Citations (30)
Keep up to date with the latest research on this topic with citation updates for this article.
Read on this site (4)
S. Cyrus Khojasteh, Upendra A. Argikar, James P. Driscoll, Carley J. S. Heck, Lloyd King, Klarissa D. Jackson, Wenying Jian, Amit S. Kalgutkar, Grover P. Miller, Valerie Kramlinger, Ivonne M. C. M. Rietjens, Aaron M. Teitelbaum, Kai Wang & Cong Wei. (2021) Novel advances in biotransformation and bioactivation research – 2020 year in review. Drug Metabolism Reviews 53:3, pages 384-433.
Read now
Read now
Bo Wen & Peter Gorycki. (2019) Bioactivation of herbal constituents: mechanisms and toxicological relevance. Drug Metabolism Reviews 51:4, pages 453-497.
Read now
Read now
Chunyong He & Hong Wan. (2018) Drug metabolism and metabolite safety assessment in drug discovery and development. Expert Opinion on Drug Metabolism & Toxicology 14:10, pages 1071-1085.
Read now
Read now
M. José Gómez-Lechón, Laia Tolosa & M. Teresa Donato. (2017) Upgrading HepG2 cells with adenoviral vectors that encode drug-metabolizing enzymes: application for drug hepatotoxicity testing. Expert Opinion on Drug Metabolism & Toxicology 13:2, pages 137-148.
Read now
Read now
Articles from other publishers (26)
Young-Heun Jung & Ju-Hyun Kim. (2023) Feature-Based Molecular Networking Combined with Multivariate Analysis for the Characterization of Glutathione Adducts as a Smoking Gun of Bioactivation. Analytical Chemistry 95:48, pages 17450-17457.
Crossref
Crossref
Benjamin Weiser, Jérôme Genzling, Mihai Burai-Patrascu, Ophélie Rostaing & Nicolas Moitessier. (2023) Machine learning-augmented docking. 1. CYP inhibition prediction. Digital Discovery 2:6, pages 1841-1849.
Crossref
Crossref
Chunyong He, Yuchang Mao & Hong Wan. (2023) Preclinical evaluation of chemically reactive metabolites and mitigation of bioactivation in drug discovery. Drug Discovery Today 28:7, pages 103621.
Crossref
Crossref
Alexander Gorbunov, Alexander Bardin, Semyon Ilyushonok, Jacob Kovach, Artem Petrenko, Nikolai Sukhodolov, Konstantin Krasnov, Nikolai Krasnov, Ivan Zorin, Alexander Obornev, Vladimir Babakov, Andrey Radilov & Ekaterina Podolskaya. (2022) Multiwell photocatalytic microreactor device integrating drug biotransformation modeling and sample preparation on a MALDI target. Microchemical Journal 178, pages 107362.
Crossref
Crossref
Min Tian, Ying Peng & Jiang Zheng. (2022) Metabolic Activation and Hepatotoxicity of Furan-Containing Compounds. Drug Metabolism and Disposition 50:5, pages 655-670.
Crossref
Crossref
Anne Labarre, Julia K. Stille, Mihai Burai Patrascu, Andrew Martins, Joshua Pottel & Nicolas Moitessier. (2022) Docking Ligands into Flexible and Solvated Macromolecules. 8. Forming New Bonds─Challenges and Opportunities. Journal of Chemical Information and Modeling 62:4, pages 1061-1077.
Crossref
Crossref
Qingping Wang & Chuang Lu. 2021. Transporters and Drug‐Metabolizing Enzymes in Drug Toxicity. Transporters and Drug‐Metabolizing Enzymes in Drug Toxicity
207
233
.
Mohamed M.Y. Kaddah, Susan Billig, Ramona Oehme & Claudia Birkemeyer. (2021) Bio-activation of simeprevir in liver microsomes and characterization of its glutathione conjugates by liquid chromatography coupled to ultrahigh-resolution quadrupole time-of-flight mass spectrometry. Journal of Chromatography A 1645, pages 462095.
Crossref
Crossref
Donald J. AbrahamDeepak K. Dalvie & Bernard Testa. 2003. Burger's Medicinal Chemistry and Drug Discovery. Burger's Medicinal Chemistry and Drug Discovery
1
139
.
Chenghong Zhang, James J. Crawford, Matthew L. Landry, Huifen Chen, Jane R. Kenny, S. Cyrus Khojasteh, Wendy Lee, Shuguang Ma & Wendy B. Young. (2020) Strategies to Mitigate the Bioactivation of Aryl Amines. Chemical Research in Toxicology 33:7, pages 1950-1959.
Crossref
Crossref
Nao Nishijo, Tadashi Hayama, Ryoko Tomita, Masatoshi Yamaguchi & Toshihiro Fujioka. (2020) Application of a fluorous derivatization method for characterization of glutathione-trapped reactive metabolites with liquid chromatography–tandem mass spectrometry analysis. Journal of Chromatography A 1622, pages 461160.
Crossref
Crossref
Praveen Kumar, Nayak Devappa Satyanarayan, Subba Rao Venkata Madhunapantula, Hulikal Shivashankara Santhosh Kumar & Rajeshwara Achur. (2020) In silico screening for the interaction of small molecules with their targets and evaluation of therapeutic efficacy by free online tools. European Journal of Chemistry 11:2, pages 168-178.
Crossref
Crossref
Yuanyuan Zhou, Mun Hwan Oh, Yeon Joon Kim, Eun-yeong Kim, Jinhong Kang, Sung Chung, Chung Ju, Won-Ki Kim & Kiho Lee. (2020) Metabolism and Pharmacokinetics of SP-8356, a Novel (1S)-(−)-Verbenone Derivative, in Rats and Dogs and Its Implications in Humans. Molecules 25:8, pages 1775.
Crossref
Crossref
Changhua Ji, Mausumee Guha, Xu Zhu, Jessica Whritenour, Michelle Hemkens, Susanna Tse, Gregory S. Walker, Ellen Evans, Nasir K. Khan, Martin B. Finkelstein, Ernesto Callegari & R. Scott Obach. (2019) Enzalutamide and Apalutamide: In Vitro Chemical Reactivity Studies and Activity in a Mouse Drug Allergy Model. Chemical Research in Toxicology 33:1, pages 211-222.
Crossref
Crossref
Karolina Słoczyńska, Paulina Koczurkiewicz, Kamil Piska, Beata Powroźnik, Katarzyna Wójcik-Pszczoła, Katarzyna Klaś, Magdalena Wyszkowska-Kolatko & Elżbieta Pękala. (2019) Similar Safety Profile of the Enantiomeric N-Aminoalkyl Derivatives of Trans-2-Aminocyclohexan-1-ol Demonstrating Anticonvulsant Activity. Molecules 24:13, pages 2505.
Crossref
Crossref
Qingping Wang, Hanlan Liu, Marina Slavsky, Maria Fitzgerald, Chuang Lu & Thomas O'Shea. (2019) A high-throughput glutathione trapping assay with combined high sensitivity and specificity in high-resolution mass spectrometry by applying product ion extraction and data-dependent neutral loss. Journal of Mass Spectrometry 54:2, pages 158-166.
Crossref
Crossref
Zhican Wang, Ying Fang, Dan Rock & Ji Ma. (2017) Rapid screening and characterization of glutathione-trapped reactive metabolites using a polarity switch-based approach on a high-resolution quadrupole orbitrap mass spectrometer. Analytical and Bioanalytical Chemistry 410:5, pages 1595-1606.
Crossref
Crossref
Camilla Stephens, M. Isabel Lucena & Raúl J. Andrade. 2018. Drug-Induced Liver Toxicity. Drug-Induced Liver Toxicity
477
496
.
Axel Pähler. 2018. Drug-Induced Liver Toxicity. Drug-Induced Liver Toxicity
263
281
.
Landon R. Whitby, R. Scott Obach, Gabriel M. Simon, Matthew M. Hayward & Benjamin F. Cravatt. (2017)
Quantitative Chemical Proteomic Profiling of the
in Vivo
Targets of Reactive Drug Metabolites
. ACS Chemical Biology 12:8, pages 2040-2050.
Crossref
Crossref
Jasleen Sodhi, Erlie Delarosa, Jason Halladay, James Driscoll, Teresa Mulder, Patrick Dansette & S. Khojasteh. (2017) Inhibitory Effects of Trapping Agents of Sulfur Drug Reactive Intermediates against Major Human Cytochrome P450 Isoforms. International Journal of Molecular Sciences 18:7, pages 1553.
Crossref
Crossref
Ju-Hyun Kim, Won-Gu Choi, Sangkyu Lee & Hye Lee. (2017) Revisiting the Metabolism and Bioactivation of Ketoconazole in Human and Mouse Using Liquid Chromatography–Mass Spectrometry-Based Metabolomics. International Journal of Molecular Sciences 18:3, pages 621.
Crossref
Crossref
R.E. White. 2017. Comprehensive Medicinal Chemistry III. Comprehensive Medicinal Chemistry III
1
33
.
M. José Gómez-Lechón, Laia Tolosa & M. Teresa Donato. (2016)
Metabolic activation and drug-induced liver injury:
in vitro
approaches for the safety risk assessment of new drugs
. Journal of Applied Toxicology 36:6, pages 752-768.
Crossref
Crossref
Bernardo Brito Palma, Charles W. Fisher, José Rueff & Michel Kranendonk. (2016) Prototype Systems Containing Human Cytochrome P450 for High-Throughput Real-Time Detection of DNA Damage by Compounds That Form DNA-Reactive Metabolites. Chemical Research in Toxicology 29:5, pages 747-756.
Crossref
Crossref
Alexander Gorbunov, Alexander Bardin, Semyon Ilyushonok, Jacob Kovach, Artem Petrenko, Nikolai Sukhodolov, Konstantin Krasnov, Nikolai Krasnov, Ivan Zorin, Alexander Obornev, Vladimir Babakov, Andrey Radilov & Ekaterina Podolskaya. (2022) Drug Biotransformation Modeling on Maldi Target Using Multiwell Photocatalytic Microreactor Device. SSRN Electronic Journal.
Crossref
Crossref