42
Views
33
CrossRef citations to date
0
Altmetric
Research-Article

Specific Antibodies and Fab Fragments to Alter the Pharmacokinetics and Reverse the Pharmacologic/Toxicologic Effects of Drugs

Pages 223-262 | Published online: 22 Sep 2008

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (8)

Martin A Rossotti, Andrés González-Techera, Julio Guarnaschelli, Lucia Yim, Ximena Camacho, Marcelo Fernández, Pablo Cabral, Carmen Leizagoyen, José A Chabalgoity & Gualberto González-Sapienza. (2015) Increasing the potency of neutralizing single-domain antibodies by functionalization with a CD11b/CD18 binding domain. mAbs 7:5, pages 820-828.
Read now
Kennon Heard, Richard C. Dart, Gregory Bogdan, Gerald F. O'Malley, Keith K. Burkhart, J. Ward Donovan & Suzanne B. Ward. (2006) A Preliminary Study of Tricyclic Antidepressant (TCA) Ovine FAB for TCA Toxicity. Clinical Toxicology 44:3, pages 275-281.
Read now
David M. Knight, Robert E. Jordan, Marian Kruszynski, Susan H. Tam, Jill Giles-Komar, George Treacy & George A. Heavner. (2004) Pharmacodynamic enhancement of the anti-platelet antibody Fab abciximab by site-specific pegylation. Platelets 15:7, pages 409-418.
Read now
Jean-Michel Scherrmann, Nicole Terrien, Michel Urtizberea, Pascale Pierson, HÉLÈNe Denis & Jean-Marie Bourre. (1989) Immunotoxicotherapy: Present status and future trends. Journal of Toxicology: Clinical Toxicology 27:1-2, pages 1-35.
Read now
R. Cadot, J. Descotes, C. Grenot, C. Y. Cuilleron & J. C. Evreux. (1985) Increased Plasma Paraquat Levels in Intoxicated Mice Following Antiparaquat F(ab′)2 Treatment. Journal of Immunopharmacology 7:4, pages 467-477.
Read now
Z. H. Israili & P. G. Dayton. (1984) Enhancement of Xenobiotic Elimination: Role of Intestinal Excretion. Drug Metabolism Reviews 15:5-6, pages 1123-1159.
Read now
Peter g. Dayton, Zafar h. Israili & James d. Henderson. (1983) Elimination of Drugs by Passive Diffusion from Blood to Intestinal Lumen: Factors Influencing Nonbiliary Excretion by the Intestinal Tract. Drug Metabolism Reviews 14:6, pages 1193-1206.
Read now
Alice A. Holazo & Wayne A. Colburn. (1982) Pharmacokinetics of Drugs during Various Detoxification Procedures for Overdose and Environmental Exposure. Drug Metabolism Reviews 13:4, pages 715-743.
Read now

Articles from other publishers (25)

Alain E Sabouraud, Michel Urtizberea, Kamel Benmoussa, Nathalie J Cano & Jean-Michel G Scherrmann. (1992) Fab-bound Colchicine Appears to Adopt Fab Fragment Disposition in Rats. Journal of Pharmacy and Pharmacology 44:12, pages 1015-1019.
Crossref
Stefan S. De Buck, Mario T. Schellenberger, Corinne Ensch & Claude P. Muller. (2010) Effects of antibodies induced by a conjugate vaccine on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone absorptive transport, metabolism, and proliferation of human lung cells. International Journal of Cancer 127:3, pages 513-520.
Crossref
Nicolas Frey, Susan Grange & Thasia Woodworth. (2013) Population Pharmacokinetic Analysis of Tocilizumab in Patients With Rheumatoid Arthritis. The Journal of Clinical Pharmacology 50:7, pages 754-766.
Crossref
Chee M. Ng, Rene Bruno, Dan Combs & Brian Davies. (2005) Population Pharmacokinetics of Rituximab (Anti-CD20 Monoclonal Antibody) in Rheumatoid Arthritis Patients During a Phase II Clinical Trial. The Journal of Clinical Pharmacology 45:7, pages 792-801.
Crossref
. 2004. Immunotoxicology of Drugs and Chemicals: an Experimental and Clinical Approach - Volume I: Principles and Methods of Immunotoxicology. Immunotoxicology of Drugs and Chemicals: an Experimental and Clinical Approach - Volume I: Principles and Methods of Immunotoxicology 311 326 .
Frank J. Vocci & C. Nora Chiang. (2001) Vaccines Against Nicotine. CNS Drugs 15:7, pages 505-514.
Crossref
Stephanie Pépin-Covatta, Charles Lutsch, Michel Grandgeorge & Jean-Michel Scherrmann. (1997) Immunoreactivity of a new generation of horse F(ab′)2 preparations against European viper venoms and the tetanus toxin. Toxicon 35:3, pages 411-422.
Crossref
Paul R. Pentel & Daniel E. Keyler. (1995) Drug-specific antibodies as antidotes for tricyclic antidepressant overdose. Toxicology Letters 82-83, pages 801-806.
Crossref
A. J. Heath. 1995. Therapeutic Antibodies. Therapeutic Antibodies 89 108 .
D.E. Keyler, W.L. Shelver, J. Landon, A. Sidki & P.R. Pentel. (1994) Toxicity of high doses of polyclonal drug-specific antibody Fab fragments. International Journal of Immunopharmacology 16:12, pages 1027-1034.
Crossref
Gregory J. Brunn, Daniel E. Keyler, Catherine A. Ross, Susan M. Pond & Paul R. Pentel. (1991) Drug-specific F(ab′)2 fragment reduces desipramine cardiotoxicity in rats. International Journal of Immunopharmacology 13:7, pages 841-851.
Crossref
Paul R Pentel, Gregory J Brunn, Susan M Pond & Daniel E Keyler. (1991) Pretreatment with drug-specific antibody reduces desipramine cardiotoxicity in rats. Life Sciences 48:7, pages 675-683.
Crossref
James F. Winchester. 1990. Therapy of Renal Diseases and Related Disorders. Therapy of Renal Diseases and Related Disorders 639 648 .
DJOKO WAHYONO, MARTINE PIECHACZYK, CHANTAL MOURTON, JEAN-MARIE BASTIDE & BERNARD PAU. (1990) Novel Anti-Digoxin Monoclonal Antibodies with Different Binding Specificities for Digoxin Metabolites and Other Glycosides. Hybridoma 9:6, pages 619-629.
Crossref
Val R. Beasley & David C. Dorman. (1990) Management of Toxicoses. Veterinary Clinics of North America: Small Animal Practice 20:2, pages 307-337.
Crossref
M. Urtizberea, A. Sabouraud, N. Terrien & J.M. Scherrmann. (1989) Immunotoxicothérapie : stratégie dans la préparation et l'administration des anticorps spécifiques. Immuno-analyse & Biologie Spécialisée 4:5, pages 17-25.
Crossref
N. Terrien, M. Urtizberea & J.M. Scherrmann. (1989) Influence of goat colchicine specific antibodies on murine colchicine disposition. Toxicology 59:1, pages 11-22.
Crossref
James F. Winchester. (1989) Poisoning: Is the Role of the Nephrologist Diminishing?. American Journal of Kidney Diseases 13:3, pages 171-183.
Crossref
James F. Winchester. 1989. Replacement of Renal Function by Dialysis. Replacement of Renal Function by Dialysis 439 459 .
Paul Pentel, Susan M. Pond & Deric Schoof. (1987) Redistribution into plasma of tracer doses of desipramine by anti-desipramine antiserum in rats. Biochemical Pharmacology 36:2, pages 293-295.
Crossref
Robert G. Peterson & Linda N. Peterson. (1986) Cleansing the Blood: Hemodialysis, Peritoneal Dialysis, Exchange Transfusion, Charcoal Hemoperfusion, Forced Diuresis. Pediatric Clinics of North America 33:3, pages 675-689.
Crossref
J.R. Zalcberg. (1985) Monoclonal antibodies to drugs: Novel diagnostic and therapeutic reagents. Pharmacology & Therapeutics 28:3, pages 273-285.
Crossref
Nina M. Griffiths, David S. Hewick & Ian H. Stevenson. (1984) The effect of immunization with digoxin-specific antibodies on digoxin disposition in the mouse. Biochemical Pharmacology 33:19, pages 3041-3046.
Crossref
J.R. Zalcberg, K. Healey, J.G.R. Hurrell & I.F.C. McKenze. (1983) Monoclonal antibodies to drugs — digoxin. International Journal of Immunopharmacology 5:5, pages 397-402.
Crossref
William M. Bennett. 1983. Contemporary Nephrology. Contemporary Nephrology 727 770 .

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.