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Research Article

The Skin as a Drug-Metabolizing Organ

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Pages 319-343 | Published online: 22 Sep 2008

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Catherine Champmartin, Lisa Chedik, Fabrice Marquet & Frédéric Cosnier. (2022) Occupational exposure assessment with solid substances: choosing a vehicle for in vitro percutaneous absorption experiments. Critical Reviews in Toxicology 52:4, pages 294-316.
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Ralph Pirow, Annegret Blume, Nicole Hellwig, Matthias Herzler, Bettina Huhse, Christoph Hutzler, Karla Pfaff, Hermann-Josef Thierse, Tewes Tralau, Bärbel Vieth & Andreas Luch. (2019) Mineral oil in food, cosmetic products, and in products regulated by other legislations. Critical Reviews in Toxicology 49:9, pages 742-789.
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KevinC. Garala & PratikH. Shah. (2010) Influence of Crosslinking Agent on the Release of Drug from the Matrix Transdermal Patches of HPMC/Eudragit RL 100 Polymer Blends. Journal of Macromolecular Science, Part A 47:3, pages 273-281.
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RuthJ. Bevan, RebeccaJ. Slack, Philip Holmes & LeonardS. Levy. (2009) An Assessment of Potential Cancer Risk Following Occupational Exposure to Ethanol. Journal of Toxicology and Environmental Health, Part B 12:3, pages 188-205.
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G. L. Qiao & J. E. Riviere. (2002) SYSTEMIC UPTAKE AND CUTANEOUS DISPOSITION OF PENTACHLOROPHENOL IN A SEQUENTIAL EXPOSURE SCENARIO: EFFECTS OF SKIN PREEXPOSURE TO BENZO[a]PYRENE. Journal of Toxicology and Environmental Health, Part A 65:18, pages 1307-1331.
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Robert L. Bronaugh, Margaret E. K. Kraeling, Jeffrey J. Yourick & Harolyn L. Hood. (2001) Cutaneous metabolism during in vitro percutaneous absorption. Journal of Toxicology: Cutaneous and Ocular Toxicology 20:2-3, pages 271-277.
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Robert L. Bronaugh. (1995) Methods for in Vitro Skin Metabolism Studies. Toxicology Methods 5:4, pages 275-281.
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Hon-Wing Leung & DennisJ. Paustenbach. (1994) Techniques for Estimating the Percutaneous Absorption of Chemicals Due to Occupational and Environmental Exposure. Applied Occupational and Environmental Hygiene 9:3, pages 187-197.
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S. W. Frantz, D. A. Dittenber, D. L. Eisenbrandt & P. G. Watanabe. (1990) Evaluation of a Flow-Through In Vitro Skin Penetration Chamber Method Using Acetone-Deposited Organic Solids. Journal of Toxicology: Cutaneous and Ocular Toxicology 9:4, pages 277-299.
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John Kao & Michael P. Carver. (1990) Cutaneous Metabolism of Xenobiotics. Drug Metabolism Reviews 22:4, pages 363-410.
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Robert L. Bronaugh, Steven W. Collier, Jan E. Storm & Raymond F. Stewart. (1989) In Vitro Evaluation of Skin Absorption and Metabolism. Journal of Toxicology: Cutaneous and Ocular Toxicology 8:4, pages 453-467.
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G. Nicolau & A. Yacobi. (1989) Transdermal Absorption and Skin Metabolism of Viprostol, A Synthetic Prostaglandin E2 Analogue. Drug Metabolism Reviews 21:3, pages 401-425.
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H. Behrendt & H. G. Kampffmeyer. (1989) Absorption and ester cleavage of methyl salicylate by skin of single-pass perfused rabbit ears. Xenobiotica 19:2, pages 131-141.
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RichardP. Moody & ClaireA. Franklin. (1987) Percutaneous absorption of the insecticides fenitrothion and aminocarb in rats and monkeys. Journal of Toxicology and Environmental Health 20:1-2, pages 209-218.
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FranklinD. Aldrich, WilliamF. Busby & JamesG. Fox$suffix/text()$suffix/text(). (1986) Excretion of radioactivity from rats and rabbits following cutaneous application of two 14C‐labeled azo dyes. Journal of Toxicology and Environmental Health 18:3, pages 347-355.
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Ronald C. Wester & Howard I. Maibach. (1983) Cutaneous Pharmacokinetics: 10 Steps to Percutaneous Absorption. Drug Metabolism Reviews 14:2, pages 169-205.
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RajendraS. Chhabra. (1981) Effect of dietary factors and environmental chemicals on intestinal drug metabolizing enzymes. Toxicological & Environmental Chemistry 3:3-4, pages 173-199.
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A. Pannatier, B. Testa & J.-C. Etter. (1981) Aryl ether O-dealkylase activity in the skin of untreated mice in vitro. Xenobiotica 11:5, pages 345-350.
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