57
Views
26
CrossRef citations to date
0
Altmetric
Research Article

Metabolism of Dehp: Effects of Prefeeding and Dose Variation, and Comparative Studies in Rodents and the Cynomolgus Monkey (CMA Studies)

Pages 35-53 | Published online: 22 Sep 2008

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (8)

Kaori Sadakane, Takamichi Ichinose, Hirohisa Takano, Rie Yanagisawa & Eiko Koike. (2014) Effects of oral administration of di-(2-ethylhexyl) and diisononyl phthalates on atopic dermatitis in NC/Nga mice. Immunopharmacology and Immunotoxicology 36:1, pages 61-69.
Read now
Yuki Tomonari, Yoshimasa Kurata, RaymondM. David, Gerhard Gans, Takeshi Kawasuso & Masanobu Katoh. (2006) Effect of Di(2-Ethylhexyl) Phthalate (DEHP) on Genital Organs from Juvenile Common Marmosets: I. Morphological and Biochemical Investigation in 65-Week Toxicity Study. Journal of Toxicology and Environmental Health, Part A 69:17, pages 1651-1672.
Read now
Ivan Rusyn, Jeffrey M. Peters & Michael L. Cunningham. (2006) Modes of Action and Species-Specific Effects of Di-(2-ethylhexyl)Phthalate in the Liver. Critical Reviews in Toxicology 36:5, pages 459-479.
Read now
James E. Klaunig, Michael A. Babich, Karl P. Baetcke, Jon C. Cook, J. Chris Corton, Raymond M. David, John G. DeLuca, David Y. Lai, Richard H. McKee, Jeffrey M. Peters, Ruth A. Roberts & Penelope A. Fenner-Crisp. (2003) PPARα Agonist-Induced Rodent Tumors: Modes of Action and Human Relevance. Critical Reviews in Toxicology 33:6, pages 655-780.
Read now
Lisa M. Kamendulis, Jason S. Isenberg, Jacqueline H. Smith, George Pugh Jr, Arthur W. Lington & James E. Klaunig. (2002) COMPARATIVE EFFECTS OF PHTHALATE MONOESTERS ON GAP JUNCTIONAL INTERCELLULAR COMMUNICATION AND PEROXISOME PROLIFERATION IN RODENT AND PRIMATE HEPATOCYTES. Journal of Toxicology and Environmental Health, Part A 65:8, pages 569-588.
Read now
D.F. Cadogan. (1999) Health and environmental effects of phthalate plasticisers for poly(vinyl chloride) – an update. Plastics, Rubber and Composites 28:10, pages 476-481.
Read now
Wolfgang W. Huber, Bettina Grasl-kraupp & Rolf Schulte-hermann. (1996) Hepatocarcinogenic Potential of Di(2-Ethylhexyl)phthalate in Rodents and its Implications on Human Risk. Critical Reviews in Toxicology 26:4, pages 365-481.
Read now
E. D. Barber, J. A. Fox & C. J. Giordano. (1994) Hydrolysis, absorption and metabolism of di(2-ethylhexyl) terephthalate in the rat. Xenobiotica 24:5, pages 441-450.
Read now

Articles from other publishers (18)

Yun-Ho Hwang, Young-Jin Son, Man-Jeong Paik & Sung-Tae Yee. (2017) Effects of diisononyl phthalate on osteopenia in intact mice. Toxicology and Applied Pharmacology 334, pages 120-128.
Crossref
Rebecca A. Clewell, Mark Sochaski, Kendra Edwards, Dianne M. Creasy, Gabrielle Willson & Melvin E. Andersen. (2013) Disposition of diiosononyl phthalate and its effects on sexual development of the male fetus following repeated dosing in pregnant rats. Reproductive Toxicology 35, pages 56-69.
Crossref
Yoshimasa Kurata, Nobuaki Shimamura & Masanobu Katoh. (2012) Metabolite profiling and identification in human urine after single oral administration of DEHP. The Journal of Toxicological Sciences 37:2, pages 401-414.
Crossref
Yoshimasa Kurata, Futoshi Makinodan, Nobuaki Shimamura & Masanobu Katoh. (2012) Metabolism of di (2-ethylhexyl) phthalate (DEHP): comparative study in juvenile and fetal marmosets and rats. The Journal of Toxicological Sciences 37:1, pages 33-49.
Crossref
Thomas Stroheker, Jean-François Regnier, Julie Lassurguere & Marie-Christine Chagnon. (2006) Effect of in utero exposure to di-(2-ethylhexyl)phthalate: Distribution in the rat fetus and testosterone production by rat fetal testis in culture. Food and Chemical Toxicology 44:12, pages 2064-2069.
Crossref
Antonia M. Calafat, John W. Brock, Manori J. Silva, L. Earl GrayJr.Jr., John A. Reidy, Dana B. Barr & Larry L. Needham. (2006) Urinary and amniotic fluid levels of phthalate monoesters in rats after the oral administration of di(2-ethylhexyl) phthalate and di-n-butyl phthalate. Toxicology 217:1, pages 22-30.
Crossref
Robert L. Brent. (2004) Utilization of juvenile animal studies to determine the human effects and risks of environmental toxicants during postnatal developmental stages. Birth Defects Research Part B: Developmental and Reproductive Toxicology 71:5, pages 303-320.
Crossref
Robert L. Brent. (2004) Utilization of Animal Studies to Determine the Effects and Human Risks of Environmental Toxicants (Drugs, Chemicals, and Physical Agents). Pediatrics 113:Supplement_3, pages 984-995.
Crossref
Richard H McKee, John H Butala, Raymond M David & Gerhard Gans. (2004) NTP center for the evaluation of risks to human reproduction reports on phthalates: addressing the data gaps. Reproductive Toxicology 18:1, pages 1-22.
Crossref
Jeremy K. Nicholson & Ian D. Wilson. (2003) Understanding 'Global' Systems Biology: Metabonomics and the Continuum of Metabolism. Nature Reviews Drug Discovery 2:8, pages 668-676.
Crossref
Thomas M. Cahill, Ian Cousins & Donald Mackay. (2009) Development and application of a generalized physiologically based pharmacokinetic model for multiple environmental contaminants. Environmental Toxicology and Chemistry 22:1, pages 26-34.
Crossref
Robert Kavlock, Kim Boekelheide, Robert Chapin, Michael Cunningham, Elaine Faustman, Paul Foster, Mari Golub, Rogene Henderson, Irwin Hinberg, Ruth Little, Jennifer Seed, Katherine Shea, Sonia Tabacova, Rochelle Tyl, Paige Williams & Timothy Zacharewski. (2002) NTP Center for the Evaluation of Risks to Human Reproduction: phthalates expert panel report on the reproductive and developmental toxicity of di-isononyl phthalate. Reproductive Toxicology 16:5, pages 679-708.
Crossref
Robert Kavlock, Kim Boekelheide, Robert Chapin, Michael Cunningham, Elaine Faustman, Paul Foster, Mari Golub, Rogene Henderson, Irwin Hinberg, Ruth Little, Jennifer Seed, Katherine Shea, Sonia Tabacova, Rochelle Tyl, Paige Williams & Timothy Zacharewski. (2002) NTP Center for the Evaluation of Risks to Human Reproduction: phthalates expert panel report on the reproductive and developmental toxicity of di-n-butyl phthalate. Reproductive Toxicology 16:5, pages 489-527.
Crossref
R. H. McKee, M. El‐Hawari, M. Stoltz, F. Pallas & A. W. Lington. (2002) Absorption, disposition and metabolism of di‐isononyl phthalate (DINP) in F‐344 rats. Journal of Applied Toxicology 22:5, pages 293-302.
Crossref
. (2016) Regulations and Advisories. Toxicology and Industrial Health 15:8, pages 718-742.
Crossref
D. F. Cadogan. 1998. Plastics Additives. Plastics Additives 505 512 .
H. A. A. M. Dirven, P. H. H. van den Broek, A. M. M. Arends, H. H. Nordkamp, A. J. G. M. de Lepper, P. Th. Henderson & F. J. Jongeneelen. (1993) Metabolites of the plasticizer di (2-ethylhexyl) phthalate in urine samples of workers in polyvinylchloride processing industries. International Archives of Occupational and Environmental Health 64:8, pages 549-554.
Crossref
Dorothy C. Gosting, M. Ellin Doyle, Carol E. Steinhart & Barbara A. Cochrane. 1991. Food Safety 1990. Food Safety 1990 171 259 .

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.