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Original Article

GDF-5 Deficiency in Mice Leads to Disruption of Tail Tendon Form and Function

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Pages 175-186 | Received 14 Nov 2000, Accepted 08 Feb 2001, Published online: 06 Aug 2009

References

  • Wolfman N. M., Hattersley G., Cox K., Celeste A. J., Nelson R., Yamaji N., Dube J. L., DiBiasio-Smith E., Nove J., Song J. J., Wozney J. M., Rosen V. Ectopic induction of tendon and ligament in rats by growth/differentiation factors 5, 6, and 7, members of the TGF-β gene family. J Clin Invest 1997; 100(2)321–330
  • Lou J., Tu Y, Ludwig F. J., Zhang J. F., Manske P. R. Effect of bone morphogenetic protein-12 gene transfer on mesenchymal progenitor cells. Clin Orthop Rel Res 1999; 369: 333–339
  • Hotten G. C., Matsumoto T., Kimura M, Bechtold R. F., Kron R., Ohara T., Tanaka H., Satoh Y., Okazaki M., Shirai T., Pan H., Kawai S., Pohl J. S., Kudo A. Recombinant human growth/differentiation factor 5 stimulates mesenchyme aggregation and chondrogenesis responsible for the skeletal development of limbs. Growth Factors 1996; 12(1–2)65–74
  • Erlacher L., McCartney J., Piek E., Ten Dijke P., Yanagis-Hita M., Oppermann H., Luyten F. P. Cartilage-derived morphogenetic proteins and osteogenic protein-1 differentially regulate osteogenesis. J Bone Min Res 1998; 13(3)383–392
  • Aspenberg P., Forslund C. Enhanced tendon healing with GDF 5 and 6. Acta Orthop Stand 1999; 70(1)51–54
  • Tashiro T., Fukui N., Hiraoka H., Tanaka S., Oda H., Nakamura K., Fukuda S. Growth and differentiation factor-5 promotes the repair process of medial collateral ligaments in rats. Trans ORS 1999; 24: 301
  • Linkhart T. A., Mohan S., Baylink D. S. Growth factors in bone growth and repair: IGF. TGF-β, and BMP. Bone 1996; 19: 1S–12S
  • Konrath G. A., Chen D., Lock T., Goitz H. T., Watson J. T., Moed B. R., D'Ambrosio G. Outcomes following repair of quadriceps tendon rupture. J Orthopaedic Trauma 1998; 12: 273–279
  • Thomas J. T., Lin K., Nandedkar M., Camargo M., Cer-Venka J., Luyten F. P. A human chondrodysplasia due to a mutation in a TGF beta superfamily member. Nat Genet 1996; 12: 315–317
  • Thomas J. T., Kilpatrick M. W., Lin K., Erlacher L., Lem-Bessis P., Costa T., Tsipouras P. Disruption of human limb morphogenesis by a dominant negative mutation in CDMP1. Nat Genet 1997; 17: 58–64
  • Polinkovsky A., Robin N. H., Thomas J. T., Irons M., Lynn A., Goodman F. R., Reardon W., Kant S. G., Brunner H. G., van der Burgt I., Chitayat D., McGaughran J., Donnai D., Luyten F. P., Warman M. L. Mutations in CDMP1 cause autosomal dominant brachydactyly type C. Nat Genet 1997; 17: 18–19
  • Mikic B., Schalet B., Clark R., Gaschen V., Hunziker E. B. GDF-5 deficiency in mice alters the ultrastruc-ture, biomechanics, and composition of the Achilles tendon. Journal of Orthopaedic Research 2001; 19(3)365–371
  • Higgins K. A., Stout J. T., Heller D. A., Parker R. F. Individual variability in tail tendon fiber break time in three age cohorts of different strains of mice. Exper Ger-ontol 1991; 26: 467–477
  • Creemers L. B., Jansen D. C., van Veen Reurings A., van den Bos T., Everts V. Microassay for the assessment of low levels of Hydroxyproline. Biotechniques 1997; 22: 656–658
  • Farndale R. W., Buttle D. J., Barrett A. J. Improved quantitation and discrimination of sulphated gly-cosaminoglycans by use of dimethylmethylene blue. Bio-chemica et Biophysics Acta 1986; 883: 173–177
  • Kim Y. J., Sah R. L., Doong J. Y., Grodzinsky A. J. Fluorometric assay of DNA in cartilage explants using Hoechst 33258. Ana Biochem 1988; 174: 168–176
  • Larsson T., Sommarin Y., Paulsson M., Antonsson P., Hedbom E., Wendel M., Heinegard D. Cartilage matrix proteins. A basic 36-kDa protein with a restricted distribution to cartilage and bone. Journal of Biological Chemistry 1991; 266(30)20428–33
  • Svensson L., Aszodi A., Reinholt F. P., Fassler R., Heinegard D., Oldberg A. Fibromodulin-null mice have abnormal collagen fibrils, tissue organization, and altered lumican deposition in tendon. J Biol Chem 1999; 274: 9636–9647
  • Bradford M. M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 1976; 72: 248–254
  • Laemmli U. K. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 1970; 227: 680–685
  • Bowen B., Steinberg J., Laemmli U. K., Weintraub H. The detection of DNA-binding proteins by protein blotting. Nucleic Acids Res. 1980; 8: 1–20
  • Heinegard D., Larsson T., Sommarin Y, Franzén A., Paulsson M., Hedbom E. Two novel matrix proteins isolated from articular cartilage show wide distributions among connective tissues. J. Biol. Chem. 1986; 261: 13866–13872
  • Oldberg A., Antonsson P., Moses J., Fransson L-A. Amino-terminal deletions in the decorin core protein leads to the biosynthesis of proteoglycans with shorter gly-cosaminoglycan chains. FEBS letters 1996; 386: 29–32
  • Gunderson H. J. Notes on the estimation of the numerical density of arbitrary profiles: the edge effect. J Microsc 1977; 111: 219–223
  • Morein G., Goldgefter L., Kobyliansky E., Gold-schmidt-Nathan M., Nathan H. Changes in the mechanical properties of rat tail tendon during postnatal ontogensis. Anat Embryol 1978; 154: 121–124
  • Parry D. A.D., Barnes G. R.G., Craig A. S. A comparison of the size distribution of collagen fibrils in connective tissues as a function of age and a possible relation between fibril size distribution and mechanical properties. Proc R Soc Lond 1978; 203: 305–321
  • Derwin KA, Soslowsky LJ. A quantitative investigation of structure-function relationships in a tendon fascicle model. J Biomechanical Engineering 1999; 121: 598–604
  • Danielson K. G., Baribault H., Holmes D. F., Graham H., Kadler K. E., Iozzo R. V. Targeted disruption of decorin leads to abnormal collagen fibril morphology and skin fragility. J Cell Biol 1997; 136: 729–743, 1997
  • Vogel KG, Trotter JA. The effect of proteoglycans on the morphology of collagen fibrils formed in vitro. Collagen Relat. Res 1987; 7: 105–114
  • Hedbom E, Heinegard D. Binding of fibromodulin and decorin to separate sites on fibrillar collagens. J Biol Chem 1993; 268: 27307–12
  • Storm E. E., Kingsley D. M. GDF5 coordinates bone and joint formation during digit development. Dev Biol 1999; 209: 11–27
  • Storm E. E., Kingsley D. M. Joint patterning defects caused by single and double mutations in members of the bone morphogenetic protein (BMP) family. Development 1996; 122: 3969–3979
  • Aszodi A., Bateman JF., Hirsch E., Baranyi M., Hunziker EB., Hauser N., Bosze Z., Fassler R. Normal skeletal development of mice lacking matrilin 1: redundant function of matrilins in cartilage?. Molecular & Cellular Biology 1999; 19(11)7841–5
  • Spindler K. P., Imro A. K., Mayes C. E., Davidson J. M. Patellar tendon and anterior cruciate ligament have different mitogenic responses to platelet-derived growth factor and transforming growth factor beta. J Orthop Res 1996; 14: 542–546

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