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Miao Yan, Wenqun Li, Wen-Bo Li, Qi Huang, Jing Li, Hua-Lin Cai, Hui Gong, Bi-Kui Zhang & Yi-Kun Wang. (2023) Metabolic activation of tyrosine kinase inhibitors: recent advance and further clinical practice. Drug Metabolism Reviews 55:1-2, pages 94-106.
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Chunyong He & Hong Wan. (2018) Drug metabolism and metabolite safety assessment in drug discovery and development. Expert Opinion on Drug Metabolism & Toxicology 14:10, pages 1071-1085.
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Articles from other publishers (21)
Ni-hong Pang, Ren-ai Xu, Lian-guo Chen, Zhe Chen, Guo-xin Hu & Bo-wen Zhang. (2024) Inhibitory effects of the main metabolites of Apatinib on CYP450 isozymes in human and rat liver microsomes. Toxicology in Vitro 95, pages 105739.
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Lloyd Wei Tat Tang & Eric Chun Yong Chan. (2022) Metabolic activation of drugs by cytochrome P450 enzymes: Biochemical insights into mechanism-based inactivation by fibroblast growth factor receptor inhibitors and chemical approaches to attenuate reactive metabolite formation. Biochemical Pharmacology 206, pages 115336.
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Crossref
Nancy H. C. Loos, Jos H. Beijnen & Alfred H. Schinkel. (2022) The Mechanism-Based Inactivation of CYP3A4 by Ritonavir: What Mechanism?. International Journal of Molecular Sciences 23:17, pages 9866.
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Lloyd Wei Tat Tang, Guoyi Wu & Eric Chun Yong Chan. (2022) Identification of Infigratinib as a Potent Reversible Inhibitor and Mechanism-Based Inactivator of CYP2J2: Nascent Evidence for a Potential In Vivo Metabolic Drug-Drug Interaction with Rivaroxaban. Journal of Pharmacology and Experimental Therapeutics 382:2, pages 123-134.
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Lloyd Wei Tat Tang, Jiaxin Fu, Siew Kwan Koh, Guoyi Wu, Lei Zhou & Eric Chun Yong Chan. (2022) Metabolic Activation of the Acrylamide Michael Acceptor Warhead in Futibatinib to an Epoxide Intermediate Engenders Covalent Inactivation of CYP3A. Drug Metabolism and Disposition 50:7, pages 931-941.
Crossref
Crossref
Eda Dogan, Hale Guler Kara, Buket Kosova & Vildan Bozok Cetintas. 2022. Metastasis. Metastasis
163
180
.
Lloyd Wei Tat Tang, Wan Wei, Ravi Kumar Verma, Siew Kwan Koh, Lei Zhou, Hao Fan & Eric Chun Yong Chan. (2022) Direct and Sequential Bioactivation of Pemigatinib to Reactive Iminium Ion Intermediates Culminates in Mechanism-Based Inactivation of Cytochrome P450 3A. Drug Metabolism and Disposition 50:5, pages 529-540.
Crossref
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Jacqueline Wen Hui Leow, Lloyd Wei Tat Tang & Eric Chun Yong Chan. 2022. Pharmacology and Toxicology of Cytochrome P450 – 60th Anniversary. Pharmacology and Toxicology of Cytochrome P450 – 60th Anniversary
131
176
.
Lloyd Wei Tat Tang, Jian Wei Teng, Ravi Kumar Verma, Siew Kwan Koh, Lei Zhou, Mei Lin Go, Hao Fan & Eric Chun Yong Chan. (2021) Infigratinib Is a Reversible Inhibitor and Mechanism-Based Inactivator of Cytochrome P450 3A4. Drug Metabolism and Disposition 49:9, pages 856-868.
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Lloyd Wei Tat Tang, Jian Wei Teng, Siew Kwan Koh, Lei Zhou, Mei Lin Go & Eric Chun Yong Chan. (2021) Mechanism-Based Inactivation of Cytochrome P450 3A4 and 3A5 by the Fibroblast Growth Factor Receptor Inhibitor Erdafitinib. Chemical Research in Toxicology 34:7, pages 1800-1813.
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Lloyd Wei Tat Tang, Ravi Kumar Verma, Hao Fan & Eric Chun Yong Chan. (2021) Mechanism-Based Inactivation of Cytochrome P450 3A4 by Benzbromarone. Molecular Pharmacology 99:4, pages 266-276.
Crossref
Crossref
Michael Mohutsky & Stephen D. Hall. 2021. Enzyme Kinetics in Drug Metabolism. Enzyme Kinetics in Drug Metabolism
51
88
.
Tingting Jiang, Ting Cheng, Jing Li, Mengyue Zhou, Rong Tan, Xiaojing Yang, Yang Wang, Weiwei Li & Jiang Zheng. (2020) Bergaptol, a mechanism-based inactivator of CYP2C9. Medicinal Chemistry Research 29:7, pages 1230-1237.
Crossref
Crossref
Jie Jack Li. 2020. Medicinal Chemistry for Practitioners. Medicinal Chemistry for Practitioners
305
379
.
Jie Jack Li. 2020. Medicinal Chemistry for Practitioners. Medicinal Chemistry for Practitioners
1
96
.
Hong Huang, Xue Bai & Lijun Yang. (2020) Intriguing generative metabolism discovery of reactive metabolite nitroso of lapatinib and relevant structural modification. International Journal of Quantum Chemistry 120:12.
Crossref
Crossref
Jennifer E. Bissada, Vivian Truong, Arsany A. Abouda, Kahari J. Wines, Rachel D. Crouch & Klarissa D. Jackson. (2019) Interindividual Variation in CYP3A Activity Influences Lapatinib Bioactivation. Drug Metabolism and Disposition 47:11, pages 1257-1269.
Crossref
Crossref
Marie‐Noëlle Paludetto, Florent Puisset, Etienne Chatelut & Cécile Arellano. (2019) Identifying the reactive metabolites of tyrosine kinase inhibitors in a comprehensive approach: Implications for drug‐drug interactions and hepatotoxicity. Medicinal Research Reviews 39:6, pages 2105-2152.
Crossref
Crossref
Anne M. Filppula, Tiffany M. Mustonen & Janne T. Backman. (2018) In Vitro Screening of Six Protein Kinase Inhibitors for Time-Dependent Inhibition of CYP2C8 and CYP3A4: Possible Implications with regard to Drug-Drug Interactions. Basic & Clinical Pharmacology & Toxicology 123:6, pages 739-748.
Crossref
Crossref
Juanita S. Lopez & Udai Banerji. (2016) Combine and conquer: challenges for targeted therapy combinations in early phase trials. Nature Reviews Clinical Oncology 14:1, pages 57-66.
Crossref
Crossref
J. K. Towles, R. N. Clark, M. D. Wahlin, V. Uttamsingh, A. E. Rettie & K. D. Jackson. (2016) Cytochrome P450 3A4 and CYP3A5-Catalyzed Bioactivation of Lapatinib. Drug Metabolism and Disposition 44:10, pages 1584-1597.
Crossref
Crossref