonda. (2000) The Ascent of Pulmonary Drug Delivery. Journal of Pharmaceutical Sciences 89:7, pages 940-945.
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Barry Brenner. 1999. Emergency Asthma. Emergency Asthma 1 31 .
Colleen Lum Lung, Michael Lum Lung & Christine Lum Lung. (1999) MEDICATIONS IN THE ALLERGY/ASTHMA OFFICE. Immunology and Allergy Clinics of North America 19:1, pages 101-127.
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Colleen Lum Lung, Michael Lum Lung & Christine Lum Lung. (1999) MEDICATIONS IN THE ALLERGY/ASTHMA OFFICE. Radiologic Clinics of North America 19:1, pages 101-127.
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KAREN J. SMITH, HAK-KIM CHAN & KENNETH F. BROWN. (1998) Influence of Flow Rate on Aerosol Particle Size Distributions from Pressurized and Breath-Actuated Inhalers. Journal of Aerosol Medicine 11:4, pages 231-245.
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J.F. Dessanges & V. Rivoal. (1998) Les chambres d'inhalation. Revue Française d'Allergologie et d'Immunologie Clinique 38:2, pages 103-108.
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Andrew M. Hoffman. (1997) Inhaled Medications and Bronchodilator Usage in the Horse. Veterinary Clinics of North America: Equine Practice 13:3, pages 519-530.
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Richard M Nowak. (1995) Inhaled beta agonists and acute asthma. The American Journal of Emergency Medicine 13:1, pages 94-95.
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