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Drug Metabolism Reviews Volume 24, 1992 - Issue 1
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Research Article

Acyl Glucuronides Revisited: Is the Glucuronidation Proces a Toxification as Well as a Detoxification Mechanism?

Hildegard Spahn Langguth Department of Pharmacy, University of California, San Francisco, California, 94143-0446; Pharmakologisches Institut für Naturwissenschaftler Johann Wolfgang Goethe-Universität, Theodor-Stern-Kai 7 Gebäude 75 A, D-6000, Frankfurt/M 70, Germany
&
Leslie Z. Benet Department of Pharmacy, University of California, San Francisco, California, 94143-0466, USA
Pages 5-47 | Published online: 22 Sep 2008

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Hiroyuki Ikuta, Hiroaki Shimada, Kenjiro Sakamoto, Rena Nakamura, Atsushi Kawase & Masahiro Iwaki. (2022) Species differences in liver microsomal hydrolysis of acyl glucuronide in humans and rats. Xenobiotica 52:7, pages 653-660.
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Norimasa Jinno, Mizuka Tagashira, Kazuyuki Tsurui & Shizuo Yamada. (2014) Contribution of cytochrome P450 and UDT-glucuronosyltransferase to the metabolism of drugs containing carboxylic acid groups: risk assessment of acylglucuronides using human hepatocytes. Xenobiotica 44:8, pages 677-686.
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K. Fujita, H. Kodaira, T. Kuwabara & H. Kobayashi. (2008) Pharmacokinetics and metabolism of KW-4490, a selective phosphodiesterase 4 inhibitor: Difference in excretion of KW-4490 and acylglucuronide metabolites between rats and cynomolgus monkeys. Xenobiotica 38:5, pages 511-526.
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Wei Tang. (2007) Drug metabolite profiling and elucidation of drug-induced hepatotoxicity. Expert Opinion on Drug Metabolism & Toxicology 3:3, pages 407-420.
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Silvio Garattini. (1997) Drug Metabolism: From Experiments to Regulatory Aspects. Drug Metabolism Reviews 29:3, pages 853-886.
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B. C. Cupid, C. R. Beddell, J. C. Lindon, I. D. Wilson & J. K. Nicholson. (1996) Quantitative structure-metabolism relationships for substituted benzoic acids in the rabbit: prediction of urinary excretion of glycine and glucuronide conjugates. Xenobiotica 26:2, pages 157-176.
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Urs A. Boelsterli, Hyman J. Zimmerman & Anke Kretz-Rommel. (1995) Idiosyncratic Liver Toxicity of Nonsteroidal Antiinflammatory Drugs: Molecular Mechanisms and Pathology. Critical Reviews in Toxicology 25:3, pages 207-235.
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P. C. Smith & J. H. Liu. (1995) Covalent binding of suprofen to renal tissue of rat correlates with excretion of its acyl glucuronide. Xenobiotica 25:5, pages 531-540.
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J. C. Ojingwa, H. Spahn-Langguth & L. Z. Benet. (1994) Irreversible binding of tolmetin to macromolecules via its glucuronide: Binding to blood constituents, tissue homogenates and subcellular fractions in vitro. Xenobiotica 24:6, pages 495-506.
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