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Review Article

Potential role of UGT pharmacogenetics in cancer treatment and prevention: focus on tamoxifen and aromatase inhibitors

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Pages 182-194 | Published online: 12 Oct 2009

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Read on this site (9)

Siyu Ding, Siyu Liu, Yaxuan Chen, Ying Peng & Jiang Zheng. (2022) Anastrozole and related glucuronic acid conjugate are electrophilic species. Xenobiotica 52:4, pages 380-388.
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Adrienne E. Borrie & Richard B. Kim. (2017) Molecular basis of aromatase inhibitor associated arthralgia: known and potential candidate genes and associated biomarkers. Expert Opinion on Drug Metabolism & Toxicology 13:2, pages 149-156.
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Xupeng Bai, Yibei Chen, Xiangyu Hou, Min Huang & Jing Jin. (2016) Emerging role of NRF2 in chemoresistance by regulating drug-metabolizing enzymes and efflux transporters. Drug Metabolism Reviews 48:4, pages 541-567.
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Xiaoman Liu, Siew-Kee Low & Alan V. Boddy. (2016) The implications of genetic variation for the pharmacokinetics and pharmacodynamics of aromatase inhibitors. Expert Opinion on Drug Metabolism & Toxicology 12:8, pages 851-863.
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Douglas F. Dluzen & Philip Lazarus. (2015) MicroRNA regulation of the major drug-metabolizing enzymes and related transcription factors. Drug Metabolism Reviews 47:3, pages 320-334.
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Helena Joyce, Andrew McCann, Martin Clynes & Annemarie Larkin. (2015) Influence of multidrug resistance and drug transport proteins on chemotherapy drug metabolism. Expert Opinion on Drug Metabolism & Toxicology 11:5, pages 795-809.
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Pilar H Saladores, Jana C Precht, Werner Schroth, Hiltrud Brauch & Matthias Schwab. (2013) Impact of metabolizing enzymes on drug response of endocrine therapy in breast cancer. Expert Review of Molecular Diagnostics 13:4, pages 349-365.
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Abdullah Turkistani & Sharon Marsh. (2012) Pharmacogenomics of third-generation aromatase inhibitors. Expert Opinion on Pharmacotherapy 13:9, pages 1299-1307.
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William R Miller. (2010) Aromatase inhibitors: prediction of response and nature of resistance. Expert Opinion on Pharmacotherapy 11:11, pages 1873-1887.
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Articles from other publishers (22)

Yuanhuang Chen, Lauren A. Marcath, Finn Magnus Eliassen, Tone Hoel Lende, Havard Soiland, Gunnar Mellgren, Thomas Helland & Daniel Louis Hertz. (2021) Effect of Genetic Variability in 20 Pharmacogenes on Concentrations of Tamoxifen and Its Metabolites. Journal of Personalized Medicine 11:6, pages 507.
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Thomas Helland, Sarah Alsomairy, Chenchia Lin, Håvard Søiland, Gunnar Mellgren & Daniel Louis Hertz. (2021) Generating a Precision Endoxifen Prediction Algorithm to Advance Personalized Tamoxifen Treatment in Patients with Breast Cancer. Journal of Personalized Medicine 11:3, pages 201.
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Vikki Ho, Romain Pasquet, Shaman Luo, Gang Chen, Paul Goss, Dongsheng Tu, Philip Lazarus & Harriet Richardson. (2020) Variation in the UGT2B17 genotype, exemestane metabolism and menopause-related toxicities in the CCTG MAP.3 trial. Breast Cancer Research and Treatment 183:3, pages 705-716.
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Kristina Bojanic, Lucija Kuna, Ines Bilic Curcic, Jasenka Wagner, Robert Smolic, Kristina Kralik, Tomislav Kizivat, Gordana Ivanac, Aleksandar Vcev, George Y. Wu & Martina Smolic. (2020) Representation of CYP3A4, CYP3A5 and UGT1A4 Polymorphisms within Croatian Breast Cancer Patients’ Population. International Journal of Environmental Research and Public Health 17:10, pages 3692.
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Yehui Zhu, Theresa A. Koleck, Catherine M. Bender & Yvette P. Conley. (2019) Genetic Underpinnings of Musculoskeletal Pain During Treatment With Aromatase Inhibitors for Breast Cancer: A Biological Pathway Analysis. Biological Research For Nursing 22:2, pages 263-276.
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Harriet Johansson, Valentina Aristarco, Sara Gandini, Jennifer Gjerde, Debora Macis, Aliana Guerrieri-Gonzaga, Davide Serrano, Matteo Lazzeroni, Agnita Rajasekaran, Clark V Williard, Gunnar Mellgren, Andrea DeCensi & Bernardo Bonanni. (2019) Prognostic impact of genetic variants of CYP19A1 and UGT2B17 in a randomized trial for endocrine-responsive postmenopausal breast cancer. The Pharmacogenomics Journal 20:1, pages 19-26.
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Laith N. AL-Eitan, Doaa M. Rababa’h, Mansour A. Alghamdi & Rame H. Khasawneh. (2019) Association between ESR1, ESR2, HER2, UGT1A4, and UGT2B7 polymorphisms and breast Cancer in Jordan: a case-control study. BMC Cancer 19:1.
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Merel van Nuland, Hilde Rosing, Alwin D. R. Huitema & Jos H. Beijnen. (2019) Predictive Value of Microdose Pharmacokinetics. Clinical Pharmacokinetics 58:10, pages 1221-1236.
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Jiangying Chen, Jialang Zhuang, Jingguo Wu, Xiaoyan Chen, Xueding Wang, Lihui Huang, Guixiong Zeng, Jie Chen, Xiaoxing Liao, Xiao Chen, Zhongfu Ma, Guoping Zhong, Min Huang, Dafang Zhong & Xianglan Zhao. (2018) Bioequivalence of Oral Formulations of Anastrozole in Healthy Chinese Male Volunteers: A Randomized, Single‐Dose, Two‐Period, Two‐Sequence Crossover Study. Clinical Pharmacology in Drug Development 8:2, pages 217-222.
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Murtala B. Abubakar, Huay Lin Tan, Venkata Murali Krishna Bhavaraju & Siew Hua Gan. (2019) Impact of CYP3A4 and CYP3A5 single nucleotide polymorphisms on anastrozole-associated adverse events among Malaysian breast cancer patients. Asia Pacific Journal of Molecular Biology and Biotechnology, pages 33-42.
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Murtala B. Abubakar, Keat Wei & Siew Hua Gan. (2014) The influence of genetic polymorphisms on the efficacy and side effects of anastrozole in postmenopausal breast cancer patients. Pharmacogenetics and Genomics 24:12, pages 575-581.
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Aleksandra K. Greer, Centdrika R. Dates, Athena Starlard-Davenport, Vineetha K. Edavana, Stacie M. Bratton, Ishwori B. Dhakal, Moshe Finel, Susan A. Kadlubar & Anna Radominska-Pandya. (2014) A Potential Role for Human UDP-Glucuronosyltransferase 1A4 Promoter Single Nucleotide Polymorphisms in the Pharmacogenomics of Tamoxifen and Its Derivatives. Drug Metabolism and Disposition 42:9, pages 1392-1400.
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Jana C. Precht, Werner Schroth, Kathrin Klein, Hiltrud Brauch, Evgeny Krynetskiy, Matthias Schwab & Thomas E. Mürdter. (2013) The Letrozole Phase 1 Metabolite Carbinol as a Novel Probe Drug for UGT2B7. Drug Metabolism and Disposition 41:11, pages 1906-1913.
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Vineetha Koroth Edavana, Ishwori B. Dhakal, Suzanne Williams, Rosalind Penney, Gunnar Boysen, Aiwei Yao-Borengasser & Susan Kadlubar. (2013) Potential Role of UGT1A4 Promoter SNPs in Anastrozole Pharmacogenomics . Drug Metabolism and Disposition 41:4, pages 870-877.
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Barbara Fedejko-Kap, Stacie M. Bratton, Moshe Finel, Anna Radominska-Pandya & Zofia Mazerska. (2012) Role of Human UDP-Glucuronosyltransferases in the Biotransformation of the Triazoloacridinone and Imidazoacridinone Antitumor Agents C-1305 and C-1311: Highly Selective Substrates for UGT1A10. Drug Metabolism and Disposition 40:9, pages 1736-1743.
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Baojian Wu, Xiaoqiang Wang, Shuxing Zhang & Ming Hu. (2012) Accurate Prediction of Glucuronidation of Structurally Diverse Phenolics by Human UGT1A9 Using Combined Experimental and In Silico Approaches. Pharmaceutical Research 29:6, pages 1544-1561.
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Matthias Schwab, Elke Schaeffeler & Hiltrud Brauch. 2012. Metabolism of Drugs and Other Xenobiotics. Metabolism of Drugs and Other Xenobiotics 365 378 .
Jana C. Precht, Boian Ganchev, Georg Heinkele, Hiltrud Brauch, Matthias Schwab & Thomas E. Mürdter. (2012) Simultaneous quantitative analysis of letrozole, its carbinol metabolite, and carbinol glucuronide in human plasma by LC-MS/MS. Analytical and Bioanalytical Chemistry 403:1, pages 301-308.
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Landry K. Kamdem, Yong Liu, Vered Stearns, Susan A. Kadlubar, Jacqueline Ramirez, Stacie Jeter, Karineh Shahverdi, Bryan A. Ward, Evan Ogburn, Mark J. Ratain, David A. Flockhart & Zeruesenay Desta. (2010) In vitro and in vivo oxidative metabolism and glucuronidation of anastrozole. British Journal of Clinical Pharmacology 70:6, pages 854-869.
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Hiroshi Hirata, Yuji Hinoda, Mohd S. Zaman, Yi Chen, Koji Ueno, Shahana Majid, Christina Tripsas, Mary Rubin, Lee-may Chen & Rajvir Dahiya. (2010) Function of UDP-glucuronosyltransferase 2B17 (UGT2B17) is involved in endometrial cancer. Carcinogenesis 31:9, pages 1620-1626.
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Roisin Connolly & Vered Stearns. (2010) Pharmacogenetics of Aromatase Inhibitors: Present Understanding and Looking to the Future. Current Breast Cancer Reports 2:3, pages 138-145.
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Jacqueline RamírezMark J RatainFederico Innocenti. (2010) Uridine 5´-diphospho-glucuronosyltransferase genetic polymorphisms and response to cancer chemotherapy. Future Oncology 6:4, pages 563-585.
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