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Connective Tissue Research Volume 52, 2011 - Issue 2
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Research Article

Inactivation of SPARC enhances high-fat diet-induced obesity in mice

Jing Nie Hope Heart Program, Benaroya Research Institute at Virginia Mason, Seattle, Washington, USA
,
Amy D. Bradshaw Gazes Cardiac Research Institute, Medical University of South Carolina, Charleston, South Carolina, USA
,
Anne M. Delany Center for Molecular Medicine, University of Connecticut Health Center, Farmington, Connecticut, USA
&
E. Helene Sage Hope Heart Program, Benaroya Research Institute at Virginia Mason, Seattle, Washington, USACorrespondence[email protected]
Pages 99-108 | Received 19 Nov 2009, Accepted 04 Apr 2010, Published online: 08 Jul 2010

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Tae-Hwa Chun. (2012) Peri-adipocyte ECM remodeling in obesity and adipose tissue fibrosis. Adipocyte 1:2, pages 89-95.
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Catalina Atorrasagasti, Agostina M. Onorato & Guillermo Mazzolini. (2022) The role of SPARC (secreted protein acidic and rich in cysteine) in the pathogenesis of obesity, type 2 diabetes, and non-alcoholic fatty liver disease. Journal of Physiology and Biochemistry 79:4, pages 815-831.
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Archana Arjunan & Juhyun Song. (2023) Pharmacological and physiological roles of adipokines and myokines in metabolic-related dementia. Biomedicine & Pharmacotherapy 163, pages 114847.
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Abdelaziz Ghanemi, Mayumi Yoshioka & Jonny St-Amand. (2023) Secreted Protein Acidic and Rich in Cysteine (SPARC)—Mediated Exercise Effects: Illustrative Molecular Pathways against Various Diseases. Diseases 11:1, pages 33.
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Laetitia Coassolo, Niels Banhos Dannieskiold-Samsøe, Meng Zhao, Hobson Allen & Katrin J. Svensson. (2022) New players of the adipose secretome: Therapeutic opportunities and challenges. Current Opinion in Pharmacology 67, pages 102302.
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Yakun Ren, Hao Zhao, Chunyan Yin, Xi Lan, Litao Wu, Xiaojuan Du, Helen R. Griffiths & Dan Gao. (2022) Adipokines, Hepatokines and Myokines: Focus on Their Role and Molecular Mechanisms in Adipose Tissue Inflammation. Frontiers in Endocrinology 13.
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Abdelaziz Ghanemi, Aicha Melouane, Mayumi Yoshioka & Jonny St-Amand. (2022) Secreted Protein Acidic and Rich in Cysteine (Sparc) KO Leads to an Accelerated Ageing Phenotype Which Is Improved by Exercise Whereas SPARC Overexpression Mimics Exercise Effects in Mice. Metabolites 12:2, pages 125.
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Abdelaziz Ghanemi, Mayumi Yoshioka & Jonny St-Amand. (2021) Secreted Protein Acidic and Rich in Cysteine as A Regeneration Factor: Beyond the Tissue Repair. Life 11:1, pages 38.
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Abdelaziz Ghanemi, Aicha Melouane, Mayumi Yoshioka & Jonny St-Amand. (2020) Exercise Training of Secreted Protein Acidic and Rich in Cysteine (Sparc) KO Mice Suggests That Exercise-Induced Muscle Phenotype Changes Are SPARC-Dependent. Applied Sciences 10:24, pages 9108.
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Li Hu, Fengli He, Meifeng Huang, Qian Zhao, Lamei Cheng, Neveen Said, Zhiguang Zhou, Feng Liu & Yan-Shan Dai. (2020) SPARC promotes insulin secretion through down-regulation of RGS4 protein in pancreatic β cells. Scientific Reports 10:1.
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Sulagna Mukherjee, Min Ji Choi, Sang Woo Kim & Jong Won Yun. (2020) Secreted protein acidic and rich in cysteine (SPARC) regulates thermogenesis in white and brown adipocytes. Molecular and Cellular Endocrinology 506, pages 110757.
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Abdelaziz Ghanemi, Aicha Melouane, Mayumi Yoshioka & Jonny St-Amand. (2019) Secreted protein acidic and rich in cysteine and bioenergetics: Extracellular matrix, adipocytes remodeling and skeletal muscle metabolism. The International Journal of Biochemistry & Cell Biology 117, pages 105627.
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Yu-Han Hung, Matt Kanke, Catherine Lisa Kurtz, Rebecca L. Cubitt, Rodica P. Bunaciu, Liye Zhou, Phillip J. White, Kasey C. Vickers, Mohammed Mahmood Hussain, Xiaoling Li & Praveen Sethupathy. (2019) MiR-29 Regulates de novo Lipogenesis in the Liver and Circulating Triglyceride Levels in a Sirt1-Dependent Manner. Frontiers in Physiology 10.
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Bincy John, Christine Naczki, Chirayu Patel, Alia Ghoneum, Shadi Qasem, Ziyan Salih & Neveen Said. (2019) Regulation of the bi-directional cross-talk between ovarian cancer cells and adipocytes by SPARC. Oncogene 38:22, pages 4366-4383.
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Catalina Atorrasagasti, Agostina Onorato, María L. Gimeno, Luz Andreone, Mariana Garcia, Mariana Malvicini, Esteban Fiore, Juan Bayo, Marcelo J. Perone & Guillermo D. Mazzolini. (2019) SPARC is required for the maintenance of glucose homeostasis and insulin secretion in mice. Clinical Science 133:2, pages 351-365.
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Haiyan Song, Lei Ding, Shuang Zhang & Wei Wang. (2018) MiR-29 family members interact with SPARC to regulate glucose metabolism. Biochemical and Biophysical Research Communications 497:2, pages 667-674.
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Guillermo Mazzolini, Catalina Atorrasagasti, Agostina Onorato, Estanislao Peixoto, Martin Schlattjan, Jan-Peter Sowa, Svenja Sydor, Guido Gerken & Ali Canbay. (2018) SPARC expression is associated with hepatic injury in rodents and humans with non-alcoholic fatty liver disease. Scientific Reports 8:1.
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Alexandre Chlenski, Marija Dobratic, Helen R. Salwen, Mark Applebaum, Lisa J. Guerrero, Ryan Miller, Gillian DeWane, Elena Solomaha, Jeremy D. Marks & Susan L. Cohn. (2016) Secreted protein acidic and rich in cysteine (SPARC) induces lipotoxicity in neuroblastoma by regulating transport of albumin complexed with fatty acids. Oncotarget 7:47, pages 77696-77706.
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Neveen Said. (2016) Roles of SPARC in urothelial carcinogenesis, progression and metastasis. Oncotarget 7:41, pages 67574-67585.
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Wojciech Blogowski, Katarzyna Dolegowska, Anna Deskur, Barbara Dolegowska & Teresa Starzyńska. (2015) An Attempt to Evaluate Selected Aspects of “Bone–Fat Axis” Function in Healthy Individuals and Patients With Pancreatic Cancer. Medicine 94:32, pages e1303.
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Gabriel Martinez-Santibañez & Carey Nien-Kai Lumeng. (2014) Macrophages and the Regulation of Adipose Tissue Remodeling. Annual Review of Nutrition 34:1, pages 57-76.
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S.H. Lee, J.A. Lee, H.S. Park, Y.S. Song, Y.J. Jang, J.H. Kim, Y.J. Lee & Y. Heo. (2013) Associations among SPARC mRNA expression in adipose tissue, serum SPARC concentration and metabolic parameters in Korean women. Obesity 21:11, pages 2296-2302.
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Cheryl L. Ackert-Bicknell & David Karasik. (2013) Impact of the Environment on the Skeleton: Is it Modulated by Genetic Factors?. Current Osteoporosis Reports 11:3, pages 219-228.
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Lorna W. Harries, Laura J. McCulloch, Janet E. Holley, Thomas J. Rawling, Hannah J. Welters & Katarina Kos. (2013) A Role for SPARC in the Moderation of Human Insulin Secretion. PLoS ONE 8:6, pages e68253.
Crossref
Neveen Said, Henry F. Frierson, Marta Sanchez-Carbayo, Rolf A. Brekken & Dan Theodorescu. (2013) Loss of SPARC in bladder cancer enhances carcinogenesis and progression. Journal of Clinical Investigation.
Crossref
Ilse Scroyen & H. Roger Lijnen. 2013. Angiogenesis in Adipose Tissue. Angiogenesis in Adipose Tissue 297 317 .
Nikolaos G. Frangogiannis. (2012) Matricellular Proteins in Cardiac Adaptation and Disease. Physiological Reviews 92:2, pages 635-688.
Crossref

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