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Research Article

Use of the Isolated Perfused Kidney as a Tool in Drug Disposition Studies

Pages 931-960 | Published online: 22 Sep 2008

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Lianne J. Stevens, Joanne M. Donkers, Jeroen Dubbeld, Wouter H. J. Vaes, Catherijne A. J. Knibbe, Ian P. J. Alwayn & Evita van de Steeg. (2020) Towards human ex vivo organ perfusion models to elucidate drug pharmacokinetics in health and disease. Drug Metabolism Reviews 52:3, pages 438-454.
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Mitalee Tamhane, Ananthsrinivas R. Chakilam, Andrew Jayaraj, Vineet Thakkar & David R. Taft. (2010) Comparative renal excretion of VX-702, a novel p38 MAPK inhibitor, and methotrexate in the perfused rat kidney model. Drug Development and Industrial Pharmacy 36:3, pages 315-322.
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Liliana A. Monasterolo, J. Elena Ochoa & María Mónica Elías. (2002) RAT RENAL FUNCTION FOUR DAYS AFTER BILE-DUCT LIGATION: EFFECTS OF INDOMETHACIN AND VASOACTIVE AGENTS. Renal Failure 24:2, pages 111-126.
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David R. Luke & Kurt L. Berens. (1992) Effects of Suprofen on the Isolated Perfused Rat Kidney. Renal Failure 14:2, pages 187-192.
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Articles from other publishers (40)

Aruna Dontabhaktuni, David R. Taft & Mayankbhai Patel. (2016) Gentamicin Renal Excretion in Rats: Probing Strategies to Mitigate Drug-Induced Nephrotoxicity. Pharmacology & Pharmacy 07:01, pages 43-55.
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Mitalee Tamhane, Manoj Maniar, Chen Ren, Kenza E. Benzeroual & David R. Taft. (2013) Disposition of ON 01210.Na (Ex-RAD(R)), a Novel Radioprotectant, in the Isolated Perfused Rat Liver: Probing Metabolic Inhibition to Increase Systemic Exposure. Journal of Pharmaceutical Sciences 102:2, pages 732-740.
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Edwin K. Jackson, Dongmei Cheng, Stevan P. Tofovic & Zaichuan Mi. (2012) Endogenous adenosine contributes to renal sympathetic neurotransmission via postjunctional A 1 receptor-mediated coincident signaling . American Journal of Physiology-Renal Physiology 302:4, pages F466-F476.
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Mariana Babayeva, Susan Cox, Michael P. White & David R. Taft. (2011) Renal excretion of apricitabine in rats: ex vivo and in vivo studies. European Journal of Drug Metabolism and Pharmacokinetics 36:3, pages 141-150.
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Rosalinde Masereeuw, Miek M Moons & Frans G M Russel. (1996) Renal Excretion and Accumulation Kinetics of 2-Methylbenzoylglycine in the Isolated Perfused Rat Kidney. Journal of Pharmacy and Pharmacology 48:6, pages 560-565.
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David S Tofovic, Victor P Bilan & Edwin K Jackson. (2010) Sitagliptin augments angiotensin II-induced renal vasoconstriction in kidneys from rats with metabolic syndrome. Clinical and Experimental Pharmacology and Physiology 37:7, pages 689-691.
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Antoinette D. Ajavon, Peter L. Bonate & David R. Taft. (2010) Renal excretion of clofarabine: Assessment of dose-linearity and role of renal transport systems on drug excretion. European Journal of Pharmaceutical Sciences 40:3, pages 209-216.
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Alfredo Rigalli & Verónica E. Di Loreto. 2009. Experimental Surgical Models in the Laboratory Rat. Experimental Surgical Models in the Laboratory Rat 169 175 .
Tomoko Nakatani‐Freshwater & David R. Taft. (2008) Renal excretion of emtricitabine I: Effects of organic anion, organic cation, and nucleoside transport inhibitors on emtricitabine excretion. Journal of Pharmaceutical Sciences 97:12, pages 5401-5410.
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Tomoko Nakatani‐Freshwater & David R. Taft. (2008) Renal excretion of emtricitabine II. Effect of trimethoprim on emtricitabine excretion: In vitro and in vivo studies. Journal of Pharmaceutical Sciences 97:12, pages 5411-5420.
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Lawrence Lash. 2007. Principles and Methods of Toxicology, Fifth Edition. Principles and Methods of Toxicology, Fifth Edition 1509 1540 .
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Christopher S. Lepsy, Robert J. Guttendorf, Alan R. Kugler & David E. Smith. (2003) Effects of Organic Anion, Organic Cation, and Dipeptide Transport Inhibitors on Cefdinir in the Isolated Perfused Rat Kidney. Antimicrobial Agents and Chemotherapy 47:2, pages 689-696.
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Thomas C. Dowling. (2016) Drug Metabolism Considerations in Patients With Chronic Kidney Disease. Journal of Pharmacy Practice 15:5, pages 419-427.
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Aránzazu Zarzuelo, José M. Lanao, Francisco G. López & Amparo Sánchez-Navarro. (2002) Influence of the infusion rate on disposition of netilmicin in the isolated rat perfused kidney. European Journal of Pharmaceutical Sciences 16:3, pages 133-141.
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Liliana A Monasterolo, Laura Trumper & M.Mónica Elı́as. (2002) Reversal of benzodiazepine-induced renal vasculature relaxation with flumazenil. European Journal of Pharmacology 449:1-2, pages 155-158.
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Aránzazu Zarzuelo, Amparo Sánchez-Navarro, Francisco G. López & José M. Lanao. (2002) Influence of dose on the disposition kinetics of netilmicin in the isolated kidney of the rat. European Journal of Drug Metabolism and Pharmacokinetics 27:2, pages 127-133.
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V. M. C. García, J. E. Ochoa & M. M. Elías. (2008) Effect of early stage of experimental diabetes on vascular functions in isolated perfused kidneys. Journal of Autonomic Pharmacology 19:2, pages 97-103.
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Marián Kukan. 1999. Handbook of Drug Metabolism. Handbook of Drug Metabolism 425 442 .
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Olga N Ilinskaya & Spiros Vamvakas. (1997) Nephrotoxic effects of bacterial ribonucleases in the isolated perfused rat kidney. Toxicology 120:1, pages 55-63.
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Alan R. Kugler, Stephen C. Olson & David E. Smith. (1996) Tubular transport mechanisms of quinapril and quinaprilat in the isolated perfused rat kidney: Effect of organic anions and cations. Journal of Pharmacokinetics and Biopharmaceutics 24:4, pages 349-368.
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O. Ilinskaja & S. Vamvakas. (1996) Alterations of the renal function in the isolated perfused rat kidney system after in vivo and in vitro application of S-(1,2-dichlorovinyl)-L-cysteine and S-(2,2-dichlorovinyl)-L-cysteine. Archives of Toxicology 70:3-4, pages 224-229.
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Gabrielle M. Hawksworth, Peter H. Bach, J. Fred Nagelkerke, Wolfgang Dekant, Jacques E. Diezi, Ernest Harpur, Edward A. Lock, Caroline MacDonald, Jean-Paul Morin, Walter Pfaller, Fons A.J.J.L. Rutten, Michael P. Ryan, Hervé J. Toutain & Andrea Trevisan. (2020) Nephrotoxicity Testing In Vitro . Alternatives to Laboratory Animals 23:5, pages 713-727.
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Alan R. Kugler, Stephen C. Olson & David E. Smith. (1995) Disposition of quinapril and quinaprilat in the isolated perfused rat kidney. Journal of Pharmacokinetics and Biopharmaceutics 23:3, pages 287-305.
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Liliana A. Monasterolo, J.Elena Ochoa, Laura Trumper & M.Mónica Elías. (1995) Vascular and tubular actions of diazepam in isolated and perfused rat kidney. European Journal of Pharmacology 276:3, pages 201-205.
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Laura Trumper, Liliana A. Monasterolo, Elena Ochoa & M. Monica Elias. (1995) Tubular effects of acetaminophen in the isolated perfused rat kidney. Archives of Toxicology 69:4, pages 248-252.
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Robert T. Muldoon, Bernard H. Eisenga, Khandoker M. Morshed & Kenneth E. McMartin. (1992) 5-Methyltetrahydrofolate Is Reabsorbed and Metabolized in Isolated Perfused Rat Kidney. The Journal of Nutrition 122:12, pages 2415-2423.
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C A RodríguezD E Smith. (1992) Influence of angiotensin II-induced alterations in renal flow on excretion of cefonicid in isolated perfused rat kidneys. Antimicrobial Agents and Chemotherapy 36:3, pages 616-619.
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C A RodriguezD E Smith. (1991) Influence of the unbound concentration of cefonicid on its renal elimination in isolated perfused rat kidneys. Antimicrobial Agents and Chemotherapy 35:11, pages 2395-2400.
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Takano Takehito, Nakata Kazuyo, Kawakami Tsuyoshi, Miyazaki Yoshifumi, Murakami Masataka, seo Yoshiteru & Suzuki Eiji. (1991) Validation of a toxicity testing model by evaluating oxygen supply and energy state in the isolated perfused rat kidney. Journal of Pharmacological Methods 25:3, pages 195-204.
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Peter G.F. Cox, Miek M. Moons, Jan F.G. Slegers, Frans G.M. Russel & Cees A.M. Van Ginneken. (1990) Isolated perfused rat kidney as a tool in the investigation of renal handling and effects of nonsteroidal antiinflammatory drugs. Journal of Pharmacological Methods 24:2, pages 89-103.
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Ryohei Hori, Yusuke Tanigawara, Yoshihiro Saito, Yoshie Hayashi, Tetsuya Aiba, Katsuhiko Okumura & Akira Kamiya. (1988) Moment analysis of drug disposition in kidney: Transcellular transport kinetics of p-Aminohippurate in the Isolated Perfused Rat Kidney. Journal of Pharmaceutical Sciences 77:6, pages 471-476.
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D. Schrenk, W. Dekant, P.H. Wünsch & D. Henschler. (1988) Role of metabolic activation in the toxicity of S-(pentachlorobutadienyl)glutathione and in the isolated perfused rat kidney. Toxicology in Vitro 2:4, pages 283-290.
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Thomas P. Gibson. (1986) Renal Disease and Drug Metabolism: An Overview. American Journal of Kidney Diseases 8:1, pages 7-17.
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Patrick W. Trown, Robert J. Wills & Jerome J. Kamm. (1986) The preclinical development of roferon®-A. Cancer 57:S8, pages 1648-1656.
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Ling-Jar Lee, Jack A. Cook & David E. Smith. (1986) Renal transport kinetics of furosemide in the isolated perfused rat kidney. Journal of Pharmacokinetics and Biopharmaceutics 14:2, pages 157-174.
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Ihor Bekersky & Andrea C. Popick. (1986) Disposition of bumetanide in the isolated perfused rat kidney: Effects of probenecid and dose response. The American Journal of Cardiology 57:2, pages A33-A37.
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