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Review Article

Metabolic phenotyping applied to pre-clinical and clinical studies of acetaminophen metabolism and hepatotoxicity

Pages 29-44 | Received 18 Sep 2014, Accepted 28 Oct 2014, Published online: 23 Dec 2014

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Dalia H. El-Kashef & Maha H. Sharawy. (2022) Hepatoprotective effect of nicorandil against acetaminophen-induced oxidative stress and hepatotoxicity in mice via modulating NO synthesis. Environmental Science and Pollution Research 30:6, pages 14253-14264.
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Qiao Wu, Pengfei Yu, Yanzhen Bi, Zhijie Li, Wei Guo, Yu Chen & Zhongping Duan. (2022) Naringin regulates mitochondrial dynamics to protect against acetaminophen-induced hepatotoxicity by activating the AMPK/Nrf2 signaling pathway in vitro. Brazilian Journal of Medical and Biological Research 55.
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Ling Ye, Zeying Feng, Longjian Huang, Chengjun Guo, Xiong Wu, Li He, Wei Tan, Yi Wang, Xuehong Wu, Biwen Hu, Tong Li, Guoping Yang, Guo Chengxian & Qingnan He. (2021) Causality Evaluation of Drug-Induced Liver Injury in Newborns and Children in the Intensive Care Unit Using the Updated Roussel Uclaf Causality Assessment Method. Frontiers in Pharmacology 12.
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Volker Behrends, Guro F. Giskeødegård, Natalia Bravo-Santano, Michal Letek & Hector C. Keun. (2018) Acetaminophen cytotoxicity in HepG2 cells is associated with a decoupling of glycolysis from the TCA cycle, loss of NADPH production, and suppression of anabolism. Archives of Toxicology 93:2, pages 341-353.
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Qiang Shi, Xi Yang, James J. Greenhaw, Alec Thomas Salminen, Gary M. Russotti & William F. Salminen. (2017) Drug-Induced Liver Injury in Children: Clinical Observations, Animal Models, and Regulatory Status. International Journal of Toxicology 36:5, pages 365-379.
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Lung-Che Chen, Li-Hong Hu & Mei-Chin Yin. (2017) Alleviative effects from boswellic acid on acetaminophen-induced hepatic injury. BioMedicine 7:2, pages 13.
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Yan Lu, Cheng Zhang, Yuan-Hua Chen, Hua Wang, Zhi-Hui Zhang, Xi Chen & De-Xiang Xu. (2017) Immature mice are more susceptible than adult mice to acetaminophen-induced acute liver injury. Scientific Reports 7:1.
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Yazhen HuoSanda WinTin Aung ThanShutao YinMin YeHongbo HuNeil Kaplowitz. (2017) Antcin H Protects Against Acute Liver Injury Through Disruption of the Interaction of c-Jun-N-Terminal Kinase with Mitochondria. Antioxidants & Redox Signaling 26:5, pages 207-220.
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Yu Toyoda, Kasumi Kashikura, Tomoyoshi Soga & Yoh-ichi Tagawa. (2017) Metabolomics of an <i>in vitro</i> liver model containing primary hepatocytes assembling around an endothelial cell network: comparative study on the metabolic stability and the effect of acetaminophen treatment. The Journal of Toxicological Sciences 42:4, pages 445-454.
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Chun Pang, Liang Shi, Yuchen Sheng, Zhiyong Zheng, Hai Wei, Zhengtao Wang & Lili Ji. (2016) Caffeic acid attenuated acetaminophen-induced hepatotoxicity by inhibiting ERK1/2-mediated early growth response-1 transcriptional activation. Chemico-Biological Interactions 260, pages 186-195.
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Michael Kyriakides, Lea Maitre, Brendan D. Stamper, Isaac Mohar, Terrance J. Kavanagh, John Foster, Ian D. Wilson, Elaine Holmes, Sidney D. Nelson & Muireann Coen. (2016) Comparative metabonomic analysis of hepatotoxicity induced by acetaminophen and its less toxic meta-isomer. Archives of Toxicology 90:12, pages 3073-3085.
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Zhenzhu Zhang, Yani Zhang, Jia Yin & Yubo Li. (2016) An integrated strategy for the rapid extraction and screening of phosphatidylcholines and lysophosphatidylcholines using semi-automatic solid phase extraction and data processing technology. Journal of Chromatography A 1461, pages 192-197.
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David S. Wishart. (2016) Emerging applications of metabolomics in drug discovery and precision medicine. Nature Reviews Drug Discovery 15:7, pages 473-484.
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Lung-Che Chen, Li-Hong Hu & Mei-Chin Yin. (2016) Alleviative effects from boswellic acid on acetaminophen-induced hepatic injury. BioMedicine 6:2.
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Jie Xing, Meitong Zang, Haiying Zhang & Mingshe Zhu. (2015) The application of high-resolution mass spectrometry-based data-mining tools in tandem to metabolite profiling of a triple drug combination in humans. Analytica Chimica Acta 897, pages 34-44.
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Mukesh Verma & Hirendra Banerjee. (2015) Metabolomic Approaches in Cancer Epidemiology. Diseases 3:3, pages 167-175.
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