621
Views
77
CrossRef citations to date
0
Altmetric
Research Article

The role of transforming growth factor beta isoforms in tendon-to-bone healing

, , , , &
Pages 87-98 | Received 21 Jan 2009, Accepted 31 Mar 2010, Published online: 08 Jul 2010

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (3)

B. Walia, T. M. Li, G. Crosio, A. M. Montero & A. H. Huang. (2022) Axin2-lineage cells contribute to neonatal tendon regeneration. Connective Tissue Research 63:5, pages 530-543.
Read now
Peng Zhang, Fei Han, Yunxia Li, Jiwu Chen, Tianwu Chen, Yunlong Zhi, Jia Jiang, Chao Lin, Shiyi Chen & Peng Zhao. (2016) Local delivery of controlled-release simvastatin to improve the biocompatibility of polyethylene terephthalate artificial ligaments for reconstruction of the anterior cruciate ligament. International Journal of Nanomedicine 11, pages 465-478.
Read now
Benjamin B Rothrauff & Rocky S Tuan. (2014) Cellular therapy in bone-tendon interface regeneration. Organogenesis 10:1, pages 13-28.
Read now

Articles from other publishers (74)

Hanyue Li, Shengyu Luo, Hongtao Li, Hongyu Pan, Li Jiang, Yixuan Chen, Hui Chen, Zhenhua Feng & Sen Li. (2023) From fetal tendon regeneration to adult therapeutic modalities: TGF-β3 in scarless healing. Regenerative Medicine.
Crossref
Li Jiang, Jingwei Lu, Yixuan Chen, Kexin Lyu, Longhai Long, Xiaoqiang Wang, Tianzhu Liu & Sen Li. (2023) Mesenchymal stem cells: An efficient cell therapy for tendon repair (Review). International Journal of Molecular Medicine 52:2.
Crossref
Scott M. Bolam, Mark F. ZhuKhoon S. LimSubhajit KonarMark H. OliverEmma BuckelsBrya G. MatthewsKaren E. CallonTim Woodfield, Josh WorkmanA. Paul MonkBrendan ColemanJillian Cornish, Jacob T. MunroDavid S. Musson. (2023) Combined Growth Factor Hydrogel Enhances Rotator Cuff Enthesis Healing in Rat But Not Sheep Model. Tissue Engineering Part A.
Crossref
Thomas J. Kremen, Brendan Y. Shi, Shannon Y. Wu, Oskar Sundberg, Varun Sriram, Won Kim, Dmitriy Sheyn, Karen M Lyons, Weiguang Wang, Charles E. McKenna & Ichiro Nishimura. (2023) Biologically‐Coupled Bisphosphonate Chaperones Effectively Deliver Molecules to the Site of Soft Tissue‐Bone Healing. Journal of Orthopaedic Research.
Crossref
Kaichi Ozone, Yuki Minegishi, Kei Takahata, Haruna Takahashi, Moe Yoneno, Shinya Hattori, Li Xianglan, Yuichiro Oka, Kenji Murata & Naohiko Kanemura. (2022) Eccentric contraction‐dominant exercise leads to molecular biological changes in enthesis and enthesopathy‐like morphological changes. Journal of Orthopaedic Research 41:3, pages 511-523.
Crossref
Qingsong Jiang, Liren Wang, Zhanhong Liu, Jinlei Su, Yajun Tang, Peijie Tan, Xiangdong Zhu, Kai Zhang, Xing Ma, Jia Jiang, Jinzhong Zhao, Hai Lin & Xingdong Zhang. (2023) Canine ACL reconstruction with an injectable hydroxyapatite/collagen paste for accelerated healing of tendon-bone interface. Bioactive Materials 20, pages 1-15.
Crossref
Chenhui Yang, Yuanjun Teng, Bin Geng, Hefang Xiao, Changshun Chen, Rongjin Chen, Fei Yang & Yayi Xia. (2023) Strategies for promoting tendon-bone healing: Current status and prospects. Frontiers in Bioengineering and Biotechnology 11.
Crossref
Xin Li, Yan Ren, Yueguang Xue, Yiming Zhang & Ying Liu. (2023) Nanofibrous scaffolds for the healing of the fibrocartilaginous enthesis: advances and prospects. Nanoscale Horizons.
Crossref
James B. CarrIIII & Scott A. Rodeo. 2023. Shoulder Arthroscopy. Shoulder Arthroscopy 33 53 .
Andrew Konopitski & Ajith Malige. 2022. Shoulder Surgery for RC Pathology, Arthropathy and Tumors. Shoulder Surgery for RC Pathology, Arthropathy and Tumors.
Mark Zhu, Mei Lin Tay, Khoon S. Lim, Scott M. Bolam, Donna Tuari, Karen Callon, Michael Dray, Jillian Cornish, Tim B.F. Woodfield, Jacob T. Munro, Brendan Coleman & David S. Musson. (2022) Novel Growth Factor Combination for Improving Rotator Cuff Repair: A Rat In Vivo Study. The American Journal of Sports Medicine 50:4, pages 1044-1053.
Crossref
Dong Hyun Kim, Jee Wook Yoon & Jong Pil Yoon. (2022) Current and Future Strategies to Enhance Healing at the Tendon-To-Bone Interface of a Rotator Cuff Tear. Journal of the Korean Orthopaedic Association 57:6, pages 457.
Crossref
Giuseppe Milano, Niccolò Vaisitti, Giuseppe Frizziero & Maristella F. Saccomanno. 2022. Fundamentals of the Shoulder. Fundamentals of the Shoulder 61 74 .
Nan Jiang, Mao Mao, Xiao Li, Weijie Zhang, Jiankang He & Dichen Li. (2021) Advanced biofabrication strategies for biomimetic composite scaffolds to regenerate ligament‐bone interface. Biosurface and Biotribology 7:4, pages 187-205.
Crossref
Helen L. Moser, Adam C. Abraham, Kristen Howell, Damien Laudier, Matthias A. Zumstein, Leesa M. Galatz & Alice H. Huang. (2020) Cell lineage tracing and functional assessment of supraspinatus tendon healing in an acute repair murine model. Journal of Orthopaedic Research 39:8, pages 1789-1799.
Crossref
Dan Wang, Xu Zhang, Shuting Huang, Yang Liu, Bruma Sai-chuen Fu, Kingston King-lun Mak, Anna Maria Blocki, Patrick Shu-hang Yung, Rocky S. Tuan & Dai Fei Elmer Ker. (2021) Engineering multi-tissue units for regenerative Medicine: Bone-tendon-muscle units of the rotator cuff. Biomaterials 272, pages 120789.
Crossref
Guanyin Chen, Wangqian Zhang, Kuo Zhang, Shuning Wang, Yuan Gao, Jintao Gu, Lei He, Weina Li, Cun Zhang, Wei Zhang, Meng Li, Qiang Hao & Yingqi Zhang. (2020) Hypoxia-Induced Mesenchymal Stem Cells Exhibit Stronger Tenogenic Differentiation Capacities and Promote Patellar Tendon Repair in Rabbits. Stem Cells International 2020, pages 1-16.
Crossref
Alexander Yu. Gerasimenko, Natalia N. Zhurbina, Nadezhda G. Cherepanova, Anna E. Semak, Vadim V. Zar, Yulia O. Fedorova, Elena M. Eganova, Alexander A. Pavlov, Dmitry V. Telyshev, Sergey V. Selishchev & Olga E. Glukhova. (2020) Frame Coating of Single-Walled Carbon Nanotubes in Collagen on PET Fibers for Artificial Joint Ligaments. International Journal of Molecular Sciences 21:17, pages 6163.
Crossref
Songya Huang, Xi Xiang, Li Qiu, Liyun Wang, Bihui Zhu, Ruiqian Guo & Xinyi Tang. (2020) Transfection of TGF-β shRNA by Using Ultrasound-targeted Microbubble Destruction to Inhibit the Early Adhesion Repair of Rats Wounded Achilles Tendon In vitro and In vivo. Current Gene Therapy 20:1, pages 71-81.
Crossref
Deepak A Kaji, Kristen L Howell, Zerina Balic, Dirk Hubmacher & Alice H Huang. (2020) Tgfβ signaling is required for tenocyte recruitment and functional neonatal tendon regeneration. eLife 9.
Crossref
Bo Han, Ian A. Jones, Zhi Yang, William Fang & C. Thomas VangsnessJr.Jr.. (2020) Repair of Rotator Cuff Tendon Defects in Aged Rats Using a Growth Factor Injectable Gel Scaffold. Arthroscopy: The Journal of Arthroscopic & Related Surgery 36:3, pages 629-637.
Crossref
Janin Reifenrath, Mathias Wellmann, Merle Kempfert, Nina Angrisani, Bastian Welke, Sarah Gniesmer, Andreas Kampmann, Henning Menzel & Elmar Willbold. (2020) TGF–β3 Loaded Electrospun Polycaprolacton Fibre Scaffolds for Rotator Cuff Tear Repair: An in Vivo Study in Rats. International Journal of Molecular Sciences 21:3, pages 1046.
Crossref
Isabel CalejoRaquel Costa-AlmeidaRui L. ReisManuela E. Gomes. (2019) Enthesis Tissue Engineering: Biological Requirements Meet at the Interface. Tissue Engineering Part B: Reviews 25:4, pages 330-356.
Crossref
Dimitrios Tsekes, Georgios Konstantopoulos, Wasim S. Khan, Daniel Rossouw, Mike Elvey & Jagwant Singh. (2019) Use of stem cells and growth factors in rotator cuff tendon repair. European Journal of Orthopaedic Surgery & Traumatology 29:4, pages 747-757.
Crossref
Spencer T. Bianco, Helen L. Moser, Leesa M. Galatz & Alice H. Huang. (2018) Biologics and stem cell‐based therapies for rotator cuff repair. Annals of the New York Academy of Sciences 1442:1, pages 35-47.
Crossref
Benjamin B. Rothrauff, Catherine A. Smith, Gerald A. Ferrer, João V. Novaretti, Thierry Pauyo, Tom Chao, David Hirsch, Mason F. Beaudry, Elmar Herbst, Rocky S. Tuan, Richard E. Debski & Volker Musahl. (2019) The effect of adipose-derived stem cells on enthesis healing after repair of acute and chronic massive rotator cuff tears in rats. Journal of Shoulder and Elbow Surgery 28:4, pages 654-664.
Crossref
Rhea S. Menon, Nicholas M. Wragg & Samantha L. Wilson. (2019) Rotator Cuff Repair Augmentation Using Osteoinductive Growth Factors. SN Comprehensive Clinical Medicine 1:4, pages 267-276.
Crossref
Xiaoning Li, Suphannee Pongkitwitoon, Hongbin Lu, Chang Lee, Richard Gelberman & Stavros Thomopoulos. (2019) CTGF induces tenogenic differentiation and proliferation of adipose‐derived stromal cells. Journal of Orthopaedic Research 37:3, pages 574-582.
Crossref
Sergei G. Kalinichenko, Natalya Yu Matveeva, Roman Ye Kostiv & Sergey S. Edranov. (2019) The topography and proliferative activity of cells immunoreactive to various growth factors in rat femoral bone tissues after experimental fracture and implantation of titanium implants with bioactive biodegradable coatings. Bio-Medical Materials and Engineering 30:1, pages 85-95.
Crossref
Kristi Hultman, Brandon J. Erickson, Meghan E. Bishop & Anthony A. Romeo. 2019. Rotator Cuff Across the Life Span. Rotator Cuff Across the Life Span 341 352 .
Xi XiangQianying Leng, Yuanjiao TangLiyun WangJianbo HuangYi Zhang & Li Qiu. (2018) Ultrasound-Targeted Microbubble Destruction Delivery of Insulin-Like Growth Factor 1 cDNA and Transforming Growth Factor Beta Short Hairpin RNA Enhances Tendon Regeneration and Inhibits Scar Formation In Vivo . Human Gene Therapy Clinical Development 29:4, pages 198-213.
Crossref
Jaydev Mistry, R. Frank Henn, Jennifer I. Etcheson, Chukwuweike U. Gwam, Nicole E. George & Ronald E. Delanois. (2018) Biologic Therapies as Adjunctive Treatments in Rotator Cuff Repair. JBJS Reviews 6:7, pages e1-e1.
Crossref
Jong Pil Yoon, Chang-Hwa Lee, Jae Wook Jung, Hyun-Joo Lee, Yong-Soo Lee, Ja-Yeon Kim, Ga Young Park, Jin Hyun Choi & Seok Won Chung. (2018) Sustained Delivery of Transforming Growth Factor β1 by Use of Absorbable Alginate Scaffold Enhances Rotator Cuff Healing in a Rabbit Model. The American Journal of Sports Medicine 46:6, pages 1441-1450.
Crossref
Mathew Baldwin, Sarah Snelling, Stephanie Dakin & Andrew Carr. (2018) Augmenting endogenous repair of soft tissues with nanofibre scaffolds. Journal of The Royal Society Interface 15:141, pages 20180019.
Crossref
Peter T. Jensen, Kate L. Lambertsen & Lars H. Frich. (2018) Assembly, maturation, and degradation of the supraspinatus enthesis. Journal of Shoulder and Elbow Surgery 27:4, pages 739-750.
Crossref
Ganesh Narayanan, Lakshmi S. Nair & Cato T. Laurencin. (2018) Regenerative Engineering of the Rotator Cuff of the Shoulder. ACS Biomaterials Science & Engineering 4:3, pages 751-786.
Crossref
Xiebo You, Yueqin Shen, Weihan Yu & Yaohua He. (2018) Enhancement of tendon‑bone healing following rotator cuff repair using hydroxyapatite with TGFβ1. Molecular Medicine Reports.
Crossref
Xiao Wang, Liang Xie, Janet Crane, Gehua Zhen, Fengfeng Li, Ping Yang, Manman Gao, Ruoxian Deng, Yiguo Wang, Xiaohua Jia, Cunyi Fan, Mei Wan & Xu Cao. (2018) Aberrant TGF-β activation in bone tendon insertion induces enthesopathy-like disease. Journal of Clinical Investigation 128:2, pages 846-860.
Crossref
Konstantinos Ditsios. (2017) Basic Science in Rotator Cuff Tears. MOJ Orthopedics & Rheumatology 9:4.
Crossref
Hitoshi Arimura, Chisa Shukunami, Takuya Tokunaga, Tatsuki Karasugi, Nobukazu Okamoto, Takuya Taniwaki, Hidetoshi Sakamoto, Hiroshi Mizuta & Yuji Hiraki. (2017) TGF-β1 Improves Biomechanical Strength by Extracellular Matrix Accumulation Without Increasing the Number of Tenogenic Lineage Cells in a Rat Rotator Cuff Repair Model. The American Journal of Sports Medicine 45:10, pages 2394-2404.
Crossref
Benjamin B. RothrauffThierry PauyoRichard E. DebskiMark W. RodoskyRocky S. TuanVolker Musahl. (2017) The Rotator Cuff Organ: Integrating Developmental Biology, Tissue Engineering, and Surgical Considerations to Treat Chronic Massive Rotator Cuff Tears. Tissue Engineering Part B: Reviews 23:4, pages 318-335.
Crossref
David Savin, Molly Meadows, Nikhil Verma & Brian Cole. (2017) Rotator Cuff Healing: Improving Biology. Operative Techniques in Sports Medicine 25:1, pages 34-40.
Crossref
Dimitrios Giotis, Ashkan Aryaei, Theofanis Vasilakakos & Nikolaos K. Paschos. (2017) Effectiveness of Biologic Factors in Shoulder Disorders. The Open Orthopaedics Journal 11:Suppl-1, M10, pages 163-182.
Crossref
Grace WaldenXin LiaoSimon DonellMike J. RaxworthyGraham P. RileyAram Saeed. (2017) A Clinical, Biological, and Biomaterials Perspective into Tendon Injuries and Regeneration. Tissue Engineering Part B: Reviews 23:1, pages 44-58.
Crossref
Johanna Buschmann & Gabriella Meier Bürgisser. 2017. Biomechanics of Tendons and Ligaments. Biomechanics of Tendons and Ligaments 301 317 .
Mohit N. Gilotra, Michael J. Shorofsky, Jason A. Stein & Anand M. Murthi. (2016) Healing of rotator cuff tendons using botulinum toxin A and immobilization in a rat model. BMC Musculoskeletal Disorders 17:1.
Crossref
Gabrielle Depr?s-tremblay, Anik Chevrier, Martyn Snow, Mark B. Hurtig, Scott Rodeo & Michael D. Buschmann. (2016) Rotator cuff repair: a review of surgical techniques, animal models, and new technologies under development. Journal of Shoulder and Elbow Surgery 25:12, pages 2078-2085.
Crossref
Jorge Díaz Heredia, M. A. Ruiz Iban, J. Martínez-Botas, M. Valencia Mora, A. Cuéllar Ayestaran, S. Moros Marco & R. Ruiz Díaz. (2016) Growth factor expression after supraspinatus tear: a quantitative polymerase chain reaction (PCR) study in rats. Archives of Orthopaedic and Trauma Surgery 136:11, pages 1563-1570.
Crossref
Alexander E. Weber, Ryan A. Mlynarek, Brian J. Cole & Asheesh Bedi. (2016) Overview on Small Molecule Biologic and Gene-Based Treatments in Sports Medicine. Operative Techniques in Orthopaedics 26:2, pages 62-67.
Crossref
Iain R. Murray, Robert F. LaPrade, Volker Musahl, Andrew G. Geeslin, Jason P. Zlotnicki, Barton J. Mann & Frank A. Petrigliano. (2016) Biologic Treatments for Sports Injuries II Think Tank—Current Concepts, Future Research, and Barriers to Advancement, Part 2. Orthopaedic Journal of Sports Medicine 4:3, pages 232596711663658.
Crossref
Nick Aresti, Wasim S. Khan & Atif A. Malik. 2016. Bone and Cartilage Regeneration. Bone and Cartilage Regeneration 265 275 .
Wenyong Fei & Weichun Guo. (2015) A biomechanical and histological comparison of the suture bridge and conventional double-row techniques of the repair of full-thickness rotator cuff tears in a rabbit model. BMC Musculoskeletal Disorders 16:1.
Crossref
Mohit Gilotra, Thao Nguyen, Matthew Christian, Derik Davis, R. Frank HennIIIIII & Syed Ashfaq Hasan. (2015) Botulinum toxin is detrimental to repair of a chronic rotator cuff tear in a rabbit model. Journal of Orthopaedic Research 33:8, pages 1152-1157.
Crossref
Nelly Andarawis‐Puri, Evan L. Flatow & Louis J. Soslowsky. (2015) Tendon basic science: Development, repair, regeneration, and healing. Journal of Orthopaedic Research 33:6, pages 780-784.
Crossref
Stavros Thomopoulos, William C. Parks, Daniel B. Rifkin & Kathleen A. Derwin. (2015) Mechanisms of tendon injury and repair. Journal of Orthopaedic Research 33:6, pages 832-839.
Crossref
MaCalus V. Hogan, Yohei Kawakami, Christopher D. Murawski & Freddie H. Fu. (2015) Tissue Engineering of Ligaments for Reconstructive Surgery. Arthroscopy: The Journal of Arthroscopic & Related Surgery 31:5, pages 971-979.
Crossref
Connor G. Ziegler, Cory Edgar, Mark Cote & Augustus D. Mazzocca. (2015) Biological Augmentation in Repair and Reconstruction of the Rotator Cuff. Operative Techniques in Sports Medicine 23:1, pages 2-10.
Crossref
Pietro Randelli, Alessandra Menon, Vincenza Ragone, Riccardo D’Ambrosi, Filippo Randelli, Paolo Cabitza & Giuseppe Banfi. 2015. Tendon Regeneration. Tendon Regeneration 205 221 .
Xiang Li, Jiankang He, Weiguo Bian, Zheng Li, Wenyou Zhang, Dichen Li & Jess G. Snedeker. (2014) A novel silk-based artificial ligament and tricalcium phosphate/polyether ether ketone anchor for anterior cruciate ligament reconstruction – Safety and efficacy in a porcine model. Acta Biomaterialia 10:8, pages 3696-3704.
Crossref
Nathan A. Mall, Miho J. Tanaka, Luke S. Choi & George A. Paletta. (2014) Factors Affecting Rotator Cuff Healing. Journal of Bone and Joint Surgery 96:9, pages 778-788.
Crossref
Kivanc Atesok, Freddie H. Fu, Megan R. Wolf, Mitsuo Ochi, Laith M. Jazrawi, M. Nedim Doral, James H. Lubowitz & Scott A. Rodeo. (2014) Augmentation of Tendon-to-Bone Healing. Journal of Bone and Joint Surgery 96:6, pages 513-521.
Crossref
Pietro Randelli, Filippo Randelli, Vincenza Ragone, Alessandra Menon, Riccardo D’Ambrosi, Davide Cucchi, Paolo Cabitza & Giuseppe Banfi. (2014) Regenerative Medicine in Rotator Cuff Injuries. BioMed Research International 2014, pages 1-9.
Crossref
Michael O. Schär & Scott A. Rodeo. 2014. Shoulder Arthroscopy. Shoulder Arthroscopy 59 72 .
Yulia Shwartz, Einat Blitz & Elazar Zelzer. (2013) One load to rule them all: Mechanical control of the musculoskeletal system in development and aging. Differentiation 86:3, pages 104-111.
Crossref
Pietro Randelli, Erika Conforti, Marco Piccoli, Vincenza Ragone, Pasquale Creo, Federica Cirillo, Pamela Masuzzo, Cristina Tringali, Paolo Cabitza, Guido Tettamanti, Nicoletta Gagliano, Luigi Anastasia, Sonia Bergante & Andrea Ghiroldi. (2013) Isolation and Characterization of 2 New Human Rotator Cuff and Long Head of Biceps Tendon Cells Possessing Stem Cell–Like Self-Renewal and Multipotential Differentiation Capacity. The American Journal of Sports Medicine 41:7, pages 1653-1664.
Crossref
Michael E. Angeline & Scott A. Rodeo. (2012) Biologics in the Management of Rotator Cuff Surgery. Clinics in Sports Medicine 31:4, pages 645-663.
Crossref
Pengfei He, Kian Siang Ng, Siew Lok Toh & James Cho Hong Goh. (2012) In Vitro Ligament–Bone Interface Regeneration Using a Trilineage Coculture System on a Hybrid Silk Scaffold. Biomacromolecules 13:9, pages 2692-2703.
Crossref
Bryan T. Leek, James P. Tasto, Lisa M. Tibor, Robert M. Healey, Anthony Freemont, Michael S. Linn, Derek E. Chase & David Amiel. (2012) Augmentation of Tendon Healing With Butyric Acid–Impregnated Sutures. The American Journal of Sports Medicine 40:8, pages 1762-1771.
Crossref
Christian Isaac, Burhan Gharaibeh, Michelle Witt, Vonda J. Wright & Johnny Huard. (2012) Biologic approaches to enhance rotator cuff healing after injury. Journal of Shoulder and Elbow Surgery 21:2, pages 181-190.
Crossref
Asheesh Bedi, Travis Maak, Christopher Walsh, Scott A. Rodeo, Dan Grande, David M. Dines & Joshua S. Dines. (2012) Cytokines in rotator cuff degeneration and repair. Journal of Shoulder and Elbow Surgery 21:2, pages 218-227.
Crossref
Lei-Yen Chen, Shu Wen Whu, Chih-Hwa Chen, Hsia-Wei Liu, Hsien-Tao Liu, Chih-Hsiang Chang, Ching-Lin Tsai, Shih-Hui Chen & Ging-Ho Hsiue. (2012) Single-layer periosteum progenitor cell sheet significantly promotes tendon–bone healing in comparison with acellular collagen sheet in anterior cruciate ligament reconstruction. Formosan Journal of Musculoskeletal Disorders 3:1, pages 1-8.
Crossref
Stavros Thomopoulos & Leesa M. Galatz. 2012. Tendon Surgery of the Hand. Tendon Surgery of the Hand 49 58 .
Lawrence V. Gulotta & Scott A. Rodeo. (2010) Emerging Ideas: Evaluation of Stem Cells Genetically Modified with Scleraxis to Improve Rotator Cuff Healing. Clinical Orthopaedics and Related Research® 469:10, pages 2977-2980.
Crossref
Amnon Sharir & Elazar Zelzer. (2011) Tendon Homeostasis: The Right Pull. Current Biology 21:12, pages R472-R474.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.