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Original Article

Current Status of Epirubicin (Farmorubicin) in the Treatment of Solid Tumours

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Pages 257-285 | Accepted 20 Jan 1990, Published online: 08 Jul 2009

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Kirsten Vang Nielsen, Bent Ejlertsen, Susanne Møller, Jan Trøst Jørgensen, Ann Knoop, Helle Knudsen & Henning T. Mouridsen. (2008) The value of TOP2A gene copy number variation as a biomarker in breast cancer: Update of DBCG trial 89D. Acta Oncologica 47:4, pages 725-734.
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Helena Earl & Mahesh Iddawela. (2004) Epirubicin as adjuvant therapy in breast cancer. Expert Review of Anticancer Therapy 4:2, pages 189-195.
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Jonas Bergh, Per-Ebbe Jönsson, Bengt Glimelius, Peter Nygren. (2001) A Systematic Overview of Chemotherapy Effects in Breast Cancer. Acta Oncologica 40:2-3, pages 253-281.
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Per Pfeiffer, SØRen Cold & Carsten Rose. (1992) Cytotoxic Treatment of Metastatic Breast Cancer: Which drugs and drug combinations to use?. Acta Oncologica 31:2, pages 219-224.
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Kerstin Wimmer, Monika Sachet, Cristiano Ramos, Sophie Frantal, Hanna Birnleitner, Christine Brostjan, Ruth Exner, Martin Filipits, Zsuzsanna Bago-Horvath, Margaretha Rudas, Rupert Bartsch, Michael Gnant, Christian F. Singer, Marija Balic, Daniel Egle, Rudolf Oehler & Florian Fitzal. (2023) Differential immunomodulatory effects of epirubicin/cyclophosphamide and docetaxel in breast cancer patients. Journal of Experimental & Clinical Cancer Research 42:1.
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Ariunbuyan Sukhbaatar, Shiro Mori, Kiyoto Shiga & Tetsuya Kodama. (2023) Intralymphatic injection of chemotherapy drugs modulated with glucose improves their anticancer effect. Biomedicine & Pharmacotherapy 165, pages 115110.
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Radwan Ansaar, Robyn Meech & Andrew Rowland. (2023) A Physiologically Based Pharmacokinetic Model to Predict Determinants of Variability in Epirubicin Exposure and Tissue Distribution. Pharmaceutics 15:4, pages 1222.
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Alexey Surov, Maciej Pech, Daniel Gessner, Martin Mikusko, Thomas Fischer, Mareike Alter & Andreas Wienke. (2021) Low skeletal muscle mass is a predictor of treatment related toxicity in oncologic patients. A meta-analysis. Clinical Nutrition 40:10, pages 5298-5310.
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Sang Hyun Yoo, Chang Wook Jeong, Cheol Kwak, Hyeon Hoe Kim, Min Soo Choo & Ja Hyeon Ku. (2019) Intravesical Chemotherapy after Radical Nephroureterectomy for Primary Upper Tract Urothelial Carcinoma: A Systematic Review and Network Meta-Analysis. Journal of Clinical Medicine 8:7, pages 1059.
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Adam J. Shuhendler, Preethy Prasad, Rui Xue Zhang, Mohammad Ali Amini, Mei Sun, Peter P. Liu, Robert G. Bristow, Andrew M. Rauth & Xiao Yu Wu. (2014) Synergistic Nanoparticulate Drug Combination Overcomes Multidrug Resistance, Increases Efficacy, and Reduces Cardiotoxicity in a Nonimmunocompromised Breast Tumor Model. Molecular Pharmaceutics 11:8, pages 2659-2674.
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Nadezhda Angelova & Georgi Yordanov. (2014) Nanoparticles of poly(styrene-co-maleic acid) as colloidal carriers for the anticancer drug epirubicin. Colloids and Surfaces A: Physicochemical and Engineering Aspects 452, pages 73-81.
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Zorka Bedzhova & Georgi Yordanov. (2013) Preparation of epirubicin-loaded poly(butyl cyanoacrylate) colloidal particles by polymerization in a mixed organic–aqueous solvent system. Colloids and Surfaces A: Physicochemical and Engineering Aspects 431, pages 27-33.
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David Cragg, Gordon Kingston & David NewmanFederico-Maria Arcamone. 2011. Anticancer Agents from Natural Products, Second Edition. Anticancer Agents from Natural Products, Second Edition 383 406 .
Ya-Chen Tina Shih, I-Wen Pan & Yi-Wen Tsai. (2009) Information Technology Facilitates Cost-Effectiveness Analysis in Developing Countries. PharmacoEconomics 27:11, pages 947-961.
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Derick Lau, Jewel Johl, Minh Huynh, Angela Davies, Michael Tanaka, Primo Lara & David Gandara. (2008) Population-Based Phase I Trial of Irinotecan and Epirubicin. American Journal of Clinical Oncology 31:3, pages 226-230.
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Bent Ejlertsen, Henning T. Mouridsen, Maj-Britt Jensen, J?rn Andersen, S?ren Cold, Per Edlund, Marianne Ewertz, Brita B. Jensen, Claus Kamby, Bo Nordenskjold & Jonas Bergh. (2007) Improved outcome from substituting methotrexate with epirubicin: Results from a randomised comparison of CMF versus CEF in patients with primary breast cancer. European Journal of Cancer 43:5, pages 877-884.
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Danyelle Townsend. 2007. xPharm: The Comprehensive Pharmacology Reference. xPharm: The Comprehensive Pharmacology Reference 1 5 .
K. -H. Zurborn. 2006. Praktische Arzneitherapie. Praktische Arzneitherapie 561 638 .
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S. Chan, N. Davidson, E. Juozaityte, F. Erdkamp, A. Pluzanska, N. Azarnia & L.W. Lee. (2004) Phase III trial of liposomal doxorubicin and cyclophosphamide compared with epirubicin and cyclophosphamide as first-line therapy for metastatic breast cancer. Annals of Oncology 15:10, pages 1527-1534.
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Fedro Peccatori, Giovanni Martinelli, Oreste Gentilini & Aron Goldhirsch. (2004) Chemotherapy during pregnancy: what is really safe?. The Lancet Oncology 5:7, pages 398.
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Bent Ejlertsen, Henning T. Mouridsen, Sven T. Langkjer, Jorn Andersen, Johanna Sjöström & Mogens Kjaer. (2004) Phase III Study of Intravenous Vinorelbine in Combination With Epirubicin Versus Epirubicin Alone in Patients With Advanced Breast Cancer: A Scandinavian Breast Group Trial (SBG9403). Journal of Clinical Oncology 22:12, pages 2313-2320.
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Virginia G. Kaklamani & William J. Gradishar. (2003) Epirubicin Versus Doxorubicin: Which Is the Anthracycline of Choice for the Treatment of Breast Cancer?. Clinical Breast Cancer 4, pages S26-S33.
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K.-H. Zurborn. 2003. Praktische Arzneitherapie. Praktische Arzneitherapie 553 632 .
Manisha Bhutani, Lalit Kumar, Amish Vora, Narendra Bhardwaj, Ashutosh Kumar Pathak, Rajvir Singh & Vinod Kochupillai. (2002) Randomized study comparing 4′‐epi‐doxorubicin (Epirubicin) versus doxorubicin as a part of induction treatment in adult acute lymphoblastic leukemia. American Journal of Hematology 71:4, pages 241-247.
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G. Mustacchi, M. Muggia, S. Milani, R. Ceccherini, M.L. Leita & C. Dellach. (2002) A phase II study of cisplatin and vinorelbine in patients with metastatic breast cancer. Annals of Oncology 13:11, pages 1730-1736.
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F.C. Maluf & D. Spriggs. (2002) Anthracyclines in the Treatment of Gynecologic Malignancies. Gynecologic Oncology 85:1, pages 18-31.
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Giuseppe Sacco, Mario Bigioni, Stefano Evangelista, Cristina Goso, Stefano Manzini & Carlo A. Maggi. (2001) Cardioprotective effects of zofenopril, a new angiotensin-converting enzyme inhibitor, on doxorubicin-induced cardiotoxicity in the rat. European Journal of Pharmacology 414:1, pages 71-78.
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Tetsuro Kobayashi, Hiroki Koyama, Takahiro Oka, Tadaki Yasumura, Norimichi Kan, Yuichi Takatsuka, Masakuni Noguchi, Ken Morimoto, Takaichiro Suzuki, Takayoshi Tobe & Takesada Mori. (1999) Prospective randomized study of cyclophosphamide, epirubicin, and 5-fluorouracil versus cyclophosphamide, adriamycin, and 5-fluorouracil in advanced or recurrent breast cancer. Breast Cancer 6:1, pages 37-42.
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Ylva A. Karlsson, Per O. Malmstr�m, Thomas Hatschek, Tommy G. Fornander, Martin S�derberg, Nils-Olof Bengtsson, Tomas E. Jansson, Sara M. Sj�berg & Jonas C. Bergh. (1998) Multimodality treatment of 128 patients with locally advanced breast carcinoma in the era of mammography screening using standard polychemotherapy with 5-fluorouracil, epirubicin, and cyclophosphamide. Cancer 83:5, pages 936-947.
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M. Michael, G. C. Toner, I. N. Olver, A. Fenessy & J. F. Bishop. (1997) Phase I Dose Intensification Study of 2-Weekly Epirubicin with GM-CSF in Advanced Cancer. American Journal of Clinical Oncology 20:3, pages 259-262.
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Elizabeth A. Lowenthal & John T. CarpenterJr.Jr.. (1995) The use of anthracyclines in the adjuvant treatment of breast cancer. Cancer Treatment Reviews 21:3, pages 199-214.
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M. Spielmann, D. Gandia, K. Fizazi, T. Guillot, E. Cvitkovic, L. Kayitalire, T. Girinsky, D. Elias, P. Rougier & J. Kac. (1994) Phase II study of 4?epirubicin in advanced squamous cell oesophageal cancer. European Journal of Cancer 30:12, pages 1908-1909.
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Sumitra Thongprasert & Kriangsak Jiamsriponges. (1993) Ifosfamide, epirubicin and cisplatin (IEP): another active combination for small cell lung cancer (SCLC). Lung Cancer 10:1-2, pages 91-94.
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A. Paul Launchbury & Nassir Habboubi. (1993) Epirubicin and doxorubicin: a comparison of their characteristics, therapeutic activity and toxicity. Cancer Treatment Reviews 19:3, pages 197-228.
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G. Bonadonna, L. Gianni, A. Santoro, V. Bonfante, P. Bidoli, P. Casali, R. Demicheli & P. Valagussa. (1993) Drugs ten years later: Epirubicin. Annals of Oncology 4:5, pages 359-369.
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Jens Benn S�rensen, Lars Stenbygaard, Lars Drivsholm, Per Dombernowsky & Heine H. Hansen. (1993) Phase II study of 4?-iodo-4?-deoxydoxorubicin in non-resectable non-small-cell lung cancer. Cancer Chemotherapy and Pharmacology 32:5, pages 399-402.
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Staffan Eksborg, Lennart Hardell, Nils-Olof Bengtsson, Marie Sjödin & Birgitta Elfsson. (1992) Epirubicin as a single agent therapy for the treatment of breast cancer — A pharmacokinetic and clinical study. Medical Oncology and Tumor Pharmacotherapy 9:2, pages 75-80.
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Seppo O Pyrh?nen & Mauri O Kouri. (1992) Phase II study of epirubicin sequential methotrexate and 5-fluorouracil for advanced colorectal cancer. European Journal of Cancer 28:11, pages 1828-1832.
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Mikael J. Kajanti & Seppo O. Pyrh?nen. (1991) Phase II intravenous study of epirubicin with 5-fluorouracil in patients with advanced hepatocellular carcinoma. European Journal of Cancer and Clinical Oncology 27:12, pages 1620-1622.
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