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Jun Wang, Gizem Keceli, Rui Cao, Jiangtao Su & Zhiyuan Mi. (2017) Molybdenum-containing nitrite reductases: Spectroscopic characterization and redox mechanism. Redox Report 22:1, pages 17-25.
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Danilo Froriep, Bernd Clement, Florian Bittner, Ralf R. Mendel, Debora Reichmann, Wolfgang Schmalix & Antje Havemeyer. (2013) Activation of the anti-cancer agent upamostat by the mARC enzyme system. Xenobiotica 43:9, pages 780-784.
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. (2012) Speaker abstracts. Drug Metabolism Reviews 44:sup1, pages 6-28.
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Articles from other publishers (53)
Simone Giovannuzzi. 2024. Metalloenzymes. Metalloenzymes
557
580
.
Sharon J. Nieter Burgmayer & Martin L. Kirk. (2023) Advancing Our Understanding of Pyranopterin-Dithiolene Contributions to Moco Enzyme Catalysis. Molecules 28:22, pages 7456.
Crossref
Crossref
Michel A. Struwe, Axel J. Scheidig & Bernd Clement. (2023) The mitochondrial amidoxime reducing component—from prodrug-activation mechanism to drug-metabolizing enzyme and onward to drug target. Journal of Biological Chemistry 299:11, pages 105306.
Crossref
Crossref
Lara C. Lewis, Lingyan Chen, L. Shahul Hameed, Robert R. Kitchen, Cyrielle Maroteau, Shilpa R. Nagarajan, Jenny Norlin, Charlotte E. Daly, Iwona Szczerbinska, Sara Toftegaard Hjuler, Rahul Patel, Eilidh J. Livingstone, Tom N. Durrant, Elisabeth Wondimu, Soumik BasuRay, Anandhakumar Chandran, Wan-Hung Lee, Sile Hu, Barak Gilboa, Megan E. Grandi, Enrique M. Toledo, Abdullah H.A. Erikat, Leanne Hodson, William G. Haynes, Natalie W. Pursell, Ken Coppieters, Jan Fleckner, Joanna M.M. Howson, Birgitte Andersen & Maxwell A. Ruby. (2023) Hepatocyte mARC1 promotes fatty liver disease. JHEP Reports 5:5, pages 100693.
Crossref
Crossref
Jing Yang, Michel Struwe, Axel Scheidig, Joshua Mengell, Bernd Clement & Martin L. Kirk. (2023)
Active Site Structures of the
Escherichia coli
N
-Hydroxylaminopurine Resistance Molybdoenzyme YcbX
. Inorganic Chemistry 62:14, pages 5315-5319.
Crossref
Crossref
Emre M. Isin. (2023) Unusual Biotransformation Reactions of Drugs and Drug Candidates. Drug Metabolism and Disposition 51:4, pages 413-426.
Crossref
Crossref
Joan Zapiter, Jeffrey R. Harmer, Michel Struwe, Axel Scheidig, Bernd Clement & Paul V. Bernhardt. (2022)
Enzyme Electrode Biosensors for
N
-Hydroxylated Prodrugs Incorporating the Mitochondrial Amidoxime Reducing Component
. Analytical Chemistry 94:25, pages 9208-9215.
Crossref
Crossref
Deepak Ahire, Abdul Basit, Lisa J. Christopher, Ramaswamy Iyer, J. Steven Leeder & Bhagwat Prasad. (2022) Interindividual Variability and Differential Tissue Abundance of Mitochondrial Amidoxime Reducing Component Enzymes in Humans. Drug Metabolism and Disposition 50:3, pages 191-196.
Crossref
Crossref
Palraj Kalimuthu, Jeffrey R. Harmer, Milena Baldauf, Ahmed H. Hassan, Tobias Kruse & Paul V. Bernhardt. (2022) Electrochemically driven catalysis of the bacterial molybdenum enzyme YiiM. Biochimica et Biophysica Acta (BBA) - Bioenergetics 1863:3, pages 148523.
Crossref
Crossref
Dehai Wu, Shuhang Liang, Hongrui Guo, Shugeng Zhang, Guangchao Yang, Yubin Yuan & Lianxin Liu. (2022) Downregulation of MARC2 Promotes Immune Escape and Is Associated With Immunosuppression of Hepatocellular Carcinoma. Frontiers in Genetics 12.
Crossref
Crossref
Teng Wang, Chun-yi Lyu, Yue-hua Jiang, Xue-yan Dong, Yan Wang, Zong-hong Li, Jin-xin Wang & Rui-rong Xu. (2020) A drug–biomarker interaction model to predict the key targets of Scutellaria barbata D. Don in adverse-risk acute myeloid leukaemia. Molecular Diversity 25:4, pages 2351-2365.
Crossref
Crossref
Simon J. Mayr, Ralf-R. Mendel & Guenter Schwarz. (2021) Molybdenum cofactor biology, evolution and deficiency. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1868:1, pages 118883.
Crossref
Crossref
Laura J. Ingersol & Martin L. Kirk. 2021. Comprehensive Coordination Chemistry III. Comprehensive Coordination Chemistry III
790
811
.
Cristina Maccallini, Lisa Marinelli, Patrick Indorf, Ivana Cacciatore, Marialuigia Fantacuzzi, Bernd Clement, Antonio Di Stefano & Rosa Amoroso. (2020) A Novel Prodrug of a nNOS Inhibitor with Improved Pharmacokinetic Potential. ChemMedChem 15:22, pages 2157-2163.
Crossref
Crossref
Sophia Rixen, Antje Havemeyer, Anita Tyl-Bielicka, Kazimiera Pysniak, Marta Gajewska, Maria Kulecka, Jerzy Ostrowski, Michal Mikula & Bernd Clement. (2019) Mitochondrial amidoxime-reducing component 2 (MARC2) has a significant role in N-reductive activity and energy metabolism. Journal of Biological Chemistry 294:46, pages 17593-17602.
Crossref
Crossref
Olivier Berger, Stéphanie Ortial, Sharon Wein, Séverine Denoyelle, Françoise Bressolle, Thierry Durand, Roger Escale, Henri J. Vial & Yen Vo-Hoang. (2019) Evaluation of amidoxime derivatives as prodrug candidates of potent bis-cationic antimalarials. Bioorganic & Medicinal Chemistry Letters 29:16, pages 2203-2207.
Crossref
Crossref
Christian KubitzaFlorian BittnerCarsten Ginsel, Antje Havemeyer, Bernd Clement & Axel J. Scheidig. (2018) Crystal structure of human mARC1 reveals its exceptional position among eukaryotic molybdenum enzymes. Proceedings of the National Academy of Sciences 115:47, pages 11958-11963.
Crossref
Crossref
Jennifer Schneider, Ulrich Girreser, Antje Havemeyer, Florian Bittner & Bernd Clement. (2018)
Detoxification of Trimethylamine
N
-Oxide by the Mitochondrial Amidoxime Reducing Component mARC
. Chemical Research in Toxicology 31:6, pages 447-453.
Crossref
Crossref
Gianpiero Vigani & Marc Hanikenne. 2018. Annual Plant Reviews online. Annual Plant Reviews online
111
142
.
Klaudia Konikowska & Anna Mandecka. 2018. Recent Advances in Trace Elements. Recent Advances in Trace Elements
339
372
.
Byeol Namgung, Jee-Hyeon Kim, Wan Seok Song & Sung-il Yoon. (2018) Crystal structure of the hydroxylaminopurine resistance protein, YiiM, and its putative molybdenum cofactor-binding catalytic site. Scientific Reports 8:1.
Crossref
Crossref
Gianpiero Vigani & Marc Hanikenne. 2018. Annual Plant Reviews, Volume 50. Annual Plant Reviews, Volume 50
111
142
.
J.Y. Cui & C.Y. Li. 2018. Comprehensive Toxicology. Comprehensive Toxicology
168
214
.
Luisa B. Maia & José J.G. Moura. 2018. Reference Module in Chemistry, Molecular Sciences and Chemical Engineering. Reference Module in Chemistry, Molecular Sciences and Chemical Engineering.
Yosef Dror & Felicia Stern. 2018. Trace Elements and Minerals in Health and Longevity. Trace Elements and Minerals in Health and Longevity
179
207
.
Angel Llamas, Alejandro Chamizo-Ampudia, Manuel Tejada-Jimenez, Aurora Galvan & Emilio Fernandez. (2017) The molybdenum cofactor enzyme mARC: Moonlighting or promiscuous enzyme?. BioFactors 43:4, pages 486-494.
Crossref
Crossref
Shi-yu Qin, Xue-cheng Sun, Cheng-xiao Hu, Qi-ling Tan & Xiao-hu Zhao. (2017) Uptake, transport and distribution of molybdenum in two oilseed rape (Brassica napus L.) cultivars under different nitrate/ammonium ratios不同NO3
−:NH4
+比对两种甘蓝型油菜钼吸收、转 运和分布的影响. Journal of Zhejiang University-SCIENCE B 18:6, pages 512-521.
Crossref
Crossref
L.D. Smith & U. Garg. 2017. Biomarkers in Inborn Errors of Metabolism. Biomarkers in Inborn Errors of Metabolism
399
426
.
Abdel A. Belaidi & Guenter Schwarz. 2017. Molecular, Genetic, and Nutritional Aspects of Major and Trace Minerals. Molecular, Genetic, and Nutritional Aspects of Major and Trace Minerals
399
410
.
B. Plitzko, A. Havemeyer, B. Bork, F. Bittner, R. Mendel & B. Clement. (2016) Defining the Role of the NADH-Cytochrome-b5 Reductase 3 in the Mitochondrial Amidoxime Reducing Component Enzyme System. Drug Metabolism and Disposition 44:10, pages 1617-1621.
Crossref
Crossref
Guenter Schwarz. (2016) Molybdenum cofactor and human disease. Current Opinion in Chemical Biology 31, pages 179-187.
Crossref
Crossref
Mineko Terao, Maria João Romão, Silke Leimkühler, Marco Bolis, Maddalena Fratelli, Catarina Coelho, Teresa Santos-Silva & Enrico Garattini. (2016) Structure and function of mammalian aldehyde oxidases. Archives of Toxicology 90:4, pages 753-780.
Crossref
Crossref
Lars Dalgaard. (2015) Comparison of minipig, dog, monkey and human drug metabolism and disposition. Journal of Pharmacological and Toxicological Methods 74, pages 80-92.
Crossref
Crossref
Birte Plitzko, Antje Havemeyer, Thomas Kunze & Bernd Clement. (2015) The Pivotal Role of the Mitochondrial Amidoxime Reducing Component 2 in Protecting Human Cells against Apoptotic Effects of the Base Analog N6-Hydroxylaminopurine. Journal of Biological Chemistry 290:16, pages 10126-10135.
Crossref
Crossref
Luisa B. Maia & José J. G. Moura. (2015) Nitrite reduction by molybdoenzymes: a new class of nitric oxide-forming nitrite reductases. JBIC Journal of Biological Inorganic Chemistry 20:2, pages 403-433.
Crossref
Crossref
Gudrun Ott, Antje Havemeyer & Bernd Clement. (2014) The mammalian molybdenum enzymes of mARC. JBIC Journal of Biological Inorganic Chemistry 20:2, pages 265-275.
Crossref
Crossref
Eva Bauch, Debora Reichmann, Ralf-Rainer Mendel, Florian Bittner, Anne-Marie Manke, Philipp Kurz, Ulrich Girreser, Antje Havemeyer & Bernd Clement. (2015)
Electrochemical and mARC-Catalyzed Enzymatic Reduction of
para
-Substituted Benzamidoximes: Consequences for the Prodrug Concept “Amidoximes instead of Amidines”
. ChemMedChem 10:2, pages 360-367.
Crossref
Crossref
Bernard Testa & Bernd Clement. 2015. The Practice of Medicinal Chemistry. The Practice of Medicinal Chemistry
561
584
.
Gudrun Ott, Birte Plitzko, Carmen Krischkowski, Debora Reichmann, Florian Bittner, Ralf R. Mendel, Thomas Kunze, Bernd Clement & Antje Havemeyer. (2014) Reduction of Sulfamethoxazole Hydroxylamine (SMX-HA) by the Mitochondrial Amidoxime Reducing Component (mARC). Chemical Research in Toxicology 27:10, pages 1687-1695.
Crossref
Crossref
Logan J. Giles, Christian Ruppelt, Jing Yang, Ralf R. Mendel, Florian Bittner & Martin L. Kirk. (2014) Molybdenum Site Structure of MOSC Family Proteins. Inorganic Chemistry 53:18, pages 9460-9462.
Crossref
Crossref
Manuel Tejada-Jiménez & Guenter Schwarz. 2014. Binding, Transport and Storage of Metal Ions in Biological Cells. Binding, Transport and Storage of Metal Ions in Biological Cells
223
259
.
Gudrun Ott, Debora Reichmann, Cornelia Boerger, Ingolf Cascorbi, Florian Bittner, Ralf-Rainer Mendel, Thomas Kunze, Bernd Clement & Antje Havemeyer. (2014)
Functional Characterization of Protein Variants Encoded by Nonsynonymous Single Nucleotide Polymorphisms in
MARC1
and
MARC2
in Healthy Caucasians
. Drug Metabolism and Disposition 42:4, pages 718-725.
Crossref
Crossref
Courtney E. Sparacino-Watkins, Jesús Tejero, Bin Sun, Marc C. Gauthier, John Thomas, Venkata Ragireddy, Bonnie A. Merchant, Jun Wang, Ivan Azarov, Partha Basu & Mark T. Gladwin. (2014) Nitrite Reductase and Nitric-oxide Synthase Activity of the Mitochondrial Molybdopterin Enzymes mARC1 and mARC2. Journal of Biological Chemistry 289:15, pages 10345-10358.
Crossref
Crossref
Paul L Wood. (2013) Mass Spectrometry Strategies for Clinical Metabolomics and Lipidomics in Psychiatry, Neurology, and Neuro-Oncology. Neuropsychopharmacology 39:1, pages 24-33.
Crossref
Crossref
Nageswara Kode, Jean Vanden Eynde, Annie Mayence, Guangdi Wang & Tien Huang. (2013) Design and Synthesis of N1,N5-bis[4-(5-Alkyl-1,2,4-oxadiazol-3-yl)phenyl]glutaramides as Potential Antifungal Prodrugs. Molecules 18:9, pages 11250-11263.
Crossref
Crossref
Birte Plitzko, Gudrun Ott, Debora Reichmann, Colin J. Henderson, C. Roland Wolf, Ralf Mendel, Florian Bittner, Bernd Clement & Antje Havemeyer. (2013) The Involvement of Mitochondrial Amidoxime Reducing Components 1 and 2 and Mitochondrial Cytochrome b5 in N-Reductive Metabolism in Human Cells. Journal of Biological Chemistry 288:28, pages 20228-20237.
Crossref
Crossref
Ulrike Kappler & Amanda S. Nouwens. (2013) The molybdoproteome of Starkeya novella ? insights into the diversity and functions of molybdenum containing proteins in response to changing growth conditions. Metallomics 5:4, pages 325.
Crossref
Crossref
Russ Hille. (2013) The molybdenum oxotransferases and related enzymes. Dalton Transactions 42:9, pages 3029.
Crossref
Crossref
Erhan Bayram, Yasemin Topcu, Pakize Karakaya, Uluc Yis, Handan Cakmakci, Kimiyoshi Ichida & Semra Hiz Kurul. (2013) Molybdenum cofactor deficiency: Review of 12 cases (MoCD and review). European Journal of Paediatric Neurology 17:1, pages 1-6.
Crossref
Crossref
Guenter Schwarz & Abdel A. Belaidi. 2013. Interrelations between Essential Metal Ions and Human Diseases. Interrelations between Essential Metal Ions and Human Diseases
415
450
.
Nina Krompholz, Carmen Krischkowski, Debora Reichmann, Dieter Garbe-Schönberg, Ralf-R. Mendel, Florian Bittner, Bernd Clement & Antje Havemeyer. (2012) The Mitochondrial Amidoxime Reducing Component (mARC) Is Involved in Detoxification of N-Hydroxylated Base Analogues. Chemical Research in Toxicology 25:11, pages 2443-2450.
Crossref
Crossref
Ralf R. Mendel & Tobias Kruse. (2012) Cell biology of molybdenum in plants and humans. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1823:9, pages 1568-1579.
Crossref
Crossref
Vadim N. Gladyshev & Yan Zhang. 2012. Encyclopedia of Inorganic and Bioinorganic Chemistry. Encyclopedia of Inorganic and Bioinorganic Chemistry
1
22
.