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Research Article

The Effect of Hepatic Metabolism on the Production and Toxicity of Reactive Metabolites in Extrahepatic Organs

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Pages 35-47 | Published online: 22 Sep 2008

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F. Peter Guengerich. (1990) Enzymatic Oxidation of Xenobiotic Chemical. Critical Reviews in Biochemistry and Molecular Biology 25:2, pages 97-153.
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James V. Bruckner, Barbara D. Davis & Jerry N. Blancato. (1989) Metabolism, Toxicity, and Carcinogenicity of Trichloroethylene. Critical Reviews in Toxicology 20:1, pages 31-50.
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Rune Becher, Jon E. Dahl, Kjell Aarstad, Odd C. Nilsen & Erik Dybing. (1989) Lung and Liver Damage in Mice After Bromobenzene Inhalation: Effects of Enzyme Inducers. Inhalation Toxicology 1:2, pages 181-196.
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James Gillette, Elizabeth K. Weisburger, Herman Kraybill & Morris Kelsey. (1985) Strategies for Determining the Mechanisms of Toxicity. Journal of Toxicology: Clinical Toxicology 23:1, pages 1-78.
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F. Peter Guengerich, Daniel C. Liebler & Donald L. Reed. (1985) Enzymatic activation of chemicals to toxic metabolites. CRC Critical Reviews in Toxicology 14:3, pages 259-307.
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Yimin Zhu, Jinghong Li & Shaojun Dong. (1998) Dimerization of hydroxylated species of m-aminophenol by cytochrome c with hydrogen peroxide. Journal of Molecular Catalysis B: Enzymatic 5:5-6, pages 475-482.
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Laurie S. Tsuruda, Michael W. Lamé & A. Daniel Jones. (1995) Formation of epoxide and quinone protein adducts in B6C3F1 mice treated with naphthalene, sulfate conjugate of 1,4-dihydroxynaphthalene and 1,4-naphthoquinone. Archives of Toxicology 69:6, pages 362-367.
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JEFFREY BARON & JEFFREY M. VOIGT. 1993. Metabolic Activation and Toxicity of Chemical Agents to Lung Tissue and Cells. Metabolic Activation and Toxicity of Chemical Agents to Lung Tissue and Cells 41 75 .
Alice M. Clark & Charles D. Hufford. (2006) Use of microorganisms for the study of drug metabolism: An update. Medicinal Research Reviews 11:5, pages 473-501.
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Jeffrey Baron & Jeffrey M. Voigt. (1990) Localization, distribution, and induction of xenobiotic-metabolizing enzymes and aryl hydrocarbon hydroxylase activity within lung. Pharmacology & Therapeutics 47:3, pages 419-445.
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MARVIN S. LEGATOR & BARBARA L. HARPER. (1988) Mutagenicity Screening/in Vitro Testing?the End of an Era; Animal and Human Studies?the Direction for the Future. Annals of the New York Academy of Sciences 534:1 Living in a C, pages 833-844.
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Jeffrey Baron, Jon P. Burke, F.Peter Guengerich, William B. Jakoby & Jeffrey M. Voigt. (1988) Sites for xenobiotic activation and detoxication within the respiratory tract: Implications for chemically induced toxicity. Toxicology and Applied Pharmacology 93:3, pages 493-505.
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Emilio Perucca & Luigi Manzo. 1988. Recent Advances in Nervous System Toxicology. Recent Advances in Nervous System Toxicology 67 86 .
Mario Comporti. (1987) Glutathione depleting agents and lipid peroxidation. Chemistry and Physics of Lipids 45:2-4, pages 143-169.
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Michael Mollière, Heidi Foth, Regine Kahl & Georg F. Kahl. (1987) Metabolism of benzo[α] pyrene in the combined rat liver —lung perfusion system. Toxicology 45:2, pages 143-154.
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Michael E. Placke, D. Stuart Wyand & Steven D. Cohen. (2016) Extrahepatic Lesions Induced by Acetaminophen in the Mouse. Toxicologic Pathology 15:4, pages 381-387.
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G. Gordon Gibson & Paul SkettG. Gordon Gibson & Paul Skett. 1986. Introduction to Drug Metabolism. Introduction to Drug Metabolism 175 198 .
Jeffrey Baron, Jeffrey M. Voigt, Tyrone B. Whitter, Thomas T. Kawabata, Shirley A. Knapp, F. Peter Guengerich & William B. Jakoby. 1986. Biological Reactive Intermediates III. Biological Reactive Intermediates III 119 144 .
Alice M. Clark, James D. McChesney & Charles D. Hufford. (2006) The use of microorganisms for the study of drug metabolism. Medicinal Research Reviews 5:2, pages 231-253.
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Kenji Shiromizu & Donald R. Mattison. (2005) Murine oocyte destruction following intraovarian treatment with 3‐methylcholanthrene or 7,12‐dimethylbenz(a)anthracene: Protection by alpha‐naphthoflavone. Teratogenesis, Carcinogenesis, and Mutagenesis 5:6, pages 463-472.
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Donna M. Radzik & Peter T. Kissinger. (1984) Determination of aniline and metabolites produced in vitro by liquid chromatography/electrochemistry. Analytical Biochemistry 140:1, pages 74-83.
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