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Connective Tissue Research Volume 42, 2001 - Issue 3
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Original Article

GDF-5 Deficiency in Mice Leads to Disruption of Tail Tendon Form and Function

Randall T. Clark Departments of Orthopaedic Surgery and Bioengineering, University of Virginia, Switzerland
,
Tiffany L. Johnson Departments of Orthopaedic Surgery and Bioengineering, University of Virginia, Switzerland
,
Benjamin J. Schalet Departments of Orthopaedic Surgery and Bioengineering, University of Virginia, Switzerland
,
Lonnie Davis Departments of Orthopaedic Surgery and Bioengineering, University of Virginia, Switzerland
,
Veronique Gaschen M.E. Mueller Institute for Biomechanics, Bern, Switzerland
,
Ernst B. Hunziker M.E. Mueller Institute for Biomechanics, Bern, Switzerland
,
Åke Oldberg Department of Cell & Molecular Biology, University of Lund, Sweden
&
Borjana Mikic Picker Engineering Program, Smith College, Northampton, MACorrespondence[email protected]
 show all
Pages 175-186 | Received 14 Nov 2000, Accepted 08 Feb 2001, Published online: 06 Aug 2009

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Lee-Chuan C. Yeh & John C. Lee. (2010) Effects of cartilage-derived morphogenetic protein-3 on the expression of chondrogenic and osteoblastic markers in the pluripotent mesenchymal C3H10T1/2 cell line. Growth Factors 28:2, pages 117-128.
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Articles from other publishers (54)

Yuki Yoshimoto & Yumiko Oishi. (2023) Mechanisms of skeletal muscle-tendon development and regeneration/healing as potential therapeutic targets. Pharmacology & Therapeutics 243, pages 108357.
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Richun Liu, Shichen Zhang & Xiao Chen. (2020) Injectable hydrogels for tendon and ligament tissue engineering. Journal of Tissue Engineering and Regenerative Medicine.
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Panayiotis T. Hadjicostas. 2018. The Anterior Cruciate Ligament. The Anterior Cruciate Ligament 73 77.e1 .
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Yang Liu, Chun-Wai Suen, Jin-fang Zhang & Gang Li. (2017) Current concepts on tenogenic differentiation and clinical applications. Journal of Orthopaedic Translation 9, pages 28-42.
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Kristen Howell, Chun Chien, Rebecca Bell, Damien Laudier, Sara F. Tufa, Douglas R. Keene, Nelly Andarawis-Puri & Alice H. Huang. (2017) Novel Model of Tendon Regeneration Reveals Distinct Cell Mechanisms Underlying Regenerative and Fibrotic Tendon Healing. Scientific Reports 7:1.
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Carolyn Holladay, Sunny-Akogwu Abbah, Colm O'Dowd, Abhay Pandit & Dimitrios I. Zeugolis. (2016) Preferential tendon stem cell response to growth factor supplementation. Journal of Tissue Engineering and Regenerative Medicine 10:9, pages 783-798.
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Alice H. Huang, Helen H. Lu & Ronen Schweitzer. (2015) Molecular regulation of tendon cell fate during development. Journal of Orthopaedic Research 33:6, pages 800-812.
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Geoffroy Nourissat, Francis Berenbaum & Delphine Duprez. (2015) Tendon injury: from biology to tendon repair. Nature Reviews Rheumatology 11:4, pages 223-233.
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Sys Hasslund, Tulin Dadali, Michael Ulrich-Vinther, Kjeld Søballe, Edward M Schwarz & Hani A Awad. (2014) Freeze-dried allograft-mediated gene or protein delivery of growth and differentiation factor 5 reduces reconstructed murine flexor tendon adhesions. Journal of Tissue Engineering 5, pages 204173141452873.
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O. A. Branford, B. R. Klass, A. O. Grobbelaar & K. J. Rolfe. (2013) The growth factors involved in flexor tendon repair and adhesion formation. Journal of Hand Surgery (European Volume) 39:1, pages 60-70.
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Tao WangBruce S. GardinerZhen LinJonas RubensonThomas B. KirkAllan WangJiake XuDavid W. SmithDavid G. LloydMing H. Zheng. (2013) Bioreactor Design for Tendon/Ligament Engineering. Tissue Engineering Part B: Reviews 19:2, pages 133-146.
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Karen Ruschke, Christian Hiepen, Jessica Becker & Petra Knaus. (2012) BMPs are mediators in tissue crosstalk of the regenerating musculoskeletal system. Cell and Tissue Research 347:3, pages 521-544.
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Scott A. Jelinsky, Li Li, Debra Ellis, Joanne Archambault, Jian Li, Michael St. Andre, Carl Morris & Howard Seeherman. (2011) Treatment with rhBMP12 or rhBMP13 increase the rate and the quality of rat Achilles tendon repair. Journal of Orthopaedic Research 29:10, pages 1604-1612.
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Macalus Hogan, Kesturu Girish, Roshan James, Gary Balian, Shepard Hurwitz & A. B. Chhabra. (2011) Growth differentiation factor-5 regulation of extracellular matrix gene expression in murine tendon fibroblasts. Journal of Tissue Engineering and Regenerative Medicine 5:3, pages 191-200.
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L. B. Sloane, J. T. Stout, D. J. Vandenbergh, G. P. Vogler, G. S. Gerhard & G. E. McClearn. (2010) Quantitative Trait Loci Analysis of Tail Tendon Break Time in Mice of C57BL/6J and DBA/2J Lineage. The Journals of Gerontology Series A: Biological Sciences and Medical Sciences 66A:2, pages 170-178.
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Borjana Mikic, Kerri Rossmeier & LouAnn Bierwert. (2009) Sexual dimorphism in the effect of GDF‐6 deficiency on murine tendon. Journal of Orthopaedic Research 27:12, pages 1603-1611.
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Liu Ou-yang, Yukun Zhang, Shuhua Yang, Shunan Ye & Weihua Xu. (2009) Effect of the gap junction blocker 1-heptanol on chondrogenic differentiation of mouse bone marrow mesenchymal stem cells in vitro. Journal of Nanjing Medical University 23:2, pages 117-121.
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Borjana Mikic, Kerri Rossmeier & Louann Bierwert. (2009) Identification of a Tendon Phenotype in GDF6 Deficient Mice. The Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology 292:3, pages 396-400.
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Charles C. Banos, Amelia H. Thomas & Catherine K. Kuo. (2008) Collagen fibrillogenesis in tendon development: Current models and regulation of fibril assembly. Birth Defects Research Part C: Embryo Today: Reviews 84:3, pages 228-244.
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Lee-Chuan C. Yeh, Alicia D. Tsai & John C. Lee. (2008) Bone morphogenetic protein-7 regulates differentially the mRNA expression of bone morphogenetic proteins and their receptors in rat achilles and patellar tendon cell cultures. Journal of Cellular Biochemistry 104:6, pages 2107-2122.
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Eugene Farng, Alfonso R. Urdaneta, David Barba, Sean Esmende & David R. McAllister. (2008) The Effects of GDF-5 and Uniaxial Strain on Mesenchymal Stem Cells in 3-D Culture. Clinical Orthopaedics and Related Research 466:8, pages 1930-1937.
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Pernilla Eliasson, Anna Fahlgren & Per Aspenberg. (2008) Mechanical Load and BMP Signaling During Tendon Repair: A Role for Follistatin?. Clinical Orthopaedics and Related Research 466:7, pages 1592-1597.
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Borjana Mikic, Rachel Entwistle, Kerri Rossmeier & LouAnn Bierwert. (2008) Effect of GDF‐7 deficiency on tail tendon phenotype in mice. Journal of Orthopaedic Research 26:6, pages 834-839.
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Patrick Basile, Tulin Dadali, Justin Jacobson, Sys Hasslund, Michael Ulrich-Vinther, Kjeld Søballe, Yasuhiko Nishio, M Hicham Drissi, Howard N Langstein, David J Mitten, Regis J O'Keefe, Edward M Schwarz & Hani A Awad. (2008) Freeze-dried Tendon Allografts as Tissue-engineering Scaffolds for Gdf5 Gene Delivery. Molecular Therapy 16:3, pages 466-473.
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Michael J. Angel, Nicholas A. Sgaglione & Daniel A. Grande. (2006) Clinical Applications of Bioactive Factors in Sports Medicine. Sports Medicine and Arthroscopy Review 14:3, pages 138-145.
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Vincent M. Wang, Trevor M. Banack, Christine W. Tsai, Evan L. Flatow & Karl J. Jepsen. (2006) Variability in tendon and knee joint biomechanics among inbred mouse strains. Journal of Orthopaedic Research 24:6, pages 1200-1207.
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Takehiko Yoshimoto, Matsuo Yamamoto, Hideshi Kadomatsu, Kenji Sakoda, Yutaka Yonamine & Yuichi Izumi. (2006) Recombinant human growth/differentiation factor-5 (rhGDF-5) induced bone formation in murine calvariae. Journal of Periodontal Research 41:2, pages 140-147.
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Borjana Mikic, LouAnn Bierwert & Danielle Tsou. (2006) Achilles Tendon characterization in GDF-7 deficient mice. Journal of Orthopaedic Research 24:4, pages 831-841.
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Toshiyuki Tashiro, Hisatada Hiraoka, Yasuko Ikeda, Toshiyuki Ohnuki, Ryuji Suzuki, Takahiro Ochi, Kozo Nakamura & Naoshi Fukui. (2005) Effect of GDF‐5 on ligament healing. Journal of Orthopaedic Research 24:1, pages 71-79.
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Todd C. Battaglia. (2005) GDF-5 deficiency alters stress–relaxation properties in mouse skin. Journal of Dermatological Science 39:3, pages 192-195.
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Samuel Tozer & Delphine Duprez. (2005) Tendon and ligament: Development, repair and disease. Birth Defects Research Part C: Embryo Today: Reviews 75:3, pages 226-236.
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Michael Lavagnino, Steven P. Arnoczky, Katherine Frank & Tao Tian. (2005) Collagen fibril diameter distribution does not reflect changes in the mechanical properties of in vitro stress-deprived tendons. Journal of Biomechanics 38:1, pages 69-75.
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Daniel H. Kim, Tae A. Jahng, Tsai-Sheng Fu, Ho-Yeol Zhang & Shannon A. Novak. (2004) Evaluation of HealosMP52 Osteoinductive Bone Graft for Instrumented Lumbar Intertransverse Process Fusion in Sheep. Spine 29:24, pages 2800-2808.
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Xiaowen Bai, Zhifeng Xiao, Yuqiong Pan, Jiang Hu, Jens Pohl, Jinhua Wen & Lingsong Li. (2004) Cartilage-derived morphogenetic protein-1 promotes the differentiation of mesenchymal stem cells into chondrocytes. Biochemical and Biophysical Research Communications 325:2, pages 453-460.
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Lee‐Chuan C. Yeh, Alicia D. Tsai, Michelle C. Zavala & John C. Lee. (2004) Cartilage‐derived morphogenetic proteins enhance the osteogenic protein‐1‐induced osteoblastic cell differentiation of C2C12 cells. Journal of Cellular Physiology 201:3, pages 401-408.
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Xudong Li, Brian M. Leo, Gina Beck, Gary Balian & Greg D. Anderson. (2004) Collagen and Proteoglycan Abnormalities in the GDF-5-Deficient Mice and Molecular Changes When Treating Disk Cells With Recombinant Growth Factor. Spine 29:20, pages 2229-2234.
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Z. Del Prete, S. Antoniucci, A.H. Hoffman & P. Grigg. (2004) Viscoelastic properties of skin in Mov-13 and Tsk mice. Journal of Biomechanics 37:10, pages 1491-1497.
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Craig D. Byron, James Borke, Jack Yu, David Pashley, Christopher J. Wingard & Mark Hamrick. (2004) Effects of increased muscle mass on mouse sagittal suture morphology and mechanics. The Anatomical Record 279A:1, pages 676-684.
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Paul S. Robinson, Tony W. Lin, Paul R. Reynolds, Kathleen A. Derwin, Renato V. Iozzo & Louis J. Soslowsky. (2004) Strain-Rate Sensitive Mechanical Properties of Tendon Fascicles From Mice With Genetically Engineered Alterations in Collagen and Decorin. Journal of Biomechanical Engineering 126:2, pages 252-257.
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Fr�d�rique Edom-Vovard & Delphine Duprez. (2004) Signals regulating tendon formation during chick embryonic development. Developmental Dynamics 229:3, pages 449-457.
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Cynthia M. Coleman, Grace A. Loredo, Cecilia W. Lo & Rocky S. Tuan. (2003) Correlation of GDF5 and connexin 43 mRNA expression during embryonic development. The Anatomical Record Part A: Discoveries in Molecular, Cellular, and Evolutionary Biology 275A:2, pages 1117-1121.
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A. Chhabra, D. Tsou, R. T. Clark, V. Gaschen, E. B. Hunziker & B. Mikic. (2006) GDF‐5 deficiency in mice delays Achilles tendon healing. Journal of Orthopaedic Research 21:5, pages 826-835.
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Cynthia M. Coleman & Rocky S. Tuan. (2003) Functional role of growth/differentiation factor 5 in chondrogenesis of limb mesenchymal cells. Mechanisms of Development 120:7, pages 823-836.
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B Mikic, T.C Battaglia, E.A Taylor & R.T Clark. (2002) The effect of growth/differentiation factor-5 deficiency on femoral composition and mechanical behavior in mice. Bone 30:5, pages 733-737.
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