1,310
Views
85
CrossRef citations to date
0
Altmetric
Review Article

Regioselective hydroxylation of steroid hormones by human cytochromes P450

, , &
Pages 89-110 | Received 27 Dec 2014, Accepted 21 Jan 2015, Published online: 13 Feb 2015

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (7)

Xiang Hu, Xusheng Li, Pan Deng, Yulin Zhang, Ruijing Liu, Dongbao Cai, Qingjie Xu, Xinwei Jiang, Jianxia Sun & Weibin Bai. (2023) The consequence and mechanism of dietary flavonoids on androgen profiles and disorders amelioration. Critical Reviews in Food Science and Nutrition 63:32, pages 11327-11350.
Read now
Xu Mao, Hui Li & Jiang Zheng. (2023) Effects of xenobiotics on CYP1 enzyme-mediated biotransformation and bioactivation of estradiol. Drug Metabolism Reviews 55:1-2, pages 1-49.
Read now
Meghan M. Conner, Haley V. Parker, Daniela R. Falcone, Gehoon Chung & Christine E. Schaner Tooley. (2022) Novel regulation of the transcription factor ZHX2 by N-terminal methylation. Transcription 13:1-3, pages 1-15.
Read now
Ewa Bromek & Władysława Anna Daniel. (2021) The regulation of liver cytochrome P450 expression and activity by the brain serotonergic system in different experimental models. Expert Opinion on Drug Metabolism & Toxicology 17:4, pages 413-424.
Read now
Sara K. Quinney, Tara Benjamin, Xiaomei Zheng & Avinash S. Patil. (2017) Characterization of Maternal and Fetal CYP3A-Mediated Progesterone Metabolism. Fetal and Pediatric Pathology 36:5, pages 400-411.
Read now
Francesca Toselli, Peter R. Dodd & Elizabeth M. J. Gillam. (2016) Emerging roles for brain drug-metabolizing cytochrome P450 enzymes in neuropsychiatric conditions and responses to drugs. Drug Metabolism Reviews 48:3, pages 379-404.
Read now

Articles from other publishers (78)

Karanpreet Singh Bhatia, Aarthi Nivasini Mahesh & Shruti Bhatt. 2024. Encyclopedia of Toxicology. Encyclopedia of Toxicology 449 456 .
Felix Bredendiek & Maria Kristina Parr. (2023) SFC‐MS/MS for orthogonal separation of hydroxylated 17α‐methyltestosterone isomers. Drug Testing and Analysis.
Crossref
Hossay Abas, Peter Blencowe, Joanna L. Brookfield & Lucy A. Harwood. (2023) Selective Hydroxylation of C(sp 3 )−H Bonds in Steroids . Chemistry – A European Journal 29:44.
Crossref
Toshiro Niwa, Misaki Tani, Anna Suzuki & Mizuho Murakami. (2023) Stimulatory and Inhibitory Effects of Steroid Hormones and Human Cytochrome P450 (CYP) 3A Inhibitors on Cortisol 6β-Hydroxylation Catalyzed by CYP3A Subfamilies. Drug Metabolism and Bioanalysis Letters 16:2, pages 73-80.
Crossref
Shuai Zhang, Tingting Wang, Ye Feng, Fei Li, Aijuan Qu, Xiuchen Guan, Hui Wang & Dan Xu. (2023) Pregnenolone 16α-carbonitrile negatively regulates hippocampal cytochrome P450 enzymes and ameliorates phenytoin-induced hippocampal neurotoxicity. Journal of Pharmaceutical Analysis.
Crossref
William L. Fitch, Steven Smith, Michael Saporito, Gregory Busse, Mingbao Zhang, Julie Ren, Michael E. Fitzsimmons, Ping Yi, Stephen English, Adam Carter & Thomas A. Baillie. (2023) Complex Metabolism of the Novel Neurosteroid, Ganaxolone, in Humans: A Unique Challenge for Metabolites in Safety Testing Assessment. Drug Metabolism and Disposition 51:6, pages 753-763.
Crossref
Yasuhiro Uno, Saho Morikuni, Mitsuya Shiraishi, Atsushi Asano, Norie Murayama & Hiroshi Yamazaki. (2023) Novel Cytochrome P450 2C94 Functionally Metabolizes Diclofenac and Omeprazole in Dogs. Drug Metabolism and Disposition 51:5, pages 637-644.
Crossref
Koichiro Adachi, Katsuhiro Ohyama, Yoichi Tanaka, Tasuku Sato, Norie Murayama, Makiko Shimizu, Yoshiro Saito & Hiroshi Yamazaki. (2023) High hepatic and plasma exposures of atorvastatin in subjects harboring impaired cytochrome P450 3A4∗16 modeled after virtual administrations and possibly associated with statin intolerance found in the Japanese adverse drug event report database. Drug Metabolism and Pharmacokinetics 49, pages 100486.
Crossref
Wei Ma, De Xin Dang, Jiehui Zhang, Chunqiang Wang & Desheng Li. (2022) Effects of dietary supplementation of N ‐carbamylglutamate on the haematology parameters, secondary sexual characteristics and testicular gene expression in roosters . Journal of Animal Physiology and Animal Nutrition 107:2, pages 621-630.
Crossref
Bashu Dev Pardhe, Kyoung Pyo Kwon, Jong Kook Park, Jun Hyuck Lee & Tae-Jin Oh. (2023) H 2 O 2 -Driven Hydroxylation of Steroids Catalyzed by Cytochrome P450 CYP105D18: Exploration of the Substrate Access Channel . Applied and Environmental Microbiology 89:1.
Crossref
Philip Hartz, Tobias Fehlmann, Gudrun Wagenpfeil, Marcus Michael Unger & Rita Bernhardt. (2023) A CYPome-wide study reveals new potential players in the pathogenesis of Parkinson’s disease. Frontiers in Pharmacology 13.
Crossref
Ruqun Zheng, Haoran Shen, Jie Li, Jiansen Zhao, Lingjing Lu, Mianhao Hu, Zixin Lin, Hongxia Ma, Huiyan Tan, Min Hu & Juan Li. (2023) Qi Gong Wan ameliorates adipocyte hypertrophy and inflammation in adipose tissue in a PCOS mouse model through the Nrf2/HO-1/Cyp1b1 pathway: Integrating network pharmacology and experimental validation in vivo. Journal of Ethnopharmacology 301, pages 115824.
Crossref
Solène Marie, Kayla L. Frost, Raymond K. Hau, Lucy Martinez-Guerrero, Jailyn M. Izu, Cassandra M. Myers, Stephen H. Wright & Nathan J. Cherrington. (2023) Predicting disruptions to drug pharmacokinetics and the risk of adverse drug reactions in non-alcoholic steatohepatitis patients. Acta Pharmaceutica Sinica B 13:1, pages 1-28.
Crossref
John William Honour. 2023. Steroids in the Laboratory and Clinical Practice. Steroids in the Laboratory and Clinical Practice 217 257 .
Pradeep Subedi, Hackwon Do, Jun Hyuck Lee & Tae-Jin Oh. (2022) Crystal Structure and Biochemical Analysis of a Cytochrome P450 CYP101D5 from Sphingomonas echinoides. International Journal of Molecular Sciences 23:21, pages 13317.
Crossref
Radhika Aiyappa‐Maudsley, Sarah J Storr, Emad A Rakha, Andrew R Green, Ian O Ellis & Stewart G Martin. (2022) CYP2S1 and CYP2W1 expression is associated with patient survival in breast cancer . The Journal of Pathology: Clinical Research 8:6, pages 550-566.
Crossref
Zhijuan Liang, Wei Jiao, Liping Wang, Yuanbin Chen, Dan Li, Zhao Zhang, Zhilei Zhang, Ye Liang & Haitao Niu. (2022) CYP27A1 inhibits proliferation and migration of clear cell renal cell carcinoma via activation of LXRs/ABCA1. Experimental Cell Research 419:1, pages 113279.
Crossref
Toshiro Niwa, Shoko Sasaki, Yuka Yamamoto & Mayu Tanaka. (2022) Effect of Human Cytochrome P450 2D6 Polymorphism on Progesterone Hydroxylation. European Journal of Drug Metabolism and Pharmacokinetics 47:5, pages 741-747.
Crossref
Rui Zhu, Yang Liu, Yueying Yang, Qing Min, Hua Li & Lixia Chen. (2022) Cytochrome P450 Monooxygenases Catalyse Steroid Nucleus Hydroxylation with Regio‐ and Stereo‐Selectivity. Advanced Synthesis & Catalysis 364:16, pages 2701-2719.
Crossref
Francesco Mascia, Sara B. Pereira, Catarina C. Pacheco, Paulo Oliveira, Jennifer Solarczek, Anett Schallmey, Robert Kourist, Véronique Alphand & Paula Tamagnini. (2022) Light-driven hydroxylation of testosterone by Synechocystis sp. PCC 6803 expressing the heterologous CYP450 monooxygenase CYP110D1 . Green Chemistry 24:16, pages 6156-6167.
Crossref
Hai-Ying Mo, Qi-Yao Wei, Qiu-Hua Zhong, Xiao-Yun Zhao, Dan Guo, Jin Han, Wachiraporn Noracharttiyapot, Lydia Visser, Anke van den Berg, Yan-Ming Xu & Andy T. Y. Lau. (2022) Cytochrome P450 27C1 Level Dictates Lung Cancer Tumorigenicity and Sensitivity towards Multiple Anticancer Agents and Its Potential Interplay with the IGF-1R/Akt/p53 Signaling Pathway. International Journal of Molecular Sciences 23:14, pages 7853.
Crossref
Toshiro Niwa & Risa Ishii. (2022) Mechanism-Based Inhibition of CYP3A Subfamilies by Macrolide Antibiotics and Piperine. Drug Metabolism and Bioanalysis Letters 15:2, pages 75-80.
Crossref
Yingqiong Zhang, Yujia Chen, Binxin Dai, Mengru Bai, Shuanghui Lu, Nengming Lin, Hui Zhou & Huidi Jiang. (2022) Bilirubin Reduces the Uptake of Estrogen Precursors and the Followed Synthesis of Estradiol in Human Placental Syncytiotrophoblasts via Inhibition and Downregulation of Organic Anion Transporter 4. Drug Metabolism and Disposition 50:4, pages 341-350.
Crossref
Zhennan Liu, Jing Huang, Yang Gu, Douglas S. Clark, Aindrila Mukhopadhyay, Jay D. Keasling & John F. Hartwig. (2022) Assembly and Evolution of Artificial Metalloenzymes within E. coli Nissle 1917 for Enantioselective and Site-Selective Functionalization of C─H and C═C Bonds . Journal of the American Chemical Society 144:2, pages 883-890.
Crossref
Xueying Ye, Tao Peng, Yuan Li, Tongwang Huang, Hui Wang & Zhong Hu. (2022) Identification of an important function of CYP123: Role in the monooxygenase activity in a novel estradiol degradation pathway in bacteria. The Journal of Steroid Biochemistry and Molecular Biology 215, pages 106025.
Crossref
Shinji Yuasa, Kaori Takanashi, Kenta Ukiana, Yoshihiro Mihara & Shinji Itoh. (2021) Comparison on Metabolism of Estradiol and Its 17-Sulfate by Recombinant Human CYP Isoforms. Biological and Pharmaceutical Bulletin 44:9, pages 1344-1347.
Crossref
Janice Jia Ni Goh, Julian Behn, Cheng-Shoong Chong, Guorui Zhong, Sebastian Maurer-Stroh, Hao Fan & Lit-Hsin Loo. (2021) Structure-based virtual screening of CYP1A1 inhibitors: towards rapid tier-one assessment of potential developmental toxicants. Archives of Toxicology 95:9, pages 3031-3048.
Crossref
Dongyi Sun, Jian Lu, Yuanjin Zhang, Jie Liu, Zongjun Liu, Bingyi Yao, Yuanqing Guo & Xin Wang. (2021) Characterization of a Novel CYP1A2 Knockout Rat Model Constructed by CRISPR/Cas9 . Drug Metabolism and Disposition 49:8, pages 638-647.
Crossref
Tzu-Yi Chiang, Hong-Jaan Wang, Yen-Cih Wang, Elise Chia-Hui Tan, I-Jung Lee, Chul-Ho Yun & Yune-Fang Ueng. (2021) Effects of Shengmai San on key enzymes involved in hepatic and intestinal drug metabolism in rats. Journal of Ethnopharmacology 271, pages 113914.
Crossref
Toshiro Niwa, Manami Toyota, Hinako Kawasaki, Risa Ishii & Shoko Sasaki. (2021) Comparison of the Stimulatory and Inhibitory Effects of Steroid Hormones and α-Naphthoflavone on Steroid Hormone Hydroxylation Catalyzed by Human Cytochrome P450 3A Subfamilies. Biological and Pharmaceutical Bulletin 44:4, pages 579-584.
Crossref
Daniel L. Villeneuve, Brett R. Blackwell, Jenna E. Cavallin, Wan‐Yun Cheng, David J. Feifarek, Kathleen M. Jensen, Michael W. Kahl, Rebecca Y. Milsk, Shane T. Poole, Eric C. Randolph, Travis W. Saari & Gerald T. Ankley. (2021) Case Study in 21st Century Ecotoxicology: Using In Vitro Aromatase Inhibition Data to Predict Short‐Term In Vivo Responses in Adult Female Fish. Environmental Toxicology and Chemistry 40:4, pages 1155-1170.
Crossref
M.J. Kuhn, V. Mavangira & L.M. Sordillo. (2021) Invited review: Cytochrome P450 enzyme involvement in health and inflammatory-based diseases of dairy cattle. Journal of Dairy Science 104:2, pages 1276-1290.
Crossref
Slobodan P. Rendic & F. Peter Guengerich. (2021) Human Family 1–4 cytochrome P450 enzymes involved in the metabolic activation of xenobiotic and physiological chemicals: an update. Archives of Toxicology 95:2, pages 395-472.
Crossref
O. A. Kazakova & O. V. Dolgikh. (2021) Polymorphism of genes controlling phase I and II detoxification in phenol-exposed women with spontaneous miscarriage diagnosis. Russian Journal of Immunology 24:1, pages 85-90.
Crossref
Alexa N. Carrera, Marianne K.O. Grant & Beshay N. Zordoky. (2020) CYP1B1 as a therapeutic target in cardio-oncology. Clinical Science 134:21, pages 2897-2927.
Crossref
Lenka Jourová, Marketa Vavreckova, Nina Zemanova, Pavel Anzenbacher, Katerina Langova, Petra Hermanova, Tomas Hudcovic & Eva Anzenbacherova. (2020) Gut Microbiome Alters the Activity of Liver Cytochromes P450 in Mice With Sex-Dependent Differences. Frontiers in Pharmacology 11.
Crossref
Kai Huang, Hai-li Cai, Jia-peng Bao & Li-dong Wu. (2020) Dehydroepiandrosterone and age-related musculoskeletal diseases: Connections and therapeutic implications. Ageing Research Reviews 62, pages 101132.
Crossref
Wenyu ChenMatthew J. FisherAaron LeungYang Cao & Luet L. Wong. (2020) Oxidative Diversification of Steroids by Nature-Inspired Scanning Glycine Mutagenesis of P450BM3 (CYP102A1). ACS Catalysis 10:15, pages 8334-8343.
Crossref
David Stucki, Heide Krahl, Moritz Walter, Julia Steinhausen, Katrin Hommel, Peter Brenneisen & Wilhelm Stahl. (2020) Effects of frequently applied carbon monoxide releasing molecules (CORMs) in typical CO-sensitive model systems – A comparative in vitro study. Archives of Biochemistry and Biophysics 687, pages 108383.
Crossref
Qumei Dai, Liting Yang, Yin Wang, Xiaodong Cao, Cheng Yao & Xuan Xu. (2020) Surface charge-controlled electron transfer and catalytic behavior of immobilized cytochrome P450 BM3 inside dendritic mesoporous silica nanoparticles. Analytical and Bioanalytical Chemistry 412:19, pages 4703-4712.
Crossref
Sara Arana-Peña, Diego Carballares, Ángel Berenguer-Murcia, Andrés Alcántara, Rafael Rodrigues & Roberto Fernandez-Lafuente. (2020) One Pot Use of Combilipases for Full Modification of Oils and Fats: Multifunctional and Heterogeneous Substrates. Catalysts 10:6, pages 605.
Crossref
Junhao Li, Yun Tang, Weihua Li & Yaoquan Tu. (2020) Mechanistic Insights into the Regio‐ and Stereoselectivities of Testosterone and Dihydrotestosterone Hydroxylation Catalyzed by CYP3A4 and CYP19A1. Chemistry – A European Journal 26:28, pages 6214-6223.
Crossref
Claudia Stapelfeld, Christine Dammann & Edmund Maser. (2019) Sex‐specificity in lung cancer risk. International Journal of Cancer 146:9, pages 2376-2382.
Crossref
Margarida Borrell, Sergio Gil-Caballero, Massimo Bietti & Miquel Costas. (2020) Site-Selective and Product Chemoselective Aliphatic C–H Bond Hydroxylation of Polyhydroxylated Substrates. ACS Catalysis 10:8, pages 4702-4709.
Crossref
Toshiro Niwa, Ayaka Okamoto, Kanae Narita, Manami Toyota, Kyoko Kato, Kyoko Kobayashi & Shoko Sasaki. (2020) Comparison of steroid hormone hydroxylation mediated by cytochrome P450 3A subfamilies. Archives of Biochemistry and Biophysics 682, pages 108283.
Crossref
Michael D. Coleman. 2020. Human Drug Metabolism. Human Drug Metabolism 109 181 .
Qianwen Wang, Bingbing Ma, Shinya Fushinobu, Chunfang Zhang & Lian-Hua Xu. (2020) Regio- and stereoselective hydroxylation of testosterone by a novel cytochrome P450 154C2 from Streptomyces avermitilis. Biochemical and Biophysical Research Communications 522:2, pages 355-361.
Crossref
Mohammad-Reza Arabnezhad, Nima Montazeri-Najafabady, Nazanin Chatrabnous, Ali Ghafarian Bahreman & Afshin Mohammadi-Bardbori. (2020) Anti-androgenic effect of 6-formylindolo[3,2-b]carbazole (FICZ) in LNCaP cells is mediated by the aryl hydrocarbon-androgen receptors cross-talk. Steroids 153, pages 108508.
Crossref
Eleonora Zakharian. 2020. Hormonal Signaling in Biology and Medicine. Hormonal Signaling in Biology and Medicine 557 564 .
Lina Schiffer, Lise Barnard, Elizabeth S. Baranowski, Lorna C. Gilligan, Angela E. Taylor, Wiebke Arlt, Cedric H.L. Shackleton & Karl-Heinz Storbeck. (2019) Human steroid biosynthesis, metabolism and excretion are differentially reflected by serum and urine steroid metabolomes: A comprehensive review. The Journal of Steroid Biochemistry and Molecular Biology 194, pages 105439.
Crossref
Tristan de Rond, Jian Gao, Amin Zargar, Markus de Raad, Jack Cunha, Trent R. Northen & Jay D. Keasling. (2019) A High‐Throughput Mass Spectrometric Enzyme Activity Assay Enabling the Discovery of Cytochrome P450 Biocatalysts. Angewandte Chemie International Edition 58:30, pages 10114-10119.
Crossref
Tristan de Rond, Jian Gao, Amin Zargar, Markus de Raad, Jack Cunha, Trent R. Northen & Jay D. Keasling. (2019) A High‐Throughput Mass Spectrometric Enzyme Activity Assay Enabling the Discovery of Cytochrome P450 Biocatalysts. Angewandte Chemie 131:30, pages 10220-10225.
Crossref
Meital Charni-Natan, Ronit Aloni-Grinstein, Etty Osher & Varda Rotter. (2019) Liver and Steroid Hormones—Can a Touch of p53 Make a Difference?. Frontiers in Endocrinology 10.
Crossref
Xabier Arzuaga, Martyn T. Smith, Catherine F. Gibbons, Niels E. Skakkebæk, Erin E. Yost, Brandiese E. J. Beverly, Andrew K. Hotchkiss, Russ Hauser, Rodrigo L. Pagani, Steven M. SchraderLauren Zeise & Gail S. Prins. (2019) Proposed Key Characteristics of Male Reproductive Toxicants as an Approach for Organizing and Evaluating Mechanistic Evidence in Human Health Hazard Assessments. Environmental Health Perspectives 127:6.
Crossref
Yu-Jie Chen, Jian Zhang, Ping-Ping Zhu, Xian-Wen Tan, Qiu-Hong Lin, Wen-Xia Wang, Shan-Shan Yin, Ling-Zhi Gao, Ming-Ming Su, Chang-Xiao Liu, Liang Xu, Wei Jia, Irina F. Sevrioukova & Ke Lan. (2019) Stereoselective Oxidation Kinetics of Deoxycholate in Recombinant and Microsomal CYP3A Enzymes: Deoxycholate 19-Hydroxylation Is an In Vitro Marker of CYP3A7 Activity. Drug Metabolism and Disposition 47:6, pages 574-581.
Crossref
Martin van den Berg & Majorie B.M. van Duursen. (2019) Mechanistic considerations for reduced endometrial cancer risk by smoking. Current Opinion in Toxicology 14, pages 52-59.
Crossref
Jian Zhang, Ling-Zhi Gao, Yu-Jie Chen, Ping-Ping Zhu, Shan-Shan Yin, Ming-Ming Su, Yan Ni, Jia Miao, Wen-Lin Wu, Hong Chen, Kim L. R. Brouwer, Chang-Xiao Liu, Liang Xu, Wei Jia & Ke Lan. (2019) Continuum of Host-Gut Microbial Co-metabolism: Host CYP3A4/3A7 are Responsible for Tertiary Oxidations of Deoxycholate Species. Drug Metabolism and Disposition 47:3, pages 283-294.
Crossref
Xuan Xu, Qiqin Zheng, Guangmin Bai, Qumei Dai, Xiaodong Cao, Yuewei Yao, Songqin Liu & Cheng Yao. (2018) Polydopamine functionalized nanoporous graphene foam as nanoreactor for efficient electrode-driven metabolism of steroid hormones. Biosensors and Bioelectronics 119, pages 182-190.
Crossref
Palraj Kalimuthu, Agnieszka M. Wojtkiewicz, Maciej Szaleniec & Paul V. Bernhardt. (2018) Electrocatalytic Hydroxylation of Sterols by Steroid C25 Dehydrogenase from Sterolibacterium denitrificans . Chemistry – A European Journal 24:30, pages 7710-7717.
Crossref
P. V. Ershov, Yu. V. Mezentsev, E. O. Yablokov, L. A. Kaluzhskiy, A. V. Florinskaya, A. V. Svirid, A. A. Gilep, S. A. Usanov, A. E. Medvedev & A. S. Ivanov. (2018) Specificity of Isatin Interaction with Cytochromes P450. Biochemistry (Moscow), Supplement Series B: Biomedical Chemistry 12:2, pages 130-135.
Crossref
Lina Schiffer, Wiebke Arlt & Karl-Heinz Storbeck. (2018) Intracrine androgen biosynthesis, metabolism and action revisited. Molecular and Cellular Endocrinology 465, pages 4-26.
Crossref
Nikhat Saba & Alpana Seal. (2018) Identification of a less toxic vinca alkaloid derivative for use as a chemotherapeutic agent, based on in silico structural insights and metabolic interactions with CYP3A4 and CYP3A5. Journal of Molecular Modeling 24:4.
Crossref
P.V. Ershov, Yu.V. Mezentsev, E.O. Yablokov, L.A. Kalushskiy, A.V. Florinskaya, A.V. Svirid, A.A. Gilep, S.A. Usanov, A.E. Medvedev & A.S. Ivanov. (2018) Study specificity of isatin interactions with P450 cytochromes. Biomeditsinskaya Khimiya 64:1, pages 61-65.
Crossref
Xuan Xu, Guangmin Bai, Lishu Song, Qiqin Zheng, Yuewei Yao, Songqin Liu & Cheng Yao. (2017) Fast steroid hormone metabolism assays with electrochemical liver microsomal bioreactor based on polydopamine encapsulated gold-graphene nanocomposite. Electrochimica Acta 258, pages 1365-1374.
Crossref
Jianhai Wang, Keqiu Li, Xiaoning Zhang, Dahong Teng, Mingyan Ju, Yaqing Jing, Yuxia Zhao & Guang Li. (2017) The correlation between the expression of genes involved in drug metabolism and the blood level of tacrolimus in liver transplant receipts. Scientific Reports 7:1.
Crossref
Jing-Jing Wu, Yun-Feng Cao, Liang Feng, Yu-Qi He, James Y. Hong, Tong-Yi Dou, Ping Wang, Da-Cheng Hao, Guang-Bo Ge & Ling Yang. (2017) A Naturally Occurring Isoform-Specific Probe for Highly Selective and Sensitive Detection of Human Cytochrome P450 3A5. Journal of Medicinal Chemistry 60:9, pages 3804-3813.
Crossref
Shotaro Uehara, Yasuhiro Uno, Kazuyuki Nakanishi, Sakura Ishii, Takashi Inoue, Erika Sasaki & Hiroshi Yamazaki. (2017) Marmoset Cytochrome P450 3A4 Ortholog Expressed in Liver and Small-Intestine Tissues Efficiently Metabolizes Midazolam, Alprazolam, Nifedipine, and Testosterone. Drug Metabolism and Disposition 45:5, pages 457-467.
Crossref
Toshiro Niwa, Marina Shizuku & Kaori Yamano. (2017) Effect of genetic polymorphism on the inhibition of dopamine formation from p -tyramine catalyzed by brain cytochrome P450 2D6. Archives of Biochemistry and Biophysics 620, pages 23-27.
Crossref
Trevor M. Penning. (2017) Genotoxicity of ortho-quinones: reactive oxygen species versus covalent modification. Toxicol. Res. 6:6, pages 740-754.
Crossref
J. Hofland & F.H. de Jong. 2017. Stress: Neuroendocrinology and Neurobiology. Stress: Neuroendocrinology and Neurobiology 359 365 .
Ilona K. Jóźwik, Flora M. Kiss, Łukasz Gricman, Ammar Abdulmughni, Elisa Brill, Josef Zapp, Juergen Pleiss, Rita Bernhardt & Andy‐Mark W. H. Thunnissen. (2016) Structural basis of steroid binding and oxidation by the cytochrome P450 CYP 109E1 from Bacillus megaterium . The FEBS Journal 283:22, pages 4128-4148.
Crossref
Martin Perreault, René Maltais, Raphaël Dutour & Donald Poirier. (2016) Explorative study on the anticancer activity, selectivity and metabolic stability of related analogs of aminosteroid RM-133. Steroids 115, pages 105-113.
Crossref
Kai Chang, Zhongyong Jiang, Chenxia Liu, Junlong Ren, Ting Wang & Jie Xiong. (2016) The Effects of CYP2C19 genotype on the susceptibility for nephrosis in cardio-cerebral vascular disease treated by anticoagulation. Medicine 95:38, pages e4954.
Crossref
Sandra Giovanna Salamanca-Pinzon, Yogan Khatri, Yvonne Carius, Lena Keller, Rolf Müller, C. Roy D. Lancaster & Rita Bernhardt. (2016) Structure-function analysis for the hydroxylation of Δ4 C21-steroids by the myxobacterial CYP260B1. FEBS Letters 590:12, pages 1838-1851.
Crossref
Toshiro Niwa & Tomomi Hata. (2016) The Effect of Genetic Polymorphism on the Inhibition of Azole Antifungal Agents Against CYP2C9-Mediated Metabolism. Journal of Pharmaceutical Sciences 105:3, pages 1345-1348.
Crossref
Toshiro Niwa, Mari Morimoto, Takako Hirai, Tomomi Hata, Misato Hayashi & Yurie Imagawa. (2016) Effect of penicillin-based antibiotics, amoxicillin, ampicillin, and piperacillin, on drug-metabolizing activities of human hepatic cytochromes P450. The Journal of Toxicological Sciences 41:1, pages 143-146.
Crossref
T. Matakova, E. Halasova, A. Dzian, R. Hruby, M. Halasa, K. Javorka & M. Skerenova. 2016. Advances in Respiratory Cancerogenesis. Advances in Respiratory Cancerogenesis 23 32 .
Yogan Khatri, Michael Ringle., Michael Lisurek, Jens Peter von Kries, Josef Zapp & Rita Bernhardt. (2016) Substrate Hunting for the Myxobacterial CYP260A1 Revealed New 1α-Hydroxylated Products from C-19 Steroids. ChemBioChem 17:1, pages 90-101.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.