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Acta Oncologica Volume 54, 2015 - Issue 4
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Original Article

Impact of regular aspirin use on overall and cancer-specific survival in patients with colorectal cancer harboring a PIK3CA mutation

Nishi KothariDepartment of Gastrointestinal Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, USA
,
Richard KimDepartment of Gastrointestinal Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, USA
,
Robert N. JorissenDivision of Systems Biology and Personalized Medicine, Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia;Faculty of Medicine, Dentistry and Health Sciences, Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia
,
Jayesh DesaiDivision of Systems Biology and Personalized Medicine, Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia;Department of Medical Oncology, The Royal Melbourne Hospital, Parkville, Victoria, Australia
,
Jeanne TieDivision of Systems Biology and Personalized Medicine, Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia;Department of Medical Oncology, The Royal Melbourne Hospital, Parkville, Victoria, Australia;Department of Medical Oncology, The Western Hospital, Footscray, Victoria, Australia
,
Hui-Li WongDivision of Systems Biology and Personalized Medicine, Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia;Department of Medical Oncology, The Royal Melbourne Hospital, Parkville, Victoria, Australia
,
Ian FarragherDepartment of Medical Oncology, The Western Hospital, Footscray, Victoria, Australia
,
Ian JonesDepartment of Medical Oncology, The Royal Melbourne Hospital, Parkville, Victoria, Australia
,
Fiona L. DayDivision of Systems Biology and Personalized Medicine, Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
,
Shan LiDivision of Systems Biology and Personalized Medicine, Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia;Faculty of Medicine, Dentistry and Health Sciences, Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia
,
Anuratha SakthinandeswarenDivision of Systems Biology and Personalized Medicine, Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia;Faculty of Medicine, Dentistry and Health Sciences, Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia
,
Michelle PalmieriDivision of Systems Biology and Personalized Medicine, Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia;Faculty of Medicine, Dentistry and Health Sciences, Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia
,
Lara LiptonDivision of Systems Biology and Personalized Medicine, Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia;Department of Medical Oncology, The Royal Melbourne Hospital, Parkville, Victoria, Australia;Department of Medical Oncology, The Western Hospital, Footscray, Victoria, Australia
,
Michael SchellDepartment of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center and Research Institute, Tampa, USA
,
Jamie K. TeerDepartment of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center and Research Institute, Tampa, USA
,
David ShibataDepartment of Gastrointestinal Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, USA;Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, USA
,
Timothy YeatmanOncology Research, Gibbs Cancer Center and Research Institute, Spartanburg, USA
,
Oliver M. SieberDivision of Systems Biology and Personalized Medicine, Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia;Faculty of Medicine, Dentistry and Health Sciences, Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia
,
Peter GibbsDivision of Systems Biology and Personalized Medicine, Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia;Department of Medical Oncology, The Royal Melbourne Hospital, Parkville, Victoria, Australia;Department of Medical Oncology, The Western Hospital, Footscray, Victoria, Australia;BioGrid Australia, Parkville, Victoria, Australia
&
Ben TranDivision of Systems Biology and Personalized Medicine, Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia;Department of Medical Oncology, The Royal Melbourne Hospital, Parkville, Victoria, Australia;Department of Medical Oncology, The Western Hospital, Footscray, Victoria, AustraliaCorrespondence[email protected]
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Pages 487-492 | Received 04 Oct 2014, Accepted 16 Nov 2014, Published online: 22 Mar 2015

Citations (37)

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Adrien Grancher, Pierre Michel, Frederic Di Fiore & David Sefrioui. (2022) Colorectal cancer chemoprevention: is aspirin still in the game?. Cancer Biology & Therapy 23:1, pages 446-461.
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Pieter-Jan Cuyle & Hans Prenen. (2017) Current and future biomarkers in the treatment of colorectal cancer. Acta Clinica Belgica 72:2, pages 103-115.
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Akihiro Nishi, Danny A Milner$suffix/text()$suffix/text(), Edward L Giovannucci, Reiko Nishihara, Andy S Tan, Ichiro Kawachi & Shuji Ogino. (2016) Integration of molecular pathology, epidemiology and social science for global precision medicine. Expert Review of Molecular Diagnostics 16:1, pages 11-23.
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Articles from other publishers (34)

Mehrnoosh Shahrivar, Caroline E. Weibull, Karin Ekström Smedby, Bengt Glimelius, Ingvar Syk, Peter Matthiessen, Caroline Nordenvall & Anna Martling. (2022) Low‐dose aspirin use and colorectal cancer survival in 32,195 patients—A national cohort study. Cancer Medicine 12:1, pages 315-324.
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Jennifer S. Davis, Janelle C. Chavez, Melissa Kok, Yazmin San Miguel, Hwa Young Lee, Henry Henderson, Michael J. Overman, Van Morris, Bryan Kee, David Fogelman, Shailesh M. Advani, Benny Johnson, Christine Parseghian, John Paul Shen, Arvind Dasari, Kenna R. Shaw, Eduardo Vilar, Kanwal P. Raghav, Imad Shureiqi, Robert A. Wolff, Funda Meric-Bernstam, Dipen Maru, David G. Menter, Scott Kopetz & Shine Chang. (2022) Association of Prediagnosis Obesity and Postdiagnosis Aspirin With Survival From Stage IV Colorectal Cancer. JAMA Network Open 5:10, pages e2236357.
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Johanna C. Mädge, Andreas Stallmach, Lisa Kleebusch & Peter Schlattmann. (2022) Meta-analysis of aspirin-guided therapy of colorectal cancer. Journal of Cancer Research and Clinical Oncology 148:6, pages 1407-1417.
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Mohammad‐Javad Sanaei, Ayda Baghery Saghchy Khorasani, Atieh Pourbagheri‐Sigaroodi, Shabnam Shahrokh, Mohammad Reza Zali & Davood Bashash. (2021) The PI3K/Akt/mTOR axis in colorectal cancer: Oncogenic alterations, non‐coding RNAs, therapeutic opportunities, and the emerging role of nanoparticles. Journal of Cellular Physiology 237:3, pages 1720-1752.
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Leonie Gebauer, Andrea Nist, Marco Mernberger, Thorsten Stiewe, Roland Moll, Kathleen Stabla, Uwe Klinge, Elisabeth Mack, Cornelia Brendel & Andreas Neubauer. (2021) Superior Overall Survival in Patients with Colorectal Cancer, Regular Aspirin Use, and Combined Wild-Type PIK3CA and KRAS-Mutated Tumors. Cancers 13:19, pages 4959.
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Shiyu Xiao, Wenhui Xie, Yihan Fan & Liya Zhou. (2021) Timing of Aspirin Use Among Patients With Colorectal Cancer in Relation to Mortality: A Systematic Review and Meta-Analysis. JNCI Cancer Spectrum 5:5.
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Jane C Figueiredo, Eric J Jacobs, Christina C Newton, Mark A Guinter, William G Cance & Peter T Campbell. (2021) Associations of Aspirin and Non-Aspirin Non-Steroidal Anti-Inflammatory Drugs With Colorectal Cancer Mortality After Diagnosis. JNCI: Journal of the National Cancer Institute 113:7, pages 833-840.
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Phu N. Tran & Jason A. Zell. 2019. Textbook of Gastrointestinal Oncology. Textbook of Gastrointestinal Oncology 509 532 .
Ronan T. Gray, Helen G. Coleman, Carmel Hughes, Liam J. Murray & Chris R. Cardwell. (2018) Low-dose aspirin use and survival in colorectal cancer: results from a population-based cohort study. BMC Cancer 18:1.
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Adrian Frick & Michaela Lang. (2018) Chemoprävention und Ernährungsfaktoren bei DarmkrebsChemoprevention and nutrition in colorectal cancer. Journal für Gastroenterologische und Hepatologische Erkrankungen 16:1, pages 9-20.
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Ronan T Gray, Marie M Cantwell, Helen G Coleman, Maurice B Loughrey, Peter Bankhead, Stephen McQuaid, Roisin F O'Neill, Kenneth Arthur, Victoria Bingham, Claire McGready, Anna T Gavin, Chris R Cardwell, Brian T Johnston, Jacqueline A James, Peter W Hamilton, Manuel Salto-Tellez & Liam J Murray. (2017) Evaluation of PTGS2 Expression, PIK3CA Mutation, Aspirin Use and Colon Cancer Survival in a Population-Based Cohort Study. Clinical and Translational Gastroenterology 8:4, pages e91.
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Antonia R. Sepulveda, Stanley R. HamiltonCarmen J. AllegraWayne GrodyAllison M. Cushman-VokounWilliam K. FunkhouserScott E. KopetzChristopher LieuNoralane M. LindorBruce D. MinskyFederico A. MonzonDaniel J. SargentVeena M. SinghJoseph WillisJennifer ClarkCarol ColasaccoR. Bryan RumbleRobyn Temple-SmolkinChristina B. VenturaJan A. Nowak. (2017) Molecular Biomarkers for the Evaluation of Colorectal Cancer. American Journal of Clinical Pathology 147:3, pages 221-260.
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Caitlin Murphy, Natalie Turner, Hui‐Li Wong, Mathu Sinnathamby, Jeanne Tie, Belinda Lee, Jayesh Desai, Iain Skinner, Michael Christie, Ryan Hutchinson, Sebastian Lunke, Paul Waring, Peter Gibbs & Ben Tran. (2017) Examining the impact of regular aspirin use and PIK3CA mutations on survival in stage 2 colon cancer . Internal Medicine Journal 47:1, pages 88-98.
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Z.B. Mei, C.Y. Duan, C.B. Li, L. Cui & S. Ogino. (2016) Prognostic role of tumor PIK3CA mutation in colorectal cancer: a systematic review and meta-analysis. Annals of Oncology 27:10, pages 1836-1848.
Crossref
Joshua C. Obuch & Dennis J. Ahnen. (2016) Colorectal Cancer. Gastroenterology Clinics of North America 45:3, pages 459-476.
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L. Paleari, M. Puntoni, M. Clavarezza, M. DeCensi, J. Cuzick & A. DeCensi. (2016) PIK3CA Mutation, Aspirin Use after Diagnosis and Survival of Colorectal Cancer. A Systematic Review and Meta-analysis of Epidemiological Studies. Clinical Oncology 28:5, pages 317-326.
Crossref
David A. Drew, Yin Cao & Andrew T. Chan. (2016) Aspirin and colorectal cancer: the promise of precision chemoprevention. Nature Reviews Cancer 16:3, pages 173-186.
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Paul J. Lochhead & Andrew T. Chan. 2016. NSAIDs and Aspirin. NSAIDs and Aspirin 219 240 .
Amikar Sehdev & Bert H. O’Neil. (2015) The Role of Aspirin, Vitamin D, Exercise, Diet, Statins, and Metformin in the Prevention and Treatment of Colorectal Cancer. Current Treatment Options in Oncology 16:9.
Crossref

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